Ellenrieder, V.

[["dc.bibliographiccitation.firstpage","861"],["dc.bibliographiccitation.issue","09"],["dc.bibliographiccitation.journal","Zeitschrift für Gastroenterologie"],["dc.bibliographiccitation.lastpage","865"],["dc.bibliographiccitation.volume","55"],["dc.contributor.author","Gliem, Nina"],["dc.contributor.author","Broekaert, Sigrid"],["dc.contributor.author","Seitz, Cornelia"],["dc.contributor.author","Schön, Michael"],["dc.contributor.author","Ellenrieder, Volker"],["dc.date.accessioned","2020-12-10T18:12:26Z"],["dc.date.available","2020-12-10T18:12:26Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1055/s-0043-113833"],["dc.identifier.eissn","1439-7803"],["dc.identifier.issn","0044-2771"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74371"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Esomeprazol-induzierter kutaner Lupus erythematodes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1470"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Leukemia"],["dc.bibliographiccitation.lastpage","1477"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Metzelder, S. K."],["dc.contributor.author","Michel, C."],["dc.contributor.author","von Bonin, Malte"],["dc.contributor.author","Rehberger, M."],["dc.contributor.author","Hessmann, Elisabeth"],["dc.contributor.author","Inselmann, S."],["dc.contributor.author","Solovey, M."],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Sohlbach, K."],["dc.contributor.author","Brendel, Cornelia"],["dc.contributor.author","Stiewe, Thorsten"],["dc.contributor.author","Charles, J."],["dc.contributor.author","Ten Haaf, A."],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Neubauer, A."],["dc.contributor.author","Gattenloehner, Stefan"],["dc.contributor.author","Bornhaeuser, Martin"],["dc.contributor.author","Burchert, Andreas"],["dc.date.accessioned","2018-11-07T09:55:10Z"],["dc.date.available","2018-11-07T09:55:10Z"],["dc.date.issued","2015"],["dc.description.abstract","Internal tandem duplications (ITD) in the Fms-related tyrosine kinase 3 receptor (FLT3) are associated with a dismal prognosis in acute myeloid leukemia (AML). FLT3 inhibitors such as sorafenib may improve outcome, but only few patients display long-term responses, prompting the search for underlying resistance mechanisms and therapeutic strategies to overcome them. Here we identified that the nuclear factor of activated T cells, NFATc1, is frequently overexpressed in FLT3-ITD-positive (FLT3-ITD+) AML. NFATc1 knockdown using inducible short hairpin RNA or pharmacological NFAT inhibition with cyclosporine A (CsA) or VIVIT significantly augmented sorafenib-induced apoptosis of FLT3-ITD+ cells. CsA also potently overcame sorafenib resistance in FLT3-ITD+ cell lines and primary AML. Vice versa, de novo expression of a constitutively nuclear NFATc1-mutant mediated instant and robust sorafenib resistance in vitro. Intriguingly, FLT3-ITD+ AML patients (n = 26) who received CsA as part of their rescue chemotherapy displayed a superior outcome when compared with wild-type FLT3 (FLT3-WT) AML patients. Our data unveil NFATc1 as a novel mediator of sorafenib resistance in FLT3-ITD+ AML. CsA counteracts sorafenib resistance and may improve treatment outcome in AML by means of inhibiting NFAT."],["dc.identifier.doi","10.1038/leu.2015.95"],["dc.identifier.isi","000357623100006"],["dc.identifier.pmid","25976987"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36691"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","1476-5551"],["dc.relation.issn","0887-6924"],["dc.title","NFATc1 as a therapeutic target in FLT3-ITD-positive AML"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S572"],["dc.bibliographiccitation.journal","Translational Cancer Research"],["dc.bibliographiccitation.lastpage","S573"],["dc.bibliographiccitation.volume","5"],["dc.contributor.author","Goetze, Robert"],["dc.contributor.author","Ellenrieder, Volker"],["dc.date.accessioned","2018-11-07T10:08:51Z"],["dc.date.available","2018-11-07T10:08:51Z"],["dc.date.issued","2016"],["dc.identifier.doi","10.21037/tcr.2016.09.12"],["dc.identifier.isi","000393310100046"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39550"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Ame Publ Co"],["dc.relation.issn","2219-6803"],["dc.relation.issn","2218-676X"],["dc.title","ETV1 combines tumor cell plasticity with constitution of a protumorigenic stroma in pancreatic cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","877"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Alimentary Pharmacology & Therapeutics"],["dc.bibliographiccitation.lastpage","887"],["dc.bibliographiccitation.volume","41"],["dc.contributor.author","Meister, T."],["dc.contributor.author","Uphoff, M.