Stahl-Hennig, Christiane

[["dc.bibliographiccitation.firstpage","300"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Virology"],["dc.bibliographiccitation.lastpage","309"],["dc.bibliographiccitation.volume","383"],["dc.contributor.author","Schulte, Reiner"],["dc.contributor.author","Suh, You-Suk"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Ochieng, Washingtone"],["dc.contributor.author","Sopper, Sieghart"],["dc.contributor.author","Kim, Kwang S."],["dc.contributor.author","Ahn, So-Shin"],["dc.contributor.author","Park, Ki S."],["dc.contributor.author","Stolte-Leeb, Nicole"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.date.accessioned","2021-06-01T10:49:57Z"],["dc.date.available","2021-06-01T10:49:57Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1016/j.virol.2008.10.012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86471"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0042-6822"],["dc.title","Mucosal prior to systemic application of recombinant adenovirus boosting is more immunogenic than systemic application twice but confers similar protection against SIV-challenge in DNA vaccine-primed macaques"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","316"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Immunology and Cell Biology"],["dc.bibliographiccitation.lastpage","320"],["dc.bibliographiccitation.volume","95"],["dc.contributor.author","Kotb, Ahmad"],["dc.contributor.author","Klippert, Antonina"],["dc.contributor.author","Daskalaki, Maria"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Stahl‐Hennig, Christiane"],["dc.contributor.author","Neumann, Berit"],["dc.date.accessioned","2021-06-01T10:50:33Z"],["dc.date.available","2021-06-01T10:50:33Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1038/icb.2016.96"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86700"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1440-1711"],["dc.relation.issn","0818-9641"],["dc.title","Elevated granzyme B + B‐cell level in SIV‐infection correlate with viral load and low CD4 T‐cell count"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","253"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Medical Primatology"],["dc.bibliographiccitation.lastpage","262"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Klippert, Antonina"],["dc.contributor.author","Stolte-Leeb, Nicole"],["dc.contributor.author","Neumann, Berit"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Daskalaki, Maria"],["dc.contributor.author","Gawanbacht, Ali"],["dc.contributor.author","Kirchhoff, Frank"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.date.accessioned","2021-06-01T10:47:23Z"],["dc.date.available","2021-06-01T10:47:23Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1111/jmp.12186"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85587"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0047-2565"],["dc.title","Frequencies of lymphoid T-follicular helper cells obtained longitudinally by lymph node fine-needle aspiration correlate significantly with viral load in SIV-infected rhesus monkeys"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","448"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Viral Immunology"],["dc.bibliographiccitation.lastpage","457"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Stolte-Leeb, Nicole"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Norley, Stephen"],["dc.contributor.author","Fagrouch, Zahra"],["dc.contributor.author","Heeney, Jonathan"],["dc.contributor.author","Franz, Monika"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.date.accessioned","2022-10-06T13:34:50Z"],["dc.date.available","2022-10-06T13:34:50Z"],["dc.date.issued","2006"],["dc.description.abstract","As part of a European multicenter study designed to determine the optimal combination and order of a mixed-modality vaccine against acquired immunodeficiency syndrome, rhesus monkeys received a combination of three different vectors, all expressing the same Simian Immunodeficiency Virus (SIV) genes followed by mucosal challenge with highly pathogenic SIV. In the study reported here, animals were primed with DNA followed by one booster immunization with Semliki Forest Virus (SFV) and two immunizations with modified Vaccinia Ankara (MVA). To address the relevance of mucosal immunization, we compared systemic versus a combination of systemic and mucosal antigen application. Although all vaccinees became infected after intrarectal challenge with SIV, most (six of eight) were protected from profound loss of CD4+ cells. In addition, vaccinees showed lower viral loads than did controls (p < 0.05). Overall, these protective effects were more pronounced in those animals whose schedule included immunization via the mucosa. In summary, the vaccine regimen used here achieved one important criterion of efficacy: the suppression of disease development as indicated by conservation of CD4+ cells."],["dc.identifier.doi","10.1089/vim.2006.19.448"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115988"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1557-8976"],["dc.relation.issn","0882-8245"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Sustained Conservation of CD4 + T Cells in Multiprotein Triple Modality-Immunized Rhesus Macaques after Intrarectal Challenge with Simian