Kazmaier, Stephan

[["dc.bibliographiccitation.firstpage","E49"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Heart Surgery Forum"],["dc.bibliographiccitation.lastpage","U2"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Baryalei, M. M."],["dc.contributor.author","Tirilomis, Theodor"],["dc.contributor.author","Buhre, W."],["dc.contributor.author","Kazmaier, Stefan"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Aleksic, I."],["dc.date.accessioned","2018-11-07T08:28:04Z"],["dc.date.available","2018-11-07T08:28:04Z"],["dc.date.issued","2005"],["dc.description.abstract","Background: Myocardial bridging of the left anterior descending ( LAD) artery may result in clinical symptoms. Surgery with cardiopulmonary bypass (CPB) is a therapeutic option with considerable risk. We hypothesized that off-pump supraarterial myotomy could be an effective treatment modality. Methods: Between October 1998 and May 2000, 13 patients were referred for surgery. All were symptomatic despite medical therapy. Anteroseptal ischemia had been proven by thallium scintigraphy in all 13 patients, exercise testing was positive in 11. All patients were operated on with an off-pump approach after median sternotomy. Results: Mean patient age was 61 +/- 8 years ( range, 43-71 years). Coronary artery disease mandating additional bypasses was present in 3 patients. The bypasses were done off pump in 2 patients. Conversion to on-pump surgery was necessary in 3 of 13 patients (23%) because of hemodynamic compromise ( 1 patient), opening of the right ventricle ( 1 patient), and injury to the LAD ( 1 patient). Supraarterial myotomy was performed in all patients. One patient who underwent surgery with CPB developed postoperative anteroseptal myocardial infarction. Postoperative exercise testing was performed in all patients and did not reveal any persistent ischemia. Mortality was 0%. All patients were free from symptoms and had not undergone repeat interventions after an average of 51 +/- 7 months of follow-up. Conclusions: Off-pump supraarterial myotomy effectively relieves coronary obstruction but has a certain periprocedural risk as evidenced by 1 myocardial infarction, 1 right ventricular injury, and 1 LAD injury. Long-term freedom from symptoms and from reintervention favor further investigation of this surgical therapy."],["dc.identifier.doi","10.1532/HSF98.20041116"],["dc.identifier.isi","000233336200012"],["dc.identifier.pmid","15769716"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16336"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Forum Multimedia Publishing, Llc"],["dc.relation.issn","1098-3511"],["dc.title","Off-pump supraarterial decompression myotomy for myocardial bridging"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","233"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","The International Journal of Artificial Organs"],["dc.bibliographiccitation.lastpage","239"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Molder, Jan Martin"],["dc.contributor.author","Hanekop, Gerd-Gunnar"],["dc.contributor.author","Weyland, Andreas"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Kazmaier, Stephan"],["dc.date.accessioned","2018-11-07T09:26:14Z"],["dc.date.available","2018-11-07T09:26:14Z"],["dc.date.issued","2013"],["dc.description.abstract","Purpose: The goal of this investigation was to examine the influence of two oxygenators with different membranes, made of either polypropylene (PPL) or polymethylpentane (PMP), on the plasma concentration of sevoflurane during cardiopulmonary bypass. Methods: The concentrations of sevoflurane during cardiopulmonary bypass were examined in patient plasma, endotracheal tubes, cardiotomy reservoirs and the outlets of the heart-lung oxygenators in twenty patients who underwent elective heart surgery. Results: The sevoflurane losses are smaller in cardiopulmonary bypass when using a polymethylpentane versus a polypropylene oxygenator. Ten minutes after beginning cardiopulmonary bypass, the sevoflurane plasma concentration in the PPL oxygenator group compared to the PMP oxygenator group fell significantly (PPL 0.48-1.79 (0.93) vs. PMP 0.80-2.15 (1.56) mu L x 100 mL(-1), p = 0.02). This difference persisted until ten minutes after the termination of cardiopulmonary bypass. Conclusion: The results of this study show that using a polymethylpentane membrane oxygenator rather than a polypropylene oxygenator significantly reduces the losses of sevoflurane, resulting in higher plasma concentrations and greater depth of anesthesia."],["dc.identifier.doi","10.5301/ijao.5000208"],["dc.identifier.isi","000320894500001"],["dc.identifier.pmid","23504814"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/30252"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wichtig Editore"],["dc.relation.issn","0391-3988"],["dc.title","Reduced sevoflurane loss