Hawellek, Thelonius

[["dc.bibliographiccitation.firstpage","e0243306"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Frosch, Stephan"],["dc.contributor.author","Buchhorn, Gottfried"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Walde, Tim Alexander"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Hubert, Jan"],["dc.contributor.editor","de Araújo, Gabriel"],["dc.date.accessioned","2021-04-14T08:31:45Z"],["dc.date.available","2021-04-14T08:31:45Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1371/journal.pone.0243306"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17806"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83704"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Comparison of the double loop knot stitch and Kessler stitch for Achilles tendon repair: A biomechanical cadaver study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Human Sport and Exercise"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Steinmetz, Gino"],["dc.contributor.author","Höller, Sebastian"],["dc.contributor.author","Hubert, Jan"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Schilling, Anrndt Friedrich"],["dc.date.accessioned","2020-06-15T13:45:39Z"],["dc.date.available","2020-06-15T13:45:39Z"],["dc.date.issued","2019"],["dc.description.abstract","The “Brocken challenge” ultramarathon takes place in the cold of February over 80 km with 1,900 m of elevation change. The purpose of this study was to evaluate the effects of an ultramarathon under extreme conditions on the lower extremities. Methods: Out of the 182 starters, 44 athletes were included into the study (n=44). We examined these athletes using a questionnaire, by measuring circumferences of their lower extremities and by standardized sonographic measurement of joint effusion of knee and ankle joints before and after the run. Results: After the run, the right leg and both feet significantly increased in circumference. Knee joints on both sides and the left ankle joint showed significantly more effusion after the run (right knee: 84%, right ankle: 43%; left knee: 80%, left ankle: 48%). Heavier and less trained athletes showed significantly more effusion in sonographic assessment of the knee and ankle. Neither swelling, nor effusion had a measurable influence on finishing time. Conclusions: Running an ultramarathon in the cold overloads the fluid draining capacity in the muscles and joints of the legs especially in heavier and less trained athletes without measurable immediate effect on performance."],["dc.identifier.doi","10.14198/jhse.2020.154.08"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17376"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66261"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1988-5202"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Significant effusion in the joints of the lower extremity after running an ultramarathon in extreme conditions"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","61"],["dc.bibliographiccitation.journal","JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY"],["dc.bibliographiccitation.lastpage","64"],["dc.bibliographiccitation.volume","60"],["dc.contributor.author","Wachowski, Martin Michael"],["dc.contributor.author","Hubert, Jan"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Mansour, Michael"],["dc.contributor.author","Dorner, J."],["dc.contributor.author","Kubein-Meesenburg, Dietmar"],["dc.contributor.author","Fanghanel, J."],["dc.contributor.author","Raab, Bjoern-Werner"],["dc.contributor.author","Dumont, B. C."],["dc.contributor.author","Nagerl, H."],["dc.date.accessioned","2018-11-07T11:21:34Z"],["dc.date.available","2018-11-07T11:21:34Z"],["dc.date.issued","2009"],["dc.description.abstract","The report presents measurements of axial rotation of lumbar motion segments (L1/L2, L3/L4, L4/L5), particularly with small angles of rotation (in the range of +/- 1 degrees) following axial force wrenches. The investigation focussed on determining the influence of geametrically varying configurations in axial wrench (consisting of axial torque and axial force) applied on the kinematics (as defined by the migrating instantaneous helical axis, IHA) of lumbar motion segments under constant resulting axial force, and relating IHA-migration to anatomical structures. In all segments, IHA migrated over several centimetres (up to 6 cm). The main portion of IHA-migration was linked to the angle of rotation interval of +/- 1 degrees. 