Bengel, Philipp

[["dc.bibliographiccitation.firstpage","179"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Current Heart Failure Reports"],["dc.bibliographiccitation.lastpage","186"],["dc.bibliographiccitation.volume","14"],["dc.contributor.author","Bengel, Philipp"],["dc.contributor.author","Ahmad, Shakil"],["dc.contributor.author","Sossalla, Samuel"],["dc.date.accessioned","2019-01-30T13:29:01Z"],["dc.date.available","2019-01-30T13:29:01Z"],["dc.date.issued","2017"],["dc.description.abstract","Over the last years, evidence is accumulating that enhanced late sodium current (INaL) in cardiac pathologies has fundamental consequences for cellular electrophysiology. This review discusses the underlying mechanisms of INaL-induced arrhythmias and the significance of INaL-inhibition as a possible therapeutic approach."],["dc.identifier.doi","10.1007/s11897-017-0333-0"],["dc.identifier.pmid","28455610"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57422"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","1546-9549"],["dc.title","Inhibition of Late Sodium Current as an Innovative Antiarrhythmic Strategy"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Pacing and Clinical Electrophysiology"],["dc.contributor.author","Schlögl, Simon"],["dc.contributor.author","Schlögl, Klaudia Stella"],["dc.contributor.author","Haarmann, Helge"],["dc.contributor.author","Bengel, Philipp"],["dc.contributor.author","Bergau, Leonard"],["dc.contributor.author","Rasenack, Eva"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Zabel, Markus"],["dc.date.accessioned","2021-12-01T09:21:15Z"],["dc.date.available","2021-12-01T09:21:15Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1111/pace.14392"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94387"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","1540-8159"],["dc.relation.issn","0147-8389"],["dc.title","Remote magnetic navigation versus manual catheter ablation of atrial fibrillation: A single center long‐term comparison"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1690"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.lastpage","1700"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Pabel, Steffen"],["dc.contributor.author","Wagner, Stefan"],["dc.contributor.author","Bollenberg, Hannah"],["dc.contributor.author","Bengel, Philipp"],["dc.contributor.author","Kovács, Árpád"],["dc.contributor.author","Schach, Christian"],["dc.contributor.author","Tirilomis, Petros"],["dc.contributor.author","Mustroph, Julian"],["dc.contributor.author","Renner, André"],["dc.contributor.author","Gummert, Jan"],["dc.contributor.author","Fischer, Thomas"],["dc.contributor.author","Van Linthout, Sophie"],["dc.contributor.author","Tschöpe, Carsten"],["dc.contributor.author","Streckfuss-Bömeke, Katrin"],["dc.contributor.author","Hasenfuss, Gerd"],["dc.contributor.author","Maier, Lars S."],["dc.contributor.author","Hamdani, Nazha"],["dc.contributor.author","Sossalla, Samuel"],["dc.date.accessioned","2019-02-19T13:12:22Z"],["dc.date.available","2019-02-19T13:12:22Z"],["dc.date.issued","2018"],["dc.description.abstract","Aims Empagliflozin, a clinically used oral antidiabetic drug that inhibits the sodium-dependent glucose co-transporter 2, has recently been evaluated for its cardiovascular safety. Surprisingly, empagliflozin reduced mortality and hospitalization for heart failure (HF) compared to placebo. However, the underlying mechanisms remain unclear. Therefore, our study aims to investigate whether empagliflozin may cause direct pleiotropic effects on the myocardium. Methods and results In order to assess possible direct myocardial effects of empagliflozin, we performed contractility experiments with in toto-isolated human systolic end-stage HF ventricular trabeculae. Empagliflozin significantly reduced diastolic tension, whereas systolic force was not changed. These results were confirmed in murine myocardium from diabetic and non-diabetic mice, suggesting independent effects from diabetic conditions. In human HF cardiomyocytes, empagliflozin did not influence calcium transient amplitude or diastolic calcium level. The mechanisms underlying the improved diastolic function were further elucidated by studying myocardial fibres from patients and rats with diastolic HF (HF with preserved ejection fraction, HFpEF). Empagliflozin beneficially reduced myofilament passive stiffness by enhancing phosphorylation levels of myofilament