Schneider, Heike E.

[["dc.bibliographiccitation.firstpage","33"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.lastpage","42"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Schneider, Heike E."],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Krause, Ulrich J."],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Ruschewski, Wolfgang"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T09:30:45Z"],["dc.date.available","2018-11-07T09:30:45Z"],["dc.date.issued","2013"],["dc.description.abstract","Left cardiac sympathetic denervation (LCSD) may be a therapeutic adjunct for young patients with catecholaminergic polymorphic ventricular tachycardia (CPVT) and long QT syndrome (LQTS) who are not fully protected by beta-blockade. The objective of this analysis was to report our institutional experience with LSCD in young patients for the management of life-threatening ventricular arrhythmias in CPVT and LQTS. Ten young patients with CPVT and LQTS underwent transaxillary LSCD at our institution. Mean age at surgery was 14.0 (range 3.9-42) years, mean body weight was 45.7 (range 15.5-90) kg. Five patients had the clinical diagnosis of CPVT, three were genotype positive for a mutation in the ryanodine-receptor-2-gene. Four of five LQTS patients were genotype positive. Indications for LCSD were recurrent syncope, symptomatic episodes of ventricular tachycardias and/or internal cardioverter-defibrillator (ICD) discharges, and aborted cardiac arrest despite high doses of beta-blockers. LCSD was performed via the transaxillary approach. No significant complications were observed. Two patients already had an ICD, 6 patients received an ICD at the same operation or shortly thereafter. Median length of follow-up after LCSD was 2.3 (range 0.6-3.9) years. After LCSD a marked reduction in arrhythmia burden and cardiac events was observed in all patients while medication was continued. None of the patients had any further ICD discharge for sustained VT. After LCSD, arrhythmia burden could significantly be reduced in all our young patients with CPVT and LQTS."],["dc.identifier.doi","10.1007/s00392-012-0492-7"],["dc.identifier.isi","000313070900004"],["dc.identifier.pmid","22821214"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8805"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31382"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Left cardiac sympathetic denervation for the management of life-threatening ventricular tachyarrhythmias in young patients with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","601"],["dc.bibliographiccitation.journal","SpringerPlus"],["dc.bibliographiccitation.volume","3"],["dc.contributor.author","Sohns, Jan Martin"],["dc.contributor.author","Steinmetz, Michael"],["dc.contributor.author","Schneider, Heike"],["dc.contributor.author","Fasshauer, Martin"],["dc.contributor.author","Staab, Wieland"],["dc.contributor.author","Kowallick, Johannes Tammo"],["dc.contributor.author","Schuster, Andreas"],["dc.contributor.author","Ritter, Christian"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Unterberg-Buchwald, Christina"],["dc.date.accessioned","2018-11-07T09:33:32Z"],["dc.date.available","2018-11-07T09:33:32Z"],["dc.date.issued","2014"],["dc.description.abstract","Introduction: Situs inversus totalis with congenitally corrected transposition of the great arteries represents a relatively rare congenital condition. Case description: The current report describes the case of a 56 year old patient with an atrio-ventricular and ventricular-arterial discordance of the heart chambers without surgical correction, incidentally detected during hepatocellular carcinoma evaluation. The systemic venous blood arrived via the right atrium and a mitral valve in the morphologically left but pulmonary arterial ventricle that gave rise to a pulmonary trunk. The pulmonary venous blood passed the left atrium and the tricuspid valve into a morphologically right but systemic ventricle that gave rise to the aorta. Discussion and evaluation: The switched anatomy was incidentally detected on echocardiography. The patient was referred to cardiac magnetic resonance imaging (CMR) including flow measurements, volumetry and late enhancement. CMR results showed a mildly impaired function and the switched anatomy. During a follow-up period of 2 years the patient was suffering from only mild heart failure and dyspnea. Conclusions: Heart failure symptoms and arrhythmias can appear with increasing age in patients with congenitally corrected transposition. Early CMR allows accurate diagnosis and timely introduction of adequate therapy thereby avoiding disease