Fleischhammer, Julius

[["dc.bibliographiccitation.firstpage","428"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Investigative Radiology"],["dc.bibliographiccitation.lastpage","433"],["dc.bibliographiccitation.volume","52"],["dc.contributor.author","Merrem, Andreas"],["dc.contributor.author","Hofer, Sabine"],["dc.contributor.author","Voit, Dirk"],["dc.contributor.author","Merboldt, K.-Dietmar"],["dc.contributor.author","Klosowski, Jakob"],["dc.contributor.author","Untenberger, Markus"],["dc.contributor.author","Fleischhammer, Julius"],["dc.contributor.author","Frahm, Jens"],["dc.date.accessioned","2020-12-10T18:20:12Z"],["dc.date.available","2020-12-10T18:20:12Z"],["dc.date.issued","2017"],["dc.description.abstract","Objective: The aim of this study was to develop a rapid diffusion-weighted (DW) magnetic resonance imaging (MRI) technique for whole-brain studies without susceptibility artifacts and measuring times below 3 minutes. Materials and Methods: The proposed method combines a DWspin-echo module with a single-shot stimulated echo acquisition mode MRI sequence. Previous deficiencies in image quality due to limited signal-to-noise ratio are compensated for (1) by radial undersampling to enhance the flip angle and thus the signal strength of stimulated echoes; (2) by defining the image reconstruction as a non-linear inverse problem, which is solved by the iteratively regularized Gauss-Newton method; and (3) by denoising with use of a modified nonlocal means filter. The method was implemented on a 3 TMRI system(64-channel head coil, 80 mT . m gradients) and evaluated for 10 healthy subjects and 2 patients with an ischemic lesion and epidermoid cyst, respectively. Results: High-quality mean DW images of the entire brain were obtained by acquiring 1 non-DW image and 6 DW images with different diffusion directions at b = 1000 s . mm. The achievable resolution for a total measuring time of 84 seconds was 1.5 mm in plane with a section thickness of 4 mm (55 sections). A measuring time of 168 seconds allowed for an in-plane resolution of 1.25 mm and a section thickness of 3 mm (54 sections). Apparent diffusion coefficient values were in agreement with literature data. Conclusions: The proposed method for DWMRI offers immunity against susceptibility problems, high spatial resolution, adequate signal-to-noise ratio and clinically feasible scan times of less than 3 minutes for whole-brain studies. More extended clinical trials require accelerated computation and online reconstruction."],["dc.identifier.doi","10.1097/RLI.0000000000000357"],["dc.identifier.isi","000403234600006"],["dc.identifier.issn","0020-9996"],["dc.identifier.pmid","28151734"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75482"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1536-0210"],["dc.relation.issn","0020-9996"],["dc.title","Rapid Diffusion-Weighted Magnetic Resonance Imaging of the Brain Without Susceptibility Artifacts"],["dc.title.subtitle","Single-Shot STEAM With Radial Undersampling and Iterative Reconstruction"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]