Immunodeficiency Virus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","392"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Virology"],["dc.bibliographiccitation.lastpage","397"],["dc.bibliographiccitation.volume","212"],["dc.contributor.author","Dittmer, Ulf"],["dc.contributor.author","Nißlein, Thomas"],["dc.contributor.author","Bodemer, Walter"],["dc.contributor.author","Petry, Harald"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Hunsmann, Gerhard"],["dc.date.accessioned","2022-10-06T13:26:57Z"],["dc.date.available","2022-10-06T13:26:57Z"],["dc.date.issued","1995"],["dc.identifier.doi","10.1006/viro.1995.1496"],["dc.identifier.pii","S0042682285714961"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115207"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0042-6822"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Cellular Immune Response of Rhesus Monkeys Infected with a Partially Attenuated nef Deletion Mutant of the Simian Immunodeficiency Virus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2273"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Journal of General Virology"],["dc.bibliographiccitation.lastpage","2284"],["dc.bibliographiccitation.volume","95"],["dc.contributor.author","Sopper, Sieghart"],["dc.contributor.author","Mätz-Rensing, Kerstin"],["dc.contributor.author","Mühl, Thorsten"],["dc.contributor.author","Heeney, Jonathan"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Sauermann, Ulrike"],["dc.date.accessioned","2021-06-01T10:47:03Z"],["dc.date.available","2021-06-01T10:47:03Z"],["dc.date.issued","2014"],["dc.description.abstract","Infection of macaques with live attenuated simian immunodeficiency virus (SIV) usually results in long-lasting efficient protection against infection with pathogenic immunodeficiency viruses. However, attenuation by deletion of regulatory genes such as nef is not complete, leading to a high viral load and fatal disease in some animals. To characterize immunological parameters and polymorphic host factors, we studied 17 rhesus macaques infected with attenuated SIVmac239ΔNU. Eight animals were able to control viral replication, whereas the remaining animals (non-controllers) displayed variable set-point viral loads. Peak viral load at 2 weeks post-infection (p.i.) correlated significantly with set-point viral load ( P <0.0001). CD4 + T-cell frequencies differed significantly soon after infection between controllers and non-controllers. Abnormal B-cell activation previously ascribed to Nef function could already be observed in non-controllers 8 weeks after infection despite the absence of Nef. Two non-controllers developed an AIDS-like disease within 102 weeks p.i. Virus from these animals transmitted to naïve animals replicated at low levels and the recipients did not develop immunodeficiency. This suggested that host factors determined differential viral load and subsequent disease course. Known Mhc class I alleles associated with disease progression in SIV WT infection only marginally influenced the viral load in Δ nef -infected animals. Protection from SIVmac251 was associated with homozygosity for MHC class II in conjunction with a TLR7 polymorphism and showed a trend with initial viral replication. We speculated that host factors whose effects were usually masked by Nef were responsible for the different disease courses in individual animals upon infection with nef -deleted viruses."],["dc.identifier.doi","10.1099/vir.0.066563-0"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85465"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1465-2099"],["dc.relation.issn","0022-1317"],["dc.title","Host factors determine differential disease progression after infection with nef-deleted simian immunodeficiency virus"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Retrovirology"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Münch, Jan"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Yolamanova, Maral"],["dc.contributor.author","Raue, Katharina"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Kirchhoff, Frank"],["dc.date.accessioned","2022-10-06T13:26:10Z"],["dc.date.available","2022-10-06T13:26:10Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1186/1742-4690-10-148"],["dc.identifier.pii","3638"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115017"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1742-4690"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Effect of semen and seminal amyloid on vaginal transmission of simian immunodeficiency virus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","247"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Immunogenetics"],["dc.bibliographiccitation.lastpage","251"],["dc.bibliographiccitation.volume","59"],["dc.contributor.author","Averdam, Anne"],["dc.contributor.author","Seelke, Sandra"],["dc.contributor.author","Gruetzner, Immanuel"],["dc.contributor.author","Rosner, Cornelia"],["dc.contributor.author","Roos, Christian"],["dc.contributor.author","Westphal, Nico"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Muppala, Vijayakumar"],["dc.contributor.author","Schrod, Annette"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Dressel, Ralf"],["dc.contributor.author","Walter, Lutz"],["dc.date.accessioned","2018-11-07T11:04:28Z"],["dc.date.available","2018-11-07T11:04:28Z"],["dc.date.issued","2007"],["dc.description.abstract","MIC