Venkataramani, Vivek

[["dc.bibliographiccitation.firstpage","395"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Clinical Cancer Research"],["dc.bibliographiccitation.lastpage","404"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Koch, Raphael"],["dc.contributor.author","Aung, Thiha"],["dc.contributor.author","Vogel, Daniel"],["dc.contributor.author","Chapuy, Björn"],["dc.contributor.author","Wenzel, Dirk"],["dc.contributor.author","Becker, Sabrina"],["dc.contributor.author","Sinzig, Ursula"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","von Mach, Tobias"],["dc.contributor.author","Jacob, Ralf"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Wulf, Gerald G."],["dc.date.accessioned","2018-11-07T10:19:22Z"],["dc.date.available","2018-11-07T10:19:22Z"],["dc.date.issued","2016"],["dc.description.abstract","Purpose: Although R-CHOP-based immunochemotherapy cures significant proportions of patients with aggressive B-cell lymphoma, tumor cell susceptibility to chemotherapy varies, with mostly fatal outcome in cases of resistant disease. We and others have shown before that export of cytostatic drugs contributes to drug resistance. Now we provide a novel approach to overcome exosome-mediated drug resistance in aggressive B-cell lymphomas. Experimental Design: We used well-established centrifugation protocols to purify exosomes from DLBCL cell lines and detected anthracyclines using FACS and HPLC. We used shRNA knockdown of ABCA3 to determine ABCA3 dependence of chemotherapy susceptibility and monitored ABCA3 expression after indomethacin treatment using qPCR. Finally, we established an in vivo assay using a chorioallantoic membrane (CAM) assay to determine the synergy of anthracycline and indomethacin treatment. Results: We show increased efficacy of the anthracycline doxorubicin and the anthracenedione pixantrone by suppression of exosomal drug resistance with indomethacin. B-cell lymphoma cells in vitro efficiently extruded doxorubicin and pixantrone, in part compacted in exosomes. Exosomal biogenesis was critically dependent on the expression of the ATP-transporter A3 (ABCA3). Genetic or chemical depletion of ABCA3 augmented intracellular retention of both drugs and shifted the subcellular drug accumulation to prolonged nuclear retention. Indomethacin increased the cytostatic efficacy of both drugs against DLBCL cell lines in vitro and in vivo in a CAM assay. Conclusions: We propose pretreatment with indomethacin toward enhanced antitumor efficacy of anthracyclines and anthracenediones. (C) 2015 AACR."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft; University Medicine Goettingen"],["dc.identifier.doi","10.1158/1078-0432.CCR-15-0577"],["dc.identifier.isi","000369076500016"],["dc.identifier.pmid","26369630"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41643"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","1557-3265"],["dc.relation.issn","1078-0432"],["dc.title","Nuclear Trapping through Inhibition of Exosomal Export by Indomethacin Increases Cytostatic Efficacy of Doxorubicin and Pixantrone"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","833"],["dc.bibliographiccitation.journal","Toxicology Reports"],["dc.bibliographiccitation.lastpage","840"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Akinyemi, Ayodele Jacob"],["dc.contributor.author","Miah, Mahfuzur R."],["dc.contributor.author","Ijomone, Omamuyovwi M."],["dc.contributor.author","Tsatsakis, Aristidis"],["dc.contributor.author","Soares, Félix Alexandre Antunes"],["dc.contributor.author","Tinkov, Alexey A."],["dc.contributor.author","Skalny, Anatoly V."],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Aschner, Michael"],["dc.date.accessioned","2020-12-10T15:21:37Z"],["dc.date.available","2020-12-10T15:21:37Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.toxrep.2019.08.001"],["dc.identifier.issn","2214-7500"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/73092"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Lead (Pb) exposure induces dopaminergic neurotoxicity in Caenorhabditis elegans: Involvement of the dopamine transporter"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","108357"],["dc.bibliographiccitation.journal","Neuropharmacology"],["dc.bibliographiccitation.volume","181"],["dc.contributor.author","Haupt, Matteo"],["dc.contributor.author","Zechmeister, Bozena"],["dc.contributor.author","Bosche, Bert"],["dc.contributor.author","Lieschke, Simone"],["dc.contributor.author","Zheng, Xuan"],["dc.contributor.author","Zhang, Lin"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Jin, Fengyan"],["dc.contributor.author","Hein, Katharina"],["dc.contributor.author","Doeppner, Thorsten R."],["dc.date.accessioned","2021-06-01T09:41:26Z"],["dc.date.available","2021-06-01T09:41:26Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.neuropharm.2020.108357"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84920"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0028-3908"],["dc.title","Lithium