Cohrs, Stefan

[["dc.bibliographiccitation.firstpage","939"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","CNS Drugs"],["dc.bibliographiccitation.lastpage","962"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Cohrs, Stefan"],["dc.date.accessioned","2018-11-07T11:19:43Z"],["dc.date.available","2018-11-07T11:19:43Z"],["dc.date.issued","2008"],["dc.description.abstract","Difficulties initiating or maintaining sleep are frequently encountered in patients with schizophrenia. Disturbed sleep can be found in 30-80% of schizophrenic patients, depending on the degree of psychotic symptomatology. Measured by polysomnography, reduced sleep efficiency and total sleep time, as well as increased sleep latency, are found in most patients with schizophrenia and appear to be an important part of the pathophysiology of this disorder. Some studies also reported alterations of stage 2 sleep, slow-wave sleep (SWS) and rapid eye movement (REM) sleep variables, i.e. reduced REM latency and REM density. A number of sleep parameters, such as the amount of SWS and the REM latency, are significantly correlated to clinical variables, including severity of illness, positive symptoms, negative symptoms, outcome, neurocognitive impairment and brain structure. Concerning specific sleep disorders, there is some evidence that schizophrenic patients carry a higher risk of experiencing a sleep-related breathing disorder, especially those demonstrating the known risk factors, including being overweight but also long-term use of antipsychotics. However, it is still unclear whether periodic leg movements in sleep or restless legs syndrome (RLS) are found with a higher or lower prevalence in schizophrenic patients than in healthy controls. There are no consistent effects of first-generation antipsychotics on measures of sleep continuity and sleep structure, including the percentage of sleep stages or sleep and REM latency in healthy controls. In contrast to first-generation antipsychotics, the studied atypical antipsychotics (clozapine, olanzapine, quetiapine, risperidone, ziprasidone and paliperidone) demonstrate a relatively consistent effect on measures of sleep continuity, with an increase in either total sleep time (TST) or sleep efficiency, and individually varying effects on other sleep parameters, such as an increase in REM latency observed for olanzapine, quetiapine and ziprasidone, and an increase in SWS documented for olanzapine and ziprasidone in healthy subjects. The treatment of schizophrenic patients with first-generation antipsychotics is consistently associated with an increase in TST and sleep efficiency, and mostly an increase in REM latency, whereas the influence on specific sleep stages is more variable. On the other hand, withdrawal of such treatment is followed by a change in sleep structure mainly in the opposite direction, indicating a deterioration of sleep quality. On the background of the rather inconsistent effects of first-generation antipsychotics observed in healthy subjects, it appears possible that the high-potency drugs exert their effects on sleep in schizophrenic patients, for the most part, in an indirect way by suppressing stressful psychotic symptomatology. In contrast, the available data concerning second-generation antipsychotics (clozapine, olanzapine, risperidone and paliperidone) demonstrate a relatively consistent effect on measures of sleep continuity in patients and healthy subjects, with an increase in TST and sleep efficiency or a decrease in wakefulness. Additionally, clozapine and olanzapine demonstrate comparable influences on other sleep variables, such as SWS or REM density, in controls and schizophrenic patients. Possibly, the effects of second-generation antipsychotics observed on sleep in healthy subjects and schizophrenic patients might involve the action of these drugs on symptomatology, such as depression, cognitive impairment, and negative and positive symptoms. Specific sleep disorders, such as RLS, sleep-related breathing disorders, night-eating syndrome, somnambulism and rhythm disorders have been described as possible adverse effects of antipsychotics and should be considered in the differential diagnosis of disturbed or unrestful sleep in this population. Difficulties initiating or maintaining sleep are frequently encountered in patients with schizophrenia. Sleep disturbance is often part of the prodromal phase before the development of manifest psychotic symptomatology, it may persist during the course of the disorder and appears to be involved in the pathophysiology of a variety of clinical aspects of this illness. Therefore, the influence of antipsychotic medication on sleep in general and specifically on sleep in patients. with schizophrenia is of special interest. This article describes the basic characteristics of sleep regulation, subjective and polysomnographic measures of sleep disturbance in schizophrenic patients, and the available information on the relationship between sleep and different areas of patients' impairment, including severity of illness, positive and negative symptoms, outcome, and cognitive