Ellenrieder, V.

[["dc.bibliographiccitation.firstpage","877"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Alimentary Pharmacology & Therapeutics"],["dc.bibliographiccitation.lastpage","887"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Meister, T."],["dc.contributor.author","Uphoff, M.-A."],["dc.contributor.author","Heinecke, Achim"],["dc.contributor.author","Domagk, Dirk"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Lindhorst, Alexander"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Heinzow, Hauke S."],["dc.date.accessioned","2018-11-07T09:58:02Z"],["dc.date.available","2018-11-07T09:58:02Z"],["dc.date.issued","2015"],["dc.description.abstract","BackgroundEarly differentiation of malignant from benign bile duct obstruction is of utmost importance. AimTo identify biochemical and clinical predictors for malignancy in patients with bile duct obstruction, and establish a predictive model by combining pre-treatment patient characteristics. A web-based application was developed for easy assessment of malignant bile duct probability (). MethodsOne thousand hundred and thirty-five patients [median age 66 (52-75) years, 53% male] with bile duct obstruction of various aetiologies were retrospectively evaluated at our tertiary referral centre. Multivariate logistic regression analysis identified factors as independently significant for malignant bile duct obstruction. A predictive risk score was established using ROC analysis and applied to an external validation cohort of 101 patients. ResultsThree hundred and ninety-four patients had malignant bile duct obstruction proven by surgery, while in 741 patients benign obstruction was observed. Multivariate analysis identified various clinical factors to be predictive for malignancy. On the basis of eight predictors, a risk score for malignancy was developed [X=0.025 [age]+1.239 [1 if weight loss, otherwise 0]-0.235 [1 if pain, otherwise 0]+0.649 [1 if diabetes, otherwise 0]+0.896 [1 if jaundice, otherwise 0]+0.109 [bilirubin]+0.0007 [-GT]+0.0003 [AP]-4.374]: A significant correlation between the predicted malignancy and the actual malignancy was found by ROC (AUC: 0.862; 95% CI 0.838-0.886, P<0.0001). ConclusionsThis predictive risk score estimates the risk of malignancy in patients with bile duct obstruction, and it seems to be very accurate. A better prediction enables both earlier diagnosis of malignant obstructive disease and improved management of patients with bile duct obstruction, which may result in reduced morbidity and mortality."],["dc.identifier.doi","10.1111/apt.13152"],["dc.identifier.isi","000352557300008"],["dc.identifier.pmid","25753000"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37290"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-2036"],["dc.relation.issn","0269-2813"],["dc.title","Novel score for prediction of malignant bile duct obstruction based on biochemical and clinical markers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","United European Gastroenterology Journal"],["dc.contributor.author","Floer, Martin"],["dc.contributor.author","Tschaikowski, Laura"],["dc.contributor.author","Schepke, Michael"],["dc.contributor.author","Kempinski, Radoslaw"],["dc.contributor.author","Neubauer, Katarzyna"],["dc.contributor.author","Poniewierka, Elzbieta"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Ameis, Detlev"],["dc.contributor.author","Heinzow, Hauke Sebastian"],["dc.contributor.author","Auer, Agneta"],["dc.contributor.author","Schmidt, Hartmut H."],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Meister, Tobias"],["dc.date.accessioned","2021-04-14T08:28:10Z"],["dc.date.available","2021-04-14T08:28:10Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1177/2050640620982952"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82523"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2050-6414"],["dc.relation.issn","2050-6406"],["dc.title","Standard versus Endocuff versus cap‐assisted colonoscopy for adenoma detection: A randomised controlled clinical trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1559"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","European Journal of Gastroenterology & Hepatology"],["dc.bibliographiccitation.lastpage","1565"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Petzold, Golo"],["dc.contributor.author","Bremer, Sebastian C.B."],["dc.contributor.author","Knoop, Richard F."],["dc.contributor.author","Amanzada, Ahmad"],["dc.contributor.author","Raddatz, Dirk"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Neesse, Albrecht"],["dc.date.accessioned","2021-04-14T08:24:50Z"],["dc.date.available","2021-04-14T08:24:50Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1097/MEG.0000000000001675"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81439"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0954-691X"],["dc.title","Noninvasive assessment of liver fibrosis in a real-world cohort of patients with known or suspected chronic liver disease using 2D-shear wave elastography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","342"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Scandinavian Journal of Gastroenterology"],["dc.bibliographiccitation.lastpage","349"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Petzold, Golo"],["dc.contributor.author","Tsaknakis, Birgit"],["dc.contributor.author","Bremer, Sebastian