during cardiopulmonary bypass when using a polymethylpentane versus a polypropylene oxygenator"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1470"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Journal of Cerebral Blood Flow & Metabolism"],["dc.bibliographiccitation.lastpage","1477"],["dc.bibliographiccitation.volume","35"],["dc.contributor.author","Grune, Frank F. G."],["dc.contributor.author","Kazmaier, Stephan"],["dc.contributor.author","Stolker, Robert Jan"],["dc.contributor.author","Visser, Gerhard H."],["dc.contributor.author","Weyland, Andreas"],["dc.date.accessioned","2018-11-07T09:52:39Z"],["dc.date.available","2018-11-07T09:52:39Z"],["dc.date.issued","2015"],["dc.description.abstract","In addition to cerebrovascular resistance (CVR) zero flow pressure (ZFP), effective cerebral perfusion pressure (CPPe) and the resistance area product (RAP) are supplemental determinants of cerebral blood flow (CBF). Until now, the interrelationship of PaCO2-induced changes in CBF, CVR, CPPe, ZFP, and RAP is not fully understood. In a controlled crossover trial, we investigated 10 anesthetized patients aiming at PaCO2 levels of 30, 37, 43, and 50 mm Hg. Cerebral blood flow was measured with a modified Kety-Schmidt-technique. Zero flow pressure and RAP was estimated by linear regression analysis of pressure-flow velocity relationships of the middle cerebral artery. Effective cerebral perfusion pressure was calculated as the difference between mean arterial pressure and ZFP, CVR as the ratio CPPe/CBF. Statistical analysis was performed by one-way RM-ANOVA. When comparing hypocapnia with hypercapnia, CBF showed a significant exponential reduction by 55% and mean V-MCA by 41%. Effective cerebral perfusion pressure linearly decreased by 17% while ZFP increased from 14 to 29 mm Hg. Cerebrovascular resistance increased by 96% and RAP by 39%; despite these concordant changes in mean CVR and Doppler-derived RAP correlation between these variables was weak (r = 0.43). In conclusion, under general anesthesia hypocapnia-induced reduction in CBF is caused by both an increase in CVR and a decrease in CPPe, as a consequence of an increase in ZFP."],["dc.identifier.doi","10.1038/jcbfm.2015.63"],["dc.identifier.isi","000360689500014"],["dc.identifier.pmid","25873428"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36175"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1559-7016"],["dc.relation.issn","0271-678X"],["dc.title","Carbon dioxide induced changes in cerebral blood flow and flow velocity: role of cerebrovascular resistance and effective cerebral perfusion pressure"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","538"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie"],["dc.bibliographiccitation.lastpage","544"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Grune, Frank F. G."],["dc.contributor.author","Buhre, W."],["dc.contributor.author","Kazmaier, Stefan"],["dc.contributor.author","Weyland, Wolfgang"],["dc.contributor.author","Rieke, H."],["dc.contributor.author","Weyland, A."],["dc.date.accessioned","2018-11-07T08:39:46Z"],["dc.date.available","2018-11-07T08:39:46Z"],["dc.date.issued","2001"],["dc.description.abstract","Objective: This controlled study was designed to investigate 1.) the effects of 0,8% halothane and 2.) the effects of a variation in PaCO2 on the relationship between global cerebral blood flow (CBF) and middle cerebral artery flow velocity (CBFVMCA). Method: With ethical committee approval and informed patient consent we investigated 10 patients undergoing coronary artery bypass surgery. Measurements were performed under fentanyl/midazolam anaesthesia prior to the start of surgery. First, during a baseline period, ventilation was changed in a random sequence to achieve two different levels of arterial PCO2. (30 and 50 mmHg, respectively). Consequently, measurements were repeated during application of 0.8% halothane at identical PaCO2 levels. Measurements of global CBF were performed by the Kety-Schmidt-technique with argon as an indicator. Simultaneously, CBFVMCA was recorded by use of a 2-MHz transcranial Doppler system. Results: Application of 0.8% halothane caused a significant decrease in cerebrovascular resistance (CVR) both at hypocapnia and hypercapnia by 36 and 23%, respectively. Because of a concomitant reduction in cerebral perfusion pressure (CPP), however, CBF remained unchanged during application of halothane. The relationship between CBF and CBFVMCA was not altered when compared to the baseline period. Similarly, CO2 reactivity of CBF and CBFVMCA remained unchanged. CO2 reactivity of CBF significantly exceeded CO2 reactivity of CBFVMCA. Conclusion: The results of this clinical study demonstrate that Doppler-sonographic estimation of relative changes in CBF is not altered by application of 1 MAC halothane indicating that the decrease in CVR is not associated with a vasodilation of the proximal segments of basal cerebral arteries. The difference between CO2 reactivity of CBF and CBFVMCA, however, suggests that CO2-induced changes in CBF are slightly underestimated by TCD monitoring of CBFVMCA."],["dc.identifier.doi","10.1055/s-2001-17259"],["dc.identifier.isi","000171381700003"],["dc.identifier.pmid","11577352"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19075"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","0939-2661"],["dc.title","The relationship between cerebral blood flow (CBF) and the cerebral blood flow velocity (CBFV): Influence of halothane and cerebral CO2 reactivity."