3. The shape of the IHA-migration was greatly dependent upon the position of the force line F(2). The-force-wrench-dependent wide IHA-migration found for the rotational angle interval of +/- 1 degrees suggests that joint guidance predominates in segment kinematics. The segment kinematics can be adjusted by means of the geometrical configuration of the force wrenches. The design of non-fusion spine implants and FE calculations have to take into consideration joint guidance and muscular force distributions with small intervals of axial rotation."],["dc.identifier.isi","000277171500011"],["dc.identifier.pmid","20400794"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/6046"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55803"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.relation.issn","0867-5910"],["dc.relation.orgunit","Universitätsmedizin Göttingen"],["dc.rights","Goescholar"],["dc.subject.ddc","610"],["dc.subject.mesh","Aged"],["dc.subject.mesh","Humans"],["dc.subject.mesh","Lumbar Vertebrae"],["dc.subject.mesh","Middle Aged"],["dc.subject.mesh","Range of Motion, Articular"],["dc.subject.mesh","Rotation"],["dc.subject.mesh","Stress, Mechanical"],["dc.subject.mesh","Torque"],["dc.subject.mesh","Torsion, Mechanical"],["dc.title","AXIAL ROTATION IN THE LUMBAR SPINE FOLLOWING AXIAL FORCE WRENCH"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Diagnostics"],["dc.bibliographiccitation.volume","12"],["dc.contributor.affiliation","Hawellek, Thelonius; 1Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany; marc-pascal.meier@med.uni-goettingen.de (M.-P.M.); mark-tilmann.seitz@med.uni-goettingen.de (M.-T.S.); ft.beil@uke.de (F.T.B.); wolfgang.lehmann@med.uni-goettingen.de (W.L.); j.hubert@uke.de (J.H.)"],["dc.contributor.affiliation","Meier, Marc-Pascal; 1Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany; marc-pascal.meier@med.uni-goettingen.de (M.-P.M.); mark-tilmann.seitz@med.uni-goettingen.de (M.-T.S.); ft.beil@uke.de (F.T.B.); wolfgang.lehmann@med.uni-goettingen.de (W.L.); j.hubert@uke.de (J.H.)"],["dc.contributor.affiliation","Seitz, Mark-Tilman; 1Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany; marc-pascal.meier@med.uni-goettingen.de (M.-P.M.); mark-tilmann.seitz@med.uni-goettingen.de (M.-T.S.); ft.beil@uke.de (F.T.B.); wolfgang.lehmann@med.uni-goettingen.de (W.L.); j.hubert@uke.de (J.H.)"],["dc.contributor.affiliation","Uhlig, Johannes; 2Department of Diagnostic and Interventional Radiology, University Medical Center Göttingen, 37075 Göttingen, Germany; johannes.uhlig@med.uni-goettingen.de (J.U.); ali.seif@med.uni-goettingen.de (A.S.A.H.)"],["dc.contributor.affiliation","Hosseini, Ali Seif Amir; 2Department of Diagnostic and Interventional Radiology, University Medical Center Göttingen, 37075 Göttingen, Germany; johannes.uhlig@med.uni-goettingen.de (J.U.); ali.seif@med.uni-goettingen.de (A.S.A.H.)"],["dc.contributor.affiliation","Beil, Frank Timo; 1Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany; marc-pascal.meier@med.uni-goettingen.de (M.-P.M.); mark-tilmann.seitz@med.uni-goettingen.de (M.-T.S.); ft.beil@uke.de (F.T.B.); wolfgang.lehmann@med.uni-goettingen.de (W.L.); j.hubert@uke.de (J.H.)"],["dc.contributor.affiliation","Lehmann, Wolfgang; 1Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany; marc-pascal.meier@med.uni-goettingen.de (M.-P.M.); mark-tilmann.seitz@med.uni-goettingen.de (M.-T.S.); ft.beil@uke.de (F.T.B.); wolfgang.lehmann@med.uni-goettingen.de (W.L.); j.hubert@uke.de (J.H.)"],["dc.contributor.affiliation","Hubert, Jan; 1Department of Trauma Surgery, Orthopedics and Plastic Surgery, University Medical Center Göttingen, 37075 Göttingen, Germany; marc-pascal.meier@med.uni-goettingen.de (M.-P.M.); mark-tilmann.seitz@med.uni-goettingen.de (M.-T.S.); ft.beil@uke.de (F.T.B.); wolfgang.lehmann@med.uni-goettingen.de (W.L.); j.hubert@uke.de (J.H.)"