Venkataramani, Vivek

[["dc.bibliographiccitation.firstpage","395"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Clinical Cancer Research"],["dc.bibliographiccitation.lastpage","404"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Koch, Raphael"],["dc.contributor.author","Aung, Thiha"],["dc.contributor.author","Vogel, Daniel"],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Wenzel, Dirk"],["dc.contributor.author","Becker, Sabrina"],["dc.contributor.author","Sinzig, Ursula"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","von Mach, Tobias"],["dc.contributor.author","Jacob, Ralf"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Wulf, Gerald G."],["dc.date.accessioned","2018-11-07T10:19:22Z"],["dc.date.available","2018-11-07T10:19:22Z"],["dc.date.issued","2016"],["dc.description.abstract","Purpose: Although R-CHOP-based immunochemotherapy cures significant proportions of patients with aggressive B-cell lymphoma, tumor cell susceptibility to chemotherapy varies, with mostly fatal outcome in cases of resistant disease. We and others have shown before that export of cytostatic drugs contributes to drug resistance. Now we provide a novel approach to overcome exosome-mediated drug resistance in aggressive B-cell lymphomas. Experimental Design: We used well-established centrifugation protocols to purify exosomes from DLBCL cell lines and detected anthracyclines using FACS and HPLC. We used shRNA knockdown of ABCA3 to determine ABCA3 dependence of chemotherapy susceptibility and monitored ABCA3 expression after indomethacin treatment using qPCR. Finally, we established an in vivo assay using a chorioallantoic membrane (CAM) assay to determine the synergy of anthracycline and indomethacin treatment. Results: We show increased efficacy of the anthracycline doxorubicin and the anthracenedione pixantrone by suppression of exosomal drug resistance with indomethacin. B-cell lymphoma cells in vitro efficiently extruded doxorubicin and pixantrone, in part compacted in exosomes. Exosomal biogenesis was critically dependent on the expression of the ATP-transporter A3 (ABCA3). Genetic or chemical depletion of ABCA3 augmented intracellular retention of both drugs and shifted the subcellular drug accumulation to prolonged nuclear retention. Indomethacin increased the cytostatic efficacy of both drugs against DLBCL cell lines in vitro and in vivo in a CAM assay. Conclusions: We propose pretreatment with indomethacin toward enhanced antitumor efficacy of anthracyclines and anthracenediones. (C) 2015 AACR."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft; University Medicine Goettingen"],["dc.identifier.doi","10.1158/1078-0432.CCR-15-0577"],["dc.identifier.isi","000369076500016"],["dc.identifier.pmid","26369630"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41643"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1557-3265"],["dc.relation.issn","1078-0432"],["dc.title","Nuclear Trapping through Inhibition of Exosomal Export by Indomethacin Increases Cytostatic Efficacy of Doxorubicin and Pixantrone"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Aung, T."],["dc.contributor.author","Kiecke, Christina"],["dc.contributor.author","Kueffer, Stefan"],["dc.contributor.author","Stroebel, Philipp"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Wulf, Gerald G."],["dc.date.accessioned","2018-11-07T09:19:02Z"],["dc.date.available","2018-11-07T09:19:02Z"],["dc.date.issued","2013"],["dc.format.extent","20"],["dc.identifier.isi","000326360900043"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28544"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","1423-0240"],["dc.relation.issn","0378-584X"],["dc.title","The biological relevance of the Amyloid Precursor Protein (APP) in prostate cancer"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Behnes, Carl Ludwig"],["dc.contributor.author","Thiele, K."],["dc.contributor.author","Wulf, Gerald G."],["dc.contributor.author","Thelen, F."],["dc.contributor.author","Opitz, Lennart"],["dc.contributor.author","Salinas-Riester, Gabriela"],["dc.contributor.author","Wirths, Oliver"],["dc.contributor.author","Bayer, Thomas A."],["dc.contributor.author","Schweyer, Stefan"],["dc.date.accessioned","2018-11-07T09:04:55Z"],["dc.date.available","2018-11-07T09:04:55Z"],["dc.date.issued","2012"],["dc.format.extent","195"],["dc.identifier.isi","000310766700509"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25208"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","0378-584X"],["dc.title","The Alzheimer Amyloid Precursor Protein (APP) is a biomarker for transformed human pluripotent stem cells - from Alzheimer's disease to cancer biology and