Ellenrieder, V.

[["dc.bibliographiccitation.firstpage","861"],["dc.bibliographiccitation.issue","09"],["dc.bibliographiccitation.journal","Zeitschrift für Gastroenterologie"],["dc.bibliographiccitation.lastpage","865"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Gliem, Nina"],["dc.contributor.author","Broekaert, Sigrid"],["dc.contributor.author","Seitz, Cornelia"],["dc.contributor.author","Schön, Michael"],["dc.contributor.author","Ellenrieder, Volker"],["dc.date.accessioned","2020-12-10T18:12:26Z"],["dc.date.available","2020-12-10T18:12:26Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1055/s-0043-113833"],["dc.identifier.eissn","1439-7803"],["dc.identifier.issn","0044-2771"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74371"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Esomeprazol-induzierter kutaner Lupus erythematodes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1470"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Leukemia"],["dc.bibliographiccitation.lastpage","1477"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Metzelder, S. K."],["dc.contributor.author","Michel, C."],["dc.contributor.author","von Bonin, Malte"],["dc.contributor.author","Rehberger, M."],["dc.contributor.author","Hessmann, Elisabeth"],["dc.contributor.author","Inselmann, S."],["dc.contributor.author","Solovey, M."],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Sohlbach, K."],["dc.contributor.author","Brendel, Cornelia"],["dc.contributor.author","Stiewe, Thorsten"],["dc.contributor.author","Charles, J."],["dc.contributor.author","Ten Haaf, A."],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Neubauer, A."],["dc.contributor.author","Gattenloehner, Stefan"],["dc.contributor.author","Bornhaeuser, Martin"],["dc.contributor.author","Burchert, Andreas"],["dc.date.accessioned","2018-11-07T09:55:10Z"],["dc.date.available","2018-11-07T09:55:10Z"],["dc.date.issued","2015"],["dc.description.abstract","Internal tandem duplications (ITD) in the Fms-related tyrosine kinase 3 receptor (FLT3) are associated with a dismal prognosis in acute myeloid leukemia (AML). FLT3 inhibitors such as sorafenib may improve outcome, but only few patients display long-term responses, prompting the search for underlying resistance mechanisms and therapeutic strategies to overcome them. Here we identified that the nuclear factor of activated T cells, NFATc1, is frequently overexpressed in FLT3-ITD-positive (FLT3-ITD+) AML. NFATc1 knockdown using inducible short hairpin RNA or pharmacological NFAT inhibition with cyclosporine A (CsA) or VIVIT significantly augmented sorafenib-induced apoptosis of FLT3-ITD+ cells. CsA also potently overcame sorafenib resistance in FLT3-ITD+ cell lines and primary AML. Vice versa, de novo expression of a constitutively nuclear NFATc1-mutant mediated instant and robust sorafenib resistance in vitro. Intriguingly, FLT3-ITD+ AML patients (n = 26) who received CsA as part of their rescue chemotherapy displayed a superior outcome when compared with wild-type FLT3 (FLT3-WT) AML patients. Our data unveil NFATc1 as a novel mediator of sorafenib resistance in FLT3-ITD+ AML. CsA counteracts sorafenib resistance and may improve treatment outcome in AML by means of inhibiting NFAT."],["dc.identifier.doi","10.1038/leu.2015.95"],["dc.identifier.isi","000357623100006"],["dc.identifier.pmid","25976987"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36691"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1476-5551"],["dc.relation.issn","0887-6924"],["dc.title","NFATc1 as a therapeutic target in FLT3-ITD-positive AML"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S572"],["dc.bibliographiccitation.journal","Translational Cancer Research"],["dc.bibliographiccitation.lastpage","S573"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Goetze, Robert"],["dc.contributor.author","Ellenrieder, Volker"],["dc.date.accessioned","2018-11-07T10:08:51Z"],["dc.date.available","2018-11-07T10:08:51Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.21037/tcr.2016.09.12"],["dc.identifier.isi","000393310100046"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39550"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ame Publ Co"],["dc.relation.issn","2219-6803"],["dc.relation.issn","2218-676X"],["dc.title","ETV1 combines tumor cell plasticity with constitution of a protumorigenic stroma in pancreatic cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","161"],["dc.bibliographiccitation.journal","EBioMedicine"],["dc.bibliographiccitation.lastpage","168"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Ramu, Iswarya"],["dc.contributor.author","Buchholz, Sören