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Meier, Marc-Pascal"],["dc.contributor.author","Seitz, Mark-Tilman"],["dc.contributor.author","Uhlig, Johannes"],["dc.contributor.author","Hosseini, Ali Seif Amir"],["dc.contributor.author","Beil, Frank Timo"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Hubert, Jan"],["dc.date.accessioned","2022-08-04T08:36:40Z"],["dc.date.available","2022-08-04T08:36:40Z"],["dc.date.issued","2022-07-22"],["dc.date.updated","2022-08-03T10:42:20Z"],["dc.description.abstract","Background: Physiological reference values for morphological parameters of the hip (MPH) are of clinical importance for the treatment of painful, degenerated or fractured hip joints, as well as to detect morphological deformities, which could result in early osteoarthritis of the hip. Currently, sufficient data for MPH are lacking. Therefore, it remains unclear if age-dependent alterations in adult hip morphology are physiological and if there are side- and gender-dependent differences. The aim of the study was to analyze MPH according to gender, side and age in a large-scaled cohort by CT scans. Methods: A total of 1576 hip joints from 788 patients (female: 257, male: 531; mean age: 58.3 years (±18.9; 18–92 years)) were analyzed by CT. For all hips, acetabular anteversion (AcetAV); lateral centrum edge angle (LCE); acetabular index (AI); femoral neck version (FNV); centrum-collum-diaphyseal angle (CCD); and anterior alpha angle (AαA) were measured. Results: The mean values in this cohort were: AcetAV 20.5° (±6.9); LCE 40.8° (±8.8); AI 0.3° (±5.3); FNV 11.0° (±9.8); CCD 129.9° (±7.4); and AαA 41.2° (±7.7). There was a detectable side-specific difference for AcetAV (p = 0.001); LCE (p < 0.001); CCD (p < 0.001); and AαA (p < 0.001). All the analyzed parameters showed a significant gender-specific difference, except for AI (p = 0.37). There was a significant correlation between age and AcetAV (r = 0.17; p < 0.001); LCE (r = 0.39; p < 0.001); AI (r = −0.25; p < 0.001); CCD (r = −0.15; p < 0.001); and AαA (r = 0.09; p < 0.001), except FNV (p = 0.79). Conclusions: There are side-, gender- and age-specific alterations in hip morphology, which have to be considered in treating hip joint pathologies."],["dc.description.sponsorship","University of Goettingen"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.doi","10.3390/diagnostics12081774"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112633"],["dc.language.iso","en"],["dc.relation.eissn","2075-4418"],["dc.rights","CC BY 4.0"],["dc.title","Morphological Parameters of the Hip Joint and Its Relation to Gender, Joint Side and Age—A CT-Based Study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","100234"],["dc.bibliographiccitation.journal","Bone Reports"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Hoffmann, Daniel Bernd"],["dc.contributor.author","Popescu, Christian"],["dc.contributor.author","Komrakova, Marina"],["dc.contributor.author","Welte, Lena"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Beil, Frank Timo"],["dc.contributor.author","Dakna, Mohammed"],["dc.contributor.author","Sehmisch, Stephan"],["dc.date.accessioned","2020-06-15T14:01:09Z"],["dc.date.available","2020-06-15T14:01:09Z"],["dc.date.issued","2020"],["dc.description.abstract","Introduction We evaluated the prevalence and influence of chronic hyponatremia in patients with low energy trauma. We also investigated the influence of medication and diseases on hyponatremia. Material and methods This retrospective study included 314 cases of proximal femoral fracture due to low energy trauma. Patients were treated in the University Medical Center Goettingen within 3 years. Hyponatremia was defined as serum sodium <135 mmol/L at admission. Results Overall, 15.6% of patients in the low energy trauma group had hyponatremia. Among patients older than 80 years, women showed distinctly higher rates of hyponatremia (female: 16.4%; male: 5.9%). In contrast only 4.7% of patients who underwent elective hip arthroplasty showed hyponatremia. Patients on sartanes and aldosterone antagonists showed significantly higher rates of hyponatremia. Alcoholism was significantly associated with hyponatremia. Conclusions We confirmed a high prevalence of chronic hyponatremia in patients with fractures due to low energy trauma. Our data underscore chronic hyponatremia as a contributing factor to hip fractures. Women older than 80 have a higher risk of developing hyponatremia. Sartanes, aldosterone antagonists, and alcohol disease are associated with hyponatremia. Treating hyponatremia may decrease the risk of fracture after low energy trauma. Therefore, physicians of different specialties should