Engel, Christoph

[["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Schaedler, D."],["dc.contributor.author","Porzilius, C."],["dc.contributor.author","Brederlau, J."],["dc.contributor.author","Joerres, A."],["dc.contributor.author","Marx, G."],["dc.contributor.author","Meier-Hellmann, Andreas"],["dc.contributor.author","Putensen, Christian"],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Spies, C. D."],["dc.contributor.author","Engel, C."],["dc.contributor.author","Kellurn, J."],["dc.contributor.author","Weiler, Norbert"],["dc.contributor.author","Kuhlmann, M. K."],["dc.date.accessioned","2018-11-07T09:19:39Z"],["dc.date.available","2018-11-07T09:19:39Z"],["dc.date.issued","2013"],["dc.identifier.isi","000342431600016"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28689"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.conference","ESICM 26th Annual Congress"],["dc.relation.eventlocation","Paris, FRANCE"],["dc.title","EXTRACORPOREAL CYTOKINE HEMOADSORPTION IN SEVERELY SEPTIC PATIENTS: A MULTICENTER RANDOMIZED CONTROLLED TRIAL"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","723"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Der Anaesthesist"],["dc.bibliographiccitation.lastpage","728"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Reinhart, Konrad"],["dc.contributor.author","Brunkhorst, Frank M."],["dc.contributor.author","Engel, C."],["dc.contributor.author","Bloos, Frank"],["dc.contributor.author","Meier-Hellmann, Andreas"],["dc.contributor.author","Ragaller, Maximilian"],["dc.contributor.author","Weiler, Norbert"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Gruendling, Matthias"],["dc.contributor.author","Oppert, Michael"],["dc.contributor.author","Grond, S."],["dc.contributor.author","Olthoff, Derk"],["dc.contributor.author","Jaschinski, Ulrich"],["dc.contributor.author","John, S."],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Welte, Tobias"],["dc.contributor.author","Schaefer, M."],["dc.contributor.author","Kern, R."],["dc.contributor.author","Kuhnt, Evelyn"],["dc.contributor.author","Kiehntopf, Michael"],["dc.contributor.author","Deufel, Thomas"],["dc.contributor.author","Hartog, Christiane"],["dc.contributor.author","Gerlach, Herwig"],["dc.contributor.author","Stueber, F."],["dc.contributor.author","Volk, H.-D."],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Loeffler, Markus"],["dc.date.accessioned","2018-11-07T11:13:08Z"],["dc.date.available","2018-11-07T11:13:08Z"],["dc.date.issued","2008"],["dc.identifier.doi","10.1007/s00101-008-1391-1"],["dc.identifier.isi","000257988500012"],["dc.identifier.pmid","18584135"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53824"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0003-2417"],["dc.title","Study protocol of the VISEP-Study. Answer of the SepNet-Study group"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2719"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Critical Care Medicine"],["dc.bibliographiccitation.lastpage","2725"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Brunkhorst, Frank M."],["dc.contributor.author","Engel, Christoph"],["dc.contributor.author","Ragaller, Max"],["dc.contributor.author","Welte, Tobias"],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Gerlach, Herwig"],["dc.contributor.author","Mayer, Konstantin"],["dc.contributor.author","John, Stefan"],["dc.contributor.author","Stuber, Frank"],["dc.contributor.author","Weiler, Norbert"],["dc.contributor.author","Oppert, Michael"],["dc.contributor.author","Moerer, Onnen"],["dc.contributor.author","Bogatsch, Holger"],["dc.contributor.author","Reinhart, Konrad"],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Hartog, Christiane"],["dc.date.accessioned","2018-11-07T11:10:25Z"],["dc.date.available","2018-11-07T11:10:25Z"],["dc.date.issued","2008"],["dc.description.abstract","Objective: To simultaneously determine perceived vs. practiced adherence to recommended interventions for the treatment of severe sepsis or septic shock. Design: One-day cross-sectional survey. Setting: Representative sample of German intensive care units stratified by hospital size. Patients: Adult patients with severe sepsis or septic shock. Interventions: None. Measurements and Main Results: Practice recommendations were selected by German Sepsis Competence Network (SepNet) investigators. External intensivists visited intensive care units randomly chosen and asked the responsible intensive care unit director how often these recommendations were used. Responses \"always\" and \"frequently\" were combined to depict perceived adherence. Thereafter patient files were audited. Three hundred sixty-six patients on 214 intensive care units fulfilled the criteria and received full support. One hundred fifty-two patients had acute lung injury or acute respiratory distress syndrome. Low-tidal volume ventilation <= 6 mL/kg/predicted body weight was documented in 2.6% of these patients. A total of 17.1% patients had tidal volume between 6 and 8 mL/kg predicted body weight and 80.3% >8 mL/kg predicted body weight. Mean tidal volume was 10.0 +/- 2.4 mL/kg predicted body weight. Perceived ence to low-tidal volume ventilation was 79.9%. Euglycemia 6.1 mmol/L) was documented in 6.2% of 355 patients. A total 33.8% of patients had blood glucose levels <= 8.3 mmol/L and 66.2% were hyperglycemic (blood glucose >8.3 mmol/L. Among 207 patients receiving insulin therapy, 1.9% were euglycemic, 20.8% had blood glucose levels <= 8.3 mmol/L, and 1.0% were hypoglycemic. Overall, mean maximal