Meller, Johannes

[["dc.bibliographiccitation.firstpage","269"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Seminars in Dialysis"],["dc.bibliographiccitation.lastpage","276"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Meller, J."],["dc.contributor.author","Sahlmann, Carsten-Oliver"],["dc.contributor.author","Becker, W."],["dc.date.accessioned","2018-11-07T10:24:06Z"],["dc.date.available","2018-11-07T10:24:06Z"],["dc.date.issued","2002"],["dc.description.abstract","Nuclear medicine (scintigraphy) studies that are performed in patients being prepared for regular dialysis treatment include the measurement of renal clearance and dynamic studies of renal perfusion and function. Static scintigraphy with 99mTc-DMSA may be used in the evaluation of children at risk of renal damage and further functional deterioration. In patients on peritoneal dialysis, nuclear medicine procedures enable the diagnosis of structural complications such as intra-abdominal herniations and leaks. Diagnosis of infections of the vascular access sites in patients on hemodialysis and of the catheter tunnel in patients on peritoneal dialysis can be made with high diagnostic accuracy using radiolabeled, autologous leukocytes. Scintigraphy is valuable in delineating the extent of deposits of amyloid and parenchymal microcalcifications, and may be helpful in the functional evaluation of organs and tissues involved in the pathophysiology of renal impairment and dialysis. If radioiodine therapy with I-131 is performed in patients on hemodialysis with benign or malignant thyroid disease, then pretherapeutic dosimetry is necessary to avoid over- and undertreatment. Radioiodine therapy in the dialysis patient leads to only insignificant contamination of dialysis equipment and marginal exposure to the medical staff."],["dc.identifier.doi","10.1046/j.1525-139x.2002.00069.x"],["dc.identifier.isi","000177597800008"],["dc.identifier.pmid","12191027"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42595"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing Inc"],["dc.relation.issn","0894-0959"],["dc.title","Nuclear medicine studies in the dialysis patient"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Journal of Nuclear Medicine"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Meller, J."],["dc.contributor.author","Altenvoerde, G."],["dc.contributor.author","Lehmann, K."],["dc.contributor.author","Sahlmann, Carsten-Oliver"],["dc.contributor.author","Behe, E."],["dc.contributor.author","Becker, W."],["dc.date.accessioned","2018-11-07T09:07:39Z"],["dc.date.available","2018-11-07T09:07:39Z"],["dc.date.issued","2001"],["dc.format.extent","332P"],["dc.identifier.isi","000168821901274"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25849"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Soc Nuclear Medicine Inc"],["dc.publisher.place","Reston"],["dc.relation.issn","0161-5505"],["dc.title","Fever of unknown origin - Prospective comparison of FDG-imaging with a double head coincidence camera (DHCC) and Ga-67-citrate SPECT."],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1073"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","Thyroid"],["dc.bibliographiccitation.lastpage","1079"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","Meller, J."],["dc.contributor.author","Jauho, A."],["dc.contributor.author","Hufner, M."],["dc.contributor.author","Gratz, S."],["dc.contributor.author","Becker, W."],["dc.date.accessioned","2018-11-07T08:29:42Z"],["dc.date.available","2018-11-07T08:29:42Z"],["dc.date.issued","2000"],["dc.description.abstract","The clinical diagnosis of disseminated autonomy (DISA) can only be established by exclusion of Graves' disease (GD). Both hyperthyroid conditions share the same scintigraphic appearance and can only be distinguished from each other clinically either by the presence or absence of endocrine ophthalmopathy (EO) or thyrotropin (TSH) binding inhibiting immunoglobulins (TBIIs). The purpose of this study was the reevaluation of thyroid autonomies originally classified as DISAs by a second-generation radioreceptor antibody assay (RAA) (DYNOtest(R) TRAKhuman) (B.R.A.H.M.S. Diagnostika, Berlin, Germany). The analysis included 32 patients (female: n = 25, male: n = 7; mean age: 46 +/- 18 years) who were initially diagnosed with DISA. All patients were TSH receptor (TSHR) antibody (TRAb) negative by a conventional radioimmunoassay (RIA) (TSH-REZAK(R) RIA) (Medipan Diagnostica, Selchow, Germany) during their first evaluation. The presence of EO was excluded by clinical signs in all patients. Surgery had been performed prior to our evaluation in 5 patients and after our survey in 1 patient. Four patients had been treated previously with I-131. Ten patients were treated with thionamides during our evaluation, and 13 had not been treated before. One hundred three patients who had