focus on treatment of chronic hyponatremia to reduce the fracture rate associated with low energy trauma."],["dc.identifier.doi","10.1016/j.bonr.2019.100234"],["dc.identifier.pmid","31909095"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17137"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66267"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","2352-1872"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Chronic hyponatremia in patients with proximal femoral fractures after low energy trauma: A retrospective study in a level-1 trauma center"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4985"],["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Journal of Clinical Medicine"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Meier, Marc-Pascal"],["dc.contributor.author","Bauer, Ina Juliana"],["dc.contributor.author","Maheshwari, Arvind K."],["dc.contributor.author","Husen, Martin"],["dc.contributor.author","Jäckle, Katharina"],["dc.contributor.author","Hubert, Jan"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Saul, Dominik"],["dc.date.accessioned","2021-12-01T09:22:51Z"],["dc.date.available","2021-12-01T09:22:51Z"],["dc.date.issued","2021"],["dc.description.abstract","Background: While primary hip arthroplasty is the most common operative procedure in orthopedic surgery, a periprosthetic joint infection is its most severe complication. Early detection and prediction are crucial. In this study, we aimed to determine the value of postoperative C-reactive protein (CRP) and develop a formula to predict this rare, but devastating complication. Methods: We retrospectively evaluated 708 patients with primary hip arthroplasty. CRP, white blood cell count (WBC), and several patient characteristics were assessed for 20 days following the operative procedure. Results: Eight patients suffered an early acute periprosthetic infection. The maximum CRP predicted an infection with a sensitivity and specificity of 75% and 56.9%, respectively, while a binary logistic regression reached values of 75% and 80%. A multinominal logistic regression, however, was able to predict an early infection with a sensitivity and specificity of 87.5% and 78.9%. With a one-phase decay, 71.6% of the postoperative CRP-variance could be predicted. Conclusion: To predict early acute periprosthetic joint infection after primary hip arthroplasty, a multinominal logistic regression is the most promising approach. Including five parameters, an early infection can be predicted on day 5 after the operative procedure with 87.5% sensitivity, while it can be excluded with 78.9% specificity."],["dc.description.abstract","Background: While primary hip arthroplasty is the most common operative procedure in orthopedic surgery, a periprosthetic joint infection is its most severe complication. Early detection and prediction are crucial. In this study, we aimed to determine the value of postoperative C-reactive protein (CRP) and develop a formula to predict this rare, but devastating complication. Methods: We retrospectively evaluated 708 patients with primary hip arthroplasty. CRP, white blood cell count (WBC), and several patient characteristics were assessed for 20 days following the operative procedure. Results: Eight patients suffered an early acute periprosthetic infection. The maximum CRP predicted an infection with a sensitivity and specificity of 75% and 56.9%, respectively, while a binary logistic regression reached values of 75% and 80%. A multinominal logistic regression, however, was able to predict an early infection with a sensitivity and specificity of 87.5% and 78.9%. With a one-phase decay, 71.6% of the postoperative CRP-variance could be predicted. Conclusion: To predict early acute periprosthetic joint infection after primary hip arthroplasty, a multinominal logistic regression is the most promising approach. Including five parameters, an early infection can be predicted on day 5 after the operative procedure with 87.5% sensitivity, while it can be excluded with 78.9% specificity."