deficits. Based on this information, we present the available knowledge about the effects of first- and second-generation antipsychotics on sleep in healthy subjects and in patients with schizophrenia. Additionally, specific sleep disorders and their relevance to the care of schizophrenic patients are described. A computer-based MEDLINE search was conducted of available articles published between January 1966 and October 2007 using the following key terms: schizophren and sleep, antipsychot or neurolept and sleep, and (amisulprid , or benperidol , or bromperidol , or chlorpromazine , or chlorprothix , or clopenthixol , or clozapine, or flupentixol, or fluphenazin , or fluspirilen , or haloperidol or levomepromazin , or melperon , or olanzapin , or perazin , or perphenazin , or pimozid , or pipamperon , or promazin , or prothipendyl, or quetiapin , or risperidon , or sertindol , or sulpirid , or thioridazin , or trifluperazin , or trifluperidol , or trifluperazin , or zotepin, or ziprasidone, or zuclopenthixol) and (sleep EEG or polysomnogra or [sleep and EEG]). The references of published articles identified from the search strategy were also examined for any additional references. The articles were limited to studies conducted with human participants."],["dc.description.sponsorship","AstraZeneca"],["dc.identifier.doi","10.2165/00023210-200822110-00004"],["dc.identifier.isi","000260569800004"],["dc.identifier.pmid","18840034"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55353"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Adis Int Ltd"],["dc.relation.issn","1172-7047"],["dc.title","Sleep Disturbances in Patients with Schizophrenia Impact and Effect of Antipsychotics"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Pharmacopsychiatry"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Meier, A."],["dc.contributor.author","Neumann, A. C."],["dc.contributor.author","Jordan, W."],["dc.contributor.author","Huther, G."],["dc.contributor.author","Rodenbeck, Andrea"],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Cohrs, Stefan"],["dc.date.accessioned","2018-11-07T10:56:36Z"],["dc.date.available","2018-11-07T10:56:36Z"],["dc.date.issued","2005"],["dc.format.extent","263"],["dc.identifier.isi","000232591900169"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50052"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.publisher.place","Stuttgart"],["dc.relation.conference","24th Symposium of the Arbeitsgemeinschaft-fur-Neuropsychopharmakologie-und-Pharmakopsychiatrie (AGNP)"],["dc.relation.eventlocation","Munich, GERMANY"],["dc.relation.issn","0176-3679"],["dc.title","Reduced cortisol excretion in healthy subjects under treatment with ziprasidone"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S69"],["dc.bibliographiccitation.journal","Journal of Neural Transmission"],["dc.bibliographiccitation.lastpage","S78"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Skarupke, Christian"],["dc.contributor.author","Schlack, Robert"],["dc.contributor.author","Lange, Karoline"],["dc.contributor.author","Goerke, Monique"],["dc.contributor.author","Dueck, Alexander"],["dc.contributor.author","Thome, Johannes"],["dc.contributor.author","Szagun, Bertram"],["dc.contributor.author","Cohrs, Stefan"],["dc.date.accessioned","2018-11-07T10:28:02Z"],["dc.date.available","2018-11-07T10:28:02Z"],["dc.date.issued","2017"],["dc.description.abstract","The purpose of the study was to study the associations of tobacco, alcohol, marijuana, and coffee use and insomnia complaints (IC) in adolescents with special consideration of the influence of coffee consumption on these relationships. 7698 Subjects aged 11-17 years were investigated in a cross-sectional study within the German Health Interview and Examination Survey for Children and Adolescents. Self-report questionnaires were distributed to the participants. Hierarchical regression analyses were performed to assess possible effects of coffee consumption on the association of tobacco, alcohol, and marijuana use with IC. Common risk factors for insomnia were included in the adjusted analyses. Tobacco, alcohol, marijuana and coffee use displayed significant bivariate associations with IC. After adjusting the first three substances for coffee consumption, their associations with IC were reduced considerably. After additionally adjusting for other potential confounders (age, gender, socio-economic status, externalizing and internalizing psychiatric problems, media use, bodyweight, medical condition), frequent coffee consumption, high alcohol intake and frequent smoking contributed to the prediction of IC in male subjects while frequent coffee consumption and high alcohol intake predicted the occurrence of IC in females. Coffee consumption could be an important risk factor for IC in adolescents and it significantly affects the association of smoking, alcohol, and marijuana with IC. Future research that includes long-term studies about psychoactive substance use (PSU) and sleep should also consider coffee consumption. Parents, educators, clinicians, and researchers should be aware of the potentially hazardous influence