Engel, Christoph

[["dc.bibliographiccitation.firstpage","723"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Der Anaesthesist"],["dc.bibliographiccitation.lastpage","728"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Reinhart, Konrad"],["dc.contributor.author","Brunkhorst, Frank M."],["dc.contributor.author","Engel, C."],["dc.contributor.author","Bloos, Frank"],["dc.contributor.author","Meier-Hellmann, Andreas"],["dc.contributor.author","Ragaller, Maximilian"],["dc.contributor.author","Weiler, Norbert"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Gruendling, Matthias"],["dc.contributor.author","Oppert, Michael"],["dc.contributor.author","Grond, S."],["dc.contributor.author","Olthoff, Derk"],["dc.contributor.author","Jaschinski, Ulrich"],["dc.contributor.author","John, S."],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Welte, Tobias"],["dc.contributor.author","Schaefer, M."],["dc.contributor.author","Kern, R."],["dc.contributor.author","Kuhnt, Evelyn"],["dc.contributor.author","Kiehntopf, Michael"],["dc.contributor.author","Deufel, Thomas"],["dc.contributor.author","Hartog, Christiane"],["dc.contributor.author","Gerlach, Herwig"],["dc.contributor.author","Stueber, F."],["dc.contributor.author","Volk, H.-D."],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Loeffler, Markus"],["dc.date.accessioned","2018-11-07T11:13:08Z"],["dc.date.available","2018-11-07T11:13:08Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1007/s00101-008-1391-1"],["dc.identifier.isi","000257988500012"],["dc.identifier.pmid","18584135"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53824"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0003-2417"],["dc.title","Study protocol of the VISEP-Study. Answer of the SepNet-Study group"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2719"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.bibliographiccitation.lastpage","2725"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Brunkhorst, Frank M."],["dc.contributor.author","Engel, Christoph"],["dc.contributor.author","Ragaller, Max"],["dc.contributor.author","Welte, Tobias"],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Gerlach, Herwig"],["dc.contributor.author","Mayer, Konstantin"],["dc.contributor.author","John, Stefan"],["dc.contributor.author","Stuber, Frank"],["dc.contributor.author","Weiler, Norbert"],["dc.contributor.author","Oppert, Michael"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Bogatsch, Holger"],["dc.contributor.author","Reinhart, Konrad"],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Hartog, Christiane"],["dc.date.accessioned","2018-11-07T11:10:25Z"],["dc.date.available","2018-11-07T11:10:25Z"],["dc.date.issued","2008"],["dc.description.abstract","Objective: To simultaneously determine perceived vs. practiced adherence to recommended interventions for the treatment of severe sepsis or septic shock. Design: One-day cross-sectional survey. Setting: Representative sample of German intensive care units stratified by hospital size. Patients: Adult patients with severe sepsis or septic shock. Interventions: None. Measurements and Main Results: Practice recommendations were selected by German Sepsis Competence Network (SepNet) investigators. External intensivists visited intensive care units randomly chosen and asked the responsible intensive care unit director how often these recommendations were used. Responses \"always\" and \"frequently\" were combined to depict perceived adherence. Thereafter patient files were audited. Three hundred sixty-six patients on 214 intensive care units fulfilled the criteria and received full support. One hundred fifty-two patients had acute lung injury or acute respiratory distress syndrome. Low-tidal volume ventilation <= 6 mL/kg/predicted body weight was documented in 2.6% of these patients. A total of 17.1% patients had tidal volume between 6 and 8 mL/kg predicted body weight and 80.3% >8 mL/kg predicted body weight. Mean tidal volume was 10.0 +/- 2.4 mL/kg predicted body weight. Perceived ence to low-tidal volume ventilation was 79.9%. Euglycemia 6.1 mmol/L) was documented in 6.2% of 355 patients. A total 33.8% of patients had blood glucose levels <= 8.3 mmol/L and 66.2% were hyperglycemic (blood glucose >8.3 mmol/L. Among 207 patients receiving insulin therapy, 1.9% were euglycemic, 20.8% had blood glucose levels <= 8.3 mmol/L, and 1.0% were hypoglycemic. Overall, mean maximal glucose level was 10.0 +/- 3.6 mmol/L. Perceived adherence to strict