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/jcm10214985"],["dc.identifier.pii","jcm10214985"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94497"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","2077-0383"],["dc.relation.orgunit","Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Predicting the Exception—CRP and Primary Hip Arthroplasty"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2507"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Diagnostics"],["dc.bibliographiccitation.volume","12"],["dc.contributor.affiliation","Meier, Marc-Pascal; 1Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Brandt, Lars Erik; 1Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Saul, Dominik; 2BG Trauma Center Tuebingen, Department of Trauma and Reconstructive Surgery, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany"],["dc.contributor.affiliation","Roch, Paul Jonathan; 1Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Klockner, Friederike Sophie; 1Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Hosseini, Ali Seif Amir; 4Department of Diagnostic and Interventional Radiology, University Medical Center Goettingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Lehmann, Wolfgang; 1Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany"],["dc.contributor.affiliation","Hawellek, Thelonius; 1Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University Medical Center Goettingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany"],["dc.contributor.author","Meier, Marc-Pascal"],["dc.contributor.author","Brandt, Lars Erik"],["dc.contributor.author","Saul, Dominik"],["dc.contributor.author","Roch, Paul Jonathan"],["dc.contributor.author","Klockner, Friederike Sophie"],["dc.contributor.author","Hosseini, Ali Seif Amir"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Hawellek, Thelonius"],["dc.date.accessioned","2022-12-01T08:31:39Z"],["dc.date.available","2022-12-01T08:31:39Z"],["dc.date.issued","2022"],["dc.date.updated","2022-11-11T13:12:20Z"],["dc.description.abstract","Background: Humeral offset (HO) and glenoidal offset (GO) are important morphological parameters in diagnostics and therapy for shoulder pathologies. However, physiological reference values have not yet been sufficiently determined. The aim of the present study was to establish physiological reference values for shoulder offset parameters (SOPs). Methods: MRI images of the shoulder joints of 800 patients (mean age: 50.13 years [±16.01]) were analysed retrospectively. HO, GO, lateral glenoidal humeral offset (LGHO), humeral shaft axis offset (HAO) and cortical offset (CO) were measured. SOPs were examined for associations with age, gender, side and osteoarthritis. Results: The mean HO was 26.19 (±2.70), the mean GO was 61.79 (±5.67), the mean LGHO was 54.49 (±4.69), the mean HAO was 28.17 (±2.82) and the mean CO was 16.70 (±3.08). For all SOPs, significantly higher values were measured in male shoulders. There was a significantly (p < 0.001) higher mean value for HO, GO and LGHO in right shoulders. There was a significant correlation between age and LGHO, and HAO and CO, but not between age and HO or GO. Shoulders with osteoarthritis and non-osteoarthritis did not differ in the mean value of HO, GO, LGHO and HAO, except for CO (p = 0.049). Conclusion: Reference values for SOPs in the adult shoulder joint were determined for the first time. Significant gender-specific differences were found for all measured SOPs. In addition, it was seen that for some SOPs, the joint side and the patient’s age has to be taken into account in shoulder diagnostics and surgery."],["dc.description.sponsorship","Open Access Publication Fund of the University of Goettingen"],["dc.identifier.doi","10.3390/diagnostics12102507"],["dc.identifier.pii","diagnostics12102507"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118227"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.eissn","2075-4418"],["dc.rights","CC BY 4.0"],["dc.title","Physiological Offset Parameters of the Adult Shoulder Joint—A MRI Study of 800 Patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","unpublished"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","104"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Arthritis Research & Therapy"],["dc.bibliographiccitation.volume","20"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Hubert, Jan"],["dc.contributor.author","Hischke, Sandra"],["dc.contributor.author","Krause, Matthias"],["dc.contributor.author","Bertrand, Jessica"],["dc.contributor.author","Schmidt, Burkhard