Ellenrieder, V.

[["dc.bibliographiccitation.firstpage","161"],["dc.bibliographiccitation.journal","EBioMedicine"],["dc.bibliographiccitation.lastpage","168"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Ramu, Iswarya"],["dc.contributor.author","Buchholz, Sören M."],["dc.contributor.author","Patzak, Melanie S."],["dc.contributor.author","Goetze, Robert G."],["dc.contributor.author","Singh, Shiv K."],["dc.contributor.author","Richards, Frances M."],["dc.contributor.author","Jodrell, Duncan I."],["dc.contributor.author","Sipos, Bence"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Hessmann, Elisabeth"],["dc.contributor.author","Neesse, Albrecht"],["dc.date.accessioned","2020-12-10T14:23:31Z"],["dc.date.available","2020-12-10T14:23:31Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.ebiom.2019.09.024"],["dc.identifier.issn","2352-3964"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16852"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71949"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1978"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Buchholz, Soeren M."],["dc.contributor.author","Goetze, Robert G."],["dc.contributor.author","Singh, Shiv K."],["dc.contributor.author","Ammer-Herrmenau, Christoph"],["dc.contributor.author","Richards, Frances M."],["dc.contributor.author","Jodrell, Duncan I."],["dc.contributor.author","Buchholz, Malte"],["dc.contributor.author","Michl, Patrick"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Hessmann, Elisabeth"],["dc.contributor.author","Neesse, Albrecht"],["dc.date.accessioned","2021-04-14T08:25:07Z"],["dc.date.available","2021-04-14T08:25:07Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3390/cancers12071978"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17498"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81527"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2072-6694"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Depletion of Macrophages Improves Therapeutic Response to Gemcitabine in Murine Pancreas Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1559"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","European Journal of Gastroenterology & Hepatology"],["dc.bibliographiccitation.lastpage","1565"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Petzold, Golo"],["dc.contributor.author","Bremer, Sebastian C.B."],["dc.contributor.author","Knoop, Richard F."],["dc.contributor.author","Amanzada, Ahmad"],["dc.contributor.author","Raddatz, Dirk"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Neesse, Albrecht"],["dc.date.accessioned","2021-04-14T08:24:50Z"],["dc.date.available","2021-04-14T08:24:50Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1097/MEG.0000000000001675"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81439"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0954-691X"],["dc.title","Noninvasive assessment of liver fibrosis in a real-world cohort of patients with known or suspected chronic liver disease using 2D-shear wave elastography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","688"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Cancer Discovery"],["dc.bibliographiccitation.lastpage","701"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Baumgart, Sandra"],["dc.contributor.author","Chen, Nai-Ming"],["dc.contributor.author","Siveke, Jens T."],["dc.contributor.author","Koenig, Alexander O."],["dc.contributor.author","Zhang, J."],["dc.contributor.author","Singh, Shiv K."],["dc.contributor.author","Wolf, Elmar"],["dc.contributor.author","Bartkuhn, Marek"],["dc.contributor.author","Esposito, Irene"],["dc.contributor.author","Hessmann, Elisabeth"],["dc.contributor.author","Reinecke, Johanna"],["dc.contributor.author","Nikorowitsch, Julius"],["dc.contributor.author","Brunner, Marius"],["dc.contributor.author","Singh, Garima"],["dc.contributor.author","Fernandez-Zapico, Martin E."],["dc.contributor.author","Smyrk, Thomas C."],["dc.contributor.author","Bamlet, William R."],["dc.contributor.author","Eilers, Martin"],["dc.contributor.author","Neesse, Albrecht"],["dc.contributor.author","Gress, Thomas M."],["dc.contributor.author","Billadeau, Daniel D."],["dc.contributor.author","Tuveson, David A."],["dc.contributor.author","Urrutia, Raul"],["dc.contributor.author","Ellenrieder, Volker"],["dc.date.accessioned","2018-11-07T09:39:31Z"],["dc.date.available","2018-11-07T09:39:31Z"],["dc.date.issued","2014"],["dc.description.abstract","Cancer-associated inflammation is a molecular key feature in pancreatic ductal adenocarcinoma. Oncogenic KRAS in conjunction with persistent