beyond"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2189"],["dc.bibliographiccitation.issue","14"],["dc.bibliographiccitation.journal","Blood"],["dc.bibliographiccitation.lastpage","2198"],["dc.bibliographiccitation.volume","123"],["dc.contributor.author","Koch, Raphael"],["dc.contributor.author","Demant, Martin"],["dc.contributor.author","Aung, Thiha"],["dc.contributor.author","Diering, Nina"],["dc.contributor.author","Cicholas, Anna"],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Wenzel, Dirk"],["dc.contributor.author","Lahmann, Marlen"],["dc.contributor.author","Guentsch, Annemarie"],["dc.contributor.author","Kiecke, Christina"],["dc.contributor.author","Becker, Sabrina"],["dc.contributor.author","Hupfeld, Timo"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Ziepert, Marita"],["dc.contributor.author","Opitz, Lennart"],["dc.contributor.author","Klapper, Wolfram"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Wulf, Gerald G."],["dc.date.accessioned","2018-11-07T09:41:23Z"],["dc.date.available","2018-11-07T09:41:23Z"],["dc.date.issued","2014"],["dc.description.abstract","Tumors are composed of phenotypically heterogeneous cell populations. The non-genomic mechanisms underlying transitions and interactions between cell populations are largely unknown. Here, we show that diffuse large B-cell lymphomas possess a self-organized infrastructure comprising side population (SP) and non-SP cells, where transitions between clonogenic states are modulated by exosome-mediated Wnt signaling. DNA methylation modulated SP-non-SP transitions and was correlated with the reciprocal expressions of Wnt signaling pathway agonist Wnt3a in SP cells and the antagonist secreted frizzled-related protein 4 in non-SP cells. Lymphoma SP cells exhibited autonomous clonogenicity and exported Wnt3a via exosomes to neighboring cells, thus modulating population equilibrium in the tumor."],["dc.identifier.doi","10.1182/blood-2013-08-523886"],["dc.identifier.isi","000335889600015"],["dc.identifier.pmid","24563408"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33715"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1528-0020"],["dc.relation.issn","0006-4971"],["dc.title","Populational equilibrium through exosome-mediated Wnt signaling in tumor progression of diffuse large B-cell lymphoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","460"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Clinical Cancer Research"],["dc.bibliographiccitation.lastpage","473"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Küffer, Stefan"],["dc.contributor.author","Cheung, Kenneth C.P."],["dc.contributor.author","Jiang, Xuejun"],["dc.contributor.author","Trümper, Lorenz"],["dc.contributor.author","Wulf, Gerald G."],["dc.contributor.author","Ströbel, Philipp"],["dc.date.accessioned","2020-12-10T18:37:46Z"],["dc.date.available","2020-12-10T18:37:46Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1158/1078-0432.CCR-17-1778"],["dc.identifier.eissn","1557-3265"],["dc.identifier.issn","1078-0432"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77086"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","CD31 Expression Determines Redox Status and Chemoresistance in Human Angiosarcomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","51"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Acta Haematologica"],["dc.bibliographiccitation.lastpage","54"],["dc.bibliographiccitation.volume","137"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Hosseini, Ali Seif Amir"],["dc.contributor.author","Schulze, M. H."],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Wulf, Gerald"],["dc.contributor.author","Bacher, Ulrike"],["dc.contributor.author","Jung, Wolfram"],["dc.date.accessioned","2018-11-07T10:29:20Z"],["dc.date.available","2018-11-07T10:29:20Z"],["dc.date.issued","2017"],["dc.description.abstract","Pneumatosis intestinalis (PI), defined as intestinal intra- and extramural gas accumulation, is a rare radiographic finding in conditions of intestinal wall damage of varied etiology. Here, we report on a 56-year-old female with multiple myeloma who presented with undulating fever, fluctuating abdominal symptoms, and a distended abdomen 5 months after allogeneic hematopoietic stem cell transplantation (HSCT). Abdominal X-ray and CT scan documented PI with gas accumulation both in the intestinal and colonic bowel walls. Concurrently, thoracic CT revealed mediastinal and bi-hilar lymphadenopathy associated with bilateral pleural effusions. Microscopy of bronchoalveolar lavage fluid (BALF) revealed acid-fast bacilli, which were identified as Mycobacterium tuberculosis. Tuberculostatic treatment resulted in timely clinical improvement, a complete clearance of the radiological and clinical findings of PI, and the control of the tuberculosis (Tbc), determined by multiple negative BALF results. Taken together, PI occurred as the initial symptom of Tbc in an allogeneic stem cell recipient, achieving complete recovery by tuberculostatic treatment only. (C) 2016 S. Karger AG, Basel"],["dc.identifier.doi","10.1159/000452436"],["dc.identifier.isi","000392168600011"],["dc.identifier.pmid","27923223"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43620"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Karger"],["dc.relation.issn","1421-9662"],["dc.relation.issn","0001-5792"],["dc.title","Intestinal