Benze, Gesine

[["dc.bibliographiccitation.firstpage","201"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","American Journal of Hospice & Palliative Medicine"],["dc.bibliographiccitation.lastpage","213"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Oechsle, Karin"],["dc.contributor.author","Ullrich, Anneke"],["dc.contributor.author","Marx, Gabriella"],["dc.contributor.author","Benze, Gesine"],["dc.contributor.author","Wowretzko, Feline"],["dc.contributor.author","Zhang, Youyou"],["dc.contributor.author","Dickel, Lisa-Marie"],["dc.contributor.author","Heine, Julia"],["dc.contributor.author","Wendt, Kim Nikola"],["dc.contributor.author","Nauck, Friedemann"],["dc.contributor.author","Bokemeyer, Carsten"],["dc.contributor.author","Bergelt, Corinna"],["dc.date.accessioned","2020-12-10T18:38:29Z"],["dc.date.available","2020-12-10T18:38:29Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1177/1049909119872755"],["dc.identifier.eissn","1938-2715"],["dc.identifier.issn","1049-9091"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77341"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.orgunit","Klinik für Palliativmedizin"],["dc.title","Prevalence and Predictors of Distress, Anxiety, Depression, and Quality of Life in Bereaved Family Caregivers of Patients With Advanced Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","36"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie"],["dc.bibliographiccitation.lastpage","44"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Nauck, Friedemann"],["dc.contributor.author","Alt-Epping, Bernd"],["dc.contributor.author","Benze, Gesine"],["dc.date.accessioned","2018-11-07T10:03:37Z"],["dc.date.available","2018-11-07T10:03:37Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1055/s-0040-100205"],["dc.identifier.isi","000348799100007"],["dc.identifier.pmid","25634376"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38512"],["dc.language.iso","de"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1439-1074"],["dc.relation.issn","0939-2661"],["dc.relation.orgunit","Klinik für Palliativmedizin"],["dc.title","Palliativmedizin - Aktueller Stand in Klinik, Forschung und Lehre"],["dc.title.alternative","Palliative Care Current Status in Hospital, Research and Education"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","481"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Der Schmerz"],["dc.bibliographiccitation.lastpage","+"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Benze, Gesine"],["dc.contributor.author","Geyer, Almut"],["dc.contributor.author","Alt-Epping, Bernd"],["dc.contributor.author","Nauck, F."],["dc.date.accessioned","2018-11-07T09:06:19Z"],["dc.date.available","2018-11-07T09:06:19Z"],["dc.date.issued","2012"],["dc.description.abstract","Various recommendations exist for the treatment of nausea and vomiting in palliative care but only few studies and even less systematic reviews look into antiemetic therapy for patients receiving palliative care. This systematic review aims to analyze the current evidence for antiemetic treatment with 5HT3 receptor antagonists, steroids, antihistamines, anticholinergics, somatostatin analogs, benzodiazepines and cannabinoids in palliative care patients with far advanced cancer not receiving chemotherapy or radiotherapy, acquired immune deficiency syndrome (AIDS), chronic obstructive pulmonary disease (COPD), progressive heart failure, amyotrophic lateral sclerosis (ALS) or multiple sclerosis (MS). Results regarding evidence of treatment with prokinetic and neuroleptic agents will be published separately. The electronic databases PubMed and EmBase were systematically searched for studies (published 1966-2011) dealing with antiemetic therapy in palliative care and electronic retrieval was completed by manual searching. Studies with patients undergoing chemotherapy or radiotherapy, pediatric studies and studies published in languages other than English or German were excluded. Studies addressing therapy with 5HT3 receptor antagonists, steroids, antihistamines, anticholinergics, somatostatin analogs, benzodiazepines or cannabinoids were identified and selected for this systematic review. In the general search 75 relevant studies were found. Of those 36 addressed 5HT3 receptor antagonists, steroids, antihistamines, anticholinergics, somatostatin analogs, benzodiazepines and cannabinoids, 13 considered 5HT3 receptor antagonists, 10 somatostatin antagonists, 9 steroids, 5 cannabinoids, 4 anticholinergics, 1 antihistamines and none benzodiazepines. Furthermore six systematic reviews exist. Evidence for any drug used as an antiemetic is low. Concerning 5HT3 receptor antagonists data are insufficient for recommendations on the treatment of patients with AIDS and MS due to the small size of included patient groups. For patients with cancer contradictory results were published: the larger studies showed a positive effect of 5HT3 receptor antagonists and better efficacy, as compared to metoclopramide, dexamethasone and neuroleptics. Heterogeneous results were found for steroids, with a positive trend for patients