Heussinger, Claus

[["dc.bibliographiccitation.artnumber","50"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","The European Physical Journal E"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Maier, M."],["dc.contributor.author","Mueller, K. W."],["dc.contributor.author","Heussinger, Claus"],["dc.contributor.author","Koehler, S."],["dc.contributor.author","Wall, W. A."],["dc.contributor.author","Bausch, A. R."],["dc.contributor.author","Lieleg, O."],["dc.date.accessioned","2018-11-07T09:57:02Z"],["dc.date.available","2018-11-07T09:57:02Z"],["dc.date.issued","2015"],["dc.description.abstract","Actin binding proteins ( ABPs) not only set the structure of actin filament assemblies but also mediate the frequency-dependent viscoelastic moduli of cross-linked and bundled actin networks. Point mutations in the actin binding domain of those ABPs can tune the association and dissociation dynamics of the actin/ABP bond and thus modulate the network mechanics both in the linear and non-linear response regime. We here demonstrate how the exchange of a single charged amino acid in the actin binding domain of the ABP fascin triggers such a modulation of the network rheology. Whereas the overall structure of the bundle networks is conserved, the transition point from strain-hardening to strain-weakening sensitively depends on the cross-linker off-rate and the applied shear rate. Our experimental results are consistent both with numerical simulations of a cross-linked bundle network and a theoretical description of the bundle network mechanics which is based on non-affine bending deformations and force-dependent cross-link dynamics."],["dc.identifier.doi","10.1140/epje/i2015-15050-3"],["dc.identifier.isi","000354960400001"],["dc.identifier.pmid","26004635"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11965"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37082"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1292-895X"],["dc.relation.issn","1292-8941"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","CC BY 4.0"],["dc.title","A single charge in the actin binding domain of fascin can independently tune the linear and non-linear response of an actin bundle network"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]