Rickmann, Michael J.

[["dc.bibliographiccitation.firstpage","2575"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA"],["dc.bibliographiccitation.lastpage","2580"],["dc.bibliographiccitation.volume","108"],["dc.contributor.author","Kunwar, Ajaya J."],["dc.contributor.author","Rickmann, Michael"],["dc.contributor.author","Backofen, Bianca"],["dc.contributor.author","Browski, Sascha M."],["dc.contributor.author","Rosenbusch, Joachim"],["dc.contributor.author","Schoening, Susanne"],["dc.contributor.author","Fleischmann, Thomas"],["dc.contributor.author","Krieglstein, Kerstin"],["dc.contributor.author","von Mollard, Gabriele Fischer"],["dc.date.accessioned","2018-11-07T08:59:16Z"],["dc.date.available","2018-11-07T08:59:16Z"],["dc.date.issued","2011"],["dc.description.abstract","Fusion between membranes is mediated by specific SNARE complexes. Here we report that fibroblasts survive the absence of the trans-Golgi network/early endosomal SNARE vti1a and the late endosomal SNARE vti1b with intact organelle morphology and minor trafficking defects. Because vti1a and vti1b are the only members of their SNARE subclass and the yeast homolog Vti1p is essential for cell survival, these data suggest that more distantly related SNAREs acquired the ability to function in endosomal traffic during evolution. However, absence of vti1a and vti1b resulted in perinatal lethality. Major axon tracts were missing, reduced in size, or misrouted in Vti1a(-/-) Vti1b(-/-) embryos. Progressive neurodegeneration was observed in most Vti1a(-/-) Vti1b(-/-) peripheral ganglia. Neurons were reduced by more than 95% in Vti1a(-/-) Vti1b(-/-) dorsal root and geniculate ganglia at embryonic day 18.5. These data suggest that special demands for endosomal membrane traffic could not be met in Vti1a(-/-) Vti1b(-/-) neurons. Vti1a(-/-) and Vti1b(-/-) single deficient mice were viable without these neuronal defects, indicating that they can substitute for each other in these processes."],["dc.identifier.doi","10.1073/pnas.1013891108"],["dc.identifier.isi","000287084500073"],["dc.identifier.pmid","21262811"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23851"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Natl Acad Sciences"],["dc.relation.issn","0027-8424"],["dc.title","Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","303"],["dc.bibliographiccitation.journal","Neuroscience"],["dc.bibliographiccitation.lastpage","316"],["dc.bibliographiccitation.volume","463"],["dc.contributor.author","Sokpor, Godwin"],["dc.contributor.author","Rosenbusch, Joachim"],["dc.contributor.author","Kunwar, Ajaya J."],["dc.contributor.author","Rickmann, Michael"],["dc.contributor.author","Tuoc, Tran"],["dc.contributor.author","Rizzoli, Silvio O."],["dc.contributor.author","Tarabykin, Victor"],["dc.contributor.author","von Mollard, Gabriele Fischer"],["dc.contributor.author","Krieglstein, Kerstin"],["dc.contributor.author","Staiger, Jochen F."],["dc.date.accessioned","2021-06-01T09:41:26Z"],["dc.date.available","2021-06-01T09:41:26Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1016/j.neuroscience.2021.03.021"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/84922"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0306-4522"],["dc.title","Ablation of Vti1a/1b Triggers Neural Progenitor Pool Depletion and Cortical Layer 5 Malformation in Late-embryonic Mouse Cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Cell Biology"],["dc.bibliographiccitation.volume","89"],["dc.contributor.author","Browski, S. M."],["dc.contributor.author","Backofen, Bianca"],["dc.contributor.author","Kunwar, Ajaya J."],["dc.contributor.author","Rickmann, Michael"],["dc.contributor.author","Krieglstein, Kerstin"],["dc.contributor.author","von Mollard, Gabriele Fischer"],["dc.date.accessioned","2018-11-07T08:45:25Z"],["dc.date.available","2018-11-07T08:45:25Z"],["dc.date.issued","2010"],["dc.format.extent","29"],["dc.identifier.isi","000276163000082"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20432"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Gmbh, Urban & Fischer Verlag"],["dc.publisher.place","Jena"],["dc.relation.conference","33rd Annual Meeting of the German-Society-for-Cell-Biology/German Melanoma Research Network"],["dc.relation.eventlocation","Univ Regensburg, Regensburg, GERMANY"],["dc.relation.issn","0171-9335"],["dc.title","Vti1a and vti1b-Two mammalian endosomal SNAREs of vital importance"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]