progression."],["dc.identifier.doi","10.1186/2193-1801-3-601"],["dc.identifier.isi","000359108200001"],["dc.identifier.pmid","25392774"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11150"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31986"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","2193-1801"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Situs inversus totalis with congenitally corrected transposition of the great arteries: insights from cardiac MRI"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","731"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Heart Rhythm"],["dc.bibliographiccitation.lastpage","739"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Schneider, Heike E."],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Jung, Klaus"],["dc.contributor.author","Gravenhorst, Verena D."],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T08:42:45Z"],["dc.date.available","2018-11-07T08:42:45Z"],["dc.date.issued","2010"],["dc.description.abstract","BACKGROUND Idiopathic ventricular tachycardia (VT) in children with a structurally normal heart can cause significant morbidity, and although rare, mortality. Conventional activation and pace mapping may be limited by nonsustained tachycardia or unstable hemodynamics. OBJECTIVE The aim of this study was to assess feasibility of catheter ablation of idiopathic VT in the pediatric population guided by noncontact mapping. METHODS Twenty consecutive pediatric patients with idiopathic VT underwent electrophysiologic study with the intention to use the noncontact mapping system EnSite 3000 (EnSite Array, St. Jude Medical Inc., Minneapolis, Minnesota). The multielectrode balloon array was introduced into the left or right ventricle, respectively, and tachycardia was analyzed using color-coded isopotential maps as well as reconstructed unipolar electrograms on the virtual geometry. The region of origin was identified in all of them, and the site of earliest activation with a QS pattern of the unipolar electrograms was guided for sites of ablation. RESULTS Idiopathic VT originated from the right ventricular outflow tract in 6 patients, from the left ventricle in 8, and from the aortic sinus cusp in 6 in this cohort with a median age of 14.4 (range: 4.8 to 20.9) years. Ablation was attempted in 18 of 20 children, and was acutely successful in 17 of these 18 (94%). During a mean follow-up of 2.3 +/- 1.7 years, VT recurred in 3, 2 of them have been treated with a second procedure, resulting in an overall intermediate-term success in 16 of 18 (89%) children with idiopathic VT. CONCLUSION Noncontact mapping can safely and effectively be used to map and guide catheter ablation of the tachycardia substrate of idiopathic VT in pediatric patients."],["dc.identifier.doi","10.1016/j.hrthm.2010.02.031"],["dc.identifier.isi","000278608300002"],["dc.identifier.pmid","20193776"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6219"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19771"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1547-5271"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Catheter ablation of idiopathic left and right ventricular tachycardias in the pediatric population using noncontact mapping"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1197"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Pacing and Clinical Electrophysiology"],["dc.bibliographiccitation.lastpage","1202"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Hermann, Hans-Peter"],["dc.contributor.author","Schneider, Heike"],["dc.contributor.author","Kroll, Maja"],["dc.contributor.author","Selle, Jakob"],["dc.contributor.author","Overwaul, Anna"],["dc.contributor.author","Sigler, Matthias"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2021-11-22T14:31:49Z"],["dc.date.available","2021-11-22T14:31:49Z"],["dc.date.issued","2009"],["dc.description.abstract","BACKGROUND: Animal studies and clinical observations have demonstrated that radiofrequency current application at growing myocardium may result in coronary artery obstruction. Recently, cryoenergy has emerged as an effective alternative to radiofrequency ablation of arrhythmogenic substrates in pediatric patients. Up to now, there has been a lack of experimental data concerning the effects of cryoenergy application at growing myocardium. METHODS: During general anesthesia, selective coronary angiography of the right and left coronary artery was performed in 10 piglets (age: 6 weeks, body weight: 14-18 kg). Subsequently, cryoenergy was delivered at -75 degrees C for 4 minutes using a 7-F catheter with a 6-mm-tip electrode at the atrial aspect of the tricuspid valve annulus in a posterior and lateral position. Additional cryoenergy lesions were induced via a retrograde approach at the lateral and posterior atrial and ventricular