enhances post-stroke blood-brain barrier integrity, activates the MAPK/ERK1/2 pathway and alters immune cell migration in mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","313"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Nature Microbiology"],["dc.bibliographiccitation.lastpage","326"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Soliman, Sameh S. M."],["dc.contributor.author","Baldin, Clara"],["dc.contributor.author","Gu, Yiyou"],["dc.contributor.author","Singh, Shakti"],["dc.contributor.author","Gebremariam, Teclegiorgis"],["dc.contributor.author","Swidergall, Marc"],["dc.contributor.author","Alqarihi, Abdullah"],["dc.contributor.author","Youssef, Eman G."],["dc.contributor.author","Alkhazraji, Sondus"],["dc.contributor.author","Pikoulas, Antonis"],["dc.contributor.author","Perske, Christina"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Rich, Abigail"],["dc.contributor.author","Bruno, Vincent M."],["dc.contributor.author","Hotopp, Julie Dunning"],["dc.contributor.author","Mantis, Nicolas J."],["dc.contributor.author","Edwards, John E."],["dc.contributor.author","Filler, Scott G."],["dc.contributor.author","Chamilos, Georgios"],["dc.contributor.author","Vitetta, Ellen S."],["dc.contributor.author","Ibrahim, Ashraf S."],["dc.date.accessioned","2021-04-14T08:30:18Z"],["dc.date.available","2021-04-14T08:30:18Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1038/s41564-020-00837-0"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83181"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2058-5276"],["dc.title","Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Aung, T."],["dc.contributor.author","Kiecke, Christina"],["dc.contributor.author","Kueffer, Stefan"],["dc.contributor.author","Stroebel, Philipp"],["dc.contributor.author","Truemper, Lorenz H."],["dc.contributor.author","Wulf, Gerald G."],["dc.date.accessioned","2018-11-07T09:19:02Z"],["dc.date.available","2018-11-07T09:19:02Z"],["dc.date.issued","2013"],["dc.format.extent","20"],["dc.identifier.isi","000326360900043"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28544"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","1423-0240"],["dc.relation.issn","0378-584X"],["dc.title","The biological relevance of the Amyloid Precursor Protein (APP) in prostate cancer"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Frontiers in Cellular Neuroscience"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Doeppner, Thorsten R."],["dc.contributor.author","Zechmeister, Bozena"],["dc.contributor.author","Kaltwasser, Britta"],["dc.contributor.author","Jin, Fengyan"],["dc.contributor.author","Zheng, Xuan"],["dc.contributor.author","Majid, Arshad"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Bähr, Mathias"],["dc.contributor.author","Hermann, Dirk M."],["dc.date.accessioned","2020-12-10T18:44:31Z"],["dc.date.available","2020-12-10T18:44:31Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.3389/fncel.2018.00383"],["dc.identifier.eissn","1662-5102"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78485"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Very Delayed Remote Ischemic Post-conditioning Induces Sustained Neurological Recovery by Mechanisms Involving Enhanced Angioneurogenesis and Peripheral Immunosuppression Reversal"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Behnes, Carl Ludwig"],["dc.contributor.author","Thiele, K."],["dc.contributor.author","Wulf, Gerald G."],["dc.contributor.author","Thelen, F."],["dc.contributor.author","Opitz, Lennart"],["dc.contributor.author","Salinas-Riester, Gabriela"],["dc.contributor.author","Wirths, Oliver"],["dc.contributor.author","Bayer, Thomas A."],["dc.contributor.author","Schweyer, Stefan"],["dc.date.accessioned","2018-11-07T09:04:55Z"],["dc.date.available","2018-11-07T09:04:55Z"],["dc.date.issued","2012"],["dc.format.extent","195"],["dc.identifier.isi","000310766700509"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25208"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.publisher.place","Basel"],["dc.relation.issn","0378-584X"],["dc.title","The Alzheimer Amyloid Precursor Protein (APP) is a biomarker for transformed human pluripotent stem cells - from Alzheimer's disease to cancer biology and beyond"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e81332"],["dc.bibliographiccitation.journal","eLife"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Charlebois, Edouard"],["dc.contributor.author","Fillebeen, Carine"],["dc.contributor.author","Katsarou, Angeliki"],["dc.contributor.author","Rabinovich, Aleksandr"],["dc.contributor.author","Wisniewski, Kazimierz"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Michalke, Bernhard"],["dc.contributor.author","Velentza, Anastasia"],["dc.contributor.author","Pantopoulos, Kostas"],["dc.date.accessioned","2022-10-04T10:21:44Z"],["dc.date.available","2022-10-04T10:21:44Z"],["dc.date.issued","2022"],["dc.description.abstract","The