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","373"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","European Journal of Anaesthesiology"],["dc.bibliographiccitation.lastpage","379"],["dc.bibliographiccitation.volume","23"],["dc.contributor.author","Kazmaier, Stefan"],["dc.contributor.author","Hanekop, Gerd-Gunnar"],["dc.contributor.author","Grossmann, Marius"],["dc.contributor.author","Dorge, H."],["dc.contributor.author","Gotze, Katharina"],["dc.contributor.author","Schondube, F."],["dc.contributor.author","Quintel, M."],["dc.contributor.author","Weyland, A."],["dc.date.accessioned","2018-11-07T09:51:53Z"],["dc.date.available","2018-11-07T09:51:53Z"],["dc.date.issued","2006"],["dc.description.abstract","Objective: The objective of this study was to describe the diastolic pressure-flow relationship and to assess critical occlusion pressure in arterial coronary bypass grafts in human beings. Methods and results: Fifteen patients were studied following elective surgical coronary artery bypass grafting. Flow in the left internal mammary artery bypass to the left anterior descending artery was measured and simultaneously, aortic pressure, coronary sinus pressure and left ventricular end-diastolic pressure were recorded. The zero-flow pressure intercept as a measure of critical occlusion pressure was extrapolated from the linear regression analysis of the instantaneous diastolic pressure-flow relationship. Mean diastolic flow was 46 +/- 17 mL min(-1), mean diastolic aortic pressure was 60.5 +/- 10.0 mmHg. Diastolic blood flow was linearly related to the respective aortic pressure in all patients (R-values 0.7-0.99). The regression lines had a mean slope of 2.1 +/- 1.2 mL min(-1) mmHg(-1). Mean critical occlusion pressure was 32.3 +/- 9.9 mmHg and exceeded mean coronary sinus pressure and mean left ventricular end-diastolic pressure by factors of 3.1 and 2.6, respectively. Conclusions: Our data demonstrate the presence of a vascular waterfall phenomenon in the coronary circulation after internal mammary artery bypass grafting. Critical occlusion pressure in arterial grafts considerably exceeds coronary sinus pressure as well as left ventricular end-diastolic pressure and should thus be used as the effective downstream pressure when calculating coronary perfusion pressure. Our data further suggest that the slope of diastolic pressure-flow relationships provides a more rational approach to assess regional coronary vascular resistance than conventional calculations of coronary vascular resistance."],["dc.identifier.doi","10.1017/S0265021505001985"],["dc.identifier.isi","000237408100002"],["dc.identifier.pmid","16438765"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36001"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Cambridge Univ Press"],["dc.relation.issn","0265-0215"],["dc.title","Instantaneous diastolic pressure-flow relationship in arterial coronary bypass grafts"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","335"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Anesthesiology"],["dc.bibliographiccitation.lastpage","342"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Grune, Frank F. G."],["dc.contributor.author","Kazmaier, Stephan"],["dc.contributor.author","Sonntag, Hans"],["dc.contributor.author","Stolker, Robert Jan"],["dc.contributor.author","Weyland, Andreas"],["dc.date.accessioned","2018-11-07T09:44:11Z"],["dc.date.available","2018-11-07T09:44:11Z"],["dc.date.issued","2014"],["dc.description.abstract","Background: Hyperventilation is known to decrease cerebral blood flow (CBF) and to impair cerebral metabolism, but the threshold in patients undergoing intravenous anesthesia is unknown. The authors hypothesized that reduced CBF associated with moderate hyperventilation might impair cerebral aerobic metabolism in patients undergoing intravenous anesthesia. Methods: Thirty male patients scheduled for coronary surgery were included in a prospective, controlled crossover trial. Measurements were performed under fentanyl-midazolam anesthesia in a randomized sequence aiming at partial pressures of carbon dioxide of 30 and 50 mmHg. Endpoints were CBF, blood flow velocity in the middle cerebral