of PSU, especially coffee, alcohol and tobacco, on sleep in young individuals."],["dc.identifier.doi","10.1007/s00702-015-1448-7"],["dc.identifier.isi","000394161800006"],["dc.identifier.pmid","26321356"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43336"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.publisher.place","Wien"],["dc.relation.issn","1435-1463"],["dc.relation.issn","0300-9564"],["dc.title","Insomnia complaints and substance use in German adolescents: did we underestimate the role of coffee consumption? Results of the KiGGS study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","414"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Psychopharmacology"],["dc.bibliographiccitation.lastpage","420"],["dc.bibliographiccitation.volume","174"],["dc.contributor.author","Cohrs, Stefan"],["dc.contributor.author","Pohlmann, K."],["dc.contributor.author","Guan, Zhenghua"],["dc.contributor.author","Jordan, W."],["dc.contributor.author","Meier, A."],["dc.contributor.author","Huether, Gerald"],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Rodenbeck, Andrea"],["dc.date.accessioned","2018-11-07T10:47:56Z"],["dc.date.available","2018-11-07T10:47:56Z"],["dc.date.issued","2004"],["dc.description.abstract","Rationale. Hypothalamic-pituitary-adrenal (HPA) axis dysfunction is a frequent finding in psychiatric disorders, including psychotic depression and schizophrenia. Conflicting results exist concerning the influence of antipsychotics on the HPA-axis. Objective. Therefore, this double-blind, placebo-controlled, randomized cross-over study investigated the effect of quetiapine on nocturnal urinary cortisol and melatonin excretion in 13 healthy male subjects under conditions of undisturbed and experimentally disturbed sleep. Methods. Volunteers were studied 3 times for 3 consecutive nights (N0, adaptation; N1, standard sleep conditions; N2, acoustic stress) 4 days apart. Placebo, quetiapine 25 mg or quetiapine 100 mg was administered orally 1 h before bedtime on nights 1 and 2. Urine produced during the 8-h bedtime period was collected for later determination of cortisol and melatonin concentrations by standard radioimmunoassays. Results. MANOVA showed a significant effect for N1 vs. N2 with elevated total amount of cortisol (p<0.005) and melatonin (p<0.05) excretion after acoustic stress. Both quetiapine 25 mg and 100 mg significantly (p<0.0005) reduced the total amount of cortisol excretion in comparison to placebo. No interaction effect of stress condition was observed. There was no effect of quetiapine on melatonin levels. Conclusion. The significant reduction of nocturnal cortisol excretion following quetiapine reflects a decreased activity of the HPA-axis in healthy subjects. This finding may be an important aspect in quetiapine's mode of action in different patient populations."],["dc.identifier.doi","10.1007/s00213-003-1766-6"],["dc.identifier.isi","000222646700013"],["dc.identifier.pmid","14735295"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48081"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0033-3158"],["dc.title","Quetiapine reduces nocturnal urinary cortisol excretion in healthy subjects"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","160"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Somnologie"],["dc.bibliographiccitation.lastpage","164"],["dc.bibliographiccitation.volume","1"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Klotz, S."],["dc.contributor.author","Jordan, Wolfgang"],["dc.contributor.author","Cohrs, S."],["dc.contributor.author","Engelke, W."],["dc.contributor.author","Ludwig, A."],["dc.contributor.author","Hajak, G."],["dc.date.accessioned","2017-11-21T12:29:46Z"],["dc.date.available","2017-11-21T12:29:46Z"],["dc.date.issued","1997"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/10138"],["dc.language.iso","de"],["dc.notes.status","final"],["dc.title","Erste Ergebnisse zum Training der suprahyoidalen Muskulatur bei Probanden und einem Patienten mit obstruktiver Schlafapnoe"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","205"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Psychiatrische Praxis"],["dc.bibliographiccitation.lastpage","210"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Jordan, Wolfgang"],["dc.contributor.author","Bielau, Hendrik"],["dc.contributor.author","Cohrs, Stefan"],["dc.contributor.author","Hauth, Iris"],["dc.contributor.author","Hornstein, Christiane"],["dc.contributor.author","Marx, Alexandra"],["dc.contributor.author","Reck, Corinna"],["dc.contributor.author","von Einsiedel, Regina"],["dc.date.accessioned","2018-11-07T09:08:19Z"],["dc.date.available","2018-11-07T09:08:19Z"],["dc.date.issued","2012"],["dc.description.abstract","Concern: The current care and financial situation of mother-child units for psychic disorders associated with pregnancies in Germany should be documented in preparation for the development of the new reimbursement system for psychiatry and psychosomatics. Method: In accordance with the last survey of 2005, a brief questionnaire was developed and a nationwide poll was conducted. Results: The survey revealed