Lüder, Carsten Günter Kurt

[["dc.bibliographiccitation.firstpage","105"],["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.lastpage","106"],["dc.bibliographiccitation.volume","293"],["dc.contributor.author","Keller, Peter"],["dc.contributor.author","Goebel, S."],["dc.contributor.author","Fischer, S. F."],["dc.contributor.author","Hacker, G."],["dc.contributor.author","Gross, U."],["dc.contributor.author","Luder, C. G. K."],["dc.date.accessioned","2018-11-07T10:50:40Z"],["dc.date.available","2018-11-07T10:50:40Z"],["dc.date.issued","2004"],["dc.identifier.isi","000222589900164"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48707"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","21st Congress of the German-Society-of-Parasitology"],["dc.relation.eventlocation","Univ Wurzburg, Wurzburg, GERMANY"],["dc.relation.issn","1438-4221"],["dc.title","Inhibition of caspase activity by Toxoplasma gondii in a cell-free system indicates novel mechanisms of interference with host cell apoptosis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","480"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Trends in Parasitology"],["dc.bibliographiccitation.lastpage","486"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Luder, C. G. K."],["dc.contributor.author","Gross, U."],["dc.contributor.author","Lopes, M. F."],["dc.date.accessioned","2018-11-07T08:38:10Z"],["dc.date.available","2018-11-07T08:38:10Z"],["dc.date.issued","2001"],["dc.description.abstract","Programmed cell death (apoptosis) is an important regulator of the host's response during infection with a variety of intracellular protozoan parasites. Parasitic pathogens have evolved diverse strategies to induce or inhibit host-cell apoptosis, thereby modulating the host's immune response, aiding dissemination within the host or facilitating intracellular survival. Here, we review the molecular and cell-biological mechanisms of the pathogen-induced modulation of host-cell apoptosis and its effects on the parasite-host interaction and the pathogenesis of parasitic diseases. We also discuss the previously unrecognized phenomenon of apoptotic cell death in (unicellular) protozoan parasites and its potential implications."],["dc.identifier.doi","10.1016/S1471-4922(01)02016-5"],["dc.identifier.isi","000171456700010"],["dc.identifier.pmid","11587962"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18705"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Sci Ltd"],["dc.relation.issn","1471-4922"],["dc.title","Intracellular protozoan parasites and apoptosis: diverse strategies to modulate parasite-host interactions"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.volume","297"],["dc.contributor.author","da Silva, Marialice da Fonseca Ferreira"],["dc.contributor.author","Barbosa, Helene Santos"],["dc.contributor.author","Gross, U."],["dc.contributor.author","Lueder, Carsten Guenter Kurt"],["dc.date.accessioned","2018-11-07T10:59:03Z"],["dc.date.available","2018-11-07T10:59:03Z"],["dc.date.issued","2007"],["dc.format.extent","23"],["dc.identifier.isi","000250104800053"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50607"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","59th Annual Meeting of the Deutschen-Gesellschaft-fur-Hygiene-und-Mikrobiologie"],["dc.relation.eventlocation","Gottingen, GERMANY"],["dc.relation.issn","1438-4221"],["dc.title","Toxoplasma gondii in skeletal muscle cells in vitro: spontaneous differentiation from the tachyzoite to the bradyzoite stage"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1079"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","Microbes and Infection"],["dc.bibliographiccitation.lastpage","1087"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Graumann, Kristin"],["dc.contributor.author","Hippe, Diana"],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","Lueder, Carsten Guenter Kurt"],["dc.date.accessioned","2018-11-07T11:22:58Z"],["dc.date.available","2018-11-07T11:22:58Z"],["dc.date.issued","2009"],["dc.description.abstract","Programmed cell death is an essential mechanism of the host to combat infectious agents and to regulate immunity during infection Consequently, activation and deactivation of the hosts' cell death pathways by protozoan parasites play critical roles in parasite control. pathogenesis, immune evasion and parasite dissemination within the host Here, we discuss advances in the understanding of these fascinating host-parasite interactions with special emphasis on how protozoa can modulate the cell death apparatus of its host. (C) 2009 Elsevier Masson SAS All rights reserved."