Sohns, Jan Martin

[["dc.bibliographiccitation.firstpage","1066"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Clinical Radiology"],["dc.bibliographiccitation.lastpage","1071"],["dc.bibliographiccitation.volume","69"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Joseph, Arun A."],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Unterberg-Buchwald, Christine"],["dc.contributor.author","Merboldt, Klaus-Dietmar"],["dc.contributor.author","Voit, Dirk"],["dc.contributor.author","Steinmetz, M."],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Schaetz, S."],["dc.contributor.author","Zhang, S."],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Sohns, J. M."],["dc.date.accessioned","2018-11-07T09:34:30Z"],["dc.date.available","2018-11-07T09:34:30Z"],["dc.date.issued","2014"],["dc.description.abstract","AIM: To evaluate the potential of real-time phase-contrast flow magnetic resonance imaging (MRI) at 40 ms resolution for the simultaneous determination of blood flow in the ascending aorta (AA) and superior vena cava (SVC) in response to reduced intrathoracic pressure (Mueller manoeuvre). MATERIALS AND METHODS: Through-plane flow was assessed in 20 healthy young subjects using real-time phase-contrast MRI based on highly undersampled radial fast low-angle shot (FLASH) with image reconstruction by regularized non-linear inversion. Haemodynamic alterations (three repetitions per subject = 60 events) were evaluated during normal breathing (10 s), inhalation with nearly closed epiglottis (10 s), and recovery (20 s). RESULTS: Relative to normal breathing and despite interindividual differences, reduced intrathoracic pressure by at least 30 mmHg significantly decreased the initial peak mean velocity (averaged across the lumen) in the AA by -24 +/- 9% and increased the velocity in the SVC by +28 +/- 25% (p < 0.0001, n = 23 successful events). Respective changes in flow volume per heartbeat were -25 +/- 9% in the AA and +49 +/- 44% in the SVC (p < 0.0001, n = 23). Flow parameters returned to baseline during sustained pressure reduction, while the heart rate was elevated by 10% (p < 0.0001) after the start (n = 24) and end (n = 17) of the manoeuvre. CONCLUSIONS: Real-time flow MRI during low intrathoracic pressure non-invasively revealed quantitative haemodynamic adjustments in both the AA and SVC. (C) 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved."],["dc.description.sponsorship","DFG [LO 1773/1]"],["dc.identifier.doi","10.1016/j.crad.2014.06.004"],["dc.identifier.isi","000342881800013"],["dc.identifier.pmid","25060931"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32184"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","W B Saunders Co Ltd"],["dc.relation.issn","1365-229X"],["dc.relation.issn","0009-9260"],["dc.title","Real-time phase-contrast flow MRI of haemodynamic changes in the ascending aorta and superior vena cava during Mueller manoeuvre"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1149"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","European Radiology"],["dc.bibliographiccitation.lastpage","1156"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Krüwel, Thomas"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Stahnke, Vera C."],["dc.contributor.author","Rave-Fränk, Margret"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Sohns, Jan M."],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Ritter, Christian"],["dc.contributor.author","Lotz, Joachim"],["dc.date.accessioned","2020-12-10T14:10:11Z"],["dc.date.available","2020-12-10T14:10:11Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1007/s00330-017-5056-9"],["dc.identifier.eissn","1432-1084"],["dc.identifier.issn","0938-7994"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/70672"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Absence of DNA double-strand breaks in human peripheral blood mononuclear cells after 3 Tesla magnetic resonance imaging assessed by γH2AX flow cytometry"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1364"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","1371"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Kastrup, Andreas"],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Schnaudigel, Sonja"],["dc.contributor.author","Huonker, Ralph"],["dc.contributor.author","Becker, Lars"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Klingner, Carsten M."],["dc.contributor.author","Witte, Otto-Wilhelm"],["dc.date.accessioned","2018-11-07T11:12:58Z"],["dc.date.available","2018-11-07T11:12:58Z"],["dc.date.issued","2008"],["dc.description.abstract","Functional