severe (10 fold) service deficits for severely and gravely mentally ill mothers, who require an inpatient treatment with specific professional competence. Compared with the last poll, these service deficits have increased. This is due to continued insufficient funding and unresolved financing in the new reimbursement system. With the establishment of an additional code for mother-child treatment the precondition for ensuring the funding of this important care form in the new reimbursement system was created. Conclusion: It is to be hoped that the decision-makers of health policy will finally face up to their social responsibility and ensure adequate funding of the additional diagnostic and therapeutic expenditure of mother-child treatment. The health care providers have an obligation to implement a transparent record of services of the additional expenditure and to augment the national evaluation approaches to inpatient mother-child treatments."],["dc.identifier.doi","10.1055/s-0032-1304918"],["dc.identifier.isi","000309031400003"],["dc.identifier.pmid","22581675"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26003"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0303-4259"],["dc.title","Actual Care and Funding Situation with Regard to Mother-Child Units for Psychic Disorders Associated with Pregnancy in Germany"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","SLEEP"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Cohrs, Stefan"],["dc.contributor.author","Erb, J."],["dc.contributor.author","Goerke, Monique"],["dc.contributor.author","Stoll, Christian"],["dc.contributor.author","Szagun, Bertram"],["dc.date.accessioned","2018-11-07T08:48:35Z"],["dc.date.available","2018-11-07T08:48:35Z"],["dc.date.issued","2010"],["dc.format.extent","A201"],["dc.identifier.isi","000208208001082"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21251"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Acad Sleep Medicine"],["dc.publisher.place","Westchester"],["dc.relation.issn","0161-8105"],["dc.title","SLEEP DISTURBANCE IN GERMAN ADOLESCENTS: ASSOCIATED RISKS AND RESOURCES"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","87"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Sleep Research"],["dc.bibliographiccitation.lastpage","93"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Kirov, Roumen"],["dc.contributor.author","Kinkelbur, J."],["dc.contributor.author","Heipke, S."],["dc.contributor.author","Kostanecka-Endress, T."],["dc.contributor.author","Westhoff, M."],["dc.contributor.author","Cohrs, Stefan"],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Hajak, Goran"],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Rothenberger, A."],["dc.date.accessioned","2018-11-07T10:50:47Z"],["dc.date.available","2018-11-07T10:50:47Z"],["dc.date.issued","2004"],["dc.description.abstract","The aim of the study was to characterize the sleep pattern in children with attention deficit/hyperactivity disorder (ADHD). By means of polysomnography (PSG), sleep patterns were studied in 17 unmedicated preadolescent boys rigorously diagnosed with ADHD and 17 control boys precisely matched for age and intelligence. Although ADHD children did not display a general sleep alteration, major PSG data showed a significant increase in the duration of the absolute rapid eye movement (REM) sleep and the number of sleep cycles in ADHD group when compared with controls. In addition, REM sleep latency tended to be shorter in ADHD children. These results suggest that in ADHD children, a forced REM sleep initiation may produce a higher incidence of sleep cycles and may also contribute to an increased duration of the absolute REM sleep. The overall pattern of the findings implies that a forced ultradian cycling appears characteristic for the sleep in ADHD children, which may be related to alterations of brain monoamines and cortical inhibitory control accompanying the ADHD psychopathology."],["dc.identifier.doi","10.1111/j.1365-2869.2004.00387.x"],["dc.identifier.isi","000189141800011"],["dc.identifier.pmid","14996040"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48733"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing Ltd"],["dc.relation.issn","0962-1105"],["dc.title","Is there a specific polysomnographic sleep pattern in children with attention deficit/hyperactivity disorder?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","867"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","SLEEP"],["dc.bibliographiccitation.lastpage","874"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Jordan, W."],["dc.contributor.author","Tumani, Hayrettin"],["dc.contributor.author","Cohrs, Stefan"],["dc.contributor.author","Eggert, S."],["dc.contributor.author","Rodenbeck, Andrea"],["dc.contributor.author","Brunner, E."],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Hajak, Goran"],["dc.date.accessioned","2018-11-07T10:47:06Z"],["dc.date.available","2018-11-07T10:47:06Z"],["dc.date.issued","2004"],["dc.description.abstract","Study Objectives: The prostaglandin D system plays an important role in animal sleep. In humans, alterations in the prostaglandin D