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [LU777/4-1]"],["dc.identifier.doi","10.1016/j.micinf.2009.08.011"],["dc.identifier.isi","000271557300011"],["dc.identifier.pmid","19733682"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/56091"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1286-4579"],["dc.title","Mammalian apoptotic signalling pathways: multiple targets of protozoan parasites to activate or deactivate host cell death"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","196"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Memórias do Instituto Oswaldo Cruz"],["dc.bibliographiccitation.lastpage","200"],["dc.bibliographiccitation.volume","104"],["dc.contributor.author","Ferreira-da-Silva, Marialice da Fonseca"],["dc.contributor.author","Rodrigues, Renata Mendonca"],["dc.contributor.author","de Andrade, Elisabete Ferreira"],["dc.contributor.author","de Carvalho, Lais"],["dc.contributor.author","Gross, Uwe"],["dc.contributor.author","Lueder, Carsten Guenter Kurt"],["dc.contributor.author","Barbosa, Helene Santos"],["dc.date.accessioned","2018-11-07T08:32:21Z"],["dc.date.available","2018-11-07T08:32:21Z"],["dc.date.issued","2009"],["dc.description.abstract","Although the predilection for Toxoplasma gondii to form cysts in the nervous system and skeletal and heart muscles has been described for more than fifty years, skeletal muscle cells (SkMCs) have not been explored as a host cell type to study the Toxoplasma-host cell interaction and investigate the intracellular development of the parasite. Morphological aspects of the initial events in the Toxoplasma-SkMC interaction were analysed and suggest that there are different processes of protozoan adhesion and invasion and of the subsequent fate of the parasite inside the parasitophorous vacuole (PV). Using scanning electron microscopy, Toxoplasma tachyzoites from the mouse-virulent RH strain were found to be attached to SkMCs by the anterior or posterior region of the body, with or without expansion of the SkMC membrane. This suggests that different types of parasite internalization occurred. Asynchronous multiplication and differentiation of T. gondii were observed. Importantly, intracellular parasites were seen to display high amounts of amylopectin granules in their cytoplasm, indicating that tachyzoites of the RH strain were able to differentiate spontaneously into bradyzoites in SkMCs. This stage conversion occurred in approximately 3% of the PVs. This is particularly intriguing as tachyzoites of virulent Toxoplasma strains are not thought to be prone to cyst formation. We discuss whether biological differences in host cells are crucial to Toxoplasma stage conversion and suggest that important questions concerning the host cell type and its relevance in Toxoplasma differentiation are still unanswered."],["dc.identifier.isi","000267051500012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17321"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Fundaco Oswaldo Cruz"],["dc.publisher.place","Rio de janeiro, rj"],["dc.relation.conference","Meeting on Toxoplasma Centennial Congress from Discovery to Public Health Management"],["dc.relation.eventlocation","Buzios, BRAZIL"],["dc.relation.issn","0074-0276"],["dc.title","Spontaneous stage differentiation of mouse-virulent Toxoplasma gondii RH parasites in skeletal muscle cells: an ultrastructural evaluation"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","119"],["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.lastpage","120"],["dc.bibliographiccitation.volume","294"],["dc.contributor.author","Keller, Peter"],["dc.contributor.author","Goebel, S."],["dc.contributor.author","Fischer, S. F."],["dc.contributor.author","Hacker, G."],["dc.contributor.author","Gross, U."],["dc.contributor.author","Luder, C. G. K."],["dc.date.accessioned","2018-11-07T10:45:58Z"],["dc.date.available","2018-11-07T10:45:58Z"],["dc.date.issued","2004"],["dc.identifier.isi","000224456000083"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47630"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","Annual Meeting of the DGHM"],["dc.relation.eventlocation","Munster, GERMANY"],["dc.relation.issn","1438-4221"],["dc.title","Excretory-secretory antigens of Toxoplasma gondii inhibit caspase 3 activity in a cell-free system: possible role in interference with host cell