Bräuer, Anselm

[["dc.bibliographiccitation.artnumber","e0284"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Critical Care Explorations"],["dc.bibliographiccitation.lastpage","5"],["dc.bibliographiccitation.volume","2"],["dc.contributor.author","Hofmann-Winkler, Heike"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Alt-Epping, Sabine"],["dc.contributor.author","Bräuer, Anselm"],["dc.contributor.author","Büttner, Benedikt"],["dc.contributor.author","Müller, Martin"],["dc.contributor.author","Fricke, Torben"],["dc.contributor.author","Grundmann, Julian"],["dc.contributor.author","Harnisch, Lars-Olav"],["dc.contributor.author","Heise, Daniel"],["dc.contributor.author","Kernchen, Andrea"],["dc.contributor.author","Pressler, Meike"],["dc.contributor.author","Stephani, Caspar"],["dc.contributor.author","Tampe, Björn"],["dc.contributor.author","Kaul, Artur"],["dc.contributor.author","Gärtner, Sabine"],["dc.contributor.author","Kramer, Stefanie"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.contributor.author","Winkler, Martin Sebastian"],["dc.date.accessioned","2020-11-27T11:23:20Z"],["dc.date.accessioned","2021-10-27T13:22:21Z"],["dc.date.available","2020-11-27T11:23:20Z"],["dc.date.available","2021-10-27T13:22:21Z"],["dc.date.issued","2020"],["dc.description.abstract","Objectives: Severe acute respiratory syndrome coronavirus 2 cell entry depends on angiotensin-converting enzyme 2 and transmembrane serine protease 2 and is blocked in cell culture by camostat mesylate, a clinically proven protease inhibitor. Whether camostat mesylate is able to lower disease burden in coronavirus disease 2019 sepsis is currently unknown. Design: Retrospective observational case series. Setting: Patient treated in ICU of University hospital Göttingen, Germany. Patients: Eleven critical ill coronavirus disease 2019 patients with organ failure were treated in ICU. Interventions: Compassionate use of camostat mesylate (six patients, camostat group) or hydroxychloroquine (five patients, hydroxychloroquine group). Measurements and Main Results: Clinical courses were assessed by Sepsis-related Organ Failure Assessment score at days 1, 3, and 8. Further, viral load, oxygenation, and inflammatory markers were determined. Sepsis-related Organ Failure Assessment score was comparable between camostat and hydroxychloroquine groups upon ICU admission. During observation, the Sepsis-related Organ Failure Assessment score decreased in the camostat group but remained elevated in the hydroxychloroquine group. The decline in disease severity in camostat mesylate treated patients was paralleled by a decline in inflammatory markers and improvement of oxygenation. Conclusions: The severity of coronavirus disease 2019 decreased upon camostat mesylate treatment within a period of 8 days and a similar effect was not observed in patients receiving hydroxychloroquine. Camostat mesylate thus warrants further evaluation within randomized clinical trials."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2020"],["dc.identifier.doi","10.1097/CCE.0000000000000284"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17663"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92088"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.eissn","2639-8028"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","610"],["dc.title","Camostat Mesylate May Reduce Severity of Coronavirus Disease 2019 Sepsis: A First Observation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","7541"],["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","International Journal of Environmental Research and Public Health"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Nemeth, Marcus"],["dc.contributor.author","Miller, Clemens"],["dc.contributor.author","Bräuer, Anselm"],["dc.date.accessioned","2021-08-12T07:45:58Z"],["dc.date.available","2021-08-12T07:45:58Z"],["dc.date.issued","2021"],["dc.description.abstract","Background: First described by paediatric anaesthesiologists, perioperative hypothermia is one of the earliest reported side effects of general anaesthesia. Deviations from normothermia are associated with numerous complications and adverse outcomes, with infants and small children at the highest risk. Nowadays, maintenance of normothermia is an important quality metric in paediatric anaesthesia. Methods: This review is based on our collection of publications regarding perioperative hypothermia and was supplemented with pertinent publications from a MEDLINE literature search. Results: We provide an overview on perioperative hypothermia in the paediatric patient, including definition, history, incidence, development, monitoring, risk factors, and adverse events, and provide management recommendations for its prevention. We also summarize the side effects and complications of perioperative temperature management. Conclusions: Perioperative hypothermia is still common in paediatric patients and may be attributed to their vulnerable physiology, but also may result from insufficient perioperative warming. An effective perioperative warming strategy incorporates the maintenance of normothermia during transportation, active warming before induction of anaesthesia, active warming during anaesthesia and surgery, and accurate measurement of core temperature. Perioperative temperature management must also prevent hyperthermia in children."],["dc.description.abstract","Background: First described by paediatric anaesthesiologists, perioperative hypothermia is one of the earliest reported side effects of general anaesthesia. Deviations from normothermia are associated with numerous complications and adverse outcomes, with infants and small children at the highest risk. Nowadays, maintenance of normothermia is an important quality metric in paediatric anaesthesia. Methods: This review is based on our collection of publications regarding perioperative hypothermia and was supplemented with pertinent publications from a MEDLINE literature search. Results: We provide an overview on perioperative hypothermia in the paediatric patient, including definition, history, incidence, development, monitoring, risk factors, and adverse events, and provide management recommendations for its prevention. We also summarize the side effects and complications of perioperative temperature management. Conclusions: Perioperative hypothermia is still common in paediatric patients and may be attributed to their vulnerable physiology, but also may result from insufficient perioperative warming. An effective perioperative warming strategy incorporates the maintenance of normothermia during transportation, active warming before induction of anaesthesia, active warming during anaesthesia and surgery, and accurate measurement of core temperature. Perioperative temperature management must also prevent hyperthermia in children."],["dc.description.sponsorship","3M San Antonio, TX, USA"],["dc.identifier.doi","10.3390/ijerph18147541"],["dc.identifier.pii","ijerph18147541"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/88585"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.publisher","MDPI"],["dc.relation.eissn","1660-4601"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Perioperative Hypothermia in Children"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Acta Anaesthesiologica Scandinavica"],["dc.bibliographiccitation.lastpage","5"],["dc.bibliographiccitation.volume","64"],["dc.contributor.author","Grote, Rolf"],["dc.contributor.author","Wetz, Anna"],["dc.contributor.author","Bräuer, Anselm"],["dc.contributor.author","Menzel, Matthias"],["dc.date.accessioned","2020-01-14T10:38:14Z"],["dc.date.accessioned","2021-10-27T13:22:05Z"],["dc.date.available","2020-01-14T10:38:14Z"],["dc.date.available","2021-10-27T13:22:05Z"],["dc.date.issued","2019"],["dc.description.abstract","BACKGROUND: Prevention of inadvertent hypothermia is recommended for procedures >30 minutes because hypothermia increases the risk of myocardial ischemia, intraoperative blood loss, transfusion and wound complications. Therefore, short warming interruptions between pre-warming and intraoperative warming might result in lower hypothermia rates. The aim of this retrospective investigation was to determine whether the incidence of inadvertent intraoperative hypothermia was affected by the warming interruption. METHODS: The lowest intraoperative body core temperature value and the warming interruption time were taken from anaesthesia records. Body core temperature was recorded continuously, and a patient was classified to be hypothermic if the lowest recorded temperature value was <36°C. Hypothermia rates and the correlation between warming interruption times and intraoperative hypothermia rates were calculated. RESULTS: Five thousand eighty-four patients were analysed. The intraoperative hypothermia rate was 15.3%. Nineteen patients (0.4%) had a recorded temperature of <35.0°C. An increase in forced-air warming interruption time was significantly associated with an increase in intraoperative hypothermia rates (P < .0001). Patients with interruptions in forced-air warming >20 minutes showed significantly higher hypothermia rates than those with interruptions of ≤20 minutes (P < .0001). CONCLUSION: Intraoperative hypothermia rates increased significantly with longer forced-air warming interruptions between pre-warming and intraoperative warming. Short warming interruptions can preserve the effect of pre-warming and are associated with low intraoperative hypothermia rates."],["dc.identifier.doi","10.1111/aas.13521"],["dc.identifier.eissn","1399-6576"],["dc.identifier.issn","0001-5172"],["dc.identifier.pmid","31828757"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17088"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/92067"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.eissn","1399-6576"],["dc.relation.issn","1399-6576"],["dc.relation.issn","0001-5172"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Short interruptions between pre‐warming and intraoperative warming are associated with low intraoperative hypothermia rates"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","183"],["dc.bibliographiccitation.journal","CRITICAL CARE"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Wetz, Anna J."],["dc.contributor.author","Braeuer, Anselm"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Heise, Daniel"],["dc.date.accessioned","2018-11-07T09:58:22Z"],["dc.date.available","2018-11-07T09:58:22Z"],["dc.date.issued","2015"],["dc.description.abstract","Introduction: Postoperative acute kidney injury (AKI) is a frequently observed phenomenon after cardiac surgery with cardio-pulmonary bypass (CPB); this severe complication is associated with adverse patient outcomes. There are multiple mechanisms involved in AKI during cardiac