aspect of the mitral valve annulus, respectively. Five animals were restudied after 48 hours by coronary angiography and intracoronary ultrasound and in the remaining five piglets after 3 and 6 months, respectively. RESULTS: Selective coronary angiography and intracoronary ultrasound studies did not demonstrate any evidence for coronary artery obstruction after 48 hours, 3 months, or 6 months after cryoenergy application. In addition, histological examinations of the cryolesions after 48 hours and after 6 months did not demonstrate any intimal proliferations of the coronary arteries, respectively. CONCLUSIONS: By means of the present study, we did not observe any affection of the coronary arteries after cryoenergy application at growing myocardium in young piglets."],["dc.description.abstract","Methods: During general anesthesia, selective coronary angiography of the right and left coronary artery was performed in 10 piglets (age: 6 weeks, body weight: 14-18 kg). Subsequently, cryoenergy was delivered at -75 degrees C for 4 minutes using a 7-F catheter with a 6-mm-tip electrode at the atrial aspect of the tricuspid valve annulus in a posterior and lateral position. Additional cryoenergy lesions were induced via a retrograde approach at the lateral and posterior atrial and ventricular aspect of the mitral valve annulus, respectively. Five animals were restudied after 48 hours by coronary angiography and intracoronary ultrasound and in the remaining five piglets after 3 and 6 months, respectively. Results: Selective coronary angiography and intracoronary ultrasound studies did not demonstrate any evidence for coronary artery obstruction after 48 hours, 3 months, or 6 months after cryoenergy application. In addition, histological examinations of the cryolesions after 48 hours and after 6 months did not demonstrate any intimal proliferations of the coronary arteries, respectively. Conclusions: By means of the present study, we did not observe any affection of the coronary arteries after cryoenergy application at growing myocardium in young piglets. (PACE 2009; 32:1197-1202)."],["dc.identifier.doi","10.1111/j.1540-8159.2009.02465.x"],["dc.identifier.isi","000269390500015"],["dc.identifier.pmid","19719499"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6288"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/93405"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell Publishing, Inc"],["dc.relation.issn","1540-8159"],["dc.rights.access","closedAccess"],["dc.subject.ddc","610"],["dc.subject.mesh","Animals"],["dc.subject.mesh","Coronary Artery Disease"],["dc.subject.mesh","Coronary Stenosis"],["dc.subject.mesh","Coronary Vessels"],["dc.subject.mesh","Cryosurgery"],["dc.subject.mesh","Risk Assessment"],["dc.subject.mesh","Swine"],["dc.title","Cryoablation at growing myocardium: no evidence of coronary artery obstruction or intimal plaque formation early and late after energy application."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","398"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","International Journal of Cardiology"],["dc.bibliographiccitation.lastpage","404"],["dc.bibliographiccitation.volume","147"],["dc.contributor.author","Vogt, Manfred Otto"],["dc.contributor.author","Kuehn, Andreas"],["dc.contributor.author","Hoerer, Juergen"],["dc.contributor.author","Schreiber, Christian"],["dc.contributor.author","Schneider, Heike"],["dc.contributor.author","Foth, Rudi"],["dc.contributor.author","Eicken, Andreas"],["dc.contributor.author","Hess, John"],["dc.contributor.author","Sigler, Matthias"],["dc.date.accessioned","2018-11-07T08:58:04Z"],["dc.date.available","2018-11-07T08:58:04Z"],["dc.date.issued","2011"],["dc.description.abstract","Background: Atrial septal defects (ASD) and persistent foramen ovale (PFO) are managed in increasing numbers by catheter interventions as an attractive alternative to surgery. Early complications have been described in clinical series whereas late complications are rare. No series are reported with clinical, echocardiographic and histological data. Methods and results: We collected clinical, echocardiographic, and histolological data of nine patients with surgically explanted devices. Occlusion devices were explanted after a mean interval of 3.4 +/- 2.4 years (range 0.9-8.3). Indications were recurrent thromboembolic events in five, residual shunt/dislocation in three, and growing mass on echocardiography despite oral anticoagulation in one patient. Two patients suffered potentially live threatening events due to coronary embolism. One of them had to be resuscitated due to ventricular fibrillation. Histologically, residues of superficial thrombus formation could be demonstrated in two of the devices. In another patient, hyperplastic tissue formation was related to a local inflammatory process but not to a thrombus as suspected by echocardiography. Conclusion: Late complications after device implantation may occur up to 8 years after device implantation and may be potentially live threatening. Echocardiographic controls should be prolonged beyond the first year after implantation and every explanted device should be histologically worked up in an experienced center. Up to now, the mechanisms of late thrombogenesis are not fully understood. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved."],["dc.identifier.doi","10.1016/j.ijcard.2009.09.544"],["dc.identifier.isi","000288168000015"],["dc.identifier.pmid","19896735"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6220"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23556"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Ireland Ltd"],["dc.relation.issn","0167-5273"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Clinical, echocardiographic and histopathologic findings in nine patients with surgically explanted ASD/PFO devices: Do we know enough about the healing process in humans?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1036"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Pediatric Cardiology"],["dc.bibliographiccitation.lastpage","1039"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Mueller, Matthias J."],["dc.contributor.author","Krause, Ulrich J."],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Schneider, Heike E."],["dc.date.accessioned","2018-11-07T08:51:24Z"],["dc.date.available","2018-11-07T08:51:24Z"],["dc.date.issued","2011"],["dc.description.abstract","Everolimus-eluting stents and paclitaxel-coated balloons are used in the interventional treatment of coronary artery disease in adults to reduce the restenosis rate and in small-vessel disease. Both substances are released into the circulation. We report systemic drug exposure after implantation of one everolimus-eluting stent and dilation with one paclitaxel-coated balloon in an 8-month-old infant, which was used as an innovative therapy for recurrent pulmonary vein stenosis."],["dc.identifier.doi","10.1007/s00246-011-0054-1"],["dc.identifier.isi","000294959700030"],["dc.identifier.pmid","21796444"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/7523"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21927"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0172-0643"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Serum Levels After Everolimus-Stent Implantation and Paclitaxel-Balloon Angioplasty in an Infant with Recurrent Pulmonary Vein Obstruction After Repaired Total Anomalous Pulmonary Venous Connection"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","461"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Heart Rhythm"],["dc.bibliographiccitation.lastpage","467"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Schneider, Heike E."],["dc.contributor.author","Kriebel, Thomas"],["dc.contributor.author","Gravenhorst, Verena D."],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2018-11-07T08:31:06Z"],["dc.date.available","2018-11-07T08:31:06Z"],["dc.date.issued","2009"],["dc.description.abstract","BACKGROUND Several case reports have documented coronary artery stenosis or even occlusion after radiofrequency energy ablation (RFA) in children and adults. Coronary involvement early and (ate after RFA has also been described in animal models. OBJECTIVE The purpose of this study was to assess prospectively the incidence of coronary artery injury early after catheter ablation for supraventricular tachycardias (SVT) in children. METHODS From October 2002 to January 2008, 212 consecutive patients younger than 21. years with SVT underwent selective coronary angiography before and 30 minutes after RFA or cryoablation. RESULTS Median patient age was 12 years (range 0.3-20.4 years), and median body weight was 47 kg (range 5.5-130 kg). An accessory pathway was diagnosed in 112 patients, AV nodal reentrant tachycardia (AVNRT) in 84 patients, and both an accessory pathway and AVNRT in 16 patients. Congenital heart disease was present in 31 patients. In 2 of 117 patients who had RFA for an accessory pathway, an acute reduction in luminal diameter of the coronary artery adjacent to the ablation site was observed. These two patients with a structurally normal heart showed ST-segment changes with normalization of the ECG within 1 week. Both were clinically asymptomatic, and two-dimensional echocardiography documented normal ventricular function. Noninvasive testing did not reveal any evidence of persistent myocardial ischemia. No coronary artery damage was noted after ablation for AVNRT or after ablation with