system have been found in diseases exhibiting sleep disturbances as a prominent symptom, such as trypanosoma infection, systemic mastocytosis, bacterial meningitis, major depression, or obstructive sleep apnea. Assessment of this system's activity in relation to human physiologic sleep was the target of the present study. Design: Serum concentrations of lipocalin-type prostaglandin D synthase (L-PGDS, former P-trace), and plasma levels of the pineal hormone melatonin were measured in 20 healthy humans (10 women, 10 men; aged: 23.3 +/- 2.39 years) at 4-hour intervals over a period of 5 days and nights, which included physiologic sleep, rapid eye movement sleep deprivation, and total sleep deprivation. In addition, the serum L-PGDS and plasma melatonin levels of 6 subjects were determined under conditions of bright white (10,000 lux) or dark red light (< 50 lux) in a crossover design during total sleep deprivation. Nocturnal blood sampling was performed by a through-the-wall tube system. L-PGDS was measured by an automated immunonephelometric assay, and melatonin was analyzed by direct radioimmunoassay. Results: Serum L-PGDS concentrations showed marked time-dependent changes with evening increases and the highest values at night (P < .0005). This nocturnal increase was suppressed during total sleep deprivation (P < .05), independent of external light conditions and melatonin secretion. Rapid eye movement sleep deprivation had no impact on circulating L-PGDS levels. Conclusions: The circadian L-PGDS pattern and its suppression by total sleep deprivation indicate an interaction of the prostaglandin D system and human sleep regulation. L-PGDS measurements may well provide new insights into physiologic and pathologic sleep regulation in humans."],["dc.identifier.isi","000223451400008"],["dc.identifier.pmid","15453544"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47897"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Academy Sleep Medicine"],["dc.relation.issn","0161-8105"],["dc.title","Prostaglandin D synthase (beta-trace) in healthy human sleep"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","23"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Psychosomatic Research"],["dc.bibliographiccitation.lastpage","29"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Kostanecka-Endress, T."],["dc.contributor.author","Banaschewski, Tobias"],["dc.contributor.author","Kinkelbur, J."],["dc.contributor.author","Wullner, I."],["dc.contributor.author","Lichtblau, S."],["dc.contributor.author","Cohrs, Stefan"],["dc.contributor.author","Ruther, Eckart"],["dc.contributor.author","Woerner, W."],["dc.contributor.author","Hajak, Goran"],["dc.contributor.author","Rothenberger, A."],["dc.date.accessioned","2018-11-07T10:38:02Z"],["dc.date.available","2018-11-07T10:38:02Z"],["dc.date.issued","2003"],["dc.description.abstract","Objective: To evaluate objective data on sleep quantity/quality and motor activity during night sleep in children with Tourette syndrome (TS). Method: Polysomnography of 17 unmedicated TS children (ages: 7;11-15;5, mean: 11;10 years) without comorbid attention-deficit hyperactivity disorder (ADHD) was compared with 16 age-, sex- and IQ-matched healthy controls. Sleep analyses according to the procedure of Rechtschaffen and Kales were supplemented by counting epochs with short arousal-related movements (less than or equal to15 s), thus allowing to calculate correlations between motor activity and sleep parameters. Results: Children with TS demonstrated changes in sleep parameters, including longer sleep period time, longer sleep latency, reduced sleep efficiency, and prolonged wakefulness after sleep onset. Their sleep profiles showed significantly more time awake and less sleep stage II. However, REM sleep variables, slow-wave sleep, and number of sleep stage changes were unaffected. Movement time was similar in both groups, but epochs with short arousal-related movements were increased in TS. Further analyses showed no significant correlations between sleep parameters and nighttime nontic movements, level of psychopathology or tic severity during daytime. Periodic limb movements during sleep (PLMS) were only seen in one TS patient (low PLMS index of 7.8/h). Conclusions: Children with TS have disturbed sleep quality with increased arousal phenomena, which both may be intrinsic to the disorder and might trigger tics and other behavioral problems during daytime. This indicates the need for sleep evaluation in patients with TS. (C) 2003 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/S0022-3999(02)00602-5"],["dc.identifier.isi","000184078300005"],["dc.identifier.pmid","12842228"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45714"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.publisher.place","Oxford"],["dc.relation.conference","International Conference of the Tourette-Syndrome-Foundation-of-Canada"],["dc.relation.eventlocation","MISSISSAUGA, CANADA"],["dc.relation.issn","0022-3999"],["dc.title","Disturbed sleep in children with Tourette syndrome - A polysomnographic study"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]