artery, and cerebral metabolic rates for oxygen, glucose, and lactate. Global CBF was measured using a modified Kety-Schmidt technique with argon as inert gas tracer. CBF velocity of the middle cerebral artery was recorded by transcranial Doppler sonography. Data were presented as mean (SD). Two-sided paired t tests and one-way ANOVA for repeated measures were used for statistical analysis. Results: Moderate hyperventilation significantly decreased CBF by 60%, blood flow velocity by 41%, cerebral oxygen delivery by 58%, and partial pressure of oxygen of the jugular venous bulb by 45%. Cerebral metabolic rates for oxygen and glucose remained unchanged; however, net cerebral lactate efflux significantly increased from -0.38 (2.18) to -2.41(2.43) mu mol min(-1) 100 g(-1). Conclusions: Moderate hyperventilation, when compared with moderate hypoventilation, in patients with cardiovascular disease undergoing intravenous anesthesia increased net cerebral lactate efflux and markedly reduced CBF and partial pressure of oxygen of the jugular venous bulb, suggesting partial impairment of cerebral aerobic metabolism at clinically relevant levels of hypocapnia."],["dc.identifier.doi","10.1097/ALN.0b013e3182a8eb09"],["dc.identifier.isi","000331559900012"],["dc.identifier.pmid","24008921"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/34337"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","1528-1175"],["dc.relation.issn","0003-3022"],["dc.title","Moderate Hyperventilation during Intravenous Anesthesia Increases Net Cerebral Lactate Efflux"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","110"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","The Annals of Thoracic Surgery"],["dc.bibliographiccitation.lastpage","119"],["dc.bibliographiccitation.volume","84"],["dc.contributor.author","Liakopoulos, Oliver Joannis"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Kazmaier, Stefan"],["dc.contributor.author","Braeuer, Anselm"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Doerge, Hilmar"],["dc.date.accessioned","2018-11-07T11:00:50Z"],["dc.date.available","2018-11-07T11:00:50Z"],["dc.date.issued","2007"],["dc.description.abstract","Background. Cardiopulmonary bypass (CPB)-related inflammatory response can be attenuated by glucocorticoid treatment, but its impact on postoperative cardiopulmonary function remains controversial. It was investigated whether the systemic and myocardial anti-inflammatory effects of glucocorticoids are associated with improved cardiopulmonary function in cardiac surgery patients. Methods. Eighty patients undergoing elective coronary artery bypass grafting were randomly assigned to receive a single shot of methylprednisolone ( 15 mg/kg) or placebo before CPB. Variables of myocardial and pulmonary function and systemic hemodynamics were measured before and 1, 4, 10, and 24 hours after CPB. Blood was sampled for measurement of proinflammatory ( tumor necrosis factor-alpha, interleukin 6, interleukin 8) and antiinflammatory ( interleukin 10) cytokines ( by enzyme-linked immunoassay), troponin T, and C-reactive protein. Phosphorylation of inhibitory kappa-B alpha and p38 mitogen-activated protein kinase was determined in right atrial biopsies before and after CPB ( phosphoprotein assay). Results. Preoperative and intraoperative characteristics of patients were not different between groups. Methylprednisolone attenuated postoperative tumor necrosis factor-alpha, interleukin 6, interleukin 8, and C-reactive protein levels while increasing interleukin 10 release. Myocardial inhibitory kappa-B alpha was preserved with methylprednisolone ( p < 0.05 versus placebo), but p38 mitogen-activated protein kinase activation occurred in both groups after CPB ( p < 0.05 versus before CPB). Methylprednisolone improved postoperative cardiac index and was associated with decreased troponin T when compared with placebo ( p < 0.05). Postoperative blood glucose, oxygen delivery index, and pulmonary shunt flow were increased in the methylprednisolone group ( p < 0.05). There was no difference in postoperative oxygenation index, ventilation time, and clinical outcome between treatment groups. Conclusions. Glucocorticoid treatment before CPB attenuates perioperative release of systemic and myocardial inflammatory mediators and improves myocardial function, suggesting potential cardioprotective effects in patients undergoing cardiac surgery."],["dc.identifier.doi","10.1016/j.athoracsur.2007.01.003"],["dc.identifier.isi","000247373200017"],["dc.identifier.pmid","17588396"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51018"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","43rd Annual Meeting of the Society-of-Thoracic-Surgeons"],["dc.relation.eventlocation","San Diego, CA"],["dc.relation.issn","0003-4975"],["dc.title","Cardiopulmonary and systemic effects of