M."],["dc.contributor.author","Patzak, Melanie S."],["dc.contributor.author","Goetze, Robert G."],["dc.contributor.author","Singh, Shiv K."],["dc.contributor.author","Richards, Frances M."],["dc.contributor.author","Jodrell, Duncan I."],["dc.contributor.author","Sipos, Bence"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Hessmann, Elisabeth"],["dc.contributor.author","Neesse, Albrecht"],["dc.date.accessioned","2020-12-10T14:23:31Z"],["dc.date.available","2020-12-10T14:23:31Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.ebiom.2019.09.024"],["dc.identifier.issn","2352-3964"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16852"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71949"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","877"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Alimentary Pharmacology & Therapeutics"],["dc.bibliographiccitation.lastpage","887"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Meister, T."],["dc.contributor.author","Uphoff, M.-A."],["dc.contributor.author","Heinecke, Achim"],["dc.contributor.author","Domagk, Dirk"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Lindhorst, Alexander"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Heinzow, Hauke S."],["dc.date.accessioned","2018-11-07T09:58:02Z"],["dc.date.available","2018-11-07T09:58:02Z"],["dc.date.issued","2015"],["dc.description.abstract","BackgroundEarly differentiation of malignant from benign bile duct obstruction is of utmost importance. AimTo identify biochemical and clinical predictors for malignancy in patients with bile duct obstruction, and establish a predictive model by combining pre-treatment patient characteristics. A web-based application was developed for easy assessment of malignant bile duct probability (). MethodsOne thousand hundred and thirty-five patients [median age 66 (52-75) years, 53% male] with bile duct obstruction of various aetiologies were retrospectively evaluated at our tertiary referral centre. Multivariate logistic regression analysis identified factors as independently significant for malignant bile duct obstruction. A predictive risk score was established using ROC analysis and applied to an external validation cohort of 101 patients. ResultsThree hundred and ninety-four patients had malignant bile duct obstruction proven by surgery, while in 741 patients benign obstruction was observed. Multivariate analysis identified various clinical factors to be predictive for malignancy. On the basis of eight predictors, a risk score for malignancy was developed [X=0.025 [age]+1.239 [1 if weight loss, otherwise 0]-0.235 [1 if pain, otherwise 0]+0.649 [1 if diabetes, otherwise 0]+0.896 [1 if jaundice, otherwise 0]+0.109 [bilirubin]+0.0007 [-GT]+0.0003 [AP]-4.374]: A significant correlation between the predicted malignancy and the actual malignancy was found by ROC (AUC: 0.862; 95% CI 0.838-0.886, P<0.0001). ConclusionsThis predictive risk score estimates the risk of malignancy in patients with bile duct obstruction, and it seems to be very accurate. A better prediction enables both earlier diagnosis of malignant obstructive disease and improved management of patients with bile duct obstruction, which may result in reduced morbidity and mortality."],["dc.identifier.doi","10.1111/apt.13152"],["dc.identifier.isi","000352557300008"],["dc.identifier.pmid","25753000"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37290"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-2036"],["dc.relation.issn","0269-2813"],["dc.title","Novel score for prediction of malignant bile duct obstruction based on biochemical and clinical markers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1978"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Buchholz, Soeren M."],["dc.contributor.author","Goetze, Robert G."],["dc.contributor.author","Singh, Shiv K."],["dc.contributor.author","Ammer-Herrmenau, Christoph"],["dc.contributor.author","Richards, Frances M."],["dc.contributor.author","Jodrell, Duncan I."],["dc.contributor.author","Buchholz, Malte"],["dc.contributor.author","Michl, Patrick"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Hessmann, Elisabeth"],["dc.contributor.author","Neesse, Albrecht"],["dc.date.accessioned","2021-04-14T08:25:07Z"],["dc.date.available","2021-04-14T08:25:07Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3390/cancers12071978"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17498"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81527"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2072-6694"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Depletion