glycemic control was 65.9%. Although perceived adherence to recommendations was higher in academic and larger hospitals, actual practice was not significantly influenced by hospital size or university affiliation. Conclusions: This representative survey shows that current therapy of severe sepsis in German intensive care units complies poorly with practice recommendations. Intensive care unit directors perceive adherence to be higher than it actually is. Implementation strategies involving all intensive care unit staff are needed to overcome this gap between current evidence-based knowledge, practice, and perception."],["dc.identifier.doi","10.1097/CCM.0b013e318186b6f3"],["dc.identifier.isi","000259766000001"],["dc.identifier.pmid","18766100"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53208"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0090-3493"],["dc.title","Practice and perception - A nationwide survey of therapy habits in sepsis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2390"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","JAMA"],["dc.bibliographiccitation.lastpage","2399"],["dc.bibliographiccitation.volume","307"],["dc.contributor.author","Brunkhorst, Frank M."],["dc.contributor.author","Oppert, Michael"],["dc.contributor.author","Marx, Gernot"],["dc.contributor.author","Bloos, Frank"],["dc.contributor.author","Ludewig, Katrin"],["dc.contributor.author","Putensen, Christian"],["dc.contributor.author","Nierhaus, Axel"],["dc.contributor.author","Jaschinski, Ulrich"],["dc.contributor.author","Meier-Hellmann, Andreas"],["dc.contributor.author","Weyland, Andreas"],["dc.contributor.author","Gruendling, Matthias"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Riessen, Reimer"],["dc.contributor.author","Seibel, Armin"],["dc.contributor.author","Ragaller, Maximilian"],["dc.contributor.author","Buechler, Markus W."],["dc.contributor.author","John, Stefan"],["dc.contributor.author","Bach, Friedhelm"],["dc.contributor.author","Spies, Claudia"],["dc.contributor.author","Reill, Lorenz"],["dc.contributor.author","Fritz, Harald"],["dc.contributor.author","Kiehntopf, Michael"],["dc.contributor.author","Kuhnt, Evelyn"],["dc.contributor.author","Bogatsch, Holger"],["dc.contributor.author","Engel, Christoph"],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Kollef, Marin H."],["dc.contributor.author","Reinhart, Konrad"],["dc.contributor.author","Welte, Tobias"],["dc.date.accessioned","2018-11-07T09:09:16Z"],["dc.date.available","2018-11-07T09:09:16Z"],["dc.date.issued","2012"],["dc.description.abstract","Context Early appropriate antimicrobial therapy leads to lower mortality rates associated with severe sepsis. The role of empirical combination therapy comprising at least 2 antibiotics of different mechanisms remains controversial. Objective To compare the effect of moxifloxacin and meropenem with the effect of meropenem alone on sepsis-related organ dysfunction. Design, Setting, and Patients A randomized, open-label, parallel-group trial of 600 patients who fulfilled criteria for severe sepsis or septic shock (n=298 for monotherapy and n=302 for combination therapy). The trial was performed at 44 intensive care units in Germany from October 16, 2007, to March 23, 2010. The number of evaluable patients was 273 in the monotherapy group and 278 in the combination therapy group. Interventions Intravenous meropenem (1 g every 8 hours) and moxifloxacin (400 mg every 24 hours) or meropenem alone. The intervention was recommended for 7 days and up to a maximum of 14 days after randomization or until discharge from the intensive care unit or death, whichever occurred first. Main Outcome Measure Degree of organ failure (mean of daily total Sequential Organ Failure Assessment [SOFA] scores over 14 days; score range: 0-24 points with higher scores indicating worse organ failure); secondary outcome: 28-day and 90-day all-cause mortality. Survivors were followed up for 90 days. Results Among 551 evaluable patients, there was no statistically significant difference in mean SOFA score between the meropenem and moxifloxacin group (8.3 points; 95% CI, 7.8-8.8 points) and the meropenem alone group (7.9 points; 95% CI, 7.5-8.4 points) (P=.36). The rates for 28-day and 90-day mortality also were not statistically significantly different. By day 28, there were 66 deaths (23.9%; 95% CI, 19.0%-29.4%) in the combination therapy group compared with 59 deaths (21.9%; 95% CI, 17.1%-27.4%) in the monotherapy group (P=.58). By