molecules are stress-inducible ligands of the activating receptor NKG2D, which is expressed on natural killer cells and subsets of T lymphocytes. In rhesus macaques (Macaca mulatta), three different MIC sequences (MIC1, MIC2, MIC3) have been described that are closely related to but, according to phylogenetic analysis, do not represent orthologues of the human MICA and MICB genes. Although a single haplotype of the rhesus macaque Mhc (Mamu) has been completely sequenced, it remained unknown so far whether these three sequences are derived from two or three Mamu-MIC genes. We genotyped a cohort of 115 rhesus macaque individuals for the presence of MIC1, MIC2, and MIC3 sequences and analysed the segregation in families. All individuals were positive for MIC2, whereas only 66.1 and 80.9 % were positive for MIC1 and MIC3, respectively. MIC1 and MIC3 sequences segregated in offspring, indicating that they behave as alleles. Thus, we conclude that two MIC genes are present in the rhesus macaque Mhc, which we propose to designate as Mamu-MICA (MIC1 and MIC3) and Mamu-MICB (MIC2). \"MIC1\" and \"MIC3\" are regarded as divergent allelic lineages of the Mamu-MICA gene. Mamu-MIC genotyping of DNA of a cohort of 68 experimentally simian immunodeficiency virus (SIV)-infected rhesus macaques revealed no significant association of either of the two Mamu-MICA allelic lineages with differences in progression to AIDS-like symptoms."],["dc.identifier.doi","10.1007/s00251-006-0187-1"],["dc.identifier.isi","000244066300007"],["dc.identifier.pmid","17216437"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51851"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0093-7711"],["dc.title","Genotyping and segregation analyses indicate the presence of only two functional MIC genes in rhesus macaques"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","61"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Virology"],["dc.bibliographiccitation.lastpage","70"],["dc.bibliographiccitation.volume","254"],["dc.contributor.author","Kirchhoff, Frank"],["dc.contributor.author","Carl, Silke"],["dc.contributor.author","Sopper, Sieghart"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Mätz-Rensing, Kerstin"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.date.accessioned","2022-10-06T13:26:58Z"],["dc.date.available","2022-10-06T13:26:58Z"],["dc.date.issued","1999"],["dc.identifier.doi","10.1006/viro.1998.9522"],["dc.identifier.pii","S0042682298995228"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115213"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0042-6822"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Selection of the R17Y Substitution in SIVmac239 Nef Coincided with a Dramatic Increase in Plasma Viremia and Rapid Progression to Death"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","13180"],["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","Journal of Virology"],["dc.bibliographiccitation.lastpage","13190"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Stahl-Hennig, Christiane"],["dc.contributor.author","Kuate, Seraphin"],["dc.contributor.author","Franz, Monika"],["dc.contributor.author","Suh, You S."],["dc.contributor.author","Stoiber, Heribert"],["dc.contributor.author","Sauermann, Ulrike"],["dc.contributor.author","Tenner-Racz, Klara"],["dc.contributor.author","Norley, Stephen"],["dc.contributor.author","Park, Ki S."],["dc.contributor.author","Sung, Young C."],["dc.contributor.author","Überla, Klaus"],["dc.date.accessioned","2022-10-06T13:25:35Z"],["dc.date.available","2022-10-06T13:25:35Z"],["dc.date.issued","2007"],["dc.description.abstract","ABSTRACT\n The development of needle-free vaccines is one of the recently defined “grand challenges in global health” (H. Varmus, R. Klausner, R. Klausner, R. Zerhouni, T. Acharya, A. S. Daar, and P. A. Singer, Science 302:398-399, 2003). To explore whether a natural pathway to the inductive site of the mucosa-associated lymphatic tissue could be exploited for atraumatic immunization purposes, replication-deficient viral vector vaccines were sprayed directly onto the tonsils of rhesus macaques. Tonsillar immunization with viral vector vaccines encoding simian immunodeficiency virus (SIV) antigens induced cellular and humoral immune responses. Viral RNA levels after a stringent SIV challenge were reduced, providing a level of protection similar to that observed after systemic immunization with the same vaccines. Thus, atraumatic oral spray immunization with replication-deficient vectors can overcome the epithelial barrier, deliver the vaccine antigen to the mucosa-associated lymphatic tissue, and avoid induction of tolerance, providing a novel approach to circumvent acceptability problems of syringe and needle vaccines for children and in developing countries."],["dc.identifier.doi","10.1128/JVI.01400-07"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114872"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1098-5514"],["dc.relation.issn","0022-538X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://journals.asm.org/non-commercial-tdm-license"],["dc.title","Atraumatic Oral Spray Immunization with Replication-Deficient Viral Vector Vaccines"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]