Dere, Ekrem

[["dc.bibliographiccitation.firstpage","58"],["dc.bibliographiccitation.journal","Pharmacology Biochemistry and Behavior"],["dc.bibliographiccitation.lastpage","63"],["dc.bibliographiccitation.volume","111"],["dc.contributor.author","Zlomuzica, Armin"],["dc.contributor.author","Dere, Dorothea"],["dc.contributor.author","Dere, Ekrem"],["dc.date.accessioned","2018-11-07T09:18:59Z"],["dc.date.available","2018-11-07T09:18:59Z"],["dc.date.issued","2013"],["dc.description.abstract","The histaminergic system in the central nervous system is involved in a variety of physiological, pathological and behavioral processes. There is now substantial evidence for an important role of histaminergic neurotransmission in learning and memory related processes. The histamine H1 receptor (H1R) is the most abundant histamine receptor in the mammalian brain. We have recently demonstrated that the genetic inactivation of the H1R in mice impairs episodic-like memory, defined as the ability to remember previous experiences with respect to their content and their temporal and spatial context. The ability to encode and retrieve the temporal order of unique events, that is its temporal context, is a core feature of episodic memory. Here we asked whether episodic-like memory deficits of H1R-KO mice are possibly due to changes in the processing, encoding or maintenance of temporal or sequence information which is critical for episodic-like memory formation. H1R-KO mice were tested in the temporal object memory (TOM) task with different inter-trial intervals (ITIs). H1R-KO mice showed impaired TOM when being tested under both, short and longer Ills. Another aim of the study was to determine whether temporal order discrimination is based on either familiarity or recollection-based memory processes. The performance of wild type (WT) animals in the TOM task suggests that they used recollection-like discrimination strategies. (C) 2013 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.pbb.2013.08.008"],["dc.identifier.isi","000326991400009"],["dc.identifier.pmid","23981314"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28532"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0091-3057"],["dc.title","The histamine H1 receptor and recollection-based discrimination in a temporal order memory task in the mouse"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","421"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Reviews in the Neurosciences"],["dc.bibliographiccitation.lastpage","434"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Breeden, Prescott"],["dc.contributor.author","Dere, Dorothea"],["dc.contributor.author","Zlomuzica, Armin"],["dc.contributor.author","Dere, Ekrem"],["dc.date.accessioned","2018-11-07T10:13:47Z"],["dc.date.available","2018-11-07T10:13:47Z"],["dc.date.issued","2016"],["dc.description.abstract","Mental time travel (MTT) is the ability to remember past events and to anticipate or imagine events in the future. MTT globally serves to optimize decision-making processes, improve problem-solving capabilities and prepare for future needs. MTT is also essential in providing our concept of self, which includes knowledge of our personality, our strengths and weaknesses, as well as our preferences and aversions. We will give an overview in which ways the capacity of animals to perform MTT is different from humans. Based on the existing literature, we conclude that MTT might represent a quantitative rather than qualitative entity with a continuum of MTT capacities in both humans and nonhuman animals. Given its high complexity, MTT requires a large processing capacity in order to integrate multimodal stimuli during the reconstruction of past and/or future events. We suggest that these operations depend on a highly specialized working memory subsystem, 'the MTT platform', which might represent a necessary additional component in the multicomponent working memory model by Alan Baddeley."],["dc.identifier.doi","10.1515/revneuro-2015-0053"],["dc.identifier.isi","000376682900007"],["dc.identifier.pmid","26756089"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40500"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Walter De Gruyter Gmbh"],["dc.relation.issn","1607-8470"],["dc.relation.issn","0334-1763"],["dc.title","The mental time travel continuum: on the architecture, capacity, versatility and extension of the mental bridge into the past and future"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","135"],["dc.bibliographiccitation.journal","Neuropharmacology"],["dc.bibliographiccitation.lastpage","145"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Zlomuzica, Armin"],["dc.contributor.author","Dere, Dorothea"],["dc.contributor.author","Binder, Sonja"],["dc.contributor.author","Silva, Maria Angelica De Souza"],["dc.contributor.author","Huston, Joseph P."],["dc.contributor.author","Dere, Ekrem"],["dc.date.accessioned","2018-11-07T10:12:18Z"],["dc.date.available","2018-11-07T10:12:18Z"],["dc.date.issued","2016"],["dc.description.abstract","Alzheimer's disease is a neurodegenerative disorder characterized by extracellular amyloid plaque deposits, mainly composed of amyloid-beta peptide and intracellular neurofibrillary tangles consisting of aggregated hyperphosphorylated tau protein. Amyloid-beta represents a neurotoxic proteolytic cleavage product of amyloid precursor protein. The progressive cognitive decline that is associated with Alzheimer's disease has been mainly attributed to a deficit in cholinergic neurotransmission due to the continuous degeneration of cholinergic neurons e.g. in the basal forebrain. There is evidence suggesting that other neurotransmitter systems including neuronal histamine also contribute to the development and maintenance of Alzheimer's disease-related cognitive deficits. Pathological changes in the neuronal histaminergic system of such patients are highly predictive of ensuing cognitive deficits. Furthermore, histamine-related drugs, including histamine 3 receptor antagonists, have been demonstrated to alleviate cognitive symptoms in Alzheimer's disease. This review summarizes findings from animal and clinical research on the relationship between the neuronal histaminergic system and cognitive deterioration in Alzheimer's disease. The significance of the neuronal histaminergic system as a promising target for the development of more effective drugs for the treatment of cognitive symptoms is discussed. Furthermore, the option to use histamine-related agents as neurogenesis-stimulating therapy that counteracts progressive brain atrophy in Alzheimer's disease is considered. This article is part of a Special Issue entitled 'Histamine Receptors'. (C) 2015 Elsevier Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.neuropharm.2015.05.007"],["dc.identifier.isi","000378964500015"],["dc.identifier.pmid","26025658"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/40210"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","1873-7064"],["dc.relation.issn","0028-3908"],["dc.title","Neuronal histamine and cognitive symptoms in Alzheimer's disease"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2"],["dc.bibliographiccitation.journal","Behavioural Brain Research"],["dc.bibliographiccitation.lastpage","7"],["dc.bibliographiccitation.volume","352"],["dc.contributor.author","Dere, Ekrem"],["dc.contributor.author","Dere, Dorothea"],["dc.contributor.author","de Souza Silva, Maria Angelica"],["dc.contributor.author","Huston, Joseph P."],["dc.contributor.author","Zlomuzica, Armin"],["dc.date.accessioned","2020-12-10T14:22:34Z"],["dc.date.available","2020-12-10T14:22:34Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.bbr.2017.03.026"],["dc.identifier.issn","0166-4328"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71657"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Fellow travellers: Working memory and mental time travel in rodents"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]