Schneider, Heike E.

[["dc.bibliographiccitation.firstpage","2586"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","Molecular and Cellular Biology"],["dc.bibliographiccitation.lastpage","2602"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Scharf, Madeleine"],["dc.contributor.author","Neef, Stefan"],["dc.contributor.author","Freund, Robert"],["dc.contributor.author","Geers-Knoerr, Cornelia"],["dc.contributor.author","Franz-Wachtel, Mirita"],["dc.contributor.author","Brandis, Almuth"],["dc.contributor.author","Krone, Dorothee"],["dc.contributor.author","Schneider, Heike"],["dc.contributor.author","Groos, Stephanie"],["dc.contributor.author","Menon, Manoj B."],["dc.contributor.author","Chang, Kin-Chow"],["dc.contributor.author","Kraft, Theresia"],["dc.contributor.author","Meissner, Joachim D."],["dc.contributor.author","Boheler, Kenneth R."],["dc.contributor.author","Maier, Lars. S."],["dc.contributor.author","Gaestel, Matthias"],["dc.contributor.author","Scheibe, Renate J."],["dc.date.accessioned","2018-11-07T09:23:26Z"],["dc.date.available","2018-11-07T09:23:26Z"],["dc.date.issued","2013"],["dc.description.abstract","The mitogen-activated protein kinase (MAPK)-activated protein kinases 2 and 3 (MK2/3) represent protein kinases downstream of the p38 MAPK. Using MK2/3 double-knockout (MK2/3(-/-)) mice, we analyzed the role of MK2/3 in cross-striated muscle by transcriptome and proteome analyses and by histology. We demonstrated enhanced expression of the slow oxidative skeletal muscle myofiber gene program, including the peroxisome proliferator-activated receptor gamma (PPAR gamma) coactivator 1 alpha (PGC-1 alpha). Using reporter gene and electrophoretic gel mobility shift assays, we demonstrated that MK2 catalytic activity directly regulated the promoters of the fast fiber-specific myosin heavy-chain IId/x and the slow fiber-specific sarco/endoplasmic reticulum Ca2+-ATPase 2 (SERCA2) gene. Elevated SERCA2a gene expression caused by a decreased ratio of transcription factor Egr-1 to Sp1 was associated with accelerated relaxation and enhanced contractility in MK2/3(-/-) cardiomyocytes, concomitant with improved force parameters in MK2/3(-/-) soleus muscle. These results link MK2/3 to the regulation of calcium dynamics and identify enzymatic activity of MK2/3 as a critical factor for modulating cross-striated muscle function by generating a unique muscle phenotype exhibiting both reduced fatigability and enhanced force in MK2/3(-/-) mice. Hence, the p38-MK2/3 axis may represent a novel target for the design of therapeutic strategies for diseases related to fiber type changes or impaired SERCA2 function."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [SCHE 309/5-1]"],["dc.identifier.doi","10.1128/MCB.01692-12"],["dc.identifier.isi","000320030900007"],["dc.identifier.pmid","23608535"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/29577"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Microbiology"],["dc.relation.issn","0270-7306"],["dc.title","Mitogen-Activated Protein Kinase-Activated Protein Kinases 2 and 3 Regulate SERCA2a Expression and Fiber Type Composition To Modulate Skeletal Muscle and Cardiomyocyte"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Interventional Cardiac Electrophysiology"],["dc.contributor.author","Krause, Ulrich"],["dc.contributor.author","Müller, Matthias J."],["dc.contributor.author","Schneider, Heike E."],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2022-05-02T08:09:42Z"],["dc.date.available","2022-05-02T08:09:42Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract Background Prevalence of atrial fibrillation (AF) is increasing in adult patients with congenital heart disease (CHD). Experience using the cryoballoon to achieve pulmonary vein isolation (PVI) in adult CHD patients is limited. The aim of the present study was to assess the value of PVI by cryoballoon in adult CHD patients and to evaluate the significance of additional radiofrequency (RF) ablation of atrial tachycardia (AT). Patients and methods Prospective data analysis; all patients with CHD and AF and PVI using the cryoballoon from January 2017 through November 2021 were included. Results Nineteen patients with various types of CHD were included. Median age was 58 (IQR 47–63) years. A total of 12/19 (63%) patients had had RF ablation of right atrial AT before. Median procedure duration was 225 (IQR 196–261) min. Median fluoroscopy time was 12.3 (IQR 5.2–19.5) min and median freeze time was 32 (IQR 