inflammation is known to accelerate carcinogenesis, although the underlying mechanisms remain poorly understood. Here, we outline a novel pathway whereby the transcription factors NFATc1 and STAT3 cooperate in pancreatic epithelial cells to promote Kras(G12D) -driven carcinogenesis. NFATc1 activation is induced by inflammation and itself accelerates inflammation-induced carcinogenesis in Kras(G12D) mice, whereas genetic or pharmacologic ablation of NFATc1 attenuates this effect. Mechanistically, NFATc1 complexes with STAT3 for enhancer-promoter communications at jointly regulated genes involved in oncogenesis, for example, Cyclin, EGFR and WNT family members. The NFATc1-STAT3 cooperativity is operative in pancreatitis-mediated carcinogenesis as well as in established human pancreatic cancer. Together, these studies unravel new mechanisms of inflammatory-driven pancreatic carcinogenesis and suggest beneficial effects of chemopreventive strategies using drugs that are currently available for targeting these factors in clinical trials. SIGNIFICANCE: Our study points to the existence of an oncogenic NFATc1-STAT3 cooperativity that mechanistically links inflammation with pancreatic cancer initiation and progression. Because NFATc1STAT3 nucleoprotein complexes control the expression of gene networks at the intersection of inflammation and cancer, our study has significant relevance for potentially managing pancreatic cancer and other inflammatory-driven malignancies. (C) 2014 AACR."],["dc.identifier.doi","10.1158/2159-8290.CD-13-0593"],["dc.identifier.isi","000337185500025"],["dc.identifier.pmid","24694735"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33304"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Assoc Cancer Research"],["dc.relation.issn","2159-8290"],["dc.relation.issn","2159-8274"],["dc.title","Inflammation-Induced NFATc1-STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by Kras(G12D)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","342"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Scandinavian Journal of Gastroenterology"],["dc.bibliographiccitation.lastpage","349"],["dc.bibliographiccitation.volume","54"],["dc.contributor.author","Petzold, Golo"],["dc.contributor.author","Tsaknakis, Birgit"],["dc.contributor.author","Bremer, Sebastian C. B."],["dc.contributor.author","Knoop, Richard F."],["dc.contributor.author","G. Goetze, Robert"],["dc.contributor.author","Amanzada, Ahmad"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Neesse, Albrecht"],["dc.contributor.author","Kunsch, Steffen"],["dc.date.accessioned","2020-12-10T18:14:44Z"],["dc.date.available","2020-12-10T18:14:44Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1080/00365521.2019.1585571"],["dc.identifier.eissn","1502-7708"],["dc.identifier.issn","0036-5521"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74599"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Evaluation of liver stiffness by 2D-SWE in combination with non-invasive parameters as predictors for esophageal varices in patients with advanced chronic liver disease"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0163651"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Rasch, Sebastian"],["dc.contributor.author","Phillip, Veit"],["dc.contributor.author","Reichel, Stephanie"],["dc.contributor.author","Rau, Bettina M."],["dc.contributor.author","Zapf, Christian"],["dc.contributor.author","Rosendahl, Jonas"],["dc.contributor.author","Halms, Ulrich"],["dc.contributor.author","Zachaeus, Markus"],["dc.contributor.author","Mueller, Martin"],["dc.contributor.author","Kleger, Alexander"],["dc.contributor.author","Neesse, Albrecht"],["dc.contributor.author","Hampe, Jochen"],["dc.contributor.author","Ellrichmann, Mark"],["dc.contributor.author","Rueckert, Felix"],["dc.contributor.author","Strauss, Peter"],["dc.contributor.author","Arlt, Alexander"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Gress, Thomas M."],["dc.contributor.author","Hartwig, Werner"],["dc.contributor.author","Klar, Ernst"],["dc.contributor.author","Moessner, Joachim"],["dc.contributor.author","Post, Stephen G."],["dc.contributor.author","Schmid, Roland M."],["dc.contributor.author","Seufferlein, Thomas"],["dc.contributor.author","Siech, Marco"],["dc.contributor.author","Werner, Jens"],["dc.contributor.author","Will, Uwe"],["dc.contributor.author","Alguel, Hana"],["dc.date.accessioned","2018-11-07T10:08:18Z"],["dc.date.available","2018-11-07T10:08:18Z"],["dc.date.issued","2016"],["dc.description.abstract","Background Necrotising pancreatitis, and particularly infected