magnetic resonance imaging (fMRI) hypothesis testing based on the blood oxygenation level dependent (BOLD) contrast mechanism typically involves a search for a positive effect during a specific task relative to a control state. However, aside from positive BOLD signal changes there is converging evidence that neuronal responses within various cortical areas also induce negative BOLD signals. Although it is commonly believed that these negative BOLD signal changes reflect suppression of neuronal activity direct evidence for this assumption is sparse. Since the somatosensory system offers the opportunity to quantitatively test sensory function during concomitant activation and has been well-characterized with fMRI in the past, the aim of this study was to determine the functional significance of ipsilateral negative BOLD signal changes during unilateral sensory stimulation. For this, we measured BOLD responses in the somatosensory system during unilateral electric stimulation of the right median nerve and additionally determined the current perception threshold of the left index finger during right-sided electrical median nerve stimulation as a quantitative measure of sensory function. As expected, positive BOLD signal changes were observed in the contralateral primary and bilateral secondary somatosensory areas, whereas a decreased BOLD signal was observed in the ipsilateral primary somatosensory cortex (SI). The negative BOLD signal changes were much more spatially extensive than the representation of the hand area within the ipsilateral SI. The negative BOLD signal changes in the area of the index finger highly correlated with an increase in current perception thresholds of the contralateral, unstimulated finger, thus supporting the notion that the ipsilateral negative BOLD response reflects a functionally effective inhibition in the somatosensory system. (c) 2008 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroimage.2008.03.049"],["dc.identifier.isi","000256620400018"],["dc.identifier.pmid","18495495"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53787"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1053-8119"],["dc.title","Behavioral correlates of negative BOLD signal changes in the primary somatosensory cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","670"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","European Heart Journal - Cardiovascular Imaging"],["dc.bibliographiccitation.lastpage","675"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Hoesch, Olga"],["dc.contributor.author","Thuy-Trang Ngyuen, Thuy-Trang Ngyuen"],["dc.contributor.author","Lauerer, Peter"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Steinmetz, Michael"],["dc.date.accessioned","2018-11-07T09:56:17Z"],["dc.date.available","2018-11-07T09:56:17Z"],["dc.date.issued","2015"],["dc.description.abstract","Aims Ebstein's anomaly (EA) involves a displaced and dysplastic tricuspid valve resulting in an atrialized portion of the right ventricle and an enlargement of the functional right ventricle and right atrium. Biomarkers targeting heart failure such as brain natriuretic peptide (BNP) or haematological parameters [haemoglobin (Hb) and haematocrit (Hct)] are upregulated in states of pulmonary hypoperfusion. We hypothesized that decreased pulmonary perfusion dependent on the stage of right heart failure is a possible mechanism in EA, and that it can be correlated with cardiac magnetic resonance (CMR) parameters. The aim of this study was to investigate the relationship between BNP and haematological parameters with functional parameters from CMR and exercise testing in patients with EA. Methods and results Twenty-five patients with non-corrected EA were studied prospectively (mean age 26 +/- 14 years). BNP level was increased (74 +/- 127 ng/L), and in 16% markedly above the heart failure cut-off level of 100 ng/L. Hb and Hct were increased above normal levels in 20 and 24% of patients, respectively. BNP and Hct/Hb correlated with CMR [total right/left (R/L)-Volume-Index, right atrium-end-diastolic volume index (EDVi), functional right ventricle (fRV)-EDVi, fRV-ejection fraction (EF), tricuspid regurgitation, pulmonary artery flow, and left ventricular EF] and exercise testing [workload/kg, oxygen uptake (VO2), ventilatory response to carbon dioxide production (VE/VCO2), oxygen (O-2) pulse, and heart rate reserve]. The higher BNP and haematological parameters, the higher was