Schumacher, Johannes

[["dc.bibliographiccitation.firstpage","1425"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","American Journal of Medical Genetics Part B Neuropsychiatric Genetics"],["dc.bibliographiccitation.lastpage","1433"],["dc.bibliographiccitation.volume","153B"],["dc.contributor.author","Mathieu, Flavie"],["dc.contributor.author","Dizier, Marie-Helene"],["dc.contributor.author","Etain, Bruno"],["dc.contributor.author","Jamain, Stephane"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Albus, Margot"],["dc.contributor.author","McKeon, Patrick"],["dc.contributor.author","Roche, Siobhan"],["dc.contributor.author","Blackwood, Douglas"],["dc.contributor.author","Muir, Walter J."],["dc.contributor.author","Henry, Chantal"],["dc.contributor.author","Malafosse, Alain"],["dc.contributor.author","Preisig, Martin"],["dc.contributor.author","Ferrero, Francois"],["dc.contributor.author","Cichon, Sven"],["dc.contributor.author","Schumacher, Johannes"],["dc.contributor.author","Ohlraun, Stephanie"],["dc.contributor.author","Propping, Peter"],["dc.contributor.author","Abou Jamra, Rami"],["dc.contributor.author","Schulze, Thomas G."],["dc.contributor.author","Zelenica, Diana"],["dc.contributor.author","Charon, Celine"],["dc.contributor.author","Marusic, Andrej"],["dc.contributor.author","Dernovsek, Mojca C."],["dc.contributor.author","Gurling, Hugh"],["dc.contributor.author","Noethen, Markus"],["dc.contributor.author","Lathrop, Mark"],["dc.contributor.author","Leboyer, Marion"],["dc.contributor.author","Bellivier, Frank"],["dc.date.accessioned","2018-11-07T08:35:56Z"],["dc.date.available","2018-11-07T08:35:56Z"],["dc.date.issued","2010"],["dc.description.abstract","Bipolar disorder has a genetic component, but the mode of inheritance remains unclear. A previous genome scan conducted in 70 European families led to detect eight regions linked to bipolar disease. Here, we present an investigation of whether the phenotypic heterogeneity of the disorder corresponds to genetic heterogeneity in these regions using additional markers and an extended sample of families. The MLS statistic was used for linkage analyses. The predivided sample test and the maximum likelihood binomial methods were used to test genetic homogeneity between early-onset bipolar type I (cut-off of 22 years) and other types of the disorder (later onset of bipolar type I and early-onset bipolar type II), using a total of 138 independent bipolar-affected sib-pairs. Analysis of the extended sample of families supports linkage in four regions (2q14, 3p14, 16p23, and 20p12) of the eight regions of linkage suggested by our previous genome scan. Heterogeneity testing revealed genetic heterogeneity between early and late-onset bipolar type I in the 2q14 region (P=0.0001). Only the early form of the bipolar disorder but not the late form appeared to be linked to this region. This region may therefore include a genetic factor either specifically involved in the early-onset bipolar type I or only influencing the age at onset (AAO). Our findings illustrate that stratification according to AAO may be valuable for the identification of genetic vulnerability polymorphisms. (C) 2010 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/ajmg.b.31121"],["dc.identifier.isi","000284623200006"],["dc.identifier.pmid","20886542"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18198"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1552-4841"],["dc.title","European Collaborative Study of Early-Onset Bipolar Disorder: Evidence for Genetic Heterogeneity on 2q14 According to Age at Onset"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","The American Journal of Human Genetics"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Cichon, Sven"],["dc.contributor.author","Muehleisen, Thomas W."],["dc.contributor.author","Degenhardt, Franziska A."],["dc.contributor.author","Mattheisen, Manuel"],["dc.contributor.author","Miro, Xavier"],["dc.contributor.author","Strohmaier, Jana"],["dc.contributor.author","Steffens, Michael"],["dc.contributor.author","Meesters, Christian"],["dc.contributor.author","Herms, Stefan"],["dc.contributor.author","Weingarten, Moritz"],["dc.contributor.author","Priebe, Lutz"],["dc.contributor.author","Haenisch, Britta"],["dc.contributor.author","Alexander, Michael