-A."],["dc.contributor.author","Heinecke, Achim"],["dc.contributor.author","Domagk, Dirk"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Lindhorst, Alexander"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Heinzow, Hauke S."],["dc.date.accessioned","2018-11-07T09:58:02Z"],["dc.date.available","2018-11-07T09:58:02Z"],["dc.date.issued","2015"],["dc.description.abstract","BackgroundEarly differentiation of malignant from benign bile duct obstruction is of utmost importance. AimTo identify biochemical and clinical predictors for malignancy in patients with bile duct obstruction, and establish a predictive model by combining pre-treatment patient characteristics. A web-based application was developed for easy assessment of malignant bile duct probability (). MethodsOne thousand hundred and thirty-five patients [median age 66 (52-75) years, 53% male] with bile duct obstruction of various aetiologies were retrospectively evaluated at our tertiary referral centre. Multivariate logistic regression analysis identified factors as independently significant for malignant bile duct obstruction. A predictive risk score was established using ROC analysis and applied to an external validation cohort of 101 patients. ResultsThree hundred and ninety-four patients had malignant bile duct obstruction proven by surgery, while in 741 patients benign obstruction was observed. Multivariate analysis identified various clinical factors to be predictive for malignancy. On the basis of eight predictors, a risk score for malignancy was developed [X=0.025 [age]+1.239 [1 if weight loss, otherwise 0]-0.235 [1 if pain, otherwise 0]+0.649 [1 if diabetes, otherwise 0]+0.896 [1 if jaundice, otherwise 0]+0.109 [bilirubin]+0.0007 [-GT]+0.0003 [AP]-4.374]: A significant correlation between the predicted malignancy and the actual malignancy was found by ROC (AUC: 0.862; 95% CI 0.838-0.886, P<0.0001). ConclusionsThis predictive risk score estimates the risk of malignancy in patients with bile duct obstruction, and it seems to be very accurate. A better prediction enables both earlier diagnosis of malignant obstructive disease and improved management of patients with bile duct obstruction, which may result in reduced morbidity and mortality."],["dc.identifier.doi","10.1111/apt.13152"],["dc.identifier.isi","000352557300008"],["dc.identifier.pmid","25753000"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37290"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1365-2036"],["dc.relation.issn","0269-2813"],["dc.title","Novel score for prediction of malignant bile duct obstruction based on biochemical and clinical markers"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","E641"],["dc.bibliographiccitation.issue","05"],["dc.bibliographiccitation.journal","Endoscopy International Open"],["dc.bibliographiccitation.lastpage","E646"],["dc.bibliographiccitation.volume","07"],["dc.contributor.author","Wedi, E."],["dc.contributor.author","Koehler, P."],["dc.contributor.author","Hochberger, J."],["dc.contributor.author","Maiss, J."],["dc.contributor.author","Milenovic, S."],["dc.contributor.author","Gromski, M."],["dc.contributor.author","Ho, N."],["dc.contributor.author","Gabor, C."],["dc.contributor.author","Baulain, U."],["dc.contributor.author","Ellenrieder, V."],["dc.contributor.author","Jung, C."],["dc.date.accessioned","2020-12-10T18:12:09Z"],["dc.date.available","2020-12-10T18:12:09Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1055/a-0874-1844"],["dc.identifier.eissn","2196-9736"],["dc.identifier.issn","2364-3722"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74261"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Endoscopic submucosal dissection with a novel high viscosity injection solution (LiftUp) in an ex vivo model: a prospective randomized