glucose level was 10.0 +/- 3.6 mmol/L. Perceived adherence to strict glycemic control was 65.9%. Although perceived adherence to recommendations was higher in academic and larger hospitals, actual practice was not significantly influenced by hospital size or university affiliation. Conclusions: This representative survey shows that current therapy of severe sepsis in German intensive care units complies poorly with practice recommendations. Intensive care unit directors perceive adherence to be higher than it actually is. Implementation strategies involving all intensive care unit staff are needed to overcome this gap between current evidence-based knowledge, practice, and perception."],["dc.identifier.doi","10.1097/CCM.0b013e318186b6f3"],["dc.identifier.isi","000259766000001"],["dc.identifier.pmid","18766100"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53208"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0090-3493"],["dc.title","Practice and perception - A nationwide survey of therapy habits in sepsis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","27"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Der Anaesthesist"],["dc.bibliographiccitation.lastpage","33"],["dc.bibliographiccitation.volume","62"],["dc.contributor.author","Schaedler, D."],["dc.contributor.author","Elke, Gunnar"],["dc.contributor.author","Engel, C."],["dc.contributor.author","Bogatsch, Holger"],["dc.contributor.author","Frerichs, Inez"],["dc.contributor.author","Kuhlen, Ralf"],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Scholz, J."],["dc.contributor.author","Brunkhorst, Frank M."],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Reinhart, Konrad"],["dc.contributor.author","Weiler, Norbert"],["dc.date.accessioned","2018-11-07T09:30:25Z"],["dc.date.available","2018-11-07T09:30:25Z"],["dc.date.issued","2013"],["dc.description.abstract","Mortality in intensive care unit (ICU) patients is affected by multiple variables. The possible impact of the mode of ventilation has not yet been clarified; therefore, a secondary analysis of the \"epidemiology of sepsis in Germany\" study was performed. The aims were (1) to describe the ventilation strategies currently applied in clinical practice, (2) to analyze the association of the different modes of ventilation with mortality and (3) to investigate whether the ratio between arterial partial pressure of oxygen and inspired fraction of oxygen (PF ratio) and/or other respiratory variables are associated with mortality in septic patients needing ventilatory support. A total of 454 ICUs in 310 randomly selected hospitals participated in this national prospective observational 1-day point prevalence of sepsis study including 415 patients with severe sepsis or septic shock according to the American College of Chest Physicians/Society of Critical Care Medicine criteria. Of the 415 patients, 331 required ventilatory support. Pressure controlled ventilation (PCV) was the most frequently used ventilatory mode (70.6 %) followed by assisted ventilation (AV 21.7 %) and volume controlled ventilation (VCV 7.7 %). Hospital mortality did not differ significantly among patients ventilated with PCV (57 %), VCV (71 %) or AV (51 %, p = 0.23). A PF ratio equal or less than 300 mmHg was found in 83.2 % of invasively ventilated patients (n = 316). In AV patients there was a clear trend to a higher PF ratio (204 +/- 70 mmHg) than in controlled ventilated patients (PCV 179 +/- 74 mmHg, VCV 175 +/- 75 mmHg, p = 0.0551). Multiple regression analysis identified the tidal volume to pressure ratio (tidal volume divided by peak inspiratory airway pressure, odds ratio OR = 0.94, 95 % confidence interval 95% CI = 0.89-0.99), acute renal failure (OR = 2.15, 95% CI = 1.01-4.55) and acute physiology and chronic health evaluation (APACHE) II score (OR = 1.09, 95% CI = 1.03-1.15) but not the PF ratio (univariate analysis OR = 0.998, 95 % CI = 0.995-1.001) as independent risk factors for in-hospital mortality. This representative survey revealed that severe sepsis or septic shock was frequently associated with acute lung injury. Different ventilatory modes did not affect mortality. The tidal volume to inspiratory pressure ratio but not the PF ratio was independently associated with mortality."],["dc.identifier.doi","10.1007/s00101-012-2121-2"],["dc.identifier.isi","000314362700005"],["dc.identifier.pmid","23319272"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31304"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0003-2417"],["dc.title","Ventilatory strategies in septic patients Results from a nationwide observational trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","American Journal of Respiratory and Critical Care Medicine"],["dc.bibliographiccitation.volume","187"],["dc.contributor.author","Schadler, D."],["dc.contributor.author","Brederlau, J."],["dc.contributor.author","Jorres, A."],["dc.contributor.author","Marx, G."],["dc.contributor.author","Meier-Hellmann, Andreas"],["dc.contributor.author","Putensen, Christian"],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Spies, C. D."],["dc.contributor.author","Porzelius, Christine"],["dc.contributor.author","Engel, C."],["dc.contributor.author","Weiler, Norbert"],["dc.contributor.author","Kuhlmann, M. K."],["dc.date.accessioned","2018-11-07T09:30:57Z"],["dc.date.available","2018-11-07T09:30:57Z"],["dc.date.issued","2013"],["dc.identifier.isi","000209838402049"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31431"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Thoracic