with cancer. Data are insufficient for antihistamines. Studies prove effectiveness of butylscopolammonium in the treatment of nausea and vomiting caused by malignant gastrointestinal obstruction, whereas octreotide is superior to butylscopolammonium. Regarding benzodiazepines for symptom control of nausea and vomiting in palliative care patients no studies were detected. Cannabinoids were found to relieve nausea and vomiting in patients with cancer and AIDS but with notable side effects. Furthermore, the studies compared cannabinoids to less recent antiemetic drugs but not, for example to 5HT3 receptor antagonists. Regarding symptom control of nausea and vomiting in patients with COPD, progressive heart failure and ALS no studies were undertaken in patients receiving palliative care. In palliative care patients with nausea and vomiting 5HT3 receptor antagonists can be used if treatment with other antiemetics, such as metoclopramide and neuroleptics is not sufficient. There is a trend that steroids in combination with other antiemetics improve symptom relief. Cannabinoids rather have a status as a second line antiemetic. In cases of nausea and vomiting caused by malignant gastrointestinal obstruction octreotide showed the best and butylscopolammonium bromide the second best results. Concerning antihistamines and benzodiazepines insufficient data was found. Recommendations in the literature are mainly based on studies in patients with cancer. The overall strength of evidence is low. More well designed studies in palliative care patients are needed in order to provide evidence-based therapy. The English full text version of this article will be available in SpringerLink as of November 2012 (under \"Supplemental\")."],["dc.identifier.doi","10.1007/s00482-012-1235-4"],["dc.identifier.isi","000309349800003"],["dc.identifier.pmid","22983450"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25532"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0932-433X"],["dc.relation.orgunit","Klinik für Palliativmedizin"],["dc.title","Treatment of nausea and vomiting with 5HT3 receptor antagonists, steroids, antihistamines, anticholinergics, somatostatinantagonists, benzodiazepines and cannabinoids in palliative care patients.A systematic review"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1303"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Supportive Care in Cancer"],["dc.bibliographiccitation.lastpage","1315"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Ullrich, Anneke"],["dc.contributor.author","Marx, Gabriella"],["dc.contributor.author","Bergelt, Corinna"],["dc.contributor.author","Benze, Gesine"],["dc.contributor.author","Zhang, Youyou"],["dc.contributor.author","Wowretzko, Feline"],["dc.contributor.author","Heine, Julia"],["dc.contributor.author","Dickel, Lisa-Marie"],["dc.contributor.author","Nauck, Friedemann"],["dc.contributor.author","Bokemeyer, Carsten"],["dc.contributor.author","Oechsle, Karin"],["dc.date.accessioned","2021-04-14T08:24:43Z"],["dc.date.available","2021-04-14T08:24:43Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1007/s00520-020-05565-z"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81401"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1433-7339"],["dc.relation.issn","0941-4355"],["dc.relation.orgunit","Klinik für Palliativmedizin"],["dc.title","Supportive care needs and service use during palliative care in family caregivers of patients with advanced cancer: a prospective longitudinal study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","62"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz"],["dc.bibliographiccitation.lastpage","68"],["dc.bibliographiccitation.volume","60"],["dc.contributor.author","Benze, Gesine"],["dc.contributor.author","Alt-Epping, Bernd"],["dc.contributor.author","Nauck, Friedemann"],["dc.date.accessioned","2018-11-07T10:29:27Z"],["dc.date.available","2018-11-07T10:29:27Z"],["dc.date.issued","2017"],["dc.description.abstract","Crisis at the end of life are exceptional challenges for patients, relatives and therapists. With respect to the individual treatment goals and the patients' autonomy, therapeutic action should be commenced in an adequate manner in order to preserve the patients' quality of life as much as possible. Advance care planning for specific critical scenarios may be helpful in order to treat patients according to their wishes and values even if they are not capable to express themselves. Furthermore, a crisis plan can define the scope of action for therapists in emergency situations. Dyspnea, pain and delirium are symptoms that may often lead to emergency calls. In such cases, pharmacological and other treatment options are available. Options for causal therapy should be checked and performed if adequate. Opioids are used to relieve pain and dyspnea. In a state of delirium, highly potent neuroleptics and atypical antipsychotics are used. For the treatment of anxiety or restlessness benzodiazepines can be prescribed. Sedative medication may reduce stress, for instance in the case of acute catastrophic bleeding. Palliative