methylprednisolone in patients undergoing cardiac surgery"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","508"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Der Schmerz"],["dc.bibliographiccitation.lastpage","516"],["dc.bibliographiccitation.volume","24"],["dc.contributor.author","Wiese, Christoph Hermann"],["dc.contributor.author","Loeffler, E. K."],["dc.contributor.author","Vormelker, J."],["dc.contributor.author","Meyer, N."],["dc.contributor.author","Taghavi, Mahmoud"],["dc.contributor.author","Strumpf, Michael"],["dc.contributor.author","Kazmaier, Stefan"],["dc.contributor.author","Roessler, M."],["dc.contributor.author","Zausig, York A."],["dc.contributor.author","Popov, A. F."],["dc.contributor.author","Lassen, Christoph L."],["dc.contributor.author","Graf, Bernhard Martin"],["dc.contributor.author","Hanekop, Gerd-Gunnar"],["dc.date.accessioned","2018-11-07T08:40:11Z"],["dc.date.available","2018-11-07T08:40:11Z"],["dc.date.issued","2010"],["dc.description.abstract","Cancer diseases are often associated with acute and chronic pain. Therefore, cancer pain is a symptom frequently reported by palliative care patients with cancer diseases. Prehospital emergency physicians may be confronted with exacerbation of pain in cancer patients. The aim of this study was to evaluate the knowledge of prehospital emergency physicians in training concerning cancer pain therapy. A total of 471 prehospital emergency physicians received a questionnaire (period of time: 2007-2009). The questionnaire was prepared for the study (\"mixed methods design\"). Twenty-four questions concerning cancer pain therapy (response options: scaling, open) were designed. The evaluation was done descriptively according to professional experience, field name and experience in treating patients with cancer as well. A total of 469 participants completed the questionnaire (response rate 99%). On average, 10.8 (SD +5.7, range 2-24) questions were answered correctly. Resident physicians answered statistically significantly more questions correctly than consultants (p=0.02). Only physicians working in internal medicine achieved statistically significantly better results than other disciplines (e.g., surgery; p=0.01). Physicians with professional experience of less than 5 years answered statistically significantly more questions correctly (p=0.004). The results of this study verify that emergency physicians in training have insufficient knowledge of pain therapy and end-of-life decisions. The data of this investigation suggest that more attention should be paid to education on pain therapy and end-of-life care in medical curricula. Prehospital emergency physicians may thus be better prepared to provide quality care for palliative patients."],["dc.identifier.doi","10.1007/s00482-010-0956-5"],["dc.identifier.isi","000282216900010"],["dc.identifier.pmid","20686791"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19166"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0932-433X"],["dc.title","Cancer pain therapy in palliative care patients: knowledge of prehospital emergency physicians in training Prospective questionnaire-based survey"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","961"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Artificial Organs"],["dc.bibliographiccitation.lastpage","968"],["dc.bibliographiccitation.volume","34"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Schulz, Egbert G."],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Coskun, Kasim Oguz"],["dc.contributor.author","Tzvetkov, Mladen Vassilev"],["dc.contributor.author","Kazmaier, Stephan"],["dc.contributor.author","Zimmermann, Janna"],["dc.contributor.author","Schoendube, Friedrich Albert"],["dc.contributor.author","Quintel, Michael"],["dc.contributor.author","Hinz, Jose"],["dc.date.accessioned","2018-11-07T08:37:19Z"],["dc.date.available","2018-11-07T08:37:19Z"],["dc.date.issued","2010"],["dc.description.abstract","Several genetic polymorphisms have been identified to play a role in the occurrence and progression of renal dysfunction after cardiac surgery with cardiopulmonary bypass (CPB). Recently, it was demonstrated that the T allele of SNP rs1617640 in the promoter of the erythropoetin (EPO) gene is significantly associated with proliferative diabetic retinopathy (PDR) and end-stage renal disease (ESRD) due to increased EPO expression. This disease risk-associated gene and its potential pathway mediating severe microvascular complications in T-allele carriers could also play a role on renal dysfunction in patients who underwent cardiac surgery with CPB. We hypothesized that the patients' ability to produce increased EPO concentrations will affect morbidity and mortality after CPB. We conducted a prospective single center study between April 2006 and May 2007. In 481 patients who underwent cardiac surgery with CPB we