study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","703"],["dc.bibliographiccitation.issue","09"],["dc.bibliographiccitation.journal","Allergologie"],["dc.bibliographiccitation.lastpage","711"],["dc.bibliographiccitation.volume","45"],["dc.contributor.author","Lex, C."],["dc.contributor.author","Beutner, D."],["dc.contributor.author","Buhl, T."],["dc.contributor.author","Czech-Zechmeister, B.A."],["dc.contributor.author","Dombrowski, T."],["dc.contributor.author","Ellenrieder, V."],["dc.contributor.author","Fischer, A."],["dc.contributor.author","Geier, J."],["dc.contributor.author","Gliem, N."],["dc.contributor.author","Hasenfuß, G."],["dc.contributor.author","Beutner, C."],["dc.date.accessioned","2022-12-01T08:31:49Z"],["dc.date.available","2022-12-01T08:31:49Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.5414/ALX02350"],["dc.identifier.pii","02350"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/118274"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-621"],["dc.relation.issn","0344-5062"],["dc.title","Allergiezentrum Südniedersachsen – Das Comprehensive Allergy Center der Universitätsmedizin Göttingen"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","United European Gastroenterology Journal"],["dc.contributor.author","Floer, Martin"],["dc.contributor.author","Tschaikowski, Laura"],["dc.contributor.author","Schepke, Michael"],["dc.contributor.author","Kempinski, Radoslaw"],["dc.contributor.author","Neubauer, Katarzyna"],["dc.contributor.author","Poniewierka, Elzbieta"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Ameis, Detlev"],["dc.contributor.author","Heinzow, Hauke Sebastian"],["dc.contributor.author","Auer, Agneta"],["dc.contributor.author","Schmidt, Hartmut H."],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Meister, Tobias"],["dc.date.accessioned","2021-04-14T08:28:10Z"],["dc.date.available","2021-04-14T08:28:10Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1177/2050640620982952"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82523"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.eissn","2050-6414"],["dc.relation.issn","2050-6406"],["dc.title","Standard versus Endocuff versus cap‐assisted colonoscopy for adenoma detection: A randomised controlled clinical trial"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1559"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","European Journal of Gastroenterology & Hepatology"],["dc.bibliographiccitation.lastpage","1565"],["dc.bibliographiccitation.volume","32"],["dc.contributor.author","Petzold, Golo"],["dc.contributor.author","Bremer, Sebastian C.B."],["dc.contributor.author","Knoop, Richard F."],["dc.contributor.author","Amanzada, Ahmad"],["dc.contributor.author","Raddatz, Dirk"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Neesse, Albrecht"],["dc.date.accessioned","2021-04-14T08:24:50Z"],["dc.date.available","2021-04-14T08:24:50Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1097/MEG.0000000000001675"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81439"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.relation.issn","0954-691X"],["dc.title","Noninvasive assessment of liver fibrosis in a real-world cohort of patients with known or suspected chronic liver disease using 2D-shear wave elastography"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","509"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Langenbeck s Archives of Surgery"],["dc.bibliographiccitation.lastpage","519"],["dc.bibliographiccitation.volume","402"],["dc.contributor.author","Dango, Sebastian"],["dc.contributor.author","Beißbarth, Tim"],["dc.contributor.author","Weiss, Elisabeth"],["dc.contributor.author","Hosseini, Ali Seif Amir"],["dc.contributor.author","Raddatz, Dirk"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Lotz, Joachim"],["dc.contributor.author","Ghadimi, Michael B."],["dc.contributor.author","Beham, Alexander Wilhelm"],["dc.date.accessioned","2018-11-07T10:24:29Z"],["dc.date.available","2018-11-07T10:24:29Z"],["dc.date.issued","2017"],["dc.description.abstract","Upper GI bleeding remains one of the most common emergencies with a substantial overall mortality rate of up to 30%. In severe ill patients, death does not occur due to failure of hemostasis, either medical or surgical, but mainly from comorbidities, treatment complications, and decreased tolerated blood loss. Management strategies have changed dramatically over the last two decades and include primarily endoscopic intervention in combination with acid-suppressive therapy and decrease in surgical intervention. Herein, we present one of the largest patient-based analysis assessing