either healthy thyroids, nontoxic goiters, or focal autonomies served as controls and were evaluated both by the TSH-REZAK(R) assay and the DYNOtest(R) TRAKhuman assay. Seven of thirty-two (22%) patients originally classified as DISA were TRAb positive in the second-generation assay. In this group, 5 of 7 patients had a total thyroid volume (TTV) <30 mt (positive predictive value [PPW] for TRAb positivity 71%), and 5 of 7 patients had a diffuse goiter (PPW for TRAb-positivity 71%). Six of seven patients were anti-thyroperoxidase (TPO) positive (PPW for TRAb positivity 85%). A hypoechoid pattern on ultrasound was present by visual analysis in 3 of 7 patients (PPW for TRAb positivity 43%). A 100% PPW for TRAb positivity could be obtained if a goiter <30 mi was combined with anti-TPO positivity, but this combination was present in only 4 of 7 (57%) patients. With the second-generation assay, one false positive test result was observed in the control group. Surgery was performed in 6 patients who were TRAb negative in both assays. In all these cases, the histologic findings were compatible with autonomous transformation of the thyroid. Our study demonstrates that a significant number (22%) of patients formerly classified as DISA may actually have GD. However, DISA still exists as a clinical entity, and its pathophysiological link to multifocal and unifocal autonomy should be further investigated."],["dc.identifier.doi","10.1089/thy.2000.10.1073"],["dc.identifier.isi","000166417700008"],["dc.identifier.pmid","11201852"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/16714"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mary Ann Liebert Inc Publ"],["dc.relation.issn","1050-7256"],["dc.title","Disseminated thyroid autonomy or Graves' disease: Reevaluation by a second generation TSH receptor antibody assay"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","PII S0959-8049(02)00534-8"],["dc.bibliographiccitation.firstpage","175"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Cancer"],["dc.bibliographiccitation.lastpage","183"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Altenvoerde, G."],["dc.contributor.author","Meller, J."],["dc.contributor.author","Zutt, Markus"],["dc.contributor.author","Funke, M."],["dc.contributor.author","Neumann, C."],["dc.contributor.author","Becker, W."],["dc.date.accessioned","2021-06-01T10:50:19Z"],["dc.date.available","2021-06-01T10:50:19Z"],["dc.date.issued","2003"],["dc.description.abstract","To date, there are no reliable criteria to identify those patients with melanoma-infiltrated sentinel lymph nodes (SLNs) of the groin who might benefit from an extended lymphadenectomy, including the pelvic lymph nodes. We hypothesised that there are pelvic lymph nodes that receive lymph directly from the primary tumour, thus being at an increased risk for metastasis. In order to determine the frequency of radioactively labelled pelvic lymph nodes and the kinetics of their appearance, we introduce here a combination of dynamic lymphoscintigraphy, single photon emission computed tomography (SPECT) and image fusion of SPECT and pelvic Computed Tomography (CT)-scans. By dynamic lymphoscintigraphy and intraoperative gamma probe detection, superficially located inguinal SLNs (median 2 nodes) could be identified in all of the 51 patients included in this analysis. The histological search for micrometastases was positive in 16 patients (median Breslow thickness of the primary melanoma 2.5 mm). In 29 patients, SPECT and the image fusion technique were additionally performed. Radioactively labelled pelvic lymph nodes were detected in 20 individuals, 6 of them presenting aberrant pelvic SLNs that, on dynamic lymphoscintigraphy, had appeared simultaneously with the superficial SLN(s). Of the 6 patients in whom radioactive pelvic lymph nodes were excised together with the superficial SLN(s), only one had positive superficial SLNs. In this patient, the aberrant pelvic SLN proved to be tumour-positive. In 9 patients, there was no radiotracer uptake in the pelvic lymph nodes at all. Image fusion of SPECT and pelvic CT-scans is an excellent tool to localise exactly the pelvic tumour-draining nodes. The significance of radioactively labelled pelvic lymph nodes for the probability of pelvic metastases should be analysed further. (C) 2002 Elsevier Science Ltd. All rights reserved."],["dc.identifier.doi","10.1016/S0959-8049(02)00534-8"],["dc.identifier.isi","000181789200017"],["dc.identifier.pmid","12509949"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86614"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Pergamon-elsevier Science Ltd"],["dc.relation.issn","0959-8049"],["dc.title","Dynamic lymphoscintigraphy and image fusion of SPECT and pelvic CT-scans allow mapping of aberrant pelvic sentinel lymph nodes in malignant melanoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","53"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","European Journal of Nuclear Medicine and Molecular Imaging"],["dc.bibliographiccitation.lastpage","60"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Meller, J."],["dc.contributor.author","Köster, G."],["dc.contributor.author","Liersch, T."],["dc.contributor.author","Siefker, U."],["dc.contributor.author","Lehmann, K."],["dc.contributor.author","Meyer, I."],["dc.contributor.author","Schreiber, K."],["dc.contributor.author","Altenvoerde, G."],["dc.contributor.author","Becker, W."],["dc.date.accessioned","2021-06-01T10:49:07Z"],["dc.date.available","2021-06-01T10:49:07Z"],["dc.date.issued","2002"],["dc.description.abstract","Indium-111-labelled white blood cells (In-111-WBCs) are currently considered the tracer of choice in the diagnostic work-up of suspected active chronic osteomyelitis (COM). Previous studies in a limited number of patients, performed with dedicated PET systems, have shown that [F-18]2'-deoxy-2-fluoro-D-glucose (FDG) imaging may offer at least similar diagnostic accuracy. The aim of this prospective study was to compare FDG imaging with a dual-head coincidence camera (DHCC) and In-111-WBC imaging in patients with suspected COM. Thirty consecutive non-diabetic patients with possible COM underwent combined skeletal scintigraphy (30/30 patients), In-111-WBC imaging (28/30 patients) and FDG-PET with a DHCC (30/30 patients). During diagnostic work-up, COM was proven in 11/36 regions of suspected skeletal infection and subsequently excluded in 25/36 regions. In addition, soft tissue infection was present in five patients and septic arthritis in three. In-111-WBC imaging in 28 patients was true positive in 2/11 regions with proven COM and true negative in 21/23 regions without further evidence of COM. False-positive results occurred in two regions and false-negative results in nine regions suspected for COM. Most of the false-negative results (7/9) occurred in the central skeleton. If the analysis was restricted to the 18 regions with available histology (n = 17) or culture (n = 1), In-111-WBC imaging was true positive in 2/18 regions, true negative in 8/18 regions, false negative in 7/18 regions and false positive in 1/18 regions. FDG-DHCC imaging was true positive in 11/11 regions with proven COM and true negative in 23/25 regions without further evidence of COM. False-positive results occurred in two regions. If the analysis was restricted to the 19 regions with avail-able histology (n = 18) or culture (n = 1), FDG-DHCC imaging was true positive in 9/9 regions with proven COM and true negative in 10/10 regions without further evidence of COM. It is concluded that FDG-DHCC imaging is superior to In-111-WBC scintigraphy in the diagnosis of COM in the central skeleton and therefore should be considered the method of choice for this indication. This seems to hold true for peripheral lesions as well, but in our series the number of cases with proven infection was too small to permit a final conclusion."],["dc.identifier.doi","10.1007/s00259-001-0661-9"],["dc.identifier.isi","000173535600007"],["dc.identifier.pmid","11807607"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86176"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.eissn","1619-7089"],["dc.relation.issn","1619-7070"],["dc.relation.issn","0340-6997"],["dc.title","Chronic bacterial osteomyelitis: prospective comparison of 18F-FDG imaging with a dual-head coincidence camera and 111In-labelled autologous leucocyte scintigraphy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","22"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Nuklearmedizin"],["dc.bibliographiccitation.lastpage","29"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Meller, J."],["dc.contributor.author","Sahlmann, Carsten-Oliver"],["dc.contributor.author","Lehmann, K."],["dc.contributor.author","Siefker, U."],["dc.contributor.author","Meyer, I."],["dc.contributor.author","Schreiber, K."],["dc.contributor.author","Altenvoerde, G."],["dc.contributor.author","Becker, W."],["dc.date.accessioned","2018-11-07T10:32:22Z"],["dc.date.available","2018-11-07T10:32:22Z"],["dc.date.issued","2002"],["dc.description.abstract","Aim: Evaluation of F-18-FDG-hybrid-camera-PET imaging in patients with undetermined postoperative fever (POF). Methods: Prospective study of 18 patients (9 women, 9 men; age 23-85 years) suffering from POF with 2-fluoro-2'-deoxyglucose (F-18-FDG) using a dual headed coincidence camera (DHCC). Surgery had been performed 5-94 days prior to our investigation. 