Berg, Sebastian

[["dc.bibliographiccitation.firstpage","830"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","American Journal of Preventive Medicine"],["dc.bibliographiccitation.lastpage","838"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Gupta, Soham"],["dc.contributor.author","Cole, Alexander P."],["dc.contributor.author","Marchese, Maya"],["dc.contributor.author","Wang, Ye"],["dc.contributor.author","Speed, Jacqueline M."],["dc.contributor.author","Fletcher, Sean A."],["dc.contributor.author","Nabi, Junaid"],["dc.contributor.author","Berg, Sebastian"],["dc.contributor.author","Lipsitz, Stuart R."],["dc.contributor.author","Choueiri, Toni K."],["dc.contributor.author","Chang, Steven L."],["dc.contributor.author","Kibel, Adam S."],["dc.contributor.author","Uhlig, Annemarie"],["dc.contributor.author","Trinh, Quoc-Dien"],["dc.date.accessioned","2020-12-10T14:22:22Z"],["dc.date.available","2020-12-10T14:22:22Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1016/j.amepre.2018.07.021"],["dc.identifier.issn","0749-3797"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71589"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Use of Preventive Health Services Among Cancer Survivors in the U.S."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4049"],["dc.bibliographiccitation.lastpage","4052"],["dc.contributor.author","Schlemmer, Alexander"],["dc.contributor.author","Berg, Sebastian"],["dc.contributor.author","Shajahan, T. K."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Parlitz, Ulrich"],["dc.date.accessioned","2019-02-27T15:58:02Z"],["dc.date.available","2019-02-27T15:58:02Z"],["dc.date.issued","2015"],["dc.description.abstract","Analyzing the dynamics of complex excitation wave patterns in cardiac tissue plays a key role for understanding the origin of life-threatening arrhythmias and for devising novel approaches to control them. The quantification of spatiotemporal complexity, however, remains a challenging task. This holds in particular for the analysis of data from fluorescence imaging (optical mapping), which allows for the measurement of membrane potential and intracellular calcium at high spatial and temporal resolution. Hitherto methods, like dominant frequency maps and the analysis of phase singularities, address important aspects of cardiac dynamics, but they consider very specific properties of excitable media, only. This article focuses on the benchmark of spatial complexity measures over time in the context of cardiac cell cultures. Standard Shannon Entropy and Spatial Permutation Entropy, an adaption of [1], have been implemented and applied to optical mapping data from embryonic chicken cell culture experiments. We introduce spatial separation of samples when generating ordinal patterns and show its importance for Spatial Permutation Entropy. Results suggest that Spatial Permutation Entropies provide a robust and interpretable measure for detecting qualitative changes in the dynamics of this excitable medium."],["dc.identifier.doi","10.1109/EMBC.2015.7319283"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57653"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/145"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.publisher","IEEE"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.conference","37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)"],["dc.relation.eventend","2015-08-29"],["dc.relation.eventlocation","Milan, Italy"],["dc.relation.eventstart","2015-08-25"],["dc.relation.isbn","978-1-4244-9270-1"],["dc.relation.ispartof","2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Quantifying spatiotemporal complexity of cardiac dynamics using ordinal patterns"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","093931"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Chaos: An Interdisciplinary Journal of Nonlinear Science"],["dc.bibliographiccitation.lastpage","14"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Berg, Sebastian"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2019-02-26T16:35:12Z"],["dc.date.available","2019-02-26T16:35:12Z"],["dc.date.issued","2017"],["dc.description.abstract","Self-organized activation patterns in excitable media such as spiral waves and spatio-temporal chaos underlie dangerous cardiac arrhythmias. While the interaction of single spiral waves with different types of heterogeneity has been studied extensively, the effect of heterogeneity on fully developed spatio-temporal chaos remains poorly understood. We investigate how the complexity and stability properties of spatio-temporal chaos in the Bär–Eiswirth model of excitable media depend on the heterogeneity of the underlying medium. We employ different measures characterizing the chaoticity of the system and find that the spatial arrangement of multiple discrete lower excitability regions has a strong impact on the complexity of the dynamics. Varying the number, shape, and spatial arrangement of the heterogeneities, we observe