apoptosis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","International Journal of Medical Microbiology"],["dc.bibliographiccitation.volume","294"],["dc.contributor.author","Lang, C."],["dc.contributor.author","Algner, M."],["dc.contributor.author","Gross, U."],["dc.contributor.author","Luder, C. G. K."],["dc.date.accessioned","2018-11-07T10:45:58Z"],["dc.date.available","2018-11-07T10:45:58Z"],["dc.date.issued","2004"],["dc.format.extent","120"],["dc.identifier.isi","000224456000084"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/47632"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","Annual Meeting of the DGHM"],["dc.relation.eventlocation","Munster, GERMANY"],["dc.relation.issn","1438-4221"],["dc.title","Differential effects of Toxoplasma gondii and parasite lysate on GAS-containing promoters driving IFN-gamma-responsive genes"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1475"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","European Journal of Immunology"],["dc.bibliographiccitation.lastpage","1484"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Luder, C. G. K."],["dc.contributor.author","Walter, W."],["dc.contributor.author","Beuerle, B."],["dc.contributor.author","Maeurer, Mathias"],["dc.contributor.author","Gross, U."],["dc.date.accessioned","2018-11-07T09:06:09Z"],["dc.date.available","2018-11-07T09:06:09Z"],["dc.date.issued","2001"],["dc.description.abstract","The obligate intracellular protozoan parasite Toxoplasma gondii is able to establish persistent infections within human and animal hosts. We have shown recently that T. gondii downregulates IFN-gamma -induced MHC class II expression in murine bone marrow-derived macrophages (BMM phi). As shown in this study, the capacity of IFN-gamma -activated murine BMM phi to present ovalbumin to CD4(+) T cell hybridomas was dose-dependently inhibited by T. gondii. IFN-gamma -induced up-regulation of H2-Aa, H2-Ab, H2-Eb, H2-Ma, H2-Mb, H2-Oa and invariant chain transcripts was prominently down-regulated by T. gondii. Furthermore, mRNA levels of class II transactivator and interferon-regulatory factor-1 were significantly diminished. Electromobility shift assays demonstrated a decrease in the binding activity of nuclear extracts to the IFN-gamma -activated site after infection with T gondii, indicating parasitic interference with IFN-gamma -induced signaling. However, neither the expression of the IFN-gammaR nor the IFN-gamma -induced tyrosine phosphorylation of IFN-gammaR alpha chain and signal transducer and activator of transcription (STAT) 1 alpha was diminished by T. gondii. IFN-gamma -induced nuclear translocation of STAT1 alpha was nevertheless inhibited after infection as demonstrated by immunofluorescence microscopy and subcellular fractionation analyses. In conclusion, this novel mechanism of microbial interference with MHC class II gene expression may contribute to intracellular survival and establishment of persistent infection with T:gondii."],["dc.identifier.doi","10.1002/1521-4141(200105)31:5<1475::AID-IMMU1475>3.0.CO;2-C"],["dc.identifier.isi","000168814900021"],["dc.identifier.pmid","11465104"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25487"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-v C H Verlag Gmbh"],["dc.relation.issn","0014-2980"],["dc.title","Toxoplasma gondii down-regulates MHC class II gene expression and antigen presentation by murine macrophages via interference with nuclear translocation of STAT1 alpha"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","312"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","FEMS Microbiology Letters"],["dc.bibliographiccitation.lastpage","319"],["dc.bibliographiccitation.volume","258"],["dc.contributor.author","Keller, Peter"],["dc.contributor.author","Schaumburg, F."],["dc.contributor.author","Fischer, S. F."],["dc.contributor.author","Hacker, G."],["dc.contributor.author","Gross, U."],["dc.contributor.author","Lüder, C. G. K."],["dc.date.accessioned","2018-11-07T09:52:22Z"],["dc.date.available","2018-11-07T09:52:22Z"],["dc.date.issued","2006"],["dc.description.abstract","The intracellular parasite Toxoplasma gondii is known to inhibit apoptosis of its host cell. The molecular mechanisms of this interference are, however, not yet completely understood. We show here that viable parasites prominently inhibited the activation of caspase 3/7 induced by cytochrome c, dATP and dithiothreitol in cytosolic extracts of human-derived Jurkat leukemic T