13 of the 18 patients received antibiotic therapy during the time of evaluation. Ton (55%) had an infectious and eight (45%) a non infectious cause of fever. Results: Increased F-18-FDG-uptake outside the surgical wound occurred in 13 regions (infection n = 11, malignancy n = 2). The sensitivity of F-18-FDG-hybrid-camera-PET in imaging infection in areas outside the surgical wound was 86% and the specificity 100%, respectively. Antibiotic therapy did not negatively influence the results of F-18-FDG-scanning. Increased F-18-FDG-uptake within the surgical wound was seen in 8 of 18 patients. The sensitivity of F-18-FDG-hybrid-camera-PET in imaging infection within the surgical wound was 100% and the specificity 56%, respectively. The interval between surgery and F-18-FDG-scanning was significantly shorter in patients with false positive results compared with patients showing true negative results (median 34 vs. 54 days; p = 0,038). Conclusion: In POF-Patients, F-18-FDG transaxial tomography performed with a F-18-FDG-hybrid-camera-PET is sensitive in the diagnosis of inflammation and malignant disease within and outside the surgical wound. Because of the accumulation of the tracer both in granulation tissue and infection, the specificity in detecting the focus of fever within the surgical wound is poor."],["dc.identifier.isi","000174205500004"],["dc.identifier.pmid","11917344"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/44329"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Schattauer Gmbh-verlag Medizin Naturwissenschaften"],["dc.relation.issn","0029-5566"],["dc.title","F-18-FDG-hybrid-camera-PET in patients with postoperative fever"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","516"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","European Journal of Nuclear Medicine and Molecular Imaging"],["dc.bibliographiccitation.lastpage","524"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Gratz, S."],["dc.contributor.author","Dorner, J."],["dc.contributor.author","Fischer, U."],["dc.contributor.author","Behr, T. M."],["dc.contributor.author","Behe, M."],["dc.contributor.author","Altenvoerde, G."],["dc.contributor.author","Meller, J."],["dc.contributor.author","Grabbe, Eckhard"],["dc.contributor.author","Becker, W."],["dc.date.accessioned","2018-11-07T10:30:49Z"],["dc.date.available","2018-11-07T10:30:49Z"],["dc.date.issued","2002"],["dc.description.abstract","This study investigated the value of fluorine-18 2'-deoxy-2-fluoro-D-glucose (FDG) imaging with a double-headed gamma camera operated in coincidence (hybrid PET) detection mode in patients with suspected spondylitis. Comparison was made with conventional nuclear medicine imaging modalities and magnetic resonance imaging (MRI). Sixteen patients with suspected spondylitis (nine male, seven female, mean age 59 years) prospectively underwent FDG hybrid PET (296 MBq) and MRI. For intra-individual comparison, the patients were also imaged with technetium-99m methylene diphosphonate (MDP) (555 MBq) (n=13) and/or gallium-67 citrate (185 MBq) (n=11). For FDG hybrid PET, two or three transverse scans were performed. Ratios of infected (target) to non-infected (background) (TB) vertebral bodies were calculated. MR images were obtained of the region of interest. Patients found positive for spondylitis with MRI and/or FDG hybrid PET underwent surgical intervention and histological grading of the individual infected foci. Twelve out of 16 patients were found to be positive for spondylitis. Independent of the grade of infection and the location in the spine, all known infected vertebrae (n=23. 9 thoracic. 12 lumbar. 2 sacral) were detected by FDG hybrid PET. T/B ratios higher than 1.45 +/- 0.05 (at 1 h p.i.) were indicative of infectious disease. whereas ratios below this value were found in cases of degenerative change. FDG hybrid PET was superior to MRI in patients who had a history of surgery and suffered from a high-grade infection in combination with paravertebral abscess formation (n=2: further computed tomography was needed) and in those with low-grade spondylitis (n=2, no oedema) or discitis (n=2, mild oedema). False-positive Ga-67 citrate images (n=5: 2 spondylodiscitis, 1 aortitis, 1 pleuritis, 1 pulmonary tuberculosis) and Tc-99m-MDP SPET (n=4: 1 osteoporosis, 2 spondylodiscitis, 1 fracture) were equally well detected by FDG hybrid PET and MRI. No diagnostic problems were seen in the other patients (n=5). In this study, FDG hybrid PET was superior to MRI, Ga-67 citrate and Tc-99m-MDP, especially in patients with low-grade spondylitis (as compared with MRI), adjacent soft tissue infections (as compared with Ga-67 citrate) and advanced bone degeneration (as compared with Tc-99m-MDP)."],["dc.identifier.doi","10.1007/s00259-001-0719-8"],["dc.identifier.isi","000175562200011"],["dc.identifier.pmid","11914890"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43953"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","1619-7070"],["dc.title","F-18-FDG hybrid PET in patients with suspected spondylitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","EUROPEAN JOURNAL OF NUCLEAR