surgery, including CPB-dependent hemolysis. An IV infusion of sodium bicarbonate, which leads to urine alkalization, may play a role in preventing AKI. Recently, several trials have investigated the effect of sodium bicarbonate and reported controversial results. The purpose of this investigation was to investigate the following question. Under what circumstances can sodium bicarbonate prevent postoperative AKI? Methods: We analyzed data from 342 patients undergoing CPB surgery at the University Hospital Goettingen, Germany. A total of 174 patients received a preemptive dose of sodium bicarbonate. Directly after the induction of anesthesia, the continuous infusion of 0.15 mmol/kg body weight/h was started and continued until 2 pm on the first postoperative day. Patients who were not treated with sodium bicarbonate formed the control group (n = 168). To verify the AKI risk configuration of each group, we surveyed risk factors and determined the commonly used clinical predictive score according to Thakar and colleagues. We recorded the concentration of free hemoglobin (fhb) to estimate the amount of CPB-dependent hemolysis. The definition of AKI was acquired by applying the AKI-network (AKIN) classification over the course of five postoperative days. Results: Patients who received the sodium bicarbonate infusion showed a significantly lower incidence (35.6 vs. 50%) of AKI than that of patients who did not receive the infusion (p = 0.01). AKIN levels 2 and 3 were also more frequent when sodium bicarbonate was not administered. Particularly, in the low-risk cohort (<3 Thakar points), the incidence of AKI was significantly reduced (26 vs. 46%) when patients received sodium bicarbonate (p = 0.01), whereas in the high-risk patients, no significant reduction was observed. Conclusion: In this study, we observed that low-risk patients particularly benefited from the preventive treatment with sodium bicarbonate. The incidence of AKI was significantly reduced in low-risk patients while there was no statistically significant difference in the high-risk patient cohort."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2015"],["dc.identifier.doi","10.1186/s13054-015-0906-9"],["dc.identifier.isi","000356480100001"],["dc.identifier.pmid","25899029"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13465"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37351"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1364-8535"],["dc.relation.issn","1466-609X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Does sodium bicarbonate infusion really have no effect on the incidence of acute kidney injury after cardiac surgery? A prospective observational trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","18"],["dc.bibliographiccitation.journal","BMC Anesthesiology"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Russo, Sebastian Giuseppe"],["dc.contributor.author","Cremer, Stephan"],["dc.contributor.author","Galli, Tamara"],["dc.contributor.author","Eich, Christoph B."],["dc.contributor.author","Braeuer, Anselm"],["dc.contributor.author","Crozier, Thomas A."],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Strack, Micha"],["dc.date.accessioned","2018-11-07T09:07:16Z"],["dc.date.available","2018-11-07T09:07:16Z"],["dc.date.issued","2012"],["dc.description.abstract","Background: The i-gel (TM), LMA-Supreme (LMA-S) and Laryngeal Tube Suction-D (LTS-D) are single-use supraglottic airway devices with an inbuilt drainage channel. We compared them with regard to their position in situ as well as to clinical performance data during elective surgery. Methods: Prospective, randomized, comparative study of three groups of 40 elective surgical patients each. Speed of insertion and success rates, leak pressures (LP) at different cuff pressures, dynamic airway compliance, and signs of postoperative airway morbidity were recorded. Fibreoptic evaluation was used to determine the devices' position in situ. Results: Leak pressures were similar (i-gel (TM) 25.9, LMA-S 27.1, LTS-D 24.0 cmH(2)O; the latter two at 60 cmH(2)O cuff pressure) as were insertion times (i-gel (TM) 10, LMA-S 11, LTS-D 14 sec). LP of the LMA-S was higher than that of the LTS-D at lower cuff pressures (p < 0.05). Insertion success rates differed significantly: i-gel (TM) 95%, LMA-S 95%, LTS-D 70% (p < 0.05). The fibreoptically assessed position was more frequently suboptimal with the LTS-D but this was not associated with impaired ventilation. Dynamic airway compliance was highest with the i-gel (TM) and lowest with the LTS-D (p < 0.05). Airway morbidity was more pronounced with the LTS-D (p < 0.01). Conclusion: All devices were suitable for ventilating the patients' lungs during elective surgery."