strong emergent effects ranging from increases in chaoticity to the complete cessation of chaos, contrasting the expectation from the homogeneous behavior. The implications of our findings for the development and treatment of arrhythmias in the heterogeneous cardiac muscle are discussed. Understanding the mechanisms that govern the onset, development, and termination of cardiac arrhythmias is essential to develop and further refine novel strategies for controlling them. However, cardiac tissue is inherently heterogeneous, and heterogeneity might be exacerbated in diseased hearts. In a generic model of excitable media, we investigate how patches of lower excitability change the characteristics of spatio-temporal chaos, which is related to lethal cardiac fibrillation. Surprisingly, the presence of multiple discrete heterogeneities may lead to the complete cessation of chaos, even though lower excitability increases complexity in a homogeneous medium. In other cases, the complexity of spatio-temporal chaos increases beyond the values expected from homogeneous behavior. Our results show that spatial variations in local parameters may have truly emergent effects and information about the distribution of natural heterogeneity in the cardiac muscle as well as the spatial scale and strength of pathological heterogeneities is an indispensable prerequisite for understanding the stability properties of cardiac arrhythmias and developing control strategies tailored to specific types of dynamics."],["dc.identifier.doi","10.1063/1.4999604"],["dc.identifier.pmid","28964139"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57628"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/184"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","1054-1500"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Emergent dynamics of spatio-temporal chaos in a heterogeneous excitable medium"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","20190420"],["dc.bibliographiccitation.issue","2230"],["dc.bibliographiccitation.journal","Proceedings of the Royal Society of London. Series A, Mathematical, Physical and Engineering Sciences"],["dc.bibliographiccitation.volume","475"],["dc.contributor.author","Punacha, Shreyas"],["dc.contributor.author","Berg, Sebastian"],["dc.contributor.author","Sebastian, Anupama"],["dc.contributor.author","Krinski, Valentin I."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Shajahan, T. K."],["dc.date.accessioned","2022-03-01T11:46:52Z"],["dc.date.available","2022-03-01T11:46:52Z"],["dc.date.issued","2019"],["dc.description.abstract","Rotating spiral waves of electrical activity in the heart can anchor to unexcitable tissue (an obstacle) and become stable pinned waves. A pinned rotating wave can be unpinned either by a local electrical stimulus applied close to the spiral core, or by an electric field pulse that excites the core of a pinned wave independently of its localization. The wave will be unpinned only when the pulse is delivered inside a narrow time interval called the unpinning window (UW) of the spiral. In experiments with cardiac monolayers, we found that other obstacles situated near the pinning centre of the spiral can facilitate unpinning. In numerical simulations, we found increasing or decreasing of the UW depending on the location, orientation and distance between the pinning centre and an obstacle. Our study indicates that multiple obstacles could contribute to unpinning in experiments with intact hearts."],["dc.description.abstract","Rotating spiral waves of electrical activity in the heart can anchor to unexcitable tissue (an obstacle) and become stable pinned waves. A pinned rotating wave can be unpinned either by a local electrical stimulus applied close to the spiral core, or by an electric field pulse that excites the core of a pinned wave independently of its localization. The wave will be unpinned only when the pulse is delivered inside a narrow time interval called the unpinning window (UW) of the spiral. In experiments with cardiac monolayers, we found that other obstacles situated near the pinning centre of the spiral can facilitate unpinning. In numerical simulations, we found increasing or decreasing of the UW depending on the location, orientation and distance between the pinning centre and an obstacle. Our study indicates that multiple obstacles could contribute to unpinning in experiments with intact hearts."],["dc.identifier.doi","10.1098/rspa.2019.0420"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103830"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/314"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.eissn","1471-2946"],["dc.relation.issn","1364-5021"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights.uri","https://royalsociety.org/journals/ethics-policies/data-sharing-mining/"],["dc.title","Spiral wave unpinning facilitated by wave emitting sites in cardiac monolayers"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]