J."],["dc.contributor.author","Vollmer, Jennifer"],["dc.contributor.author","Breuer, Rene"],["dc.contributor.author","Schmael, Christine"],["dc.contributor.author","Tessmann, Peter"],["dc.contributor.author","Moebus, Susanne"],["dc.contributor.author","Wichmann, Heinz-Erich"],["dc.contributor.author","Schreiber, Stefan"],["dc.contributor.author","Mueller-Myhsok, Bertram"],["dc.contributor.author","Lucae, Susanne"],["dc.contributor.author","Jamain, Stephane"],["dc.contributor.author","Leboyer, Marion"],["dc.contributor.author","Bellivier, Frank"],["dc.contributor.author","Etain, Bruno"],["dc.contributor.author","Henry, Chantal"],["dc.contributor.author","Kahn, Jean-Pierre"],["dc.contributor.author","Heath, Simon"],["dc.contributor.author","Hamshere, Marian L."],["dc.contributor.author","O'Donovan, Michael C."],["dc.contributor.author","Owen, Michael J."],["dc.contributor.author","Craddock, Nick"],["dc.contributor.author","Schwarz, Markus"],["dc.contributor.author","Vedder, Helmut"],["dc.contributor.author","Kammerer-Ciernioch, Jutta"],["dc.contributor.author","Reif, Andreas"],["dc.contributor.author","Sasse, Johanna"],["dc.contributor.author","Bauer, Michael"],["dc.contributor.author","Hautzinger, Martin"],["dc.contributor.author","Wright, Adam"],["dc.contributor.author","Mitchell, Philip B."],["dc.contributor.author","Schofield, Peter R."],["dc.contributor.author","Montgomery, Grant W."],["dc.contributor.author","Medland, Sarah E."],["dc.contributor.author","Gordon, Scott D."],["dc.contributor.author","Martin, Nicholas G."],["dc.contributor.author","Gustafsson, Omar"],["dc.contributor.author","Andreassen, Ole A."],["dc.contributor.author","Djurovic, Srdjan"],["dc.contributor.author","Sigurdsson, Engilbert"],["dc.contributor.author","Steinberg, Stacy"],["dc.contributor.author","Stefansson, Hreinn"],["dc.contributor.author","Stefansson, Kari"],["dc.contributor.author","Kapur-Pojskic, Lejla"],["dc.contributor.author","Oruc, Liliana"],["dc.contributor.author","Rivas, Fabio"],["dc.contributor.author","Mayoral, Fermin"],["dc.contributor.author","Chuchalin, Alexander"],["dc.contributor.author","Babadjanova, Gulja"],["dc.contributor.author","Tiganov, Alexander S."],["dc.contributor.author","Pantelejeva, Galina"],["dc.contributor.author","Abramova, Lilia I."],["dc.contributor.author","Grigoroiu-Serbanescu, Maria"],["dc.contributor.author","Diaconu, Carmen C."],["dc.contributor.author","Czerski, Piotr M."],["dc.contributor.author","Hauser, Joanna"],["dc.contributor.author","Zimmer, Andreas"],["dc.contributor.author","Lathrop, Mark"],["dc.contributor.author","Schulze, Thomas G."],["dc.contributor.author","Wienker, Thomas F."],["dc.contributor.author","Schumacher, Johannes"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Propping, Peter"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Noethen, Markus M."],["dc.date.accessioned","2018-11-07T08:58:10Z"],["dc.date.available","2018-11-07T08:58:10Z"],["dc.date.issued","2011"],["dc.format.extent","396"],["dc.identifier.doi","10.1016/j.ajhg.2011.03.001"],["dc.identifier.isi","000288589000019"],["dc.identifier.pmid","21353194"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23581"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cell Press"],["dc.relation.issn","0002-9297"],["dc.title","Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder (vol 88, pg 372, 2011)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","24"],["dc.bibliographiccitation.issue","1-3"],["dc.bibliographiccitation.journal","Schizophrenia Research"],["dc.bibliographiccitation.lastpage","30"],["dc.bibliographiccitation.volume","122"],["dc.contributor.author","Nieratschker, Vanessa"],["dc.contributor.author","Frank, Josef"],["dc.contributor.author","Muehleisen, Thomas W."],["dc.contributor.author","Strohmaier, Jana"],["dc.contributor.author","Wendland, Jens R."],["dc.contributor.author","Schumacher, Johannes"],["dc.contributor.author","Treutlein, Jens"],["dc.contributor.author","Breuer, Rene"],["dc.contributor.author","Abou Jamra, Rami"],["dc.contributor.author","Mattheisen, Manuel"],["dc.contributor.author","Herms, Stefan"],["dc.contributor.author","Schmael, Christine"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Noethen, Markus M."],["dc.contributor.author","Cichon, Sven"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Schulze, Thomas G."],["dc.date.accessioned","2018-11-07T08:40:11Z"],["dc.date.available","2018-11-07T08:40:11Z"],["dc.date.issued","2010"],["dc.description.abstract","The aim of the present study was to investigate possible associations between schizophrenia and 13 SNP markers in COMT. No association was observed in 631 cases, 207 nuclear families, and 776 controls. A cognitive performance phenotype (Trail Marking Test) was available for a subgroup of the patients. No association was found between the 13 markers and this phenotype. Four clinically-defined subgroups (early age at onset, negative symptoms, family history of