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2012"],["dc.identifier.doi","10.1186/1471-2253-12-18"],["dc.identifier.isi","000314842600001"],["dc.identifier.pmid","22871204"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7856"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25756"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2253"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Randomized comparison of the i-gel (TM), the LMA Supreme (TM), and the Laryngeal Tube Suction-D using clinical and fibreoptic assessments in elective patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","3"],["dc.bibliographiccitation.journal","CRITICAL CARE"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Wetz, Anna J."],["dc.contributor.author","Richardt, Eva M."],["dc.contributor.author","Wand, Saskia"],["dc.contributor.author","Kunze, Nils"],["dc.contributor.author","Schotola, Hanna"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Braeuer, Anselm"],["dc.contributor.author","Moerer, Onnen"],["dc.date.accessioned","2018-11-07T10:02:21Z"],["dc.date.available","2018-11-07T10:02:21Z"],["dc.date.issued","2015"],["dc.description.abstract","Introduction: Postoperative acute kidney injury (AKI) is a frequently observed complication after on-pump cardiac surgery (CS) and is associated with adverse patient outcomes. Early identification of patients at risk is essential for the prevention of AKI after CS. In this study, we analysed whether urinary tissue inhibitor of metalloproteinase 2 (TIMP-2) combined with urine insulin-like growth factor binding protein 7 (IGFBP-7) ([TIMP-2] x [IGFBP-7]) is an adequate diagnostic test to identify early AKI after on-pump CS. Methods: In 42 patients undergoing coronary artery bypass graft surgery, we surveyed individual risk factors for AKI and defined AKI by applying the Kidney Disease: Improving Global Outcomes (KDIGO) classification during the day of surgery and the following 2 days after surgery. Concentrations of urinary TIMP-2 multiplied by IGFBP-7 were recorded at four time points: at baseline pre-surgery, at the end of surgery, 4 hours after cardiopulmonary bypass (CPB) and at 8: 00 AM on the first postoperative day. Results: In total, 38% of the patients experienced AKI. The results showed a median baseline [TIMP-2] x [IGFBP-7] concentration of 0.3 (ng/ml)(2)/1,000, decreasing at the end of surgery and then increasing at the next measurement point 4 hours after CPB and further on the first postoperative day. On the first postoperative day, patients with AKI had significantly higher concentrations of [TIMP-2] x [IGFBP-7]. On the day of surgery, the concentration did not significantly differ between patients classified as KDIGO 0 or KDIGO 1 or 2. Previously published cutoff points of 0.3 and 2 were not confirmed in our study cohort. Conclusion: [TIMP-2] x [IGFBP-7] concentration can be used as a diagnostic test to identify patients at increased risk of AKI after CS on the first postoperative day. At earlier time points, no significant difference in [TIMP-2] x [IGFBP-7] concentration was found between patients classified as KDIGO 0 or KDIGO 1 or 2."],["dc.description.sponsorship","Astute Medical"],["dc.identifier.doi","10.1186/s13054-014-0717-4"],["dc.identifier.isi","000351851200001"],["dc.identifier.pmid","25560277"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11548"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38205"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1364-8535"],["dc.relation.issn","1466-609X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Quantification of urinary TIMP-2 and IGFBP-7: an adequate diagnostic test to predict acute kidney injury after cardiac surgery?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","3"],["dc.bibliographiccitation.journal","BMC Anesthesiology"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Bergmann, Ingo"],["dc.contributor.author","Szabanowski, Torsten"],["dc.contributor.author","Braeuer, Anselm"],["dc.contributor.author","Crozier, Thomas A."],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Hinz, Jose Maria"],["dc.date.accessioned","2018-11-07T10:02:06Z"],["dc.date.available","2018-11-07T10:02:06Z"],["dc.date.issued","2015"],["dc.description.abstract","Background: Even extremely high-doses of the potent opioid, sufentanil, cannot reliably suppress stress responses to intense surgical stimuli such as sternotomy. The chemically related opioid remifentanil with its different pharmacokinetics and binding affinities for delta-and kappa-opioid receptors might be more effective in attenuating these responses. Methods: ASA I-III patients scheduled for a surgical procedure with sternotomy under balanced anesthesia (sevoflurane and sufentanil 3 mu g center dot kg(-1) bolus, 0.017 mu g center dot kg(-1) center dot min(-1) infusion) were randomized into two groups. Patients in the study group were supplemented with remifentanil (2 mu g center dot kg(-1) bolus, 2-7 mu g center dot kg(-1) center dot min(-1) infusion) starting ten minutes before sternotomy. Heart rate, arterial blood pressures, cardiac index, ejection fraction, systemic vascular resistance index (SVRI), total body oxygen uptake (VO2) and electric dermal response were measured and compared between the groups. Results: 62 patients were studied (study group 32, control group 30). Systolic and mean arterial blood pressures, SVRI, VO2 and skin conductance increased during sternotomy and sternal spread in the control group but not in the study group. Systolic blood pressure increase: 7.5 +/- 19 mmHg vs. -3.4 +/- 8.9 (p = 0.005); VO2 increase: 31 +/- 46% vs. -0.4 +/- 32%; incidence of systolic blood pressure increase greater than 15 percent: 20% vs. 3% (p = 0.035) (control vs. study group). Conclusion: High-dose remifentanil added to sevoflurane-sufentanil anesthesia suppresses the sympathoadrenergic response to sternotomy and sternal spread better than high-dose sufentanil