28–36.3) min. Procedural success was achieved in all patients. Additional RF catheter ablation of intraatrial reentrant tachycardia within the left atrium was performed in 3/19 (16%) subjects and within the right atrium in 6/19 (32%) patients. Median follow-up was 26 (IQR 9–49) months. Excluding a 90-day blanking period, recurrence of AF was observed in 6/19 subjects (32%). After one redo procedure deploying RF energy only, 84% of all patients remained free from recurrence. Phrenic nerve palsy was observed in 1 subject. Conclusion Results after PVI using the cryoballoon plus additional RF ablation of AT were promising (84% success including one redo procedure). Success of AF ablation was unsatisfactory in all patients who had no additional AT ablation. Ablation of any AT in these patients should therefore be considered in addition to PVI."],["dc.description.abstract","Abstract Background Prevalence of atrial fibrillation (AF) is increasing in adult patients with congenital heart disease (CHD). Experience using the cryoballoon to achieve pulmonary vein isolation (PVI) in adult CHD patients is limited. The aim of the present study was to assess the value of PVI by cryoballoon in adult CHD patients and to evaluate the significance of additional radiofrequency (RF) ablation of atrial tachycardia (AT). Patients and methods Prospective data analysis; all patients with CHD and AF and PVI using the cryoballoon from January 2017 through November 2021 were included. Results Nineteen patients with various types of CHD were included. Median age was 58 (IQR 47–63) years. A total of 12/19 (63%) patients had had RF ablation of right atrial AT before. Median procedure duration was 225 (IQR 196–261) min. Median fluoroscopy time was 12.3 (IQR 5.2–19.5) min and median freeze time was 32 (IQR 28–36.3) min. Procedural success was achieved in all patients. Additional RF catheter ablation of intraatrial reentrant tachycardia within the left atrium was performed in 3/19 (16%) subjects and within the right atrium in 6/19 (32%) patients. Median follow-up was 26 (IQR 9–49) months. Excluding a 90-day blanking period, recurrence of AF was observed in 6/19 subjects (32%). After one redo procedure deploying RF energy only, 84% of all patients remained free from recurrence. Phrenic nerve palsy was observed in 1 subject. Conclusion Results after PVI using the cryoballoon plus additional RF ablation of AT were promising (84% success including one redo procedure). Success of AF ablation was unsatisfactory in all patients who had no additional AT ablation. Ablation of any AT in these patients should therefore be considered in addition to PVI."],["dc.description.sponsorship","Georg-August-Universität Göttingen"],["dc.identifier.doi","10.1007/s10840-022-01213-0"],["dc.identifier.pii","1213"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107443"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-561"],["dc.relation.eissn","1572-8595"],["dc.relation.issn","1383-875X"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Catheter ablation of atrial fibrillation using 2nd-generation cryoballoon in congenital heart disease patients — significance of RF ablation of additional atrial macro-reentrant tachycardia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","107575"],["dc.bibliographiccitation.journal","Ecological Indicators"],["dc.bibliographiccitation.volume","125"],["dc.contributor.author","Meyer, Peter"],["dc.contributor.author","Aljes, Maria"],["dc.contributor.author","Culmsee, Heike"],["dc.contributor.author","Feldmann, Eike"],["dc.contributor.author","Glatthorn, Jonas"],["dc.contributor.author","Leuschner, Christoph"],["dc.contributor.author","Schneider, Heike"],["dc.date.accessioned","2021-06-01T09:41:16Z"],["dc.date.available","2021-06-01T09:41:16Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.ecolind.2021.107575"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84864"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","1470-160X"],["dc.title","Quantifying old-growthness of lowland European beech forests by a multivariate indicator for forest structure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","179"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Klinische Pädiatrie"],["dc.bibliographiccitation.lastpage","182"],["dc.bibliographiccitation.volume","224"],["dc.contributor.author","Krause, Ulrich J."],["dc.contributor.author","Schneider, Heike