C"],["dc.contributor.author","Kronz, Andreas"],["dc.contributor.author","Püschel, Klaus"],["dc.contributor.author","Rüther, Wolfgang"],["dc.contributor.author","Niemeier, Andreas"],["dc.date.accessioned","2019-07-09T11:45:30Z"],["dc.date.available","2019-07-09T11:45:30Z"],["dc.date.issued","2018"],["dc.description.abstract","Abstract Background Meniscal calcification is considered to play a relevant role in the pathogenesis of osteoarthritis of the knee. Little is known about the biology of acetabular labral disease and its importance in hip pathology. Here, we analyze for the first time the calcification of the acetabular labrum of the hip (ALH) and its relation to hip cartilage degeneration. Methods In this cross-sectional post-mortem study of an unselected sample of the general population, 170 ALH specimens and 170 femoral heads from 85 donors (38 female, 47 male; mean age 62.1 years) were analyzed by high-resolution digital contact radiography (DCR) and histological degeneration grade. The medial menisci (MM) from the same 85 donors served as an intra-individual reference for cartilage calcification (CC). Scanning electron microscopy (SEM), energy dispersive analysis (ED) and Raman spectroscopy were performed for characterization of ALH CC. Results The prevalence of CC in the ALH was 100% and that in the articular cartilage of the hip (ACH) was 96.5%. Quantitative analysis revealed that the amount of ALH CC was higher than that in the ACH (factor 3.0, p < 0.001) and in the MM (factor 1.3, p < 0.001). There was significant correlation between the amount of CC in the fibrocartilage of the left and right ALH (r = 0.70, p < 0.001). Independent of age, the amount of ALH CC correlated with histological degeneration of the ALH (Krenn score) (r = 0.55; p < 0.001) and the ACH (Osteoarthritis Research Society International (OARSI), r = 0.69; p < 0.001). Calcification of the ALH was characterized as calcium pyrophosphate dihydrate deposition. Conclusion The finding that ALH fibrocartilage is a strongly calcifying tissue is unexpected and novel. The fact that ALH calcification correlates with cartilage degeneration independent of age is suggestive of an important role of ALH calcification in osteoarthritis of the hip and renders it a potential target for the prevention and treatment of hip joint degeneration."],["dc.identifier.doi","10.1186/s13075-018-1595-y"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15231"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59244"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.relation.orgunit","Fakultät für Geowissenschaften und Geographie"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Calcification of the acetabular labrum of the hip: prevalence in the general population and relation to hip articular cartilage and fibrocartilage degeneration"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","9887"],["dc.bibliographiccitation.issue","18"],["dc.bibliographiccitation.journal","International Journal of Molecular Sciences"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Shang, Xiaobin"],["dc.contributor.author","Böker, Kai Oliver"],["dc.contributor.author","Taheri, Shahed"],["dc.contributor.author","Hawellek, Thelonius"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Schilling, Arndt F."],["dc.date.accessioned","2021-10-01T09:58:22Z"],["dc.date.available","2021-10-01T09:58:22Z"],["dc.date.issued","2021"],["dc.date.updated","2022-09-04T00:18:30Z"],["dc.description.abstract","Osteoarthritis (OA) is a chronic disease affecting the whole joint, which still lacks a disease-modifying treatment. This suggests an incomplete understanding of underlying molecular mechanisms. The Wnt/β-catenin pathway is involved in different pathophysiological processes of OA. Interestingly, both excessive stimulation and suppression of this pathway can contribute to the pathogenesis of OA. microRNAs have been shown to regulate different cellular processes in different diseases, including the metabolic activity of chondrocytes and osteocytes. To bridge these findings, here we attempt to give a conclusive overview of microRNA regulation of the Wnt/β-catenin pathway in bone and cartilage, which may provide insights to advance the development of miRNA-based therapeutics for OA treatment."],["dc.description.abstract","Osteoarthritis (OA) is a chronic disease affecting the whole joint, which still lacks a