Drummer, Charis

[["dc.bibliographiccitation.firstpage","175"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Journal of Endocrinology"],["dc.bibliographiccitation.lastpage","187"],["dc.bibliographiccitation.volume","241"],["dc.contributor.author","Wahab, Fazal"],["dc.contributor.author","Khan, Ikram Ullah"],["dc.contributor.author","Polo, Ignacio Rodriguez"],["dc.contributor.author","Zubair, Hira"],["dc.contributor.author","Drummer, Charis"],["dc.contributor.author","Shahab, Muhammad"],["dc.contributor.author","Behr, Rüdiger"],["dc.date.accessioned","2022-10-06T13:26:25Z"],["dc.date.available","2022-10-06T13:26:25Z"],["dc.date.issued","2019"],["dc.description.abstract","Irisin, encoded by the\n FNDC5\n gene, is a recently discovered endocrine factor mainly secreted as a myokine and adipokine. However, irisin/\n FNDC5\n expression has also been reported in different other organs including components of the reproductive axis. Yet, there is the scarcity of data on\n FNDC5\n /irisin expression, regulation and its reproductive effects, particularly in primates. Here, we report the expression of\n FNDC5\n /irisin, along with\n PGC1A\n (peroxisome proliferator-activated receptor gamma coactivator 1-alpha) and\n ERRA\n (estrogen-related receptor alpha), in components of the reproductive axis of marmoset monkeys. Hypothalamic\n FNDC5\n and\n ERRA\n transcript levels are developmentally regulated in both male and female. We further uncovered sex-specific differences in\n FNDC5\n ,\n ERRA\n and\n PGC1A\n expression in muscle and the reproductive axis. Moreover, irisin and ERRα co-localize in the marmoset hypothalamus. Additionally, in the arcuate nucleus of rhesus monkeys, the number of irisin+ cells was significantly increased in short-term fasted monkeys as compared to\n ad libitum\n -fed monkeys. More importantly, we observed putative interaction of irisin-immunoreactive fibers and few GnRH\n -\n immunoreactive cell bodies in the mediobasal hypothalamus of the rhesus monkeys. Functionally, we noted a stimulatory effect of irisin on GnRH synthesis and release in mouse hypothalamic neuronal GT1-7 cells. In summary, our findings show that\n FNDC5\n and irisin are developmentally, metabolic-status dependently and sex-specifically expressed in the primate hypothalamic–pituitary–gonadal axis and exert a stimulatory effect on GnRH expression and release in mouse hypothalamic cells. Further studies are required to confirm the reproductive effects of irisin\n in vivo\n and to illuminate the mechanisms of its regulation."],["dc.identifier.doi","10.1530/JOE-18-0574"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115084"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1479-6805"],["dc.relation.issn","0022-0795"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.title","Irisin in the primate hypothalamus and its effect on GnRH in vitro"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","110670"],["dc.bibliographiccitation.journal","Molecular and Cellular Endocrinology"],["dc.bibliographiccitation.volume","504"],["dc.contributor.author","Wahab, Fazal"],["dc.contributor.author","Drummer, Charis"],["dc.contributor.author","Mätz-Rensing, Kerstin"],["dc.contributor.author","Fuchs, Eberhard"],["dc.contributor.author","Behr, Rüdiger"],["dc.date.accessioned","2022-10-06T13:33:14Z"],["dc.date.available","2022-10-06T13:33:14Z"],["dc.date.issued","2020"],["dc.description.sponsorship"," http://dx.doi.org/10.13039/100005156 Alexander von Humboldt Foundation"],["dc.description.sponsorship"," http://dx.doi.org/10.13039/501100004938 German Primate Center"],["dc.identifier.doi","10.1016/j.mce.2019.110670"],["dc.identifier.pii","S0303720719303727"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115584"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0303-7207"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Irisin is expressed by undifferentiated spermatogonia and modulates gene expression in organotypic primate testis cultures"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","R780"],["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","Current Biology"],["dc.bibliographiccitation.lastpage","R782"],["dc.bibliographiccitation.volume","25"],["dc.contributor.author","Wahab, Fazal"],["dc.contributor.author","Drummer, Charis"],["dc.contributor.author","Behr, Rüdiger"],["dc.date.accessioned","2022-10-06T13:33:03Z"],["dc.date.available","2022-10-06T13:33:03Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1016/j.cub.2015.06.042"],["dc.identifier.pii","S0960982215007368"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115533"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.issn","0960-9822"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://www.elsevier.com/tdm/userlicense/1.0/"],["dc.title","Marmosets"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","8447"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Molecular Neurobiology"],["dc.bibliographiccitation.lastpage","8457"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Wahab, Fazal"],["dc.contributor.author","Drummer, Charis"],["dc.contributor.author","Schlatt, Stefan"],["dc.contributor.author","Behr, Rüdiger"],["dc.date.accessioned","2022-10-06T13:32:34Z"],["dc.date.available","2022-10-06T13:32:34Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.1007/s12035-016-0329-x"],["dc.identifier.pii","329"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/115409"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1559-1182"],["dc.relation.issn","0893-7648"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0"],["dc.title","Dynamic Regulation of Hypothalamic DMXL2, KISS1, and RFRP Expression During Postnatal Development in Non-Human Primates"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]