iron hormone hepcidin is transcriptionally activated by iron or inflammation via distinct, partially overlapping pathways. We addressed how iron affects inflammatory hepcidin levels and the ensuing hypoferremic response. Dietary iron overload did not mitigate hepcidin induction in lipopolysaccharide (LPS)-treated wild type mice but prevented effective inflammatory hypoferremia. Likewise, LPS modestly decreased serum iron in hepcidin-deficient\n \n Hjv\n -/-\n \n mice, model of hemochromatosis. Synthetic hepcidin triggered hypoferremia in control but not iron-loaded wild type animals. Furthermore, it dramatically decreased hepatic and splenic ferroportin in\n \n Hjv\n -/-\n \n mice on standard or iron-deficient diet, but only triggered hypoferremia in the latter. Mechanistically, iron antagonized hepcidin responsiveness by inactivating IRPs in the liver and spleen to stimulate\n f\n erroportin mRNA translation. Prolonged LPS treatment eliminated ferroportin mRNA and permitted hepcidin-mediated hypoferremia in iron-loaded mice. Thus, de novo ferroportin synthesis is a critical determinant of serum iron and finetunes hepcidin-dependent functional outcomes. Our data uncover a crosstalk between hepcidin and IRE/IRP systems that controls tissue ferroportin expression and determines serum iron levels. Moreover, they suggest that hepcidin supplementation therapy is more efficient when combined with iron depletion."],["dc.description.sponsorship"," Canadian Institutes of Health Research http://dx.doi.org/10.13039/501100000024"],["dc.description.sponsorship"," Fonds de Recherche du Québec - Santé http://dx.doi.org/10.13039/501100000156"],["dc.description.sponsorship"," Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659"],["dc.identifier.doi","10.7554/eLife.81332"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114486"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-600"],["dc.relation.eissn","2050-084X"],["dc.rights.uri","http://creativecommons.org/licenses/by/4.0/"],["dc.title","A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Translational Stroke Research"],["dc.contributor.author","Zheng, X."],["dc.contributor.author","Zhang, L."],["dc.contributor.author","Kuang, Y."],["dc.contributor.author","Venkataramani, V."],["dc.contributor.author","Jin, F."],["dc.contributor.author","Hein, K."],["dc.contributor.author","Zafeiriou, Maria Patapia"],["dc.contributor.author","Lenz, Christof"],["dc.contributor.author","Moebius, W."],["dc.contributor.author","Kilic, E."],["dc.contributor.author","Doeppner, Thorsten R."],["dc.date.accessioned","2021-12-01T09:23:27Z"],["dc.date.available","2021-12-01T09:23:27Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s12975-021-00961-x"],["dc.identifier.pii","961"],["dc.identifier.pmid","34751929"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94655"],["dc.identifier.url","https://mbexc.uni-goettingen.de/literature/publications/441"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/421"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation","EXC 2067: Multiscale Bioimaging"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation.eissn","1868-601X"],["dc.relation.iserratumof","/handle/2/71426"],["dc.relation.issn","1868-4483"],["dc.relation.workinggroup","RG Bähr (Neurobiological Research Laboratory)"],["dc.relation.workinggroup","RG Möbius"],["dc.relation.workinggroup","RG Zafeiriou (3D Electrically Excitable Cell Networks – Brain and Heart)"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.relation.workinggroup","RG Lenz"],["dc.title","Correction to: Extracellular Vesicles Derived from Neural Progenitor Cells––a Preclinical Evaluation for Stroke Treatment in Mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","103"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Alzheimer's Disease"],["dc.bibliographiccitation.lastpage","114"],["dc.bibliographiccitation.volume","44"],["dc.contributor.author","Sieczkowski, Evelyn"],["dc.contributor.author","Milenkovic, Ivan"],["dc.contributor.author","Venkataramani, Vivek"],["dc.contributor.author","Giera, Regina"],["dc.contributor.author","Ströbel, Thomas"],["dc.contributor.author","Höftberger, Romana"],["dc.contributor.author","Liberski, Paweł P."],["dc.contributor.author","Auff, Eduard"],["dc.contributor.author","Wirths, Oliver"],["dc.contributor.author","Kovacs, Gabor G."],["dc.date.accessioned","2021-06-01T10:48:43Z"],["dc.date.available","2021-06-01T10:48:43Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.3233/JAD-141524"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86033"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1875-8908"],["dc.relation.issn","1387-2877"],["dc.title","I716F AβPP Mutation Associates with the Deposition of Oligomeric Pyroglutamate Amyloid-β and α-Synucleinopathy with Lewy Bodies"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]