MEDICINE"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Sahlmann, Carsten-Oliver"],["dc.contributor.author","Meller, J."],["dc.contributor.author","Lehmann, K."],["dc.contributor.author","Schreiber, K."],["dc.contributor.author","Meyer, I."],["dc.contributor.author","Altenvoerde, G."],["dc.contributor.author","Becker, W."],["dc.date.accessioned","2018-11-07T08:47:36Z"],["dc.date.available","2018-11-07T08:47:36Z"],["dc.date.issued","2001"],["dc.format.extent","1091"],["dc.identifier.isi","000170528300502"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20994"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","0340-6997"],["dc.title","Therapeutic efficacy of iodine-131-therapy in thyroid cancer patients with positive thyroglobulin but negative iodine-131 whole body scans"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1286"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","EUROPEAN JOURNAL OF NUCLEAR MEDICINE"],["dc.bibliographiccitation.lastpage","1291"],["dc.bibliographiccitation.volume","27"],["dc.contributor.author","Meller, J."],["dc.contributor.author","Wisheu, S."],["dc.contributor.author","Munzel, U."],["dc.contributor.author","Behe, M."],["dc.contributor.author","Gratz, S."],["dc.contributor.author","Becker, W."],["dc.date.accessioned","2018-11-07T10:30:16Z"],["dc.date.available","2018-11-07T10:30:16Z"],["dc.date.issued","2000"],["dc.description.abstract","The aim of this retrospective study was the evaluation of a TcTUs (global technetium-99m pertechnetate thyroid uptake under suppression)-based approach in 370 patients with thyroid autonomy (Plummer's disease) treated by radioiodine therapy (RIT) under standardised conditions. The analysis included 370 patients (309 females, 61 males; mean age 64 +/- 11.6 years) treated for thyroid autonomy [unifocal (UFA), 36.8%; multifocal (MFA), 55.7%; disseminated (DISA), 7.6%]. During RIT all patients were under thyroid suppression (TSH < 0.1 mu U/ml) and without thionamide treatment. Of the 370 patients, 73% (n = 271) were manifestly hyperthyroid and 27% (n = 99) subclinically hyperthyroid. A dosimetric study included uptake measurements 24, 48, and 96 h p.i. For dose estimation the Marinelli algorithm was used. For retrospective definition of the target volume we used the equation: Autonomous volume = TcTUs x 5. The spectrum of doses given in our patients ranged from 81 to 1933 Gy. After 18 months of follow-up, RIT was successful (TSH > 0.5 mu U/l and/or TcTUs < 1.6%) in 310 patients (84%). Of these patients, 291 (94%) were euthyroid (with or without L-thyroxine) and 19 (6%) subclinically hypothyroid (TSH > 4 mu U/ml). A dose of 350-450 Gy to the autonomous tissue resulted in a success rate of 97% in the UFA group and 81% in the MFA/DISA group. Decrease in total thyroid volume and TcTUs did not differ significantly between successfully treated patients and patients with persistent autonomy. Multivariate analysis of all 370 patients identified four independent factors that negatively influenced the therapeutic success: high pretherapeutic thyroid volume (P = 0.0001: odds ratio: 1.017), high pretherapeutic TcTUs values (P = 0.0001; odds ratio: 1.378), multifocal/disseminated autonomy (P = 0.0056; odds ratio: 3.245) and low target dose (P = 0.017; odds ratio: 0.997). It is concluded that the high success rate in the treatment of UFA indicates the concept of TcTUs-based RIT to be valid, but that in the therapy of MFA/DISA the target dose has to be corrected if the total thyroid volume exceeds a critical threshold."],["dc.identifier.doi","10.1007/s002590000285"],["dc.identifier.isi","000089201700003"],["dc.identifier.pmid","11007508"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43827"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-6997"],["dc.title","Radioiodine therapy for Plummer's disease based on the thyroid uptake of technetium-99m pertechnetate"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","EUROPEAN JOURNAL OF NUCLEAR MEDICINE"],["dc.bibliographiccitation.volume","28"],["dc.contributor.author","Meller, J."],["dc.contributor.author","Altenvoerde, G."],["dc.contributor.author","Lehmann, K."],["dc.contributor.author","Sahlmann, Carsten-Oliver"],["dc.contributor.author","Meyer, I."],["dc.contributor.author","Behe, M."],["dc.contributor.author","Luig, H."],["dc.contributor.author","Becker, W."],["dc.date.accessioned","2018-11-07T08:47:30Z"],["dc.date.available","2018-11-07T08:47:30Z"],["dc.date.issued","2001"],["dc.format.extent","1060"],["dc.identifier.isi","000170528300387"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/20970"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.publisher.place","New york"],["dc.relation.issn","0340-6997"],["dc.title","Fever of unknown origin - Prospective comparison of 18 FDG-imaging with a double head coincidence camera (DHCC) and Ga-67 citrate SPECT"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]