Soc"],["dc.publisher.place","New york"],["dc.title","Extracorporeal Cytokine Hemoadsorption In Patients With Severe Sepsis And Acute Lung Injury"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Infection"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Schaedler, D."],["dc.contributor.author","Schmitz, G."],["dc.contributor.author","Frerichs, Inez"],["dc.contributor.author","Ragaller, Maximilian"],["dc.contributor.author","Kuhlen, Ralf"],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Engel, C."],["dc.contributor.author","Scholz, J."],["dc.contributor.author","Weiler, Norbert"],["dc.contributor.author","Reinhart, Konrad"],["dc.date.accessioned","2018-11-07T10:56:13Z"],["dc.date.available","2018-11-07T10:56:13Z"],["dc.date.issued","2005"],["dc.format.extent","46"],["dc.identifier.isi","000207064700114"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49961"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.issn","0300-8126"],["dc.title","How is mechanical ventilation employed in septic patients in Germany? - Results from the SepNet Prevalence Study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Infection"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Schaedler, D."],["dc.contributor.author","Schmitz, G."],["dc.contributor.author","Engel, C."],["dc.contributor.author","Bogatsch, Holger"],["dc.contributor.author","Frerichs, Inez"],["dc.contributor.author","Kuhlen, Ralf"],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Scholz, J."],["dc.contributor.author","Brunkhorst, Frank M."],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Reinhart, Konrad"],["dc.contributor.author","Weiler, Norbert"],["dc.date.accessioned","2018-11-07T10:59:01Z"],["dc.date.available","2018-11-07T10:59:01Z"],["dc.date.issued","2007"],["dc.format.extent","16"],["dc.identifier.isi","000249997100037"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/50598"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Urban & Vogel"],["dc.publisher.place","Munich"],["dc.relation.issn","0300-8126"],["dc.title","The ventilation strageties influence outcome in patients with severe sepsis - results from a national prospective multicenter study"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","606"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Intensive Care Medicine"],["dc.bibliographiccitation.lastpage","618"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Engel, Christoph"],["dc.contributor.author","Brunkhorst, Frank M."],["dc.contributor.author","Bone, Hans-Georg"],["dc.contributor.author","Brunkhorst, Reinhard"],["dc.contributor.author","Gerlach, Herwig"],["dc.contributor.author","Grond, Stefan"],["dc.contributor.author","Gruendling, Matthias"],["dc.contributor.author","Huhle, Guenter"],["dc.contributor.author","Jaschinski, Ulrich"],["dc.contributor.author","John, Stefan"],["dc.contributor.author","Mayer, Konstantin"],["dc.contributor.author","Oppert, Michael"],["dc.contributor.author","Olthoff, Derk"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Ragaller, Max"],["dc.contributor.author","Rossaint, Rolf"],["dc.contributor.author","Stuber, Frank"],["dc.contributor.author","Weiler, Norbert"],["dc.contributor.author","Welte, Tobias"],["dc.contributor.author","Bogatsch, Holger"],["dc.contributor.author","Hartog, Christiane"],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Reinhart, Konrad"],["dc.date.accessioned","2018-11-07T11:03:32Z"],["dc.date.available","2018-11-07T11:03:32Z"],["dc.date.issued","2007"],["dc.description.abstract","Objective: To determine the prevalence and mortality of ICU patients with severe sepsis in Germany, with consideration of hospital size. Design: Prospective, observational, cross-sectional 1-day point-prevalence study. Setting: 454 ICUs from a representative nationwide sample of 310 hospitals stratified by size. Data were collected via 1-day on-site audits by trained external study physicians. Visits were randomly distributed over 1 year (2003). Patients: Inflammatory response of all ICU patients was assessed using the ACCP/SCCM consensus conference criteria. Patients with severe sepsis were followed up after 3 months for hospital mortality and length of ICU stay. Measurements and results: Main outcome measures were prevalence and mortality. A total of 3,877 patients were screened. Prevalence was 12.4% (95% CI, 10.9-13.8%) for sepsis and 11.0% (95% CI, 9.7-12.2%) for severe sepsis including septic shock. The ICU and hospital mortality of patients with severe sepsis was 48.4 and 55.2%, respectively, without significant differences between hospital size. Prevalence and mean length of ICU stay of patients with severe sepsis were significantly higher in larger hospitals and universities (<= 200 beds: 6% and 11.5 days, universities: 19% and 19.2 days, respectively). Conclusions: The expected number of newly diagnosed cases with severe sepsis in Germany amounts to 76-110 per 100,000 adult inhabitants. To allow better comparison between countries, future epidemiological studies should use standardized study methodologies with respect to sepsis definitions, hospital size, and daily and monthly variability."],["dc.identifier.doi","10.1007/s00134-006-0517-7"],["dc.identifier.isi","000245170300006"],["dc.identifier.pmid","17323051"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51641"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0342-4642"],["dc.title","Epidemiology of sepsis in Germany: results from a national prospective multicenter study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]