Kastrup, Andreas

[["dc.bibliographiccitation.firstpage","2309"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","2318"],["dc.bibliographiccitation.volume","259"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Hildebrandt, Helmut"],["dc.contributor.author","Groeschel, Sonja"],["dc.contributor.author","Stojanovic, Tomislav"],["dc.contributor.author","Schmidt, Holger"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Pilgram-Pastor, Sara M."],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Kastrup, Andreas"],["dc.date.accessioned","2018-11-07T09:04:12Z"],["dc.date.available","2018-11-07T09:04:12Z"],["dc.date.issued","2012"],["dc.description.abstract","Although evidence is accumulating that age modifies the risk of carotid angioplasty and stenting (CAS) versus endarterectomy (CEA) for patients with significant carotid stenosis, the impact of age on cognition after either CEA or CAS remains unclear. In this study, we analyzed the effects of age on cognitive performance after either CEA or CAS using a comprehensive neuropsychological test battery with parallel test forms and a control group to exclude a learning effect. The neuropsychological outcomes after revascularization were determined in 19 CAS and 27 CEA patients with severe carotid stenosis. The patients were subdivided according to their median age (< 68 years and a parts per thousand yen68 years); 27 healthy subjects served as a control group. In all patients clinical examinations, MRI scans and a neuropsychological test battery that assessed four major cognitive domains were performed immediately before, within 72 h, and 3 months after CEA or CAS. While patients < 68 years of age showed no significant cognitive alteration after either CEA or CAS, a significant cognitive decline was observed in patients a parts per thousand yen68 years in both treatment groups (p = 0.001). Notably, this cognitive deterioration persisted in patients after CEA, whereas it was only transient in patients treated with CAS. These results demonstrate an age-dependent effect of CEA and CAS on cognitive functions. In contrast to the recently observed increased clinical complication rates in older subjects after CAS compared with CEA, CEA appears to be associated with a greater, persistent decline in cognitive performance than CAS in this subgroup of patients."],["dc.identifier.doi","10.1007/s00415-012-6491-9"],["dc.identifier.isi","000310472100006"],["dc.identifier.pmid","22527231"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8810"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25062"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Age-dependent effects of carotid endarterectomy or stenting on cognitive performance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","338"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Neurology"],["dc.bibliographiccitation.lastpage","343"],["dc.bibliographiccitation.volume","62"],["dc.contributor.author","Terborg, Christoph"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Petrovitch, Alexander"],["dc.contributor.author","Ringer, Thomas"],["dc.contributor.author","Schnaudigel, Sonja"],["dc.contributor.author","Witte, Otto-Wilhelm"],["dc.contributor.author","Kastrup, Andreas"],["dc.date.accessioned","2018-11-07T08:34:27Z"],["dc.date.available","2018-11-07T08:34:27Z"],["dc.date.issued","2009"],["dc.description.abstract","Background: In acute stroke patients, there is a need for noninvasive measurement to monitor blood flow-based therapies. We investigated the utility of near-infrared spectroscopy (NIRS) to determine cerebral perfusion in these patients. Methods: Eleven patients were investigated within 1.4 +/- 2.2 days after onset of an ischemic middle cerebral artery infarction by monitoring the kinetics of an intravenous bolus of indocyanine green (ICG). For ICG kinetics, bolus peak time, time to peak (TTP = time between 0 and 100% ICG maximum), maximum ICG concentration, rise time (time between 10 and 90% ICG maximum), slope (maximum ICG/TTP), and blood flow index (BFI = maximum ICG/rise time) were obtained. Perfusion-weighted MRI (PWI) and NIRS measurements were performed within 24 h, and the interhemispherical differences of TTP values were compared. Results: Stroke patients showed an increased bolus peak time (p < 0.02), TTP (p < 0.01), and rise time (p < 0.01), whereas slope (p < 0.01) and BFI ( p ! 0.01) were diminished at the site of infarction as compared to the unaffected hemisphere. The interhemispherical differences of TTP as measured by PWI and NIRS were closely correlated (r = 0.86). Conclusions: Noninvasive measurements of cerebral ICG kinetics by NIRS provide a useful means of detecting cerebral perfusion deficits in patients with acute stroke, which correlate well with those obtained by PWI. Copyright (C) 2009 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000239794"],["dc.identifier.isi","000270366000004"],["dc.identifier.pmid","19776588"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9319"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17815"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0014-3022"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Noninvasive Assessment of Cerebral Perfusion and Oxygenation in Acute Ischemic Stroke by Near-Infrared Spectroscopy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1228"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.lastpage","1233"],["dc.bibliographiccitation.volume","258"],["dc.contributor.author","Groeschel, Klaus"],["dc.contributor.author","Schnaudigel, Sonja"],["dc.contributor.author","Wasser, Katrin"],["dc.contributor.author","Pilgram-Pastor, Sara M."],["dc.contributor.author","Ernemann, Ulrike"],["dc.contributor.author","Knauth, Michael"],["dc.contributor.author","Kastrup, Andreas"],["dc.date.accessioned","2018-11-07T08:54:42Z"],["dc.date.available","2018-11-07T08:54:42Z"],["dc.date.issued","2011"],["dc.description.abstract","Treatment of a symptomatic stenosis is known to be most beneficial within 14 days after the presenting event but this can frequently not be achieved in daily practice. The aim of this study was the assessment of factors responsible for this time delay to treatment. A retrospective analysis of a prospective two-center CAS database was carried out to investigate the potential factors that influence a delayed CAS treatment. Of 374 patients with a symptomatic carotid stenosis, 59.1% were treated beyond a parts per thousand yen14 days. A retinal TIA event (OR = 3.59, 95% CI 1.47-8.74, p < 0.01) was found to be a predictor for a delayed treatment, whereas the year of the intervention (OR = 0.32, 95% CI 0.20-0.50, p < 0.01) and a contralateral carotid occlusion (OR = 0.42, 95% CI 0.21-0.86, p = 0.02) were predictive of an early treatment. Similarly, within the subgroup of patients with transient symptoms, the year of the intervention (OR = 0.28, 95% CI 0.14-0.59, p < 0.01) was associated with an early treatment, whereas a retinal TIA as the qualifying event (OR = 6.96, 95% CI 2.37-20.47, p < 0.01) was associated with a delayed treatment. Treatment delay was most pronounced in patients with an amaurosis fugax, whereas a contralateral carotid occlusion led to an early intervention. Although CAS is increasingly performed faster in the last years, there is still scope for an even more accelerated treatment strategy, which might prevent future recurrent strokes prior to treatment."],["dc.identifier.doi","10.1007/s00415-011-5909-0"],["dc.identifier.isi","000292554700004"],["dc.identifier.pmid","21264472"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8055"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22731"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","0340-5354"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Factors associated with time delay to carotid stenting in patients with a symptomatic carotid artery stenosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]