cryoenergy. CONCLUSION Coronary artery narrowing adjacent to the RFA site was noted in 2 of 117 patients with an accessory pathway and occurred only in patients with a posteroseptal pathway. Coronary angiography could be helpful in avoiding coronary lesions in these settings."],["dc.identifier.doi","10.1016/j.hrthm.2009.01.029"],["dc.identifier.isi","000264919500004"],["dc.identifier.pmid","19324303"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6217"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/17044"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.relation.issn","1547-5271"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Incidence of coronary artery injury immediately after catheter ablation for supraventricular tachycardias in infants and children"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","jce.15544"],["dc.bibliographiccitation.firstpage","1757"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Journal of Cardiovascular Electrophysiology"],["dc.bibliographiccitation.lastpage","1766"],["dc.bibliographiccitation.volume","33"],["dc.contributor.affiliation","Müller, Matthias J.; 1\r\nDepartment of Pediatric Cardiology and Intensive Care Medicine\r\nGeorg August University Medical Center\r\nGöttingen Germany"],["dc.contributor.affiliation","Betz, Teresa; 1\r\nDepartment of Pediatric Cardiology and Intensive Care Medicine\r\nGeorg August University Medical Center\r\nGöttingen Germany"],["dc.contributor.affiliation","Arnold, Andreas; 1\r\nDepartment of Pediatric Cardiology and Intensive Care Medicine\r\nGeorg August University Medical Center\r\nGöttingen Germany"],["dc.contributor.affiliation","Schneider, Heike; 1\r\nDepartment of Pediatric Cardiology and Intensive Care Medicine\r\nGeorg August University Medical Center\r\nGöttingen Germany"],["dc.contributor.affiliation","Paul, Thomas; 1\r\nDepartment of Pediatric Cardiology and Intensive Care Medicine\r\nGeorg August University Medical Center\r\nGöttingen Germany"],["dc.contributor.affiliation","Krause, Ulrich; 1\r\nDepartment of Pediatric Cardiology and Intensive Care Medicine\r\nGeorg August University Medical Center\r\nGöttingen Germany"],["dc.contributor.author","Backhoff, David"],["dc.contributor.author","Müller, Matthias J."],["dc.contributor.author","Betz, Teresa"],["dc.contributor.author","Arnold, Andreas"],["dc.contributor.author","Schneider, Heike"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Krause, Ulrich"],["dc.date.accessioned","2022-06-01T09:39:30Z"],["dc.date.available","2022-06-01T09:39:30Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:14:13Z"],["dc.description.abstract","Abstract\r\n\r\nIntroduction\r\nCatheter contact is a key determinant for lesion size in radiofrequency catheter ablation (RFA). Monitoring of contact force (CF) during RFA has been shown to improve efficacy of RFA in experimental settings as well as in adult patients. Coronary artery narrowing after RFA has been described in experimental settings as well as in children and adults and may be dependent from catheter contact. The value of CF monitoring concerning these issues has not been systematically studied yet.\r\n\r\nValue of high versus low CF during RFA in piglets was studied to assess lesion size and potential coronary artery involvement mimicking RFA in small children.\r\n\r\n\r\nMethods\r\nRFA with continuous CF monitoring was performed in 24 piglets (median weight 18.5 kg) using a 7 F TactiCath Quartz radiofrequency (RF) ablation catheter (Abbott). A total of 7 lesions were induced in each animal applying low (10−20 g) or high (40−60 g) CF. RF energy was delivered with a target temperature of 65°C at 30 W for 30 s. Coronary angiography was performed prior and immediately after RF application. Animals were assigned to repeat coronary angiography followed by heart removal after 48 h (n = 12) or 6 months (n = 12). Lesions with surrounding myocardium were excised, fixated, and stained. Lesion volumes were measured by microscopic planimetry.\r\n\r\n\r\nResults\r\nA total of 148 RF lesions were identified in the explanted hearts. Only in the subset of lesions at the AV annulus 6 month after ablation, lesion size and number of lesions exhibiting transmural extension were higher in the high CF group compared to low CF. In all other locations CF had no impact on lesion size and mural extension after 48 h as well as after 6 months. Additional parameters such as lesion size index and force time integral were also not related to lesion size. Coronary artery damage was present in two animals after 48 h and in one after 6 months and was not related to CF.