prospectively examined the SNP rs1617640 in the promoter of the EPO gene by DNA sequencing. The patients were grouped according to their genotype (GG, GT, and TT). The genotype distribution of SNP rs1617640 in the promoter of the EPO gene was 36% (TT), 49% (TG), and 15% (GG). There was no difference in age, body mass index, gender, CPB time, or length of stay in intensive care unit. The hospitalization was irrespective of the patients' genotypes. The baseline creatinine in the TT group was 0.2 points higher than in the other groups; however this was without statistical significance in the multivariate analysis. No significant difference was shown in Euroscore, the Simplified Acute Physiology Score II, the Acute Physiology and Chronic Health Evaluation Score II, Acute Renal Failure Score, or the Risk, Injury, Failure, Loss of Kidney Function Score. The mortality was equal across the genotypes. However, an association between the TT genotype and acute renal replacement therapy (P = 0.03), intraaortic balloon pump usage (P = 0.02), and serum creatine phosphokinase-MB increase (P = 0.03) were observed after cardiac surgery. Our analysis suggests that the risk allele (T) of rs1617640 plays a role in the development of renal dysfunction after cardiac surgery with CPB. Patients with the TT risk allele required more frequent acute renal replacement therapy. Since our result is close to the border of significance, this hypothesis should be investigated in larger prospective studies with long-term follow-up to emphasize this polymorphism as a potential risk factor."],["dc.identifier.doi","10.1111/j.1525-1594.2010.01108.x"],["dc.identifier.isi","000284588300017"],["dc.identifier.pmid","21092038"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/18500"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","6th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","1525-1594"],["dc.relation.issn","0160-564X"],["dc.title","Relation Between Renal Dysfunction Requiring Renal Replacement Therapy and Promoter Polymorphism of the Erythropoietin Gene in Cardiac Surgery"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","262"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Anesthesiology"],["dc.bibliographiccitation.lastpage","265"],["dc.bibliographiccitation.volume","110"],["dc.contributor.author","Timmermann, Arnd"],["dc.contributor.author","Cremer, Stefan"],["dc.contributor.author","Eich, Christoph"],["dc.contributor.author","Kazmaier, Stephan"],["dc.contributor.author","Bräuer, Anselm"],["dc.contributor.author","Graf, Bernhard M."],["dc.contributor.author","Russo, Sebastian G."],["dc.date.accessioned","2021-06-01T10:46:55Z"],["dc.date.available","2021-06-01T10:46:55Z"],["dc.date.issued","2009"],["dc.description.abstract","Background In March 2007, a new disposable laryngeal mask airway (LMA) became available. The LMA Supreme (The Laryngeal Mask Company Limited, St. Helier, Jersey, Channel Islands) aims to combine the LMA Fastrach feature of easy insertion with the gastric access and high oropharyngeal leak pressures of the LMA ProSeal. Methods The authors performed an evaluative study with the LMA Supreme, size 4, on 100 women to measure the ease of insertion, determinate the laryngeal fit by fiberoptic classification, evaluate the oropharyngeal leak pressure, and report adverse events. Results Insertion of the LMA Supreme was possible in 94 patients (94%) during the first attempt, and in 5 patients (5%) during the second attempt. In one small patient, the LMA Supreme could not be inserted because of limited pharyngeal space. This patient was excluded from further analysis. Insertion of a gastric tube was possible in all patients at the first attempt. The median time for LMA Supreme insertion was 10.0 s (+/-4.7 s; range, 8-30 s). Laryngeal fit, evaluated by fiberscopic view, was rated as optimal in all patients, both immediately after insertion of the LMA Supreme and at the end of surgery. After equalization to room pressure, the mean cuff volume needed to achieve 60 cm H2O cuff pressure was 18.4 ml (+/-3.8 ml; range, 8-31 ml). The mean oropharyngeal leak pressure at the level of 60 cm H2O cuff pressure was 28.1 cm H2O (+/-3.8 cm H2O, range, 21-35 cm H2O). Eight patients (8.1%) complained of a mild sore throat. No patient reported dysphagia or dysphonia. Conclusions Clinical evaluation of the LMA Supreme showed easy insertion, optimal laryngeal fit, and low airway morbidity. Oropharyngeal leak pressure results were comparable to earlier data from the LMA ProSeal."],["dc.identifier.doi","10.1097/ALN.0b013e3181942c4d"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85425"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","0003-3022"],["dc.title","Prospective Clinical and Fiberoptic Evaluation of the Supreme Laryngeal Mask Airway  ™"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]