E."],["dc.contributor.author","Webel, Martin"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T09:10:35Z"],["dc.date.available","2018-11-07T09:10:35Z"],["dc.date.issued","2012"],["dc.description.abstract","Background: Aortic thrombosis is rarely observed in neonates and infants. Underlying conditions include the presence of umbilical artery catheters, thrombosed aneurysm of the ductus arteriosus, sepsis and different states of inherited thrombophilia. Treatment options include anticoagulation, thrombolytic therapy and thrombectomy. Due to the lack of large studies, neither diagnosis nor treatment of neonatal aortic thrombosis are standardized. Patients: From 2008-2010, 1 neonate and 1 infant were admitted to our hospital with symptomatic aortic thrombosis. Methods and Results: In both patients, diagnosis was made by Doppler ultrasound. Both patients were effectively treated with recombinant tissuetype plasminogen activator. Diagnosis and treatment of 2 infants with symptomatic aortic thrombosis are discussed and the literature is reviewed. Conclusions: Since aortic thrombosis is a life-threatening condition, early diagnosis by Doppler ultrasound is mandatory to initiate treatment without delay. Thrombolytic therapy is a safe measure to treat this condition if administered with caution and if the patient has not suffered from serious complications such as mesenteric infarction or renal failure prior to begin of therapy."],["dc.identifier.doi","10.1055/s-0031-1295421"],["dc.identifier.isi","000305171500013"],["dc.identifier.pmid","22377739"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26525"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0300-8630"],["dc.title","Thrombosis of the Aorta Abdominalis in Infants - Diagnosis and Thrombolytic Therapy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E308"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","The Heart Surgery Forum"],["dc.bibliographiccitation.lastpage","E309"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Schneider, Heike"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.date.accessioned","2021-06-01T10:48:26Z"],["dc.date.available","2021-06-01T10:48:26Z"],["dc.date.issued","2009"],["dc.description.abstract","The case of a newborn with malignant tachyarrhythmia after heart surgery treated with cardiac extracorporeal membrane oxygenation (ECMO) is presented. After emergency surgery for a large right atrial tumor, the newborn developed supraventricular and ventricular arrhythmias. Despite antiarrhythmic medication, tachyarrhythmia remained, and low cardiac output syndrome developed progressively. Mechanical circulatory support was started, and soon thereafter sinus rhythm recovered. Four days after implantation, mechanical circulatory support was terminated, and the ECMO device was explanted. At discharge from the hospital, the baby had had stable sinus rhythm without any antiarrhythmic medication."],["dc.identifier.doi","10.1532/HSF98.20091058"],["dc.identifier.isi","000271489400015"],["dc.identifier.pmid","20077633"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85936"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Forum Multimedia Publishing, Llc"],["dc.relation.eissn","1522-6662"],["dc.relation.issn","1098-3511"],["dc.title","Mechanical Circulatory Support for Low Cardiac Output Syndrome Due to Tachyarrhythmia after Cardiac Surgery in a Newborn"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","292"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Catheterization and Cardiovascular Interventions"],["dc.bibliographiccitation.lastpage","295"],["dc.bibliographiccitation.volume","91"],["dc.contributor.author","Schneider, Heike E."],["dc.contributor.author","Gravenhorst, Verena"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.date.accessioned","2021-06-01T10:49:45Z"],["dc.date.available","2021-06-01T10:49:45Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1002/ccd.27445"],["dc.identifier.issn","1522-1946"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86404"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","1522-1946"],["dc.title","Insufficiency of a Damus-Kaye-Stansel anastomosis in a Fontan patient: Transfemoral implantation of an Edwards Sapien 3 