of Macrophages Improves Therapeutic Response to Gemcitabine in Murine Pancreas Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E641"],["dc.bibliographiccitation.issue","05"],["dc.bibliographiccitation.journal","Endoscopy International Open"],["dc.bibliographiccitation.lastpage","E646"],["dc.bibliographiccitation.volume","07"],["dc.contributor.author","Wedi, E."],["dc.contributor.author","Koehler, P."],["dc.contributor.author","Hochberger, J."],["dc.contributor.author","Maiss, J."],["dc.contributor.author","Milenovic, S."],["dc.contributor.author","Gromski, M."],["dc.contributor.author","Ho, N."],["dc.contributor.author","Gabor, C."],["dc.contributor.author","Baulain, U."],["dc.contributor.author","Ellenrieder, V."],["dc.contributor.author","Jung, C."],["dc.date.accessioned","2020-12-10T18:12:09Z"],["dc.date.available","2020-12-10T18:12:09Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1055/a-0874-1844"],["dc.identifier.eissn","2196-9736"],["dc.identifier.issn","2364-3722"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74261"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Endoscopic submucosal dissection with a novel high viscosity injection solution (LiftUp) in an ex vivo model: a prospective randomized study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","703"],["dc.bibliographiccitation.issue","09"],["dc.bibliographiccitation.journal","Allergologie"],["dc.bibliographiccitation.lastpage","711"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Lex, C."],["dc.contributor.author","Beutner, D."],["dc.contributor.author","Buhl, T."],["dc.contributor.author","Czech-Zechmeister, B.A."],["dc.contributor.author","Dombrowski, T."],["dc.contributor.author","Ellenrieder, V."],["dc.contributor.author","Fischer, A."],["dc.contributor.author","Geier, J."],["dc.contributor.author","Gliem, N."],["dc.contributor.author","Hasenfuß, G."],["dc.contributor.author","Beutner, C."],["dc.date.accessioned","2022-12-01T08:31:49Z"],["dc.date.available","2022-12-01T08:31:49Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.5414/ALX02350"],["dc.identifier.pii","02350"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118274"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.issn","0344-5062"],["dc.title","Allergiezentrum Südniedersachsen – Das Comprehensive Allergy Center der Universitätsmedizin Göttingen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","United European Gastroenterology Journal"],["dc.contributor.author","Floer, Martin"],["dc.contributor.author","Tschaikowski, Laura"],["dc.contributor.author","Schepke, Michael"],["dc.contributor.author","Kempinski, Radoslaw"],["dc.contributor.author","Neubauer, Katarzyna"],["dc.contributor.author","Poniewierka, Elzbieta"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Ameis, Detlev"],["dc.contributor.author","Heinzow, Hauke Sebastian"],["dc.contributor.author","Auer, Agneta"],["dc.contributor.author","Schmidt, Hartmut H."],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Meister, Tobias"],["dc.date.accessioned","2021-04-14T08:28:10Z"],["dc.date.available","2021-04-14T08:28:10Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1177/2050640620982952"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82523"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2050-6414"],["dc.relation.issn","2050-6406"],["dc.title","Standard versus Endocuff versus cap‐assisted colonoscopy for adenoma detection: A randomised controlled clinical trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1559"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","European Journal of Gastroenterology & Hepatology"],["dc.bibliographiccitation.lastpage","1565"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Petzold, Golo"],["dc.contributor.author","Bremer, Sebastian C.B."],["dc.contributor.author","Knoop, Richard F."],["dc.contributor.author","Amanzada, Ahmad"],["dc.contributor.author","Raddatz, Dirk"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Neesse, Albrecht"],["dc.date.accessioned","2021-04-14T08:24:50Z"],["dc.date.available","2021-04-14T08:24:50Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1097/MEG.0000000000001675"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81439"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0954-691X"],["dc.title","Noninvasive assessment of liver fibrosis in a real-world cohort of patients with known or suspected chronic liver disease using 2D-shear wave elastography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]