day 90, there were 96 deaths (35.3%; 95% CI, 29.6%-41.3%) in the combination therapy group compared with 84 deaths (32.1%; 95% CI, 26.5%-38.1%) in the monotherapy group (P=.43). Conclusion Among adult patients with severe sepsis, treatment with combined meropenem and moxifloxacin compared with meropenem alone did not result in less organ failure."],["dc.identifier.doi","10.1001/jama.2012.5833"],["dc.identifier.isi","000305115900024"],["dc.identifier.pmid","22692171"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26219"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Medical Assoc"],["dc.relation.issn","0098-7484"],["dc.title","Effect of Empirical Treatment With Moxifloxacin and Meropenem vs Meropenem on Sepsis-Related Organ Dysfunction in Patients With Severe Sepsis A Randomized Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","27"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Der Anaesthesist"],["dc.bibliographiccitation.lastpage","33"],["dc.bibliographiccitation.volume","62"],["dc.contributor.author","Schaedler, D."],["dc.contributor.author","Elke, Gunnar"],["dc.contributor.author","Engel, C."],["dc.contributor.author","Bogatsch, Holger"],["dc.contributor.author","Frerichs, Inez"],["dc.contributor.author","Kuhlen, Ralf"],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Scholz, J."],["dc.contributor.author","Brunkhorst, Frank M."],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Reinhart, Konrad"],["dc.contributor.author","Weiler, Norbert"],["dc.date.accessioned","2018-11-07T09:30:25Z"],["dc.date.available","2018-11-07T09:30:25Z"],["dc.date.issued","2013"],["dc.description.abstract","Mortality in intensive care unit (ICU) patients is affected by multiple variables. The possible impact of the mode of ventilation has not yet been clarified; therefore, a secondary analysis of the \"epidemiology of sepsis in Germany\" study was performed. The aims were (1) to describe the ventilation strategies currently applied in clinical practice, (2) to analyze the association of the different modes of ventilation with mortality and (3) to investigate whether the ratio between arterial partial pressure of oxygen and inspired fraction of oxygen (PF ratio) and/or other respiratory variables are associated with mortality in septic patients needing ventilatory support. A total of 454 ICUs in 310 randomly selected hospitals participated in this national prospective observational 1-day point prevalence of sepsis study including 415 patients with severe sepsis or septic shock according to the American College of Chest Physicians/Society of Critical Care Medicine criteria. Of the 415 patients, 331 required ventilatory support. Pressure controlled ventilation (PCV) was the most frequently used ventilatory mode (70.6 %) followed by assisted ventilation (AV 21.7 %) and volume controlled ventilation (VCV 7.7 %). Hospital mortality did not differ significantly among patients ventilated with PCV (57 %), VCV (71 %) or AV (51 %, p = 0.23). A PF ratio equal or less than 300 mmHg was found in 83.2 % of invasively ventilated patients (n = 316). In AV patients there was a clear trend to a higher PF ratio (204 +/- 70 mmHg) than in controlled ventilated patients (PCV 179 +/- 74 mmHg, VCV 175 +/- 75 mmHg, p = 0.0551). Multiple regression analysis identified the tidal volume to pressure ratio (tidal volume divided by peak inspiratory airway pressure, odds ratio OR = 0.94, 95 % confidence interval 95% CI = 0.89-0.99), acute renal failure (OR = 2.15, 95% CI = 1.01-4.55) and acute physiology and chronic health evaluation (APACHE) II score (OR = 1.09, 95% CI = 1.03-1.15) but not the PF ratio (univariate analysis OR = 0.998, 95 % CI = 0.995-1.001) as independent risk factors for in-hospital mortality. This representative survey revealed that severe sepsis or septic shock was frequently associated with acute lung injury. Different ventilatory modes did not affect mortality. The tidal volume to inspiratory pressure ratio but not the PF ratio was independently associated with mortality."],["dc.identifier.doi","10.1007/s00101-012-2121-2"],["dc.identifier.isi","000314362700005"],["dc.identifier.pmid","23319272"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31304"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0003-2417"],["dc.title","Ventilatory strategies in septic patients Results from a nationwide observational trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Infection"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Schaedler, D."],["dc.contributor.author","Schmitz, G."],["dc.contributor.author","Frerichs, Inez"],["dc.contributor.author","Ragaller, Maximilian"],["dc.contributor.author","Kuhlen, Ralf"],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Engel, C."],["dc.contributor.author","Scholz, J."],["dc.contributor.author","Weiler, Norbert"],["dc.contributor.author","Reinhart, Konrad"],["dc.date.accessioned","2018-11-07T10:56:13Z"],["dc.date.available","2018-11-07T10:56:13Z"],["dc.date.issued","2005"],["dc.format.extent","46"],["dc.identifier.isi","000207064700114"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49961"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.issn","0300-8126"],["dc.title","How is mechanical ventilation employed in septic patients in Germany? - Results from the SepNet Prevalence Study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","125"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","New England Journal of Medicine"],["dc.bibliographiccitation.lastpage","139"],["dc.bibliographiccitation.volume","358"],["dc.contributor.author","Brunkhorst, Frank M."],["dc.contributor.author","Engel, Christoph"],["dc.contributor.author","Bloos, Frank"],["dc.contributor.author","Meier-Hellmann, Andreas"],["dc.contributor.author","Ragaller, Max"],["dc.contributor.author","Weiler, Norbert"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Gruendling, Matthias"],["dc.contributor.author","Oppert, Michael"],["dc.contributor.author","Grond, Stefan"],["dc.contributor.author","Olthoff, Derk"],["dc.contributor.author","Jaschinski, Ulrich"],["dc.contributor.author","John, Stefan"],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Welte, Tobias"],["dc.contributor.author","Schaefer, Martin"],["dc.contributor.author","Kern, Peter"],["dc.contributor.author","Kuhnt, Evelyn"],["dc.contributor.author","Kiehntopf, Michael"],["dc.contributor.author","Hartog, Christiane"],["dc.contributor.author","Natanson, Charles"],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Reinhart, Konrad"],["dc.date.accessioned","2018-11-07T11:19:10Z"],["dc.date.available","2018-11-07T11:19:10Z"],["dc.date.issued","2008"],["dc.description.abstract","Background: The role of intensive insulin therapy in patients with severe sepsis is uncertain. Fluid resuscitation improves survival among patients with septic shock, but evidence is lacking to support the choice of either crystalloids or colloids. Methods: In a multicenter, two-by-two factorial trial, we randomly assigned patients with severe sepsis to receive either intensive insulin therapy to maintain euglycemia or conventional insulin therapy and either 10% pentastarch, a low-molecular-weight hydroxyethyl starch (HES 200/0.5), or modified Ringer's lactate for fluid resuscitation. The rate of death at 28 days and the mean score for organ failure were coprimary end points. Results: The trial was stopped early for safety reasons. Among 537 patients who could be evaluated, the mean morning blood glucose level was lower in the intensive-therapy group (112 mg per deciliter [6.2 mmol per liter]) than in the conventional-therapy group (151 mg per deciliter [8.4 mmol per liter], P<0.001). However, at 28 days, there was no significant difference between the two groups in the rate of death or the mean score for organ failure. The rate of severe hypoglycemia (glucose level, <= 40 mg per deciliter [2.2 mmol per liter]) was higher in the intensive-therapy group than in the conventional-therapy group (17.0% vs. 4.1%, P<0.001), as was the rate of serious adverse events (10.9% vs. 5.2%, P=0.01). HES therapy was associated with higher rates of acute renal failure and renal-replacement therapy than was Ringer's lactate. Conclusions: The use of intensive insulin therapy placed critically ill patients with sepsis at increased risk for serious adverse events related to hypoglycemia. As used in this study, HES was harmful, and its toxicity increased with accumulating doses. (ClinicalTrials.gov number, NCT00135473.)