\r\n\r\n\r\nConclusion\r\nIn our experimental setting, lesion size in piglets was not related to catheter CF. Transmural extension of the RF lesions involving the layers of the coronary arteries was frequently noted irrespective of CF. Coronary artery narrowing was present in 3/24 animals and was not related to CF. In infants and toddlers, low CF (10−20 g) may be of adequate effect. Impact of CF monitoring during conventional RF ablation in children requires further investigation."],["dc.description.sponsorship","Fördergemeinschaft Deutsche Kinderherzzentren"],["dc.identifier.doi","10.1111/jce.15544"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/108493"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-572"],["dc.relation.eissn","1540-8167"],["dc.relation.issn","1045-3873"],["dc.rights","This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made."],["dc.rights.uri","http://onlinelibrary.wiley.com/termsAndConditions#vor"],["dc.title","Contact force guided radiofrequency current application at developing myocardium"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","469"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Clinical Research in Cardiology"],["dc.bibliographiccitation.lastpage","470"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Eichler, Thorsten"],["dc.contributor.author","Paul, Thomas"],["dc.contributor.author","Schneider, Heike E."],["dc.date.accessioned","2018-11-07T08:56:38Z"],["dc.date.available","2018-11-07T08:56:38Z"],["dc.date.issued","2011"],["dc.identifier.doi","10.1007/s00392-010-0265-0"],["dc.identifier.isi","000289729300010"],["dc.identifier.pmid","21165627"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6611"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23199"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","Heidelberg"],["dc.relation.issn","1861-0684"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Hemangioma as a rare cause of a neonatal cardiac tumor resulting in inflow obstruction of the tricuspid valve"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","805"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Pacing and Clinical Electrophysiology"],["dc.bibliographiccitation.lastpage","813"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Backhoff, David"],["dc.contributor.author","Müller, Matthias J."],["dc.contributor.author","Dakna, Mohammed"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Schneider, Heike"],["dc.contributor.author","Krause, Ulrich"],["dc.contributor.author","Paul, Thomas"],["dc.date.accessioned","2021-04-14T08:24:04Z"],["dc.date.available","2021-04-14T08:24:04Z"],["dc.date.issued","2020"],["dc.description.abstract","Abstract Background Nontransvenous implanted cardioverter defibrillators (NT‐ICD) are used in infants and small children with life‐threatening ventricular tachyarrhythmias. With growth, shock vector shift may result in increase of defibrillation threshold (DFT) and fatal ICD failure. Objectives To date, the only way to verify ICD function in children with NT‐ICD is repetitive DFT testing, which is potentially harmful and may even be life threatening. The aim of the study was to analyze data from NT‐ICD DFT testing to prospectively predict individual DFT. Patients and methods Data from all pediatric patients with NT‐ICD implanted in our center from July 2004 to August 2019 were collected. Postoperative DFT testing was scheduled according to individual DFT but at least annually. Surgical revision of NT‐ICD was performed if DFT was \\u0026gt; 25 J. Selected noninvasive parameters from DFT testing were analyzed as predictors for DFT using a logistic regression model. Results A total of 46 children with NT‐ICD underwent a total of 402 DFT tests. Mean age at implantation had been 5.4 ± 3.3 years, mean follow‐up was 5.6 ± 3.7 years in 5 (1%) DFT testing, maximum device output failed, and external defibrillation was necessary. A retrospective multiple mixed logistic regression model was able to predict a DFT ≥25 J (area under the curve [AUC] = 0.836). However, when prospectively validated the model showed moderate performance only (AUC = 0.70). Conclusion A significant number of NT‐ICD failures were detected by serial DFT testing. Serial DFT testing was safe in pediatric patients with an NT‐ICD as all induced arrhythmia could be terminated. Prediction of DFT with noninvasive markers remains difficult and might help to schedule intervals for routine DFT tests to avoid unnecessary tests."],["dc.identifier.doi","10.1111/pace.14003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81153"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1540-8159"],["dc.relation.issn","0147-8389"],["dc.title","Value of defibrillation threshold testing in children with nontransvenous implantable cardioverter defibrillators: Are routine DFT tests indicated?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]