C. B."],["dc.contributor.author","Knoop, Richard F."],["dc.contributor.author","G. Goetze, Robert"],["dc.contributor.author","Amanzada, Ahmad"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Neesse, Albrecht"],["dc.contributor.author","Kunsch, Steffen"],["dc.date.accessioned","2020-12-10T18:14:44Z"],["dc.date.available","2020-12-10T18:14:44Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1080/00365521.2019.1585571"],["dc.identifier.eissn","1502-7708"],["dc.identifier.issn","0036-5521"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74599"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Evaluation of liver stiffness by 2D-SWE in combination with non-invasive parameters as predictors for esophageal varices in patients with advanced chronic liver disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0233811"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Mavropoulou, Eirini"],["dc.contributor.author","Mechie, Nicolae-Catalin"],["dc.contributor.author","Knoop, Richard"],["dc.contributor.author","Petzold, Golo"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Amanzada, Ahmad"],["dc.contributor.editor","Bonaz, Bruno"],["dc.date.accessioned","2021-04-14T08:25:13Z"],["dc.date.available","2021-04-14T08:25:13Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1371/journal.pone.0233811"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17632"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81557"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Association of serum interleukin-6 and soluble interleukin-2-receptor levels with disease activity status in patients with inflammatory bowel disease: A prospective observational study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","469"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Digestion"],["dc.bibliographiccitation.lastpage","479"],["dc.bibliographiccitation.volume","102"],["dc.contributor.author","Jung, Carlo Felix Maria"],["dc.contributor.author","Müller-Dornieden, Annegret"],["dc.contributor.author","Gaedcke, Jochen"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Gromski, Mark A."],["dc.contributor.author","Biggemann, Lorenz"],["dc.contributor.author","Seif Amir Hosseini, Ali"],["dc.contributor.author","Ghadimi, Michael"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Wedi, Edris"],["dc.date.accessioned","2021-06-01T09:42:09Z"],["dc.date.available","2021-06-01T09:42:09Z"],["dc.date.issued","2020"],["dc.description.abstract","Introduction: Management of esophageal anastomotic leaks (AL) and esophageal perforations (EP) remains difficult and often requires an interdisciplinary treatment modality. For primary endoscopic management, self-expanding metallic stent (SEMS) placement is often considered first-line therapy. Recently, endoscopic vacuum therapy (EVT) has emerged as an alternative or adjunct for management of these conditions. So far, data for EVT in the upper gastrointestinal-tract is restricted to single centre, non-randomized trials. No studies on optimal negative pressure application during EVT exist. The aim of our study is to describe our centre’s experience with low negative pressure (LNP) EVT for these indications over the past 5-years. Patients and Methods: Between January 2014 and December 2018, 30 patients were endoscopically treated for AL (n = 23) or EP (n = 7). All patients were primarily treated with EVT and LNP between –20 and –50 mm Hg. Additional endoscopic treatment was added when EVT failed. Procedural and peri-procedural data, as well as clinical outcomes including morbidity and mortality, were analysed. Results: Clinical successful endoscopic treatment of EP and AL was achieved in 83.3% (n = 25/30), with 73.3% success using EVT alone (n = 22/30). Mean treatment duration until leak closure was 16.1 days (range 2–58 days). Additional treatment modalities for complete leak resolution was necessary in 10% (n = 3/30), including SEMS placement and fibrin glue injection. Mean hospital stay for patients with EP was shorter with 33.7 days compared to AL with 54.4 days (p = 0.08). Estimated preoperative 10-year overall survival (Charlson comorbidity score) was 39.4% in patients with AL and 59.9% in patients with EP (p = 0.26). A mean of 5.1 EVT changes (range 1–12) was needed in EP and 3.6 changes (range 1–13) in AL to achieve complete closure, switch to other treatment modality, or reach endoscopic failure (p = 0.38). Conclusion: LNP EVT enables effective minimally – invasive endoluminal leak closure from anastomotic esophageal leaks and EP in high-morbid patients. In this study, EVT was combined with other endoscopic treatment options such as SEMS placement or fibrin glue injection in order to achieve leak or perforation closure in the vast majority of patients (83.3%). Low aspiration pressures led to slower but still sufficient clinical results."],["dc.identifier.doi","10.1159/000506101"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85161"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1421-9867"],["dc.relation.issn","0012-2823"],["dc.title","Impact of Endoscopic Vacuum Therapy with Low Negative Pressure for Esophageal Perforations and Postoperative Anastomotic Esophageal