."],["dc.identifier.doi","10.1056/NEJMoa070716"],["dc.identifier.isi","000252204200004"],["dc.identifier.pmid","18184958"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6229"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55209"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Massachusetts Medical Soc"],["dc.relation.issn","0028-4793"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Intensive insulin therapy and pentastarch resuscitation in severe sepsis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1266"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","JAMA Internal Medicine"],["dc.bibliographiccitation.lastpage","1276"],["dc.bibliographiccitation.volume","176"],["dc.contributor.author","Bloos, Frank"],["dc.contributor.author","Trips, Evelyn"],["dc.contributor.author","Nierhaus, Axel"],["dc.contributor.author","Briegel, Josef"],["dc.contributor.author","Heyland, Daren K."],["dc.contributor.author","Jaschinski, Ulrich"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Weyland, Andreas"],["dc.contributor.author","Marx, Gernot"],["dc.contributor.author","Gruendling, Matthias"],["dc.contributor.author","Kluge, Stefan"],["dc.contributor.author","Kaufmann, Ines"],["dc.contributor.author","Ott, Klaus"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Jelschen, Florian"],["dc.contributor.author","Meybohm, Patrick"],["dc.contributor.author","Rademacher, Sibylle"],["dc.contributor.author","Meier-Hellmann, Andreas"],["dc.contributor.author","Utzolino, Stefan"],["dc.contributor.author","Kaisers, Udo X."],["dc.contributor.author","Putensen, Christian"],["dc.contributor.author","Elke, Gunnar"],["dc.contributor.author","Ragaller, Maximilian"],["dc.contributor.author","Gerlach, Herwig"],["dc.contributor.author","Ludewig, Katrin"],["dc.contributor.author","Kiehntopf, Michael"],["dc.contributor.author","Bogatsch, Holger"],["dc.contributor.author","Engel, Christoph"],["dc.contributor.author","Brunkhorst, Frank M."],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Reinhart, Konrad"],["dc.date.accessioned","2018-11-07T10:09:20Z"],["dc.date.available","2018-11-07T10:09:20Z"],["dc.date.issued","2016"],["dc.description.abstract","IMPORTANCE High-dose intravenous administration of sodium selenite has been proposed to improve outcome in sepsis by attenuating oxidative stress. Procalcitonin-guided antimicrobial therapy may hasten the diagnosis of sepsis, but effect on outcome is unclear. OBJECTIVE To determine whether high-dose intravenous sodium selenite treatment and procalcitonin-guided anti-infectious therapy in patients with severe sepsis affect mortality. DESIGN, SETTING, AND PARTICIPANTS The Placebo-Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis (SISPCT), a multicenter, randomized, clinical, 2 x 2 factorial trial performed in 33 intensive care units in Germany, was conducted from November 6, 2009, to June 6, 2013, including a 90-day follow-up period. INTERVENTIONS Patients were randomly assigned to receive an initial intravenous loading dose of sodium selenite, 1000 mu g, followed by a continuous intravenous infusion of sodium selenite, 1000 mu g, daily until discharge from the intensive care unit, but not longer than 21 days, or placebo. Patients also were randomized to receive anti-infectious therapy guided by a procalcitonin algorithm or without procalcitonin guidance. MAIN OUTCOMES AND MEASURES The primary end point was 28-day mortality. Secondary outcomes included 90-day all-cause mortality, intervention-free days, antimicrobial costs, antimicrobial-free days, and secondary infections. RESULTS Of 8174 eligible patients, 1089 patients (13.3%) with severe sepsis or septic shock were included in an intention-to-treat analysis comparing sodium selenite (543 patients [49.9%]) with placebo (546 [50.1%]) and procalcitonin guidance (552 [50.7%]) vs no procalcitonin guidance (537 [49.3%]). The 28-day mortality rate was 28.3%(95% CI, 24.5%-32.3%) in the sodium selenite group and 25.5%(95% CI, 21.8%-29.4%) (P =.30) in the placebo group. There was no significant difference in 28-day mortality between patients assigned to procalcitonin guidance (25.6%[95% CI, 22.0%-29.5%]) vs no procalcitonin guidance (28.2%[95% CI, 24.4%-32.2%]) (P =.34). Procalcitonin guidance did not affect frequency of diagnostic or therapeutic procedures but did result in a 4.5% reduction of antimicrobial exposure. CONCLUSIONS AND RELEVANCE Neither high-dose intravenous administration of sodium selenite nor anti-infectious therapy guided by a procalcitonin algorithm was associated with an improved outcome in patients with severe sepsis. These findings do not support administration of high-dose sodium selenite in these patients; the application of a procalcitonin-guided algorithm needs further evaluation."],["dc.identifier.doi","10.1001/jamainternmed.2016.2514"],["dc.identifier.isi","000384204800011"],["dc.identifier.pmid","27428731"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39633"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Medical