clinical parameters and outcome in patients undergoing endoscopy with an upper GI bleeding. Data were further analyzed to identify potential new risk factors and to investigate the role of surgery. In this retrospective study, we aimed to analyze outcome of patients with an UGIB and data were analyzed to identify potential new risk factors and the role of surgery. Data collection included demographic data, laboratory results, endoscopy reports, and details of management including blood administration, and surgery was carried out. Patient events were grouped and defined as \"overall\" events and \"operated,\" \"non-operated,\" and \"operated and death\" as well as \"non-operated and death\" where appropriate. Blatchford, clinical as well as complete Rockall-score analysis, risk stratification, and disease-related mortality rate were calculated for each group for comparison. Overall, 253 patients were eligible for analysis: endoscopy was carried out in 96% of all patients, 17% needed surgical intervention after endoscopic failure of bleeding control due to persistent bleeding, and the remaining 4% of patients were subjected directly to surgery. The median length of stay to discharge was 26 days. Overall mortality was 22%; out of them, almost 5% were operated and died. Anticoagulation was associated with a high in-hospital mortality risk (23%) and was increased once patients were taken to surgery (43%). Patients taking steroids presented with a risk of death of 26%, once taken to surgery the risk increased to 80%. Patients with liver cirrhosis had a risk of death of 42%; we observed a better outcome for these patients once taken to theater. Clinically, once scored with Blatchford score, statistical correlation was found for initial need for blood transfusion and surgical intervention. Clinical as well as complete Rockall score revealed a correlation between need for blood transfusion as well as surgical intervention in addition with a decreased outcome with increasing Rockall scores. Risk factor analysis including comorbidity, drug administration, and anticoagulation therapy introduced the combination of tumor and non-steroidal antirheumatic medication as independent risk factors for increased disease-related mortality. UGIB remains challenging and endoscopy is the first choice of intervention. Care must be taken once a patient is taking antirheumatic non-steroidal pain medication and suffers from cancer. In patients with presence of liver cirrhosis, an earlier surgical intervention may be considered, in particular for patients with recurrent bleeding. Embolization is not widely available and carries the risk of necrosis of the affected organ and should be restricted to a subgroup of patients not primarily eligible for surgery once endoscopy has failed. Taken together, an interdisciplinary approach including gastroenterologists as well as surgeons should be used once the patient is admitted to the hospital to define the best treatment option."],["dc.identifier.doi","10.1007/s00423-017-1552-2"],["dc.identifier.isi","000400365500012"],["dc.identifier.pmid","28091770"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/42673"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.publisher","Springer"],["dc.relation.issn","1435-2451"],["dc.relation.issn","1435-2443"],["dc.title","Relevance of surgery in patients with non-variceal upper gastrointestinal bleeding"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","361"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","Der Gastroenterologe"],["dc.bibliographiccitation.lastpage","365"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Gliem, N."],["dc.contributor.author","Ellenrieder, V."],["dc.date.accessioned","2020-12-10T14:12:00Z"],["dc.date.available","2020-12-10T14:12:00Z"],["dc.date.issued","2018"],["dc.identifier.doi","10.1007/s11377-018-0277-2"],["dc.identifier.eissn","1861-969X"],["dc.identifier.issn","1861-9681"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71271"],["dc.language.iso","de"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Seltene Formen der intestinalen Polyposis"],["dc.title.alternative","Rare forms of intestinal polyposis. Cronkhite–Canada syndrome and other hamartomatous polyposis syndromes"],["dc.title.subtitle","Cronkhite-Canada-Syndrom und andere hamartomatöse Polyposissyndrome"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]