Pneumatosis Associated with Tuberculosis after Allogeneic Hematopoietic Stem Cell Transplantation"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","831"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Journal of Neurochemistry"],["dc.bibliographiccitation.lastpage","848"],["dc.bibliographiccitation.volume","147"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Doeppner, Thorsten R."],["dc.contributor.author","Willkommen, Desiree"],["dc.contributor.author","Cahill, Catherine M."],["dc.contributor.author","Xin, Yongjuan"],["dc.contributor.author","Ye, Guilin"],["dc.contributor.author","Liu, Yanyan"],["dc.contributor.author","Southon, Adam"],["dc.contributor.author","Aron, Allegra"],["dc.contributor.author","Au-Yeung, Ho Yu"],["dc.contributor.author","Huang, Xudong"],["dc.contributor.author","Lahiri, Debomoy K."],["dc.contributor.author","Wang, Fudi"],["dc.contributor.author","Bush, Ashley I."],["dc.contributor.author","Wulf, Gerald G."],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Michalke, Bernhard"],["dc.contributor.author","Rogers, Jack T."],["dc.date.accessioned","2020-12-10T18:29:01Z"],["dc.date.available","2020-12-10T18:29:01Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1111/jnc.14580"],["dc.identifier.issn","0022-3042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76492"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Manganese causes neurotoxic iron accumulation via translational repression of amyloid precursor protein and H-Ferritin"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Antimicrobial Agents and Chemotherapy"],["dc.bibliographiccitation.volume","62"],["dc.contributor.author","Shumilov, Evgenii"],["dc.contributor.author","Bacher, Ulrike"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Mohr, Alexander"],["dc.contributor.author","Eiffert, Helmut"],["dc.contributor.author","Hasenkamp, Justin"],["dc.contributor.author","Trümper, Lorenz"],["dc.contributor.author","Wulf, Gerald G."],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Ibrahim, Ashraf S."],["dc.contributor.author","Venkataramani, Vivek"],["dc.date.accessioned","2020-12-10T18:36:50Z"],["dc.date.available","2020-12-10T18:36:50Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1128/AAC.00172-18"],["dc.identifier.eissn","1098-6596"],["dc.identifier.issn","0066-4804"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76754"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","In Situ Validation of the Endothelial Cell Receptor GRP78 in a Case of Rhinocerebral Mucormycosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1636"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The American Journal of Pathology"],["dc.bibliographiccitation.lastpage","1652"],["dc.bibliographiccitation.volume","180"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Thiele, Knut"],["dc.contributor.author","Behnes, Carl Ludwig"],["dc.contributor.author","Wulf, Gerald G."],["dc.contributor.author","Thelen, Paul"],["dc.contributor.author","Opitz, Lennart"],["dc.contributor.author","Salinas-Riester, Gabriella"],["dc.contributor.author","Wirths, Oliver"],["dc.contributor.author","Bayer, Thomas A."],["dc.contributor.author","Schweyer, Stefan"],["dc.date.accessioned","2019-07-09T11:54:33Z"],["dc.date.available","2019-07-09T11:54:33Z"],["dc.date.issued","2012"],["dc.description.abstract","Increasing evidence suggests an important function of the -amyloid precursor protein (APP) in malignant disease in humans; however, the biological basis for this evidence is not well understood at present. To understand the role of APP in transformed pluripotent stem cells, we studied its expression levels in human testicular germ cell tumors using patient tissues, model cell lines, and an established xenograft mouse model. In the present study, we demonstrate the cooperative expression of APP with prominent pluripotency-related genes such as Sox2, NANOG, and POU5F1 (Oct3/4). The closest homologue family member, APLP2, showed no correlation to these stem cell factors. In addition, treatment with histone deacetylase (HDAC) inhibitors suppressed the levels of APP and stem cell markers. Loss of pluripotency, either spontaneously or as a consequence of treatment with an HDAC inhibitor, was accompanied by decreased APP protein levels both in vitro and in vivo. These observations suggest that APP represents a novel and specific biomarker in human transformed pluripotent stem cells that can be selectively modulated by HDAC inhibitors."],["dc.identifier.doi","10.1016/j.ajpath.2011.12.015"],["dc.identifier.fs","584577"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9289"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/60677"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Amyloid Precursor Protein Is a Biomarker for Transformed Human Pluripotent Stem Cells"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]