Kutschka, Ingo

[["dc.bibliographiccitation.artnumber","4"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Cardiothoracic Surgery"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Wittlinger, Thomas"],["dc.contributor.author","Maus, Martin"],["dc.contributor.author","Kutschka, Ingo"],["dc.contributor.author","Baraki, Hassina"],["dc.contributor.author","Friedrich, Martin G."],["dc.date.accessioned","2021-04-14T08:29:56Z"],["dc.date.accessioned","2022-08-18T12:40:00Z"],["dc.date.available","2021-04-14T08:29:56Z"],["dc.date.available","2022-08-18T12:40:00Z"],["dc.date.issued","2021-01-06"],["dc.date.updated","2022-07-29T12:17:46Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Acute kidney injury (AKI) is a frequent and serious complication of cardiac surgery, associated with a high incidence of morbidity and mortality. Although the RIFLE criteria serve as a prominent tool to identify patients at high risk of AKI, an optimized diagnosis model in clinical practice is desired.\r\n \r\n \r\n Methods\r\n Based on the SOP-criteria, 365 patients (10%) developed AKI following surgery and were subjected to RRT. In contrast, the incidence of AKI, defined according to the RIFLE criteria, was only 7% (n = 251 patients). Prominent risk factors identified by SOP were patients’ sex, valve and combined valve and bypass surgery, deep hypothermia, use of intra-aortic balloon pump (IABP) and previous coronary interventions. Ischemia, reperfusion, blood loss and surgery time also served as significant risk factors for patient evaluated by SOP.\r\n \r\n \r\n Results\r\n Risk assessment by RIFLE differed in as much as most patients with normothermia and those receiving only cardiovascular bypass developed AKI. However, patients’ sex and valve surgery did not serve as a risk factor.\r\n \r\n \r\n Conclusion\r\n Evaluation of patients by the RIFLE versus SOP criteria yielded different results with more AKI patients detected by SOP. Based on the present data, it is concluded that patients may not prone to AKI when surgery and ischemia time will be kept short, when blood loss is mitigated to a minimum and when surgery is performed under non-hypothermic conditions."],["dc.identifier.citation","Journal of Cardiothoracic Surgery. 2021 Jan 06;16(1):4"],["dc.identifier.doi","10.1186/s13019-020-01382-x"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17720"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83039"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112976"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1749-8090"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject","Acute kidney injury"],["dc.subject","Extracorporeal circulation"],["dc.subject","RIFLE classification"],["dc.subject","Continuous veno-venous hemodialysis"],["dc.subject","Cardiac surgery"],["dc.title","Risk assessment of acute kidney injury following cardiopulmonary bypass"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","299"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Cardiovascular Disorders"],["dc.bibliographiccitation.volume","22"],["dc.contributor.author","Sadlonova, Monika"],["dc.contributor.author","Vogelgsang, Jonathan"],["dc.contributor.author","Lange, Claudia"],["dc.contributor.author","Günther, Irina"],["dc.contributor.author","Wiesent, Adriana"],["dc.contributor.author","Eberhard, Charlotte"],["dc.contributor.author","Ehrentraut, Julia"],["dc.contributor.author","Kirsch, Mareike"],["dc.contributor.author","Hansen, Niels"],["dc.contributor.author","Esselmann, Hermann"],["dc.contributor.author","Timäus, Charles"],["dc.contributor.author","Asendorf, Thomas"],["dc.contributor.author","Breitling, Benedict"],["dc.contributor.author","Chebbok, Mohammed"],["dc.contributor.author","Heinemann, Stephanie"],["dc.contributor.author","Celano, Christopher"],["dc.contributor.author","Kutschka, Ingo"],["dc.contributor.author","Wiltfang, Jens"],["dc.contributor.author","Baraki, Hassina"],["dc.contributor.author","von Arnim, Christine A. F."],["dc.date.accessioned","2022-08-04T12:01:17Z"],["dc.date.available","2022-08-04T12:01:17Z"],["dc.date.issued","2022-06-30"],["dc.date.updated","2022-07-25T11:18:49Z"],["dc.description.abstract","Background Postoperative delirium is a common complication of cardiac surgery associated with higher morbidity, longer hospital stay, risk of cognitive decline, dementia, and mortality. Geriatric patients, patients undergoing cardiac surgery, and intensive care patients are at a high risk of developing postoperative delirium. Gold standard assessments or biomarkers to predict risk factors for delirium, cognitive decline, and dementia in patients undergoing cardiac surgery are not yet available. Methods The FINDERI trial (FINd DElirium RIsk factors) is a prospective, single-center, observational study. In total, 500 patients aged ≥ 50 years undergoing cardiac surgery at the Department of Cardiovascular and Thoracic Surgery of the University of Göttingen Medical Center will be recruited. Our primary aim is to validate a delirium risk assessment in context of cardiac surgery. Our secondary aims are to identify specific preoperative and perioperative factors associated with delirium, cognitive decline, and accelerated dementia after cardiac surgery, and to identify blood-based biomarkers that predict the incidence of postoperative delirium, cognitive decline, or dementia in patients undergoing cardiac surgery. Discussion This prospective, observational study might help to identify patients at high risk for delirium prior to cardiac surgery, and to identify important biological mechanisms by which cardiac surgery is associated with delirium. The predictive value of a delirium screening questionnaire in cardiac surgery might be revealed. Finally, the identification of specific blood biomarkers might help to predict delirium, cognitive decline, and dementia in patients undergoing cardiac surgery. Trial registration: Ethics approval for this study was obtained from the IRB of the University of Göttingen Medical Center. The investigators registered this study in the German Clinical Trials Register (DRKS; https://www.drks.de ) (DRKS00025095) on April 19th, 2021."],["dc.description.sponsorship","Open-Access-Publikationsfonds 2022"],["dc.identifier.citation","BMC Cardiovascular Disorders. 2022 Jun 30;22(1):299"],["dc.identifier.doi","10.1186/s12872-022-02732-4"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112643"],["dc.language.iso","en"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Delirium"],["dc.subject","Cognitive decline"],["dc.subject","Dementia"],["dc.subject","Delirium risk assessment"],["dc.subject","Cardiac surgery"],["dc.subject","Biomarkers"],["dc.title","Identification of risk factors for delirium, cognitive decline, and dementia after cardiac surgery (FINDERI—find delirium risk factors): a study protocol of a prospective observational study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]