Berger, Joachim

[["dc.bibliographiccitation.firstpage","653"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Onkologie"],["dc.bibliographiccitation.lastpage","656"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Nitsche, M."],["dc.contributor.author","Hermann, Robert Michael"],["dc.contributor.author","Christiansen, H."],["dc.contributor.author","Berger, J."],["dc.contributor.author","Pradier, Olivier"],["dc.date.accessioned","2018-11-07T08:45:02Z"],["dc.date.available","2018-11-07T08:45:02Z"],["dc.date.issued","2005"],["dc.description.abstract","Background: Sinonasal Teratocarcinosarcoma (SNTC) is a very unusual and aggressive neoplasm characterized by the combination of malignant teratoma and carcinosarcoma features. We present the first case of malignant SNTC treated with individualized multimodal therapy including a histology-specific chemotherapy. Case Report: A 31-year-old man presented with an obstruction of the right pansinus. Histology showed an SNTC with major parts of small cell, poorly differentiated carcinoma and a small proportion of highly differentiated embryonal rhabdomyosarcoma. An operation was performed followed by intraoperative application of a 5-FU ointment. Adjuvant chemotherapy with cisplatin, etoposid and ifosfamid were given in regard to the major components of this heterogeneous tumor. Radiotherapy up to 59.4 Gy was applied. Conclusion: 36 months after the end of therapy, there is no sign of tumor recurrence or metastasis in our patient. We suggest that surgery, radiotherapy and a histology-specific multidrug chemotherapy seems to be a therapeutic approach that is appropriate for this heterogeneous tumor."],["dc.identifier.doi","10.1159/000089146"],["dc.identifier.isi","000233952500007"],["dc.identifier.pmid","16330889"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20335"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Karger"],["dc.relation.issn","0378-584X"],["dc.title","Rationale for individualized therapy in sinonasal teratocarcinosarcoma (SNTC): Case report"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]