valve"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6150"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Virology"],["dc.bibliographiccitation.lastpage","6160"],["dc.bibliographiccitation.volume","87"],["dc.contributor.author","Bertram, Stephanie"],["dc.contributor.author","Dijkman, Ronald"],["dc.contributor.author","Habjan, Matthias"],["dc.contributor.author","Heurich, Adeline"],["dc.contributor.author","Gierer, Stefanie"],["dc.contributor.author","Glowacka, Ilona"],["dc.contributor.author","Welsch, Kathrin"],["dc.contributor.author","Winkler, Michael"],["dc.contributor.author","Schneider, Heike"],["dc.contributor.author","Hofmann-Winkler, Heike"],["dc.contributor.author","Pöhlmann, Stefan"],["dc.date.accessioned","2022-10-06T13:25:38Z"],["dc.date.available","2022-10-06T13:25:38Z"],["dc.date.issued","2013"],["dc.description.abstract","ABSTRACT\n \n Infection with human coronavirus 229E (HCoV-229E) is associated with the common cold and may result in pneumonia in immunocompromised patients. The viral spike (S) protein is incorporated into the viral envelope and mediates infectious entry of HCoV-229E into host cells, a process that depends on the activation of the S-protein by host cell proteases. However, the proteases responsible for HCoV-229E activation are incompletely defined. Here we show that the type II transmembrane serine proteases TMPRSS2 and HAT cleave the HCoV-229E S-protein (229E-S) and augment 229E-S-driven cell-cell fusion, suggesting that TMPRSS2 and HAT can activate 229E-S. Indeed, engineered expression of TMPRSS2 and HAT rendered 229E-S-driven virus-cell fusion insensitive to an inhibitor of cathepsin L, a protease previously shown to facilitate HCoV-229E infection. Inhibition of endogenous cathepsin L or TMPRSS2 demonstrated that both proteases can activate 229E-S for entry into cells that are naturally susceptible to infection. In addition, evidence was obtained that activation by TMPRSS2 rescues 229E-S-dependent cell entry from inhibition by IFITM proteins. Finally, immunohistochemistry revealed that TMPRSS2 is coexpressed with CD13, the HCoV-229E receptor, in human airway epithelial (HAE) cells, and that CD13\n +\n TMPRSS2\n +\n cells are preferentially targeted by HCoV-229E, suggesting that TMPRSS2 can activate HCoV-229E in infected humans. In sum, our results indicate that HCoV-229E can employ redundant proteolytic pathways to ensure its activation in host cells. In addition, our observations and previous work suggest that diverse human respiratory viruses are activated by TMPRSS2, which may constitute a target for antiviral intervention."],["dc.identifier.doi","10.1128/JVI.03372-12"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114884"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1098-5514"],["dc.relation.issn","0022-538X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://journals.asm.org/non-commercial-tdm-license"],["dc.title","TMPRSS2 Activates the Human Coronavirus 229E for Cathepsin-Independent Host Cell Entry and Is Expressed in Viral Target Cells in the Respiratory Epithelium"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","459"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Pediatric Cardiology"],["dc.bibliographiccitation.lastpage","464"],["dc.bibliographiccitation.volume","37"],["dc.contributor.author","Dieks, Jana-Katharina"],["dc.contributor.author","Mueller, Matthias J."],["dc.contributor.author","Schneider, Heike E."],["dc.contributor.author","Krause, Ulrich J."],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Kriebel, Thomas"],["dc.date.accessioned","2018-11-07T10:17:25Z"],["dc.date.available","2018-11-07T10:17:25Z"],["dc.date.issued","2016"],["dc.description.abstract","Experience of catheter ablation of pediatric focal atrial tachycardia (FAT) is still limited. There are data which were gathered prior to the introduction of modern 3D mapping and navigation systems into the clinical routine. Accordingly, procedures were associated with significant fluoroscopy and low success rates. The aim of this study was to present clinical and electrophysiological details of catheter ablation of pediatric FAT using modern mapping systems. Since March 2003, 17 consecutive patients < 20 years underwent electrophysiological study (EPS) for FAT using the NavX(A (R)) system (n = 7), the non-contact mapping system (n = 6) or the LocaLisa(A (R)) system (n = 4), respectively. Radiofrequency was the primary energy source; cryoablation was performed in selected patients with a focus close to the AV node. In 16 patients, a total number of 19 atrial foci (right-sided n = 13, left-sided n = 6) could be targeted. In the remaining patient, FAT was not present/inducible during EPS. On an intention-to-treat basis, acute success was achieved in 14/16 patients (87.5 %) with a median number of 11 (1-31) energy applications. Ablation