Kazmaier, Stephan

[["dc.bibliographiccitation.artnumber","216"],["dc.bibliographiccitation.journal","BMC Neurology"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","von Eckardstein, Kajetan L."],["dc.contributor.author","Sixel-Doering, Friederike"],["dc.contributor.author","Kazmaier, Stephan"],["dc.contributor.author","Trenkwalder, Claudia"],["dc.contributor.author","Hoover, Jason M."],["dc.contributor.author","Rohde, Veit"],["dc.date.accessioned","2018-11-07T10:05:52Z"],["dc.date.available","2018-11-07T10:05:52Z"],["dc.date.issued","2016"],["dc.description.abstract","Background: In accordance with German neurosurgical and neurological consensus recommendations, lead placements for deep brain stimulation (DBS) in patients with Parkinson's disease (PD) are usually performed with the patient awake and in \"medication off\" state. This allows for optimal lead position adjustment according to the clinical response to intraoperative test stimulation. However, exacerbation of Parkinsonian symptoms after withdrawal of dopaminergic medication may endanger the patient by inducing severe \"off\" state motor phenomena. In particular, this can be a problem in awake craniotomies utilizing intraoperative airway management and resuscitation. Case presentation: We report the case of a PD patient with progressive orofacial and neck muscle dystonia resulting in laryngeal spasm during DBS lead placement. This led to upper airway compromise and asphyxia, requiring resuscitation. Conclusions: Laryngeal spasms may occur as a rare \"off\" state motor complication in patients with PD. Other potential causes of intraoperative difficulties breathing include bilateral vocal cord palsy, positional asphyxia, and silent aspiration. In our practice, we have adjusted our medication regimen and now allow patients to receive their standard dopaminergic medication until the morning of surgery. Neurologists and neurosurgeons performing lead placement procedures for PD should be aware of this rare but unsafe condition to most optimized treatment."],["dc.identifier.doi","10.1186/s12883-016-0736-7"],["dc.identifier.isi","000387017700002"],["dc.identifier.pmid","27821134"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13909"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38985"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Biomed Central Ltd"],["dc.relation.issn","1471-2377"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Asphyxia due to laryngeal spasm as a severe complication of awake deep brain stimulation for Parkinson's disease: a case report"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e1619"],["dc.bibliographiccitation.journal","PeerJ"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Hinz, Jose"],["dc.contributor.author","Mansur, Ashham"],["dc.contributor.author","Hanekop, Gerd-Gunnar"],["dc.contributor.author","Weyland, Andreas"],["dc.contributor.author","Popov, Aron-Frederik"],["dc.contributor.author","Schmitto, Jan Dieter"],["dc.contributor.author","Grune, Frank F. G."],["dc.contributor.author","Bauer, Martin"],["dc.contributor.author","Kazmaier, Stephan"],["dc.date.accessioned","2018-11-07T10:19:11Z"],["dc.date.available","2018-11-07T10:19:11Z"],["dc.date.issued","2016"],["dc.description.abstract","The effects of isoflurane on the determinants of blood flow during Coronary Artery Bypass Graft (CABG) surgery are not completely understood. This study characterized the influence of isoflurane on the diastolic Pressure-Flow (P-F) relationship and Critical Occlusion Pressure (COP) during CABG surgery. Twenty patients undergoing CABG surgery were studied. Patients were assigned to an isoflurane or control group. Hemodynamic and flow measurements during CABG surgery were performed twice (15 minutes after the discontinuation of extracorporeal circulation (T15) and again 15 minutes later (T30)). The zero flow pressure intercept (a measure of COP) was extrapolated from a linear regression analysis of the instantaneous diastolic P-F relationship. In the isoflurane group, the application of isoflurane significantly increased the slope of the diastolic P-F relationship by 215% indicating a mean reduction of Coronary Vascular Resistance (CVR) by 46%. Simultaneously, the Mean Diastolic Aortic Pressure (MDAP) decreased by 19% mainly due to a decrease in the systemic vascular resistance index by 21%. The COP, cardiac index, heart rate, Left Ventricular End-Diastolic Pressure (LVEDP) and Coronary Sinus Pressure (CSP) did not change significantly. In the control group, the parameters remained unchanged. In both groups, COP significantly exceeded the CSP and LVEDP at both time points. We conclude that short-term application of isoflurane at a sedative concentration markedly increases the slope of the instantaneous diastolic P-F relationship during CABG surgery implying a distinct decrease with CVR in patients undergoing CABG surgery."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2016"],["dc.identifier.doi","10.7717/peerj.1619"],["dc.identifier.isi","000369406400004"],["dc.identifier.pmid","26966644"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/12920"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/41614"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Peerj Inc"],["dc.relation.issn","2167-8359"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Influence of isoflurane on the diastolic pressure-flow relationship and critical occlusion pressure during arterial CABG surgery: a randomized controlled trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0171962"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Grune, Frank F. G."],["dc.contributor.author","Kazmaier, Stephan"],["dc.contributor.author","Hoeks, Sanne Elisabeth"],["dc.contributor.author","Stolker, Robert Jan"],["dc.contributor.author","Coburn, Marc"],["dc.contributor.author","Weyland, Andreas"],["dc.date.accessioned","2018-11-07T10:27:23Z"],["dc.date.available","2018-11-07T10:27:23Z"],["dc.date.issued","2017"],["dc.description.abstract","Objective Accumulating data have recently underlined argon As neuroprotective potential. However, to the best of our knowledge, no data are available on the cerebrovascular effects of argon (Ar) in humans. We hypothesized that argon inhalation does not affect mean blood flow velocity of the middle cerebral artery (Vmca), cerebral flow index (FI), zero flow pressure (ZFP), effective cerebral perfusion pressure (CPPe), resistance area product (RAP) and the arterio-jugular venous content differences of oxygen (AJVDO(2)), glucose (AJVDG), and lactate (AJVDL) in anesthetized patients. Materials and methods In a secondary analysis of an earlier controlled cross-over trial we compared parameters of the cerebral circulation under 15 minutes exposure to 70%Ar/30%O-2 versus 70%N-2/30%O-2 in 29 male patients under fentanyl-midazolam anaesthesia before coronary surgery. Vmca was measured by transcranial Doppler sonography. ZFP and RAP were estimated by linear regression analysis of pressure-flow velocity relationships of the middle cerebral artery. CPPe was calculated as the difference between mean arterial pressure and ZFP. AJVDO2, AJVDG and AJVDL were calculated as the differences in contents between arterial and jugular-venous blood of oxygen, glucose, and lactate. Statistical analysis was done by t-tests and ANOVA. Results Mechanical ventilation with 70% Ar did not cause any significant changes in mean arterial pressure, Vmca, FI, ZFP, CPPe, RAP, AJVDO2, AJVDG, and AJVDL. Discussion Short-term inhalation of 70% Ar does not affect global cerebral circulation or metabolism in male humans under general anaesthesia."],["dc.identifier.doi","10.1371/journal.pone.0171962"],["dc.identifier.isi","000394424500064"],["dc.identifier.pmid","28207907"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14323"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43223"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Argon does not affect cerebral circulation or metabolism in male humans"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]