necrosis, are still associated with high morbidity and mortality. Since 2011, a step-up approach with lower morbidity rates compared to initial open necrosectomy has been established. However, mortality and complication rates of this complex treatment are hardly studied thereafter. Methods The German Pancreatitis Study Group performed a multicenter, retrospective study including 220 patients with necrotising pancreatitis requiring intervention, treated at 10 hospitals in Germany between January 2008 and June 2014. Data were analysed for the primary endpoints \"severe complications\" and \"mortality\" as well as secondary endpoints including \"length of hospital stay\", \"follow up\", and predisposing or prognostic factors. Results Of all patients 13.6% were treated primarily with surgery and 86.4% underwent a step-up approach. More men (71.8%) required intervention for necrotising pancreatitis. The most frequent etiology was biliary (41.4%) followed by alcohol (29.1%). Compared to open necrosectomy, the step-up approach was associated with a lower number of severe complications (primary composite endpoint including sepsis, persistent multiorgan dysfunction syndrome (MODS) and erosion bleeding: 44.7% vs. 73.3%), lower mortality (10.5% vs. 33.3%) and lower rates of diabetes mellitus type 3c (4.7% vs. 33.3%). Low hematocrit and low blood urea nitrogen at admission as well as a history of acute pancreatitis were prognostic for less complications in necrotising pancreatitis. A combination of drainage with endoscopic necrosectomy resulted in the lowest rate of severe complications. Conclusion A step-up approach starting with minimal invasive drainage techniques and endoscopic necrosectomy results in a significant reduction of morbidity and mortality in necrotising pancreatitis compared to a primarily surgical intervention."],["dc.identifier.doi","10.1371/journal.pone.0163651"],["dc.identifier.isi","000384167300063"],["dc.identifier.pmid","27668746"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13762"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39449"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Open Surgical versus Minimal Invasive Necrosectomy of the Pancreas-A Retrospective Multicenter Analysis of the German Pancreatitis Study Group"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","211"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Gut"],["dc.bibliographiccitation.lastpage","212"],["dc.bibliographiccitation.volume","66"],["dc.contributor.author","Neesse, Albrecht"],["dc.contributor.author","Ellenrieder, Volker"],["dc.date.accessioned","2018-11-07T10:28:11Z"],["dc.date.available","2018-11-07T10:28:11Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1136/gutjnl-2016-312874"],["dc.identifier.isi","000392293100003"],["dc.identifier.pmid","27590996"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43367"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Bmj Publishing Group"],["dc.relation.issn","1468-3288"],["dc.relation.issn","0017-5749"],["dc.title","NEMO-CXCL12/CXCR4 axis: a novel vantage point for antifibrotic therapies in chronic pancreatitis?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","304"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Gastroenterology"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Ammer-Herrmenau, C."],["dc.contributor.author","Asendorf, T."],["dc.contributor.author","Beyer, G."],["dc.contributor.author","Buchholz, S. M."],["dc.contributor.author","Cameron, S."],["dc.contributor.author","Damm, M."],["dc.contributor.author","Frost, F."],["dc.contributor.author","Henker, R."],["dc.contributor.author","Jaster, R."],["dc.contributor.author","Phillip, V."],["dc.contributor.author","Placzek, M."],["dc.contributor.author","Ratei, C."],["dc.contributor.author","Sirtl, S."],["dc.contributor.author","van den Berg, T."],["dc.contributor.author","Weingarten, M. J."],["dc.contributor.author","Woitalla, J."],["dc.contributor.author","Mayerle, J."],["dc.contributor.author","Ellenrieder, V."],["dc.contributor.author","Neesse, A."],["dc.date.accessioned","2021-11-25T11:03:17Z"],["dc.date.accessioned","2022-08-18T12:35:27Z"],["dc.date.available","2021-11-25T11:03:17Z"],["dc.date.available","2022-08-18T12:35:27Z"],["dc.date.issued","2021-07-31"],["dc.date.updated","2022-07-29T12:07:19Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Acute pancreatitis (AP) is an inflammatory disorder that causes a considerable economic health burden. While the overall mortality is low, around 20% of patients have a complicated course of disease resulting in increased morbidity and mortality. There is an emerging body of evidence that the microbiome exerts a crucial impact on the pathophysiology and course of AP. For several decades multiple clinical and laboratory parameters have been evaluated, and complex scoring systems were developed to predict the clinical course of AP upon admission. However, the majority of scoring systems are determined after several days and achieve a sensitivity around 70% for early prediction of severe AP. Thus, continued efforts are required to investigate reliable biomarkers for the early prediction of severity in order to guide early clinical management of AP patients.