regulatory proteins. Intravenous injection of empagliflozin in anaesthetized HFpEF rats significantly improved diastolic function measured by echocardiography, while systolic contractility was unaffected. Conclusion Empagliflozin causes direct pleiotropic effects on the myocardium by improving diastolic stiffness and hence diastolic function. These effects were independent of diabetic conditions. Since pharmacological therapy of diastolic dysfunction and HF is an unmet need, our results provide a rationale for new translational studies and might also contribute to the understanding of the EMPA-REG OUTCOME trial."],["dc.identifier.doi","10.1002/ejhf.1328"],["dc.identifier.pmid","30328645"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57583"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/239"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A11: Absolute Arrhythmie bei Vorhofflimmern - ein neuer Mechanismus, der zu einer Störung von Ca2+-Homöostase und elektrischer Stabilität in der Transition zur Herzinsuffizienz führt"],["dc.relation.issn","1879-0844"],["dc.relation.workinggroup","RG Hasenfuß (Transition zur Herzinsuffizienz)"],["dc.relation.workinggroup","RG L. Maier (Experimentelle Kardiologie)"],["dc.relation.workinggroup","RG Sossalla (Kardiovaskuläre experimentelle Elektrophysiologie und Bildgebung)"],["dc.relation.workinggroup","RG T. Fischer"],["dc.title","Empagliflozin directly improves diastolic function in human heart failure"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Journal of Interventional Cardiac Electrophysiology"],["dc.contributor.author","Schlögl, Simon"],["dc.contributor.author","Schlögl, Klaudia Stella"],["dc.contributor.author","Bengel, Philipp"],["dc.contributor.author","Bergau, Leonard"],["dc.contributor.author","Haarmann, Helge"],["dc.contributor.author","Rasenack, Eva"],["dc.contributor.author","Hasenfuss, Gerd"],["dc.contributor.author","Zabel, Markus"],["dc.date.accessioned","2022-09-01T09:49:21Z"],["dc.date.available","2022-09-01T09:49:21Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract\n \n Background\n In atrial fibrillation (AF) patients, catheter ablation of pulmonary veins (PVI) is the most effective therapeutic option to maintain sinus rhythm. To improve successful PVI, contact force–sensing (CF) catheters became routinely available. Previous studies did not clearly show superior clinical efficacy in comparison with non-CF catheters.\n \n \n Methods\n We investigated consecutive patients, who underwent index PVI for AF at our hospital between 2012 and 2018. Three hundred and fifty-four patients were ablated without CF. After availability of CF catheters in 2016, 317 patients were ablated using CF. In case of crossover between the groups, follow-up was censored. The primary endpoint was any documented atrial tachycardia (AT) or atrial fibrillation > 30 s after a 3-month blanking period. Secondary endpoints were procedural characteristics and periprocedural complications.\n \n \n Results\n \n There was no significant difference between the groups at baseline except hyperlipidemia. After 365 days of follow-up, 67% of patients in the CF group remained free from AF/AT recurrence compared to 59% in non-CF group (\n P\n  = 0.038). In multivariable Cox regression analysis, non-CF ablation was an independent risk factor for AF recurrence besides age and persistent AF. Total fluoroscopy time (15 ± 7.6 vs. 28 ± 15.9 min) and total procedure time (114 ± 29.6 vs. 136 ± 38.5 min) were significantly lower for CF-guided PVI (\n P\n  < 0.001). Complication rates did not differ between groups (\n P\n  = 0.661).\n \n \n \n Conclusions\n In our study, the AT/AF recurrence rate and pulmonary vein reconnection rate is lower after CF PVI with a similar complication rate but lower total procedure time and total fluoroscopy time compared to non-CF PVI."],["dc.identifier.doi","10.1007/s10840-022-01316-8"],["dc.identifier.pii","1316"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113401"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","1572-8595"],["dc.relation.issn","1383-875X"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Impact of open-irrigated radiofrequency catheter with contact force measurement on the efficacy and safety of atrial fibrillation ablation: a single-center direct comparison"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