was unsuccessful in two patients due to an epicardial location of a right atrial focus (n = 1) and a focus close to the His bundle (n = 1), respectively. Median procedure time was 210 (84-332) min, and median fluoroscopy time was 13.1 (4.5-22.5) min. In pediatric patients with FAT, 3D mapping and catheter ablation provided improved clinical quality of care. Catheter ablation may be considered early in the course of treatment of this tachyarrhythmia in symptomatic patients."],["dc.identifier.doi","10.1007/s00246-015-1299-x"],["dc.identifier.isi","000373308800004"],["dc.identifier.pmid","26538211"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41220"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1432-1971"],["dc.relation.issn","0172-0643"],["dc.title","Catheter Ablation of Pediatric Focal Atrial Tachycardia: Ten-Year Experience Using Modern Mapping Systems"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Pediatrics"],["dc.bibliographiccitation.volume","170"],["dc.contributor.author","Schneider, Heike E."],["dc.contributor.author","Kriebel, TA"],["dc.contributor.author","Schill, Manfred"],["dc.contributor.author","Stahl, M."],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T08:59:28Z"],["dc.date.available","2018-11-07T08:59:28Z"],["dc.date.issued","2011"],["dc.format.extent","270"],["dc.identifier.isi","000286334200053"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23905"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","0340-6199"],["dc.title","Intracoronary ultrasound and selective coronary artery angiography early and late after a new modified cryoenergy application at growing myocardium"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","663"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Pediatric Cardiology"],["dc.bibliographiccitation.lastpage","668"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Krause, Ulrich"],["dc.contributor.author","Abreu da Cunha, Filipe D."],["dc.contributor.author","Backhoff, David"],["dc.contributor.author","Jacobshagen, Claudius"],["dc.contributor.author","Klehs, Sophia"],["dc.contributor.author","Schneider, Heike E."],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T10:25:38Z"],["dc.date.available","2018-11-07T10:25:38Z"],["dc.date.issued","2017"],["dc.description.abstract","To improve long-term outcome after cryoablation of substrates of supraventricular tachycardia, application of two and three consecutive freeze-thaw cycles has been performed. The effect of triple freeze-thaw cycles on lesion formation within developing myocardium and coronary arteries, however, has not been studied yet. In eight piglets (mean age 15 weeks, weight 15-20 kg), 30 cryolesions (three consecutive freeze-thaw cycles) were applied to the atrial aspect of both AV valve annuli (n = 18) as well as to ventricular myocardium below the valves (n = 12). Coronary angiography was performed before and after cryoenergy application. The animals were reevaluated by coronary angiography and intracoronary ultrasound (ICUS) after 48 h. All hearts were removed for histological examination of the lesions subsequently. After staining (hematoxylin-eosin, desmin immunohistochemistry), lesions was measured by planimetry with a digital virtual miscroscope analysis system and volumes of the cryolesions were calculated. Mean atrial lesion volume was 190.68 +/- 167.53 mm(3) (n = 18), and mean ventricular lesion volume was 184.34 +/- 107.42 mm(3) (n = 12). Compared with previously reported data on lesion volumes after single and double freeze-thaw cycles, lesions were significantly larger. Coronary arteries were unaffected on coronary angiography as well as on ICUS. No affection of coronary arteries was found on histological examination. Application of three consecutive freeze-thaw cycles resulted in increased lesion volume compared with single and double freeze-thaw cycles. No affection of the coronary arteries was evident. To evaluate the clinical benefit and safety of triple cryoenergy application for catheter ablation, prospective randomized trials are required."],["dc.identifier.doi","10.1007/s00246-016-1564-7"],["dc.identifier.isi","000399219800004"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42893"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.issn","1432-1971"],["dc.relation.issn","0172-0643"],["dc.title","Effects of Triple Cryoenergy Application on Lesion Formation and Coronary Arteries in the Developing Myocardium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]