sedation is an ultima ratio concept for refractory symptoms at the end of life. Clinical practice guidelines (such as the German guideline \"Palliative care for patients with incurable cancer\") may provide an overview of the evidence base on symptom-guided therapy at the end of life."],["dc.identifier.doi","10.1007/s00103-016-2477-6"],["dc.identifier.isi","000391359100009"],["dc.identifier.pmid","27878605"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43649"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.issn","1437-1588"],["dc.relation.issn","1436-9990"],["dc.relation.orgunit","Klinik für Palliativmedizin"],["dc.title","Specialmedical problems in end-of-life care. Crisis at the end of life - Which therapy is adequate and when is redefining treatment goals appropriate?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Palliative Care"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Oechsle, Karin"],["dc.contributor.author","Ullrich, Anneke"],["dc.contributor.author","Marx, Gabriella"],["dc.contributor.author","Benze, Gesine"],["dc.contributor.author","Heine, Julia"],["dc.contributor.author","Dickel, Lisa-Marie"],["dc.contributor.author","Zhang, Youyou"],["dc.contributor.author","Wowretzko, Feline"],["dc.contributor.author","Wendt, Kim Nikola"],["dc.contributor.author","Nauck, Friedemann"],["dc.contributor.author","Bokemeyer, Carsten"],["dc.contributor.author","Bergelt, Corinna"],["dc.date.accessioned","2020-12-10T18:38:56Z"],["dc.date.available","2020-12-10T18:38:56Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1186/s12904-019-0469-7"],["dc.identifier.eissn","1472-684X"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16702"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77486"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.relation.orgunit","Klinik für Palliativmedizin"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Psychological burden in family caregivers of patients with advanced cancer at initiation of specialist inpatient palliative care"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","500"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Der Schmerz"],["dc.bibliographiccitation.lastpage","514"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Benze, Gesine"],["dc.contributor.author","Alt-Epping, Bernd"],["dc.contributor.author","Geyer, Almut"],["dc.contributor.author","Nauck, F."],["dc.date.accessioned","2018-11-07T09:06:21Z"],["dc.date.available","2018-11-07T09:06:21Z"],["dc.date.issued","2012"],["dc.description.abstract","Many recommendations concerning the treatment of nausea and vomiting in palliative care patients exist but what is the evidence for this? Most studies dealing with this topic have focused on cancer patients under chemotherapy and/or radiation therapy or on patients with postoperative nausea. Cancer patients without chemotherapy or radiation therapy, patients without postoperative nausea, and patients having other diseases with palliative care aspects, such as acquired immunodeficiency syndrome (AIDS), chronic obstructive pulmonary disease (COPD), progressive heart failure, amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) have been underrepresented in studies on nausea and vomiting so far. The aim of this review was to determine the level of evidence for the treatment of nausea and vomiting with prokinetics and neuroleptics in palliative care patients suffering from far advanced cancer and no longer being treated with chemotherapy or radiation therapy, AIDS, COPD, progressive heart failure, ALS or MS. Two different electronic databases (PubMed und Embase) were used to identify studies. Furthermore, a hand search for related articles was performed. No restriction was made concerning study types. Studies with patients undergoing chemotherapy radiation therapy or suffering from postoperative nausea, pediatric studies and studies published neither in English nor in German were excluded. A total of 30 studies fulfilling the inclusion criteria were found. All studies focused on cancer patients. Despite intensive research studies in patients with AIDS, COPD, heart failure, ALS or MS were not detected. Metoclopramide is seen as an effective drug in many studies whereas the evidence for it is moderate at best. Within the group of neuroleptics, levosupiride and levomepromazine seem to have good antiemetic potential but the evidence level is low. In patients with advanced cancer not being treated with chemotherapy or radiation therapy, metoclopramide can be used to reduce nausea and vomiting. Neuroleptics, such as levosulpiride or levomepromazine are alternatives but their adverse effects have to be considered carefully. The evidence level for prokinetics and neuroleptics is moderate to low. Concerning palliative care of patients with diseases other than cancer no studies exist. More well designed studies in palliative care patients are needed in order to facilitate evidence based antiemetic therapy. The English full text version of this article will be available in SpringerLink as of November 2012 (under \"Supplemental\")."],["dc.identifier.doi","10.1007/s00482-012-1216-7"],["dc.identifier.isi","000309349800004"],["dc.identifier.pmid","22968365"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25536"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-2129"],["dc.relation.issn","0932-433X"],["dc.relation.orgunit","Klinik für Palliativmedizin"],["dc.title","Treatment of nausea and vomiting with prokinetics and neuroleptics in palliative care patients. A review"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","60"],["dc.bibliographiccitation.journal","BMC Medical Education"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Alt-Epping, Bernd"],["dc.contributor.author","Lohse, Constanze"],["dc.contributor.author","Viebahn, Christoph"],["dc.contributor.author","von Steinbuechel, Nicole"],["dc.contributor.author","Benze, Gesine"],["dc.contributor.author","Nauck, Friedemann"],["dc.date.accessioned","2018-11-07T09:45:01Z"],["dc.date.available","2018-11-07T09:45:01Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: Teaching in palliative care aims not only at providing students with specialized knowledge insymptom therapy in advanced disease but also at developing a professional attitude consistent with the principles and philosophy of palliative care. Reflecting about one's own or the patient's death and dying is considered essential for empathic patient care. In medical education the dissection course is often the first encounter with the issue of death and dying and represents a significant emotional challenge to many medical students. Against this background we implemented a new course element in preparation for the dissection course offering opportunity to reflect own experiences with death and dying and providing support in finding a balance between authentic empathy and pragmatic action towards deceased persons. We discuss issues such as dignity and professional distance and reason whether guided support for medical students regarding these issues might influence their future attitude as doctors caring for their patients. Methods: In tandem we performed a formal evaluation of the seminar and explored the students' experiences with death and dying their expectations and fears in the run-up to the dissection course and their attitude towards dissection. Results: This article describes the structure and the concept of this new interdisciplinary course element and presents the results of the formal course evaluation as well as the explorative part of the accompanying research. Medical students had broad experiences with death and dying even before the dissection course. 89.1% of students had worried about some kind of emotional stress during the dissection course before but 61.7% stated to have actually perceived emotional stress afterwards. The willingness to donate one's own body for anatomy purposes decreased significantly during the course. The given room for reflection and discussion was appreciated by the students who felt that the effects of this seminar might be of use even beyond the dissection course. Conclusion: This new course element successfully assisted medical students during the dissection room experience and gave opportunity to reflection and discussion on death and dying. The accompanying research confirmed the demand for support and gave insight into experiences emotions and attitudes of medical students."],["dc.identifier.doi","10.1186/1472-6920-14-15"],["dc.identifier.isi","000334377500001"],["dc.identifier.pmid","24467685"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9770"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34525"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1472-6920"],["dc.relation.orgunit","Klinik für Palliativmedizin"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","On death and dying - an exploratory and evaluative study of a reflective, interdisciplinary course element in undergraduate anatomy teaching"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","104"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Annals of palliative medicine"],["dc.bibliographiccitation.lastpage","111"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Benze, Gesine"],["dc.contributor.author","Nauck, Friedemann"],["dc.contributor.author","Alt-Epping, Bernd"],["dc.contributor.author","Gianni, Giuseppe"],["dc.contributor.author","Bauknecht, Thomas"],["dc.contributor.author","Ettl, Johannes"],["dc.contributor.author","Munte, Anna"],["dc.contributor.author","Kretzschmar, Luisa"],["dc.contributor.author","Gaertner, Jan"],["dc.date.accessioned","2020-12-10T18:42:52Z"],["dc.date.available","2020-12-10T18:42:52Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.21037/apm.2017.07.05"],["dc.identifier.eissn","2224-5839"],["dc.identifier.issn","2224-5820"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78115"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation.orgunit","Klinik für Palliativmedizin"],["dc.title","PROutine: a feasibility study assessing surveillance of electronic patient reported outcomes and adherence via smartphone app in advanced cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]