disease-modifying treatment. This suggests an incomplete understanding of underlying molecular mechanisms. The Wnt/β-catenin pathway is involved in different pathophysiological processes of OA. Interestingly, both excessive stimulation and suppression of this pathway can contribute to the pathogenesis of OA. microRNAs have been shown to regulate different cellular processes in different diseases, including the metabolic activity of chondrocytes and osteocytes. To bridge these findings, here we attempt to give a conclusive overview of microRNA regulation of the Wnt/β-catenin pathway in bone and cartilage, which may provide insights to advance the development of miRNA-based therapeutics for OA treatment."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.3390/ijms22189887"],["dc.identifier.pii","ijms22189887"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90051"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation.eissn","1422-0067"],["dc.relation.orgunit","Klinik für Unfallchirurgie, Orthopädie und Plastische Chirurgie"],["dc.rights","CC BY 4.0"],["dc.title","The Interaction between microRNAs and the Wnt/β-Catenin Signaling Pathway in Osteoarthritis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","169"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Musculoskeletal Disorders"],["dc.bibliographiccitation.volume","19"],["dc.contributor.author","Hubert, Jan"],["dc.contributor.author","Weiser, Lukas"],["dc.contributor.author","Hischke, Sandra"],["dc.contributor.author","Uhlig, Annemarie"],["dc.contributor.author","Rolvien, Tim"],["dc.contributor.author","Schmidt, Tobias"],["dc.contributor.author","Butscheidt, Sebastian K"],["dc.contributor.author","Püschel, Klaus"],["dc.contributor.author","Lehmann, Wolfgang"],["dc.contributor.author","Beil, Frank T"],["dc.contributor.author","Hawellek, Thelonius"],["dc.date.accessioned","2019-07-09T11:45:29Z"],["dc.date.available","2019-07-09T11:45:29Z"],["dc.date.issued","2018"],["dc.description.abstract","Abstract Background Cartilage calcification (CC) is associated with osteoarthritis (OA) in weight-bearing joints, such as the hip and the knee. However, little is known about the impact of CC and degeneration on other weight-bearing joints, especially as it relates to the occurrence of OA in the ankles. The goal of this study is to analyse the prevalence of ankle joint cartilage calcification (AJ CC) and to determine its correlation with factors such as histological OA grade, age and BMI in the general population. Methods CC of the distal tibia and talus in 160 ankle joints obtained from 80 donors (mean age 62.4 years, 34 females, 46 males) was qualitatively and quantitatively analysed using high-resolution digital contact radiography (DCR). Correlations with factors, such as the joint’s histological OA grade (OARSI score), donor’s age and BMI, were investigated. Results The prevalence of AJ CC was 51.3% (95% CI [0.40, 0.63]), independent of gender (p = 0.18) and/or the joint’s side (p = 0.82). CC of the distal tibia was detected in 35.0% (28/80) (95% CI [0.25, 0.47]) and talar CC in 47.5% (38/80) (95% CI [0.36, 0.59]) of all cases. Significant correlations were noted between the mean amount of tibial and talar CC (r = 0.59, p = 0.002), as well as between the mean amount of CC observed in one ankle joint with that of the contralateral side (r = 0.52, p = 0.02). Furthermore, although the amount of AJ CC observed in the distal tibia and talus correlated with the histological OA-grade of the joint (r = 0.70, p < 0.001 and r = 0.72, p < 0.001, respectively), no such correlation was seen in the general population with relation to age (p = 0.32 and p = 0.49) or BMI (p = 0.51 and p = 0.87). Conclusion The prevalence of AJ CC in the general population is much higher than expected. The relationship between the amount of AJ CC and OA, independent of the donors’ age and BMI, indicates that CC may play a causative role in the development of OA in ankles."],["dc.identifier.doi","10.1186/s12891-018-2094-7"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15227"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59240"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Cartilage calcification of the ankle joint is associated with osteoarthritis in the general population"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]