the disease severity and the more limited was the physical exercise capacity. Conclusion In this EA cohort, BNP levels and haematological parameters correlated well with functional data from CMR and exercise testing. The total R/L-Volume-Index and BNP, and to some extent hematological parameters, may be useful as prognostic markers in patients with EA."],["dc.description.sponsorship","Faculty of Medicine, Georg-August-University Gottingen, Germany"],["dc.identifier.doi","10.1093/ehjci/jeu312"],["dc.identifier.isi","000358014000013"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36927"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","2047-2412"],["dc.relation.issn","2047-2404"],["dc.title","BNP and haematological parameters are markers of severity of Ebstein's anomaly: correlation with CMR and cardiopulmonary exercise testing"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","92"],["dc.bibliographiccitation.journal","Clinical Imaging"],["dc.bibliographiccitation.lastpage","95"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Sohns, Christian"],["dc.contributor.author","Wienbeck, Susanne"],["dc.contributor.author","Bauer, Lukas"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Konietschke, Frank"],["dc.contributor.author","Derlin, Thorsten"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Sohns, Jan Martin"],["dc.date.accessioned","2020-12-10T14:23:07Z"],["dc.date.available","2020-12-10T14:23:07Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1016/j.clinimag.2017.06.005"],["dc.identifier.issn","0899-7071"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71842"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Prevalence and clinical significance of incidental extra-mammary findings in breast magnetic resonance imaging: A retrospective study of 1070 patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","10"],["dc.bibliographiccitation.journal","NeuroImage"],["dc.bibliographiccitation.lastpage","18"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Groeschel, Sonja"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Schmidt-Samoa, Carsten"],["dc.contributor.author","Baudewig, Juergen"],["dc.contributor.author","Becker, Lars"],["dc.contributor.author","Dechent, Peter"],["dc.contributor.author","Kastrup, Andreas"],["dc.date.accessioned","2018-11-07T09:25:40Z"],["dc.date.available","2018-11-07T09:25:40Z"],["dc.date.issued","2013"],["dc.description.abstract","In addition to a contralateral activation of the primary and secondary somatosensory cortices, peripheral sensory stimulation has been shown to elicit responses in the ipsilateral primary somatosensory cortex (SI). In particular, evidence is accumulating that processes of interhemispheric inhibition as depicted by negative blood oxygenation level dependent (BOLD) signal changes are part of somatosensory processes. The aim of the study was to analyze age-related differences in patterns of cerebral activation in the somatosensory system in general and processes of interhemispheric inhibition in particular. For this, a functional magnetic resonance imaging (fMRI) study was performed including 14 younger (mean age 23.3 0.9 years) and 13 healthy older participants (mean age 73.2 +/- 8.3 years). All subjects were scanned during peripheral electrical median nerve stimulation (40 Hz) to obtain BOLD responses in the somatosensory system. Moreover, the individual current perception threshold (CPT) as a quantitative measure of sensory function was determined in a separate psychophysical testing. Significant increases in BOLD signal across the entire group could be measured within the contralateral SI, in the bilateral secondary somatosensory cortex (SII), the contralateral supplementary motor area and the insula. Negative BOLD signal changes were delineated in ipsilateral SI/MI as well as in the ipsilateral thalamus and basal ganglia. After comparing the two groups, only the cortical deactivation in ipsilateral SI in the early stimulation phase as well as the activation in contralateral SI and SII in the late stimulation block remained as statistically significant differences between the two groups. The psychophysical experiments yielded a significant age-dependent effect of CPT change with less difference in the older group which is in line with the significantly smaller alterations in maximal BOLD signal change in the contra- and ipsilateral SI found between the two groups. Healthy aging seems to be associated with a decrease in intracerebral inhibition as reflected by