Assoc"],["dc.relation.issn","2168-6114"],["dc.relation.issn","2168-6106"],["dc.title","Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock A Randomized Clinical Trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Infection"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Schaedler, D."],["dc.contributor.author","Schmitz, G."],["dc.contributor.author","Engel, C."],["dc.contributor.author","Bogatsch, Holger"],["dc.contributor.author","Frerichs, Inez"],["dc.contributor.author","Kuhlen, Ralf"],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Scholz, J."],["dc.contributor.author","Brunkhorst, Frank M."],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Reinhart, Konrad"],["dc.contributor.author","Weiler, Norbert"],["dc.date.accessioned","2018-11-07T10:59:01Z"],["dc.date.available","2018-11-07T10:59:01Z"],["dc.date.issued","2007"],["dc.format.extent","16"],["dc.identifier.isi","000249997100037"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50598"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.issn","0300-8126"],["dc.title","The ventilation strageties influence outcome in patients with severe sepsis - results from a national prospective multicenter study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","606"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","618"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Engel, Christoph"],["dc.contributor.author","Brunkhorst, Frank M."],["dc.contributor.author","Bone, Hans-Georg"],["dc.contributor.author","Brunkhorst, Reinhard"],["dc.contributor.author","Gerlach, Herwig"],["dc.contributor.author","Grond, Stefan"],["dc.contributor.author","Gruendling, Matthias"],["dc.contributor.author","Huhle, Guenter"],["dc.contributor.author","Jaschinski, Ulrich"],["dc.contributor.author","John, Stefan"],["dc.contributor.author","Mayer, Konstantin"],["dc.contributor.author","Oppert, Michael"],["dc.contributor.author","Olthoff, Derk"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Ragaller, Max"],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Stuber, Frank"],["dc.contributor.author","Weiler, Norbert"],["dc.contributor.author","Welte, Tobias"],["dc.contributor.author","Bogatsch, Holger"],["dc.contributor.author","Hartog, Christiane"],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Reinhart, Konrad"],["dc.date.accessioned","2018-11-07T11:03:32Z"],["dc.date.available","2018-11-07T11:03:32Z"],["dc.date.issued","2007"],["dc.description.abstract","Objective: To determine the prevalence and mortality of ICU patients with severe sepsis in Germany, with consideration of hospital size. Design: Prospective, observational, cross-sectional 1-day point-prevalence study. Setting: 454 ICUs from a representative nationwide sample of 310 hospitals stratified by size. Data were collected via 1-day on-site audits by trained external study physicians. Visits were randomly distributed over 1 year (2003). Patients: Inflammatory response of all ICU patients was assessed using the ACCP/SCCM consensus conference criteria. Patients with severe sepsis were followed up after 3 months for hospital mortality and length of ICU stay. Measurements and results: Main outcome measures were prevalence and mortality. A total of 3,877 patients were screened. Prevalence was 12.4% (95% CI, 10.9-13.8%) for sepsis and 11.0% (95% CI, 9.7-12.2%) for severe sepsis including septic shock. The ICU and hospital mortality of patients with severe sepsis was 48.4 and 55.2%, respectively, without significant differences between hospital size. Prevalence and mean length of ICU stay of patients with severe sepsis were significantly higher in larger hospitals and universities (<= 200 beds: 6% and 11.5 days, universities: 19% and 19.2 days, respectively). Conclusions: The expected number of newly diagnosed cases with severe sepsis in Germany amounts to 76-110 per 100,000 adult inhabitants. To allow better comparison between countries, future epidemiological studies should use standardized study methodologies with respect to sepsis definitions, hospital size, and daily and monthly variability."],["dc.identifier.doi","10.1007/s00134-006-0517-7"],["dc.identifier.isi","000245170300006"],["dc.identifier.pmid","17323051"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51641"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0342-4642"],["dc.title","Epidemiology of sepsis in Germany: results from a national prospective multicenter study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]