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[["dc.bibliographiccitation.firstpage","45"],["dc.bibliographiccitation.journal","International Journal of Cardiology"],["dc.bibliographiccitation.lastpage","51"],["dc.bibliographiccitation.volume","318"],["dc.contributor.author","Spiesshoefer, Jens"],["dc.contributor.author","Orwat, Stefan"],["dc.contributor.author","Henke, Carolin"],["dc.contributor.author","Kabitz, Hans-Joachim"],["dc.contributor.author","Katsianos, Stratis"],["dc.contributor.author","Borrelli, Chiara"],["dc.contributor.author","Baumgartner, Helmut"],["dc.contributor.author","Nofer, Jerzy-Roch"],["dc.contributor.author","Spieker, Maximilian"],["dc.contributor.author","Bengel, Philipp"],["dc.contributor.author","Giannoni, Alberto"],["dc.contributor.author","Dreher, Michael"],["dc.contributor.author","Boentert, Matthias"],["dc.contributor.author","Diller, Gerhard Paul"],["dc.date.accessioned","2021-04-14T08:32:02Z"],["dc.date.available","2021-04-14T08:32:02Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.ijcard.2020.06.055"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83784"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0167-5273"],["dc.title","Inspiratory muscle dysfunction and restrictive lung function impairment in congenital heart disease: Association with immune inflammatory response and exercise intolerance"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","35"],["dc.bibliographiccitation.journal","Journal of Molecular and Cellular Cardiology"],["dc.bibliographiccitation.lastpage","46"],["dc.bibliographiccitation.volume","144"],["dc.contributor.author","Bengel, Philipp"],["dc.contributor.author","Ahmad, Shakil"],["dc.contributor.author","Tirilomis, Petros"],["dc.contributor.author","Trum, Maximilian"],["dc.contributor.author","Dybkova, Nataliya"],["dc.contributor.author","Wagner, Stefan"],["dc.contributor.author","Maier, Lars S."],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Sossalla, Samuel"],["dc.date.accessioned","2021-04-14T08:25:53Z"],["dc.date.available","2021-04-14T08:25:53Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1016/j.yjmcc.2020.05.002"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81759"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0022-2828"],["dc.title","Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1728"],["dc.bibliographiccitation.issue","13"],["dc.bibliographiccitation.journal","Cardiovascular Research"],["dc.bibliographiccitation.lastpage","1737"],["dc.bibliographiccitation.volume","114"],["dc.contributor.author","Dybkova, Nataliya"],["dc.contributor.author","Ahmad, Shakil"],["dc.contributor.author","Pabel, Steffen"],["dc.contributor.author","Tirilomis, Petros"],["dc.contributor.author","Hartmann, Nico"],["dc.contributor.author","Fischer, Thomas H"],["dc.contributor.author","Bengel, Philipp"],["dc.contributor.author","Tirilomis, Theodoros"],["dc.contributor.author","Ljubojevic, Senka"],["dc.contributor.author","Renner, André"],["dc.contributor.author","Gummert, Jan"],["dc.contributor.author","Ellenberger, David"],["dc.contributor.author","Wagner, Stefan"],["dc.contributor.author","Frey, Norbert"],["dc.contributor.author","Maier, Lars S"],["dc.contributor.author","Streckfuss-Bömeke, Katrin"],["dc.contributor.author","Hasenfuss, Gerd"],["dc.contributor.author","Sossalla, Samuel"],["dc.date.accessioned","2020-12-10T18:18:48Z"],["dc.date.available","2020-12-10T18:18:48Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1093/cvr/cvy152"],["dc.identifier.pmid","29931291"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/75097"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/294"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A03: Bedeutung CaMKII-abhängiger Mechanismen für die Arrhythmogenese bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A11: Absolute Arrhythmie bei Vorhofflimmern - ein neuer Mechanismus, der zu einer Störung von Ca2+-Homöostase und elektrischer Stabilität in der Transition zur Herzinsuffizienz führt"],["dc.relation","SFB 1002 | D01: Erholung aus der Herzinsuffizienz – Einfluss von Fibrose und Transkriptionssignatur"],["dc.relation.workinggroup","RG Hasenfuß (Transition zur Herzinsuffizienz)"],["dc.relation.workinggroup","RG L. Maier (Experimentelle Kardiologie)"],["dc.relation.workinggroup","RG Sossalla (Kardiovaskuläre experimentelle Elektrophysiologie und Bildgebung)"],["dc.relation.workinggroup","RG T. Fischer"],["dc.title","Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]