smaller negative BOLD signal changes during fMRI tasks. This finding could constitute an important link between age-related neurophysiological changes and behavioral alterations in humans. (C) 2012 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.neuroimage.2012.12.039"],["dc.identifier.isi","000316154400002"],["dc.identifier.pmid","23296182"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30119"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","1095-9572"],["dc.relation.issn","1053-8119"],["dc.title","Effects of age on negative BOLD signal changes in the primary somatosensory cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","128"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Schulte, Christina"],["dc.contributor.author","Zapf, Antonia"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Kowallick, Johannes"],["dc.contributor.author","Preuss, Christoph"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Thuy-Trang Nguyen, Thuy-Trang Nguyen"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Steinmetz, Michael"],["dc.date.accessioned","2018-11-07T09:17:27Z"],["dc.date.available","2018-11-07T09:17:27Z"],["dc.date.issued","2013"],["dc.identifier.isi","000332162907028"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28173"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.conference","Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association"],["dc.relation.eventlocation","Dallas, TX"],["dc.relation.issn","1524-4539"],["dc.relation.issn","0009-7322"],["dc.title","Right Atrial Volume in Tetralogy of Fallot Correlates With the Incidence of Supra-Ventricular Arrhythmia: A MRI Study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","99"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Vascular"],["dc.bibliographiccitation.lastpage","110"],["dc.bibliographiccitation.volume","26"],["dc.contributor.author","Sohns, Jan M"],["dc.contributor.author","Menke, Jan"],["dc.contributor.author","Bergau, Leonard"],["dc.contributor.author","Weiss, Bernhard G"],["dc.contributor.author","Kröhn, Hannah"],["dc.contributor.author","Weiberg, Desiree"],["dc.contributor.author","Derlin, Thorsten"],["dc.contributor.author","Schmuck, Sebastian"],["dc.date.accessioned","2020-12-10T18:38:35Z"],["dc.date.available","2020-12-10T18:38:35Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1177/1708538117724628"],["dc.identifier.eissn","1708-539X"],["dc.identifier.issn","1708-5381"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77377"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Screening of extravascular findings in pulmonary embolism computer tomography: 397 patients with 1950 non-pulmonary artery findings"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","601"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Circulation Cardiovascular Imaging"],["dc.bibliographiccitation.lastpage","609"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Hoesch, Olga"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Thuy-Trang Nguyen, Thuy-Trang Nguyen"],["dc.contributor.author","Lauerer, Peter"],["dc.contributor.author","Rosenberg, Christina"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Kutty, Shelby"],["dc.contributor.author","Unterberg, Christina"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Steinmetz, Michael"],["dc.date.accessioned","2018-11-07T09:38:08Z"],["dc.date.available","2018-11-07T09:38:08Z"],["dc.date.issued","2014"],["dc.description.abstract","Background-The classification of clinical severity of Ebstein anomaly still remains a challenge. The aim of this study was to focus on the interaction of the pathologically altered right heart with the anatomically-supposedly-normal left heart and to derive from cardiac magnetic resonance (CMR) a simple imaging measure for the clinical severity of Ebstein anomaly. Methods and Results-Twenty-five patients at a mean age of 26 +/- 14 years with unrepaired Ebstein anomaly were examined in a prospective study. Disease severity was classified using CMR volumes and functional measurements in comparison with heart failure markers from clinical data, ECG, laboratory and cardiopulmonary exercise testing, and echocardiography. All examinations were completed within 24 hours. A total right/left-volume index was defined from end-diastolic volume measurements in CMR: total right/left-volume index=(RA+aRV+fRV)/(LA+LV). Mean total right/left-volume index was 2.6 +/- 1.7 (normal values: 1.1 +/- 0.1). This new total right/left-volume index correlated with almost all clinically used