\r\n\r\n \r\n \r\n Methods\r\n We designed a multi-center, prospective clinical-translational study to test whether the orointestinal microbiome may serve as novel early predictor of the course, severity and outcome of patients with AP. We will recruit 400 AP patients and obtain buccal and rectal swabs within 72 h of admission to the hospital. Following DNA extraction, microbiome analysis will be performed using 3rd generation sequencing Oxford Nanopore Technologies (ONT) for 16S rRNA and metagenomic sequencing. Alpha- and beta-diversity will be determined and correlated to the revised Atlanta classification and additional clinical outcome parameters such as the length of hospital stay, number and type of complications, number of interventions and 30-day mortality.\r\n \r\n \r\n Discussion\r\n If AP patients show a distinct orointestinal microbiome dependent on the severity and course of the disease, microbiome sequencing could rapidly be implemented in the early clinical management of AP patients in the future.\r\n Trial registration: ClinicalTrials.gov Identifier: NCT04777812"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","BMC Gastroenterology. 2021 Jul 31;21(1):304"],["dc.identifier.doi","10.1186/s12876-021-01885-4"],["dc.identifier.pii","1885"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/93521"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112940"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1471-230X"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Acute pancreatitis"],["dc.subject","Biomarker"],["dc.subject","Orointestinale microbiome"],["dc.subject","Metagenomic sequencing"],["dc.subject","Multicentric"],["dc.subject","Oxford nanopore technologies"],["dc.subject","ONT"],["dc.subject","P-MAPS"],["dc.subject","Prospective"],["dc.subject","Severity"],["dc.subject","NCT04777812"],["dc.title","Study protocol P-MAPS: microbiome as predictor of severity in acute pancreatitis—a prospective multicentre translational study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","497"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Gut"],["dc.bibliographiccitation.lastpage","507"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Hessmann, E."],["dc.contributor.author","Patzak, M S"],["dc.contributor.author","Klein, L"],["dc.contributor.author","Chen, N"],["dc.contributor.author","Kari, V"],["dc.contributor.author","Ramu, I"],["dc.contributor.author","Bapiro, T E"],["dc.contributor.author","Frese, K K"],["dc.contributor.author","Gopinathan, A"],["dc.contributor.author","Richards, F M"],["dc.contributor.author","Jodrell, D I"],["dc.contributor.author","Verbeke, C"],["dc.contributor.author","Li, X"],["dc.contributor.author","Heuchel, R"],["dc.contributor.author","Löhr, J M"],["dc.contributor.author","Johnsen, S A"],["dc.contributor.author","Gress, T M"],["dc.contributor.author","Ellenrieder, V"],["dc.contributor.author","Neesse, A"],["dc.date.accessioned","2020-12-10T18:37:14Z"],["dc.date.available","2020-12-10T18:37:14Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1136/gutjnl-2016-311954"],["dc.identifier.eissn","1468-3288"],["dc.identifier.issn","0017-5749"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/76887"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","185"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Digestion"],["dc.bibliographiccitation.lastpage","186"],["dc.bibliographiccitation.volume","96"],["dc.contributor.author","Petzold, Golo"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Neesse, Albrecht"],["dc.date.accessioned","2019-03-13T10:20:59Z"],["dc.date.available","2019-03-13T10:20:59Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1159/000481251"],["dc.identifier.pmid","28957805"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57671"],["dc.language.iso","en"],["dc.notes.status","zu prüfen"],["dc.title","Autoimmune Pancreatitis in Germany: Rare but Relevant"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]