alone."],["dc.identifier.doi","10.1186/1471-2253-15-3"],["dc.identifier.isi","000348943000001"],["dc.identifier.pmid","25670917"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12519"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38162"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2253"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Remifentanil added to sufentanil-sevoflurane anesthesia suppresses hemodynamic and metabolic stress responses to intense surgical stimuli more effectively than high-dose sufentanil-sevoflurane alone"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","112"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Jebran, Ahmad Fawad"],["dc.contributor.author","Bireta, Christian"],["dc.contributor.author","Friedrich, Martin"],["dc.contributor.author","Rajaruthnam, Direndra"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Braeuer, Anselm"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.date.accessioned","2018-11-07T08:51:42Z"],["dc.date.available","2018-11-07T08:51:42Z"],["dc.date.issued","2011"],["dc.description.abstract","The reported incidence of deep sternal wound infection (DSWI) after cardiac surgery is 0.4-5% with Staphylococcus aureus being the most common pathogen isolated from infected wound sternotomies and bacteraemic blood cultures. This infection is associated with a higher morbidity and mortality than other known aetiologies. Little is reported about the optimal antibiotic management. The aim of the study is to quantify the application of daptomycin treatment of DSWI due to gram-positive organisms post cardiac surgery. We performed an observational analysis in 23 cases of post sternotomy DSWI with gram-positive organisms February 2009 and September 2010. When the wound appeared viable and the microbiological cultures were negative, the technique of chest closure was individualised to the patient. The incidence of DSWI was 1.46%. The mean dose of daptomycin application was 4.4 +/- 0.9 mg/kg/d and the average duration of the daptomycin application was 14.47 +/- 7.33 days. In 89% of the patients VAC therapy was used. The duration from daptomycin application to sternal closure was 18 +/- 13.9 days. The parameters of infection including, fibrinogen (p = 0.03), white blood cell count (p = 0.001) and C-reactive protein (p = 0.0001) were significantly reduced after daptomycin application. We had no mortality and wound healing was successfully achieved in all patients. Treatment of DSWI due to gram-positive organisms with a daptomycin-containing antibiotic regimen is safe, effective and promotes immediate improvement of local wound conditions. Based on these observations, daptomycin may offer a new treatment option for expediting surgical management of DSWI after cardiac surgery."],["dc.identifier.doi","10.1186/1749-8090-6-112"],["dc.identifier.isi","000295483400002"],["dc.identifier.pmid","21929771"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6983"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21999"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1749-8090"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","Treatment of gram-positive deep sternal wound infections in cardiac surgery -experiences with daptomycin-"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","21"],["dc.bibliographiccitation.journal","Frontiers in Surgery"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Schöndube, Friedrich A."],["dc.contributor.author","Bräuer, Anselm"],["dc.date.accessioned","2019-07-09T11:43:19Z"],["dc.date.available","2019-07-09T11:43:19Z"],["dc.date.issued","2017"],["dc.description.abstract","Kawasaki disease is very rare in Western Europe. The disease may involve coronary art eries. A 2-year-old boy diagnosed with Kawasaki disease had had seizure-like symp toms. Further evaluation revealed recurrent myocardial ischemia and myocardial infarction. Due to extraordinary extension of the coronary disease, myocardial revascularization was not feasible and the toddler underwent successful heart transplantation after 97 days on waiting list."],["dc.identifier.doi","10.3389/fsurg.2017.00021"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14422"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58859"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","Frontiers Media S.A."],["dc.relation.eissn","2296-875X"],["dc.relation.issn","2296-875X"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Heart Transplantation in a Toddler with Cardiac Kawasaki Disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0528"],["dc.bibliographiccitation.issue","17"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","97"],["dc.contributor.author","Emmert, Alexander"],["dc.contributor.author","Gries, Gereon"],["dc.contributor.author","Wand, Saskia"],["dc.contributor.author","Buentzel, Judith"],["dc.contributor.author","Bräuer, Anselm"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Brandes, Ivo F."],["dc.date.accessioned","2020-12-10T18:20:04Z"],["dc.date.available","2020-12-10T18:20:04Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1097/MD.0000000000010528"],["dc.identifier.issn","0025-7974"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15265"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75454"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nd/4.0"],["dc.title","Association between perioperative hypothermia and patient outcomes after thoracic surgery"],["dc.title.alternative","A single center retrospective analysis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]