biomarkers of heart failure: brain natriuretic peptide (r=0.691; P=0.0003), QRS (r=0.432; P=0.039), peak oxygen consumption/kg (r=-0.479; P=0.024), ventilatory response to carbon dioxide production at anaerobic threshold (r=0.426; P=0.048), the severity of tricuspid regurgitation (r=0.692; P=0.009), tricuspid valve offset (r=0.583; P=0.004), and tricuspid annular plane systolic excursion (r=0.554; P=0.006). Previously described severity indices ([RA+aRV]/[fRV+LA+LV]) and fRV/LV end-diastolic volume corresponded only to some parameters. Conclusions-In patients with Ebstein anomaly, the easily acquired index of right-sided to left-sided heart volumes from CMR correlated well with established heart failure markers. Our data suggest that the total right/left-volume index should be used as a new and simplified CMR measure, allowing more accurate assessment of disease severity than previously described scoring systems."],["dc.identifier.doi","10.1161/CIRCIMAGING.113.001467"],["dc.identifier.isi","000339172100006"],["dc.identifier.pmid","24807407"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33001"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1942-0080"],["dc.relation.issn","1941-9651"],["dc.title","The Total Right/Left-Volume Index: A New and Simplified Cardiac Magnetic Resonance Measure to Evaluate the Severity of Ebstein Anomaly of the Tricuspid Valve A Comparison With Heart Failure Markers From Various Modalities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","S 01"],["dc.bibliographiccitation.journal","RöFo"],["dc.bibliographiccitation.volume","185"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Unterberg-Buchwald, Susan C."],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Baur, Joseph A."],["dc.contributor.author","Merboldt, K. D."],["dc.contributor.author","Uecker, Martin"],["dc.contributor.author","Voit, D."],["dc.contributor.author","Zhang, S."],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Lotz, Joachim"],["dc.date.accessioned","2020-05-13T13:45:52Z"],["dc.date.available","2020-05-13T13:45:52Z"],["dc.date.issued","2013"],["dc.description.abstract","Ziele: Hochaufgelöste Echtzeit-Phasenkontrast-MRT-Flussmessungen wurden u.a. in der Aorta ascendens angewendet. Die MRT-Technik basiert auf einer stark unterabgetasteten radialen FLASH-Sequenz und anschließender Bildrekonstruktion mit nicht-linearer Inversion. Normale Flussmessungen und Flusswerte wurden während physiologischer Stresstests wie dem Valsalva- (erhöhter intrathorakaler Druck) und Müllermaneuver (erniedrigter intrathorakaler Druck) bei gesunden Probanden durchgeführt. Methode: Der Blutfluss wurde in den großen thorakalen Gefäßen gemessen, In-plane 1.2 mm, Schichtdicke 6 mm und realer Echtzeitauflösung von 40 ms. Die TR betrug 3.44 ms, TE 2.76 ms. Alle Scans wurden in einem 3T MRT durchgeführt. Das EKG-Signal wurde zur besseren Zuordnung der Herzphasen mit aufgezeichnet. Die Echtzeitmessungen wurden in Ruhe sowie 10 s Valsalva und 10 s Müllermanöver durchgeführt. Die Bildanalyse erfolgte in einer modifizierten Standardsoftware QFlow, Medis, Leiden NL. Ergebnis: Echtzeitflussmessungen konnten erfolgreich bei allen Probanden (n = 10) durchgeführt werden. Wir beobachteten unter Stressbedingungen einen Abfall des Blutflusses, der Maximalgeschwindigkeit und der kardialen Auswurfleistung sowie eine Herzfrequenzzunahme unter Valsalva- und Müllermaneuver in der Aorta ascendens. Zu Beginn der Stressmaneuver stieg der Blutfluss und die Auswurfleitung initial an unter erhöhten und reduzierten intrathorakalen Druckverhältnissen, gefolgt von einer kontinuierlichen 10 s dauernden Abnahme. Anschließend folgte wieder eine Normalisierung nach Stressbeendigung. Schlussfolgerung: Hoch aufgelöste Echtzeit-MRT-Flussmessungen sind sehr gut dafür geeignet um physiologische Blutflussveränderungen während dem Valsalva- und Müllermaneuver bei Stressbedingungen darzustellen. Die Ergebnisse stimmen mit Beobachtungen aus der Echokardiografie überein. Mit dieser neuen Echtzeit-Flusstechnik gibt es neue Möglichkeiten um pathologische Veränderungen am Herzen darzustellen wie bei angeborenen Herzfehlern oder Kardiomyopathien."],["dc.identifier.doi","10.1055/s-0033-1346232"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/65375"],["dc.language.iso","de"],["dc.relation.eissn","1438-9010"],["dc.relation.issn","1438-9029"],["dc.title","Echtzeit-Cardio-MRT-Phasenkontrast-Flussmessungen mit dem Valsalva- und Müllermaneuver als Stresstest"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]