Chapuy, Björn

[["dc.bibliographiccitation.firstpage","395"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Clinical Cancer Research"],["dc.bibliographiccitation.lastpage","404"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Koch, Raphael"],["dc.contributor.author","Aung, Thiha"],["dc.contributor.author","Vogel, Daniel"],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Wenzel, Dirk"],["dc.contributor.author","Becker, Sabrina"],["dc.contributor.author","Sinzig, Ursula"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","von Mach, Tobias"],["dc.contributor.author","Jacob, Ralf"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Wulf, Gerald G."],["dc.date.accessioned","2018-11-07T10:19:22Z"],["dc.date.available","2018-11-07T10:19:22Z"],["dc.date.issued","2016"],["dc.description.abstract","Purpose: Although R-CHOP-based immunochemotherapy cures significant proportions of patients with aggressive B-cell lymphoma, tumor cell susceptibility to chemotherapy varies, with mostly fatal outcome in cases of resistant disease. We and others have shown before that export of cytostatic drugs contributes to drug resistance. Now we provide a novel approach to overcome exosome-mediated drug resistance in aggressive B-cell lymphomas. Experimental Design: We used well-established centrifugation protocols to purify exosomes from DLBCL cell lines and detected anthracyclines using FACS and HPLC. We used shRNA knockdown of ABCA3 to determine ABCA3 dependence of chemotherapy susceptibility and monitored ABCA3 expression after indomethacin treatment using qPCR. Finally, we established an in vivo assay using a chorioallantoic membrane (CAM) assay to determine the synergy of anthracycline and indomethacin treatment. Results: We show increased efficacy of the anthracycline doxorubicin and the anthracenedione pixantrone by suppression of exosomal drug resistance with indomethacin. B-cell lymphoma cells in vitro efficiently extruded doxorubicin and pixantrone, in part compacted in exosomes. Exosomal biogenesis was critically dependent on the expression of the ATP-transporter A3 (ABCA3). Genetic or chemical depletion of ABCA3 augmented intracellular retention of both drugs and shifted the subcellular drug accumulation to prolonged nuclear retention. Indomethacin increased the cytostatic efficacy of both drugs against DLBCL cell lines in vitro and in vivo in a CAM assay. Conclusions: We propose pretreatment with indomethacin toward enhanced antitumor efficacy of anthracyclines and anthracenediones. (C) 2015 AACR."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft; University Medicine Goettingen"],["dc.identifier.doi","10.1158/1078-0432.CCR-15-0577"],["dc.identifier.isi","000369076500016"],["dc.identifier.pmid","26369630"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41643"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1557-3265"],["dc.relation.issn","1078-0432"],["dc.title","Nuclear Trapping through Inhibition of Exosomal Export by Indomethacin Increases Cytostatic Efficacy of Doxorubicin and Pixantrone"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.journal","Bone Marrow Transplantation"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Hasenkamp, J."],["dc.contributor.author","Missal, Inga"],["dc.contributor.author","Borgerding, Andrea"],["dc.contributor.author","Falk, C. S."],["dc.contributor.author","Wommelsdorf, T."],["dc.contributor.author","Dingeldein, S."],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Wulf, Gerald"],["dc.contributor.author","Jung, Werner"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Glass, Bertram"],["dc.date.accessioned","2018-11-07T11:03:23Z"],["dc.date.available","2018-11-07T11:03:23Z"],["dc.date.issued","2007"],["dc.format.extent","S139"],["dc.identifier.isi","000245207400373"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51607"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.publisher.place","London"],["dc.relation.conference","33rd Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation"],["dc.relation.eventlocation","Lyon, FRANCE"],["dc.relation.issn","0268-3369"],["dc.title","Incidence of allo-reactive NK cells after allogeneic haematopoietic stem cell transplantation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","33"],["dc.contributor.author","Diering, Nina"],["dc.contributor.author","Aung, T."],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Koch, R."],["dc.contributor.author","Becker, S."],["dc.contributor.author","Krause, D."],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Wulf, Gerald G."],["dc.date.accessioned","2018-11-07T08:38:49Z"],["dc.date.available","2018-11-07T08:38:49Z"],["dc.date.issued","2010"],["dc.format.extent","188"],["dc.identifier.isi","000282988401085"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18846"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","0378-584X"],["dc.title","Putative tumor stem cells of SP phenotype in aggressive B-cell lymphoma"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.issue","23"],["dc.bibliographiccitation.journal","Blood"],["dc.bibliographiccitation.volume","126"],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Dunford, Andrew J."],["dc.contributor.author","Stewart, Chip"],["dc.contributor.author","Kamburov, Atanas"],["dc.contributor.author","Kim, Jaegil"],["dc.contributor.author","Roemer, Margaretha G. M."],["dc.contributor.author","Ziepert, Marita"],["dc.contributor.author","Li, Amy Jiayue"],["dc.contributor.author","Lawrence, Mike"],["dc.contributor.author","Hess, Julian"],["dc.contributor.author","Rosenburg, Mara"],["dc.contributor.author","Taylor-Weiner, Amaro N."],["dc.contributor.author","Redd, Robert A."],["dc.contributor.author","Horn, Heike"],["dc.contributor.author","Novak, Anne"],["dc.contributor.author","Cerhan, James R."],["dc.contributor.author","Haberman, Thomas M."],["dc.contributor.author","Feldman, Andrew L."],["dc.contributor.author","Link, Brian K."],["dc.contributor.author","Golub, Todd R."],["dc.contributor.author","Neuberg, Donna S."],["dc.contributor.author","Ott, German"],["dc.contributor.author","Siebert, Reiner"],["dc.contributor.author","Rosenwald, Andreas"],["dc.contributor.author","Wulf, Gerald G."],["dc.contributor.author","Monti, Stefano"],["dc.contributor.author","Rodig, Scott J."],["dc.contributor.author","Loeffler, Markus"],["dc.contributor.author","Pfreundschuh, Michael"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Getz, Gad"],["dc.contributor.author","Shipp, Margaret A."],["dc.date.accessioned","2018-11-07T09:47:44Z"],["dc.date.available","2018-11-07T09:47:44Z"],["dc.date.issued","2015"],["dc.identifier.isi","000368021800179"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35166"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Soc Hematology"],["dc.publisher.place","Washington"],["dc.relation.conference","57th Annual Meeting of the American-Society-of-Hematology"],["dc.relation.eventlocation","Orlando, FL"],["dc.relation.issn","1528-0020"],["dc.relation.issn","0006-4971"],["dc.title","Comprehensive Analyses of Genetic Features Identify Coordinate Signatures in Diffuse Large B-Cell Lymphoma"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dspace.entity.type","Publication"]]