schizophrenia, and life-time major depressive episode) were also investigated. Associations were observed for 3 of these subgroups, although none withstood correction for multiple testing. COMT does not appear to be a risk factor for schizophrenia in this population. (C) 2010 Elsevier B.V. All rights reserved."],["dc.identifier.doi","10.1016/j.schres.2010.06.018"],["dc.identifier.isi","000286406900002"],["dc.identifier.pmid","20643532"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19164"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","0920-9964"],["dc.title","The catechol-O-methyl transferase (COMT) gene and its potential association with schizophrenia: Findings from a large German case-control and family-based sample"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","906"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Molecular Psychiatry"],["dc.bibliographiccitation.lastpage","917"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Mattheisen, Manuel"],["dc.contributor.author","Degenhardt, Franziska A."],["dc.contributor.author","Muehleisen, Thomas W."],["dc.contributor.author","Kirsch, Peter"],["dc.contributor.author","Esslinger, Christine"],["dc.contributor.author","Herms, Stefan"],["dc.contributor.author","Demontis, D."],["dc.contributor.author","Steffens, Michael"],["dc.contributor.author","Strohmaier, Jana"],["dc.contributor.author","Haenisch, Britta"],["dc.contributor.author","Breuer, Rene"],["dc.contributor.author","Czerski, Piotr M."],["dc.contributor.author","Giegling, Ina"],["dc.contributor.author","Strengman, E."],["dc.contributor.author","Schmael, C."],["dc.contributor.author","Mors, Ole"],["dc.contributor.author","Mortensen, Preben Bo"],["dc.contributor.author","Hougaard, D. M."],["dc.contributor.author","Orntoft, Torben F."],["dc.contributor.author","Kapelski, P."],["dc.contributor.author","Priebe, Lutz"],["dc.contributor.author","Basmanav, F. Buket U."],["dc.contributor.author","Forstner, Andreas J."],["dc.contributor.author","Hoffmann, P."],["dc.contributor.author","Meier, Sandra"],["dc.contributor.author","Nikitopoulos, J."],["dc.contributor.author","Moebus, Susanne"],["dc.contributor.author","Alexander, M."],["dc.contributor.author","Moessner, R."],["dc.contributor.author","Wichmann, H-E"],["dc.contributor.author","Schreiber, S."],["dc.contributor.author","Rivandeneira, Fernando"],["dc.contributor.author","Hofman, Albert"],["dc.contributor.author","Uitterlinden, Andre G."],["dc.contributor.author","Wienker, Thomas F."],["dc.contributor.author","Schumacher, J."],["dc.contributor.author","Hauser, Joanna"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Cantor, R. M."],["dc.contributor.author","Erk, S."],["dc.contributor.author","Schulze, Thomas G."],["dc.contributor.author","Craddock, N."],["dc.contributor.author","Owen, M. J."],["dc.contributor.author","O'Donovan, M. C."],["dc.contributor.author","Borglum, Anders D."],["dc.contributor.author","Rujescu, Dan"],["dc.contributor.author","Walter, H."],["dc.contributor.author","Meyer-Lindenberg, Andreas"],["dc.contributor.author","Noethen, M. M."],["dc.contributor.author","Ophoff, Roel A."],["dc.contributor.author","Cichon, Sven"],["dc.date.accessioned","2018-11-07T09:06:48Z"],["dc.date.available","2018-11-07T09:06:48Z"],["dc.date.issued","2012"],["dc.description.abstract","Recent molecular studies have implicated common alleles of small to moderate effect and rare alleles with larger effect sizes in the genetic architecture of schizophrenia (SCZ). It is expected that the reliable detection of risk variants with very small effect sizes can only be achieved through the recruitment of very large samples of patients and controls (that is tens of thousands), or large, potentially more homogeneous samples that have been recruited from confined geographical areas using identical diagnostic criteria. Applying the latter strategy, we performed a genome-wide association study (GWAS) of 1169 clinically well characterized and ethnically homogeneous SCZ patients from a confined area of Western Europe (464 from Germany, 705 from The Netherlands) and 3714 ethnically matched controls (1272 and 2442, respectively). In a subsequent follow-up study of our top GWAS results, we included an additional 2569 SCZ patients and 4088 controls (from Germany, The Netherlands and Denmark). Genetic variation in a region on chromosome 11 that contains the candidate genes AMBRA1, DGKZ, CHRM4 and MDK was significantly associated with SCZ in the combined sample (n = 11 540; P = 3.89 x 10(-9), odds ratio (OR) = 1.25). This finding was replicated in 23 206 independent samples of European ancestry (P = 0.0029, OR= 1.11). In a subsequent imaging genetics study, healthy carriers of the risk allele exhibited altered activation in the cingulate cortex during a cognitive control task. The area of interest is a critical interface between emotion regulation and cognition that is structurally and functionally abnormal in SCZ and bipolar disorder. Molecular Psychiatry (2012) 17, 906-917; doi: 10.1038/mp.2011.80; published online 12 July 2011"],["dc.identifier.doi","10.1038/mp.2011.80"],["dc.identifier.isi","000308063900007"],["dc.identifier.pmid","21747397"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25636"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1476-5578"],["dc.relation.issn","1359-4184"],["dc.title","Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","3339"],["dc.bibliographiccitation.journal","Nature Communications"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Muehleisen, Thomas W."],["dc.contributor.author","Leber, Markus"],["dc.contributor.author","Schulze, Thomas G."],["dc.contributor.author","Strohmaier, Jana"],["dc.contributor.author","Degenhardt, Franziska A."],["dc.contributor.author","Treutlein, Jens"],["dc.contributor.author","Mattheisen, Manuel"],["dc.contributor.author","Forstner, Andreas J."],["dc.contributor.author","Schumacher, Johannes"],["dc.contributor.author","Breuer, Rene"],["dc.contributor.author","Meier, Sandra"],["dc.contributor.author","Herms, Stefan"],["dc.contributor.author","Hoffmann, Per"],["dc.contributor.author","Lacour, Andre"],["dc.contributor.author","Witt, Stephanie H."],["dc.contributor.author","Reif, Andreas"],["dc.contributor.author","Müller-Myhsok, Bertram"],["dc.contributor.author","Lucae, Susanne"],["dc.contributor.author","Maier, Wolfgang"],["dc.contributor.author","Schwarz, Markus"],["dc.contributor.author","Vedder, Helmut"],["dc.contributor.author","Kammerer-Ciernioch, Jutta"],["dc.contributor.author","Pfennig, Andrea"],["dc.contributor.author","Bauer, Michael"],["dc.contributor.author","Hautzinger, Martin"],["dc.contributor.author","Moebus, Susanne"],["dc.contributor.author","Priebe, Lutz"],["dc.contributor.author","Czerski, Piotr M."],["dc.contributor.author","Hauser, Joanna"],["dc.contributor.author","Lissowska, Jolanta"],["dc.contributor.author","Szeszenia-Dabrowska, Neonila"],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Wright, Adam"],["dc.contributor.author","Mitchell, Philip B."],["dc.contributor.author","Fullerton, Janice M."],["dc.contributor.author","Schofield, Peter R."],["dc.contributor.author","Montgomery, Grant W."],["dc.contributor.author","Medland, Sarah E."],["dc.contributor.author","Gordon, Scott D."],["dc.contributor.author","Martin, Nicholas G."],["dc.contributor.author","Krasnow, Valery"],["dc.contributor.author","Chuchalin, Alexander"],["dc.contributor.author","Babadjanova, Gulja"],["dc.contributor.author","Pantelejeva, Galina"],["dc.contributor.author","Abramova, Lilia I."],["dc.contributor.author","Tiganov, Alexander S."],["dc.contributor.author","Polonikov, Alexey"],["dc.contributor.author","Khusnutdinova, Elza"],["dc.contributor.author","Alda, Martin"],["dc.contributor.author","Grof, Paul"],["dc.contributor.author","Rouleau, Guy A."],["dc.contributor.author","Turecki, Gustavo"],["dc.contributor.author","Laprise, Catherine"],["dc.contributor.author","Rivas, Fabio"],["dc.contributor.author","Mayoral, Fermin"],["dc.contributor.author","Kogevinas, Manolis"],["dc.contributor.author","Grigoroiu-Serbanescu, Maria"],["dc.contributor.author","Propping, Peter"],["dc.contributor.author","Becker, Tim"],["dc.contributor.author","Rietschel, Marcella"],["dc.contributor.author","Nöthen, Markus M."],["dc.contributor.author","Cichon, Sven"],["dc.date.accessioned","2018-11-07T09:42:56Z"],["dc.date.available","2018-11-07T09:42:56Z"],["dc.date.issued","2014"],["dc.description.abstract","Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility. Large samples are necessary to detect these risk loci. Here we present results from the largest BD GWAS to date by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls. We detect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3, ODZ4 and TRANK1, as well as the risk locus ADCY2 (5p15.31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD."],["dc.identifier.doi","10.1038/ncomms4339"],["dc.identifier.isi","000334295200001"],["dc.identifier.pmid","24618891"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34073"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","2041-1723"],["dc.title","Genome-wide association study reveals two new risk loci for bipolar disorder"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]