Leaks"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","761"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Digestion"],["dc.bibliographiccitation.lastpage","770"],["dc.bibliographiccitation.volume","101"],["dc.contributor.author","Mechie, Nicolae-Catalin"],["dc.contributor.author","Mavropoulou, Eirini"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Cameron, Silke"],["dc.contributor.author","Amanzada, Ahmad"],["dc.date.accessioned","2021-04-14T08:31:24Z"],["dc.date.available","2021-04-14T08:31:24Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1159/000502515"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/83581"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","1421-9867"],["dc.relation.issn","0012-2823"],["dc.title","Distinct Association of Serum Vitamin D Concentration with Disease Activity and Trough Levels of Infliximab and Adalimumab during Inflammatory Bowel Disease Treatment"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e25111"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Mechie, Nicolae-Catalin"],["dc.contributor.author","Burmester, Merle"],["dc.contributor.author","Mavropoulou, Eirini"],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Amanzada, Ahmad"],["dc.date.accessioned","2021-06-01T10:47:00Z"],["dc.date.available","2021-06-01T10:47:00Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1097/MD.0000000000025111"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17849"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85446"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1536-5964"],["dc.relation.issn","0025-7974"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Evaluation of ustekinumab trough levels during induction and maintenance therapy with regard to disease activity status in difficult to treat Crohn disease patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","123"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Gastroenterology"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Tsaknakis, Birgit"],["dc.contributor.author","Masri, Rawan"],["dc.contributor.author","Amanzada, Ahmad"],["dc.contributor.author","Petzold, Golo"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Neesse, Albrecht"],["dc.contributor.author","Kunsch, Steffen"],["dc.date.accessioned","2019-07-09T11:45:36Z"],["dc.date.available","2019-07-09T11:45:36Z"],["dc.date.issued","2018"],["dc.description.abstract","BACKGROUND: The mortality due to hemorrhage of esophageal varices (EV) is still high. The predominant cause for EV is liver cirrhosis, which has a high prevalence in Western Europe. Therefore, non-invasive screening markers for the presence of EV are of interest. Here, we aim to investigate whether non-inflammatory gall bladder wall thickening (GBWT) may serve as predictor for the presence of EV in comparison and combination with other non-invasive clinical and laboratory parameters. METHODS: One hundred ninety four patients were retrospectively enrolled in the study. Abdominal ultrasound, upper endoscopy and blood tests were evaluated. GBWT, spleen size and the presence of ascites were evaluated by ultrasound. Platelet count and Child-Pugh-score were also recorded. The study population was categorized in two groups: 122 patients without esophageal varices (non EV) compared to 72 patients with EV were analyzed by uni-and multivariate analysis. RESULTS: In the EV group 46% showed a non-inflammatory GBWT of ≥4 mm, compared to 12% in the non-EV group (p < 0.01). GBWT was significantly higher in EV patients compared to the non-EV group (mean: 4.4 mm vs. 2.8 mm, p < 0.0001), and multivariate analysis confirmed GBWT as independent predictor for EV (p < 0.04). The platelets/GBWT ratio (cut-off > 46.2) had a sensitivity and specificity of 78 and 86%, PPV 76% and NPV of 87%, and ROC analysis calculated the AUC of 0.864 (CI 0.809-0.919). CONCLUSIONS: GBWT occurs significantly more often in patients with EV. However, because of the low sensitivity, combination with other non-invasive parameters such as platelet count is recommended."],["dc.identifier.doi","10.1186/s12876-018-0852-5"],["dc.identifier.pmid","30071840"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15253"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/59263"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.publisher","BioMed Central"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Gall bladder wall thickening as non-invasive screening parameter for esophageal varices – a comparative endoscopic – sonographic study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Gastrointestinal Endoscopy"],["dc.bibliographiccitation.volume","81"],["dc.contributor.author","Domagk, Dirk"],["dc.contributor.author","Meister, Tobias"],["dc.contributor.author","Uphoff, Maria-Anna"],["dc.contributor.author","Heinecke, Achim"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Lindhorst, Alexander"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Heinzow, Hauke S."],["dc.date.accessioned","2018-11-07T09:58:06Z"],["dc.date.available","2018-11-07T09:58:06Z"],["dc.date.issued","2015"],["dc.format.extent","AB365"],["dc.identifier.isi","000209931500044"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37301"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Mosby-elsevier"],["dc.publisher.place","New york"],["dc.relation.issn","1097-6779"],["dc.relation.issn","0016-5107"],["dc.title","Combined Biochemical and Clinical Markers in Bile Duct Obstruction: Novel Score for Prediction of Bile Duct Malignancy"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]