cells. In contrast, granzyme B-induced caspase activity was only slightly diminished. De novo protein biosynthesis by T. gondii was dispensable for the inhibition of cytochrome c-induced caspase activation. Furthermore, a complete parasite lysate or, more importantly, molecules released by extracellular parasites mediated the interaction with the caspase cascade. The cell-free system applied here is thus a valuable tool to study the interaction of T. gondii and possibly other intracellular pathogens with host cell apoptosis."],["dc.identifier.doi","10.1111/j.1574-6968.2006.00241.x"],["dc.identifier.isi","000237096000023"],["dc.identifier.pmid","16640590"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36112"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0378-1097"],["dc.title","Direct inhibition of cytochrome c-induced caspase activation in vitro by Toxoplasma gondii reveals novel mechanisms of interference with host cell apoptosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","833"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","International Journal for Parasitology"],["dc.bibliographiccitation.lastpage","844"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Luder, Carsten G. K."],["dc.contributor.author","Algner, Michaela"],["dc.contributor.author","Lang, Christine"],["dc.contributor.author","Bleicher, Nadja"],["dc.contributor.author","Groß, Uwe"],["dc.date.accessioned","2018-11-07T10:37:35Z"],["dc.date.available","2018-11-07T10:37:35Z"],["dc.date.issued","2003"],["dc.description.abstract","Production of nitric oxide by activated murine macrophages is thought to represent an important mechanism to restrict replication of the obligate intracellular parasite Toxoplasma gondii. In this study, we characterised the effect of T. gondii on nitric oxide production and expression of the inducible nitric oxide synthase and determined the functional significance of a parasite-induced evasion of this potential effector mechanism. Infection of primary bone marrow-derived macrophages or monocytic/macrophage RAW264.7 cells with a mouse-avirulent T. gondii strain significantly decreased nitric oxide production that had been induced by activation with either interferon-gamma or lipopolysaccharide or interferon-gamma plus lipopolysaccharide. Importantly, down-regulation of nitric oxide production by T. gondii enabled considerable parasite replication in macrophages activated with interferon-gamma alone or lipopolysaccharide, alone. Furthermore, supplementation of endogenous nitric oxide by addition of sodium nitroprusside to levels as observed in uninfected interferon-gamma- or lipopolysaccharide-activated macrophages almost completely abrogated replication of T. gondii. Although T. gondii also partially inhibited the vigorous nitric oxide production induced by interferon-gamma along with lipopolysaccharide, the magnitude of inhibition did not suffice to allow intracellular propagation of the parasite in these synergistically activated macrophages. Inhibition of interferon-gamma-, lipopolysaccharide- and interferon--y plus lipopolysaccharide-induced nitric oxide production coincided with reduced inducible nitric oxide synthase protein levels. Such down-regulation required the presence of intracellular parasites as determined by immunofluorescence microscopy. Inducible nitric oxide synthase transcripts induced by interferon--y alone or in combination with lipopolysaccharide were also dose-dependently down-regulated after infection of RAW264.7 cells with T gondii. In conclusion, this evasion strategy enables parasite replication in macrophages moderately activated by interferon-gamma or lipopolysaccharide, but does not suffice to evade the anti-parasitic activity of macrophages fully activated by interferon-gamma plus lipopolysaccharide. Nitric oxide production and its partial inhibition by the parasite may modulate the parasite-host equilibrium during toxoplasmosis. (C) 2003 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0020-7519(03)00092-4"],["dc.identifier.isi","000184375800007"],["dc.identifier.pmid","12865083"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/45603"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","Najko"],["dc.relation.issn","0020-7519"],["dc.title","Reduced expression of the inducible nitric oxide synthase after infection with Toxoplasma gondii facilitates parasite replication in activated murine macrophages"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]