Ellenrieder, V.

[["dc.bibliographiccitation.firstpage","161"],["dc.bibliographiccitation.journal","EBioMedicine"],["dc.bibliographiccitation.lastpage","168"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Ramu, Iswarya"],["dc.contributor.author","Buchholz, Sören M."],["dc.contributor.author","Patzak, Melanie S."],["dc.contributor.author","Goetze, Robert G."],["dc.contributor.author","Singh, Shiv K."],["dc.contributor.author","Richards, Frances M."],["dc.contributor.author","Jodrell, Duncan I."],["dc.contributor.author","Sipos, Bence"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Hessmann, Elisabeth"],["dc.contributor.author","Neesse, Albrecht"],["dc.date.accessioned","2020-12-10T14:23:31Z"],["dc.date.available","2020-12-10T14:23:31Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1016/j.ebiom.2019.09.024"],["dc.identifier.issn","2352-3964"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16852"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/71949"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1978"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Cancers"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Buchholz, Soeren M."],["dc.contributor.author","Goetze, Robert G."],["dc.contributor.author","Singh, Shiv K."],["dc.contributor.author","Ammer-Herrmenau, Christoph"],["dc.contributor.author","Richards, Frances M."],["dc.contributor.author","Jodrell, Duncan I."],["dc.contributor.author","Buchholz, Malte"],["dc.contributor.author","Michl, Patrick"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Hessmann, Elisabeth"],["dc.contributor.author","Neesse, Albrecht"],["dc.date.accessioned","2021-04-14T08:25:07Z"],["dc.date.available","2021-04-14T08:25:07Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.3390/cancers12071978"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17498"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81527"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2072-6694"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Depletion of Macrophages Improves Therapeutic Response to Gemcitabine in Murine Pancreas Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0188876"],["dc.bibliographiccitation.issue","12"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Koenig, Alexander"],["dc.contributor.author","Krug, Sebastian"],["dc.contributor.author","Mueller, Daniela"],["dc.contributor.author","Barth, Peter J."],["dc.contributor.author","Koenig, Ute"],["dc.contributor.author","Scharf, Michael"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Michl, Patrick"],["dc.contributor.author","Moll, Roland"],["dc.contributor.author","Homayunfar, Kia"],["dc.contributor.author","Kann, Peter Herbert"],["dc.contributor.author","Stroebel, Philipp"],["dc.contributor.author","Gress, Thomas M."],["dc.contributor.author","Rinke, Anja"],["dc.contributor.editor","Ahmad, Aamir"],["dc.date.accessioned","2020-12-10T18:42:05Z"],["dc.date.available","2020-12-10T18:42:05Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1371/journal.pone.0188876"],["dc.identifier.eissn","1932-6203"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15672"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77798"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Clinicopathological hallmarks and biomarkers of colorectal neuroendocrine neoplasms"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e66"],["dc.bibliographiccitation.issue","S 01"],["dc.bibliographiccitation.journal","Methods of Information in Medicine"],["dc.bibliographiccitation.lastpage","e81"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Haarbrandt, Birger"],["dc.contributor.author","Schreiweis, Björn"],["dc.contributor.author","Rey, Sabine"],["dc.contributor.author","Sax, Ulrich"],["dc.contributor.author","Scheithauer, Simone"],["dc.contributor.author","Rienhoff, Otto"],["dc.contributor.author","Knaup-Gregori, Petra"],["dc.contributor.author","Bavendiek, Udo"],["dc.contributor.author","Dieterich, Christoph"],["dc.contributor.author","Brors, Benedikt"],["dc.contributor.author","Kraus, Inga"],["dc.contributor.author","Thoms, Caroline"],["dc.contributor.author","Jäger, Dirk"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Bergh, Björn"],["dc.contributor.author","Yahyapour, Ramin"],["dc.contributor.author","Eils, Roland"],["dc.contributor.author","Consortium, HiGHmed"],["dc.contributor.author","Marschollek, Michael"],["dc.date.accessioned","2020-12-10T18:47:27Z"],["dc.date.available","2020-12-10T18:47:27Z"],["dc.date.issued","2018"],["dc.description.abstract","This article is part of the Focus Theme of Methods of Information in Medicine on the German Medical Informatics Initiative. HiGHmed brings together 24 partners from academia and industry, aiming at improvements in care provision, biomedical research and epidemiology. By establishing a shared information governance framework, data integration centers and an open platform architecture in cooperation with independent healthcare providers, the meaningful reuse of data will be facilitated. Complementary, HiGHmed integrates a total of seven Medical Informatics curricula to develop collaborative structures and processes to train medical informatics professionals, physicians and researchers in new forms of data analytics."],["dc.identifier.doi","10.3414/ME18-02-0002"],["dc.identifier.eissn","2511-705X"],["dc.identifier.issn","0026-1270"],["dc.identifier.pmid","30016813"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/15525"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78770"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","2511-705X"],["dc.relation.issn","0026-1270"],["dc.relation.issn","2511-705X"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","HiGHmed – An Open Platform Approach to Enhance Care and Research across Institutional Boundaries"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e0233811"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","PLoS One"],["dc.bibliographiccitation.volume","15"],["dc.contributor.author","Mavropoulou, Eirini"],["dc.contributor.author","Mechie, Nicolae-Catalin"],["dc.contributor.author","Knoop, Richard"],["dc.contributor.author","Petzold, Golo"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Amanzada, Ahmad"],["dc.contributor.editor","Bonaz, Bruno"],["dc.date.accessioned","2021-04-14T08:25:13Z"],["dc.date.available","2021-04-14T08:25:13Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1371/journal.pone.0233811"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17632"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/81557"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1932-6203"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Association of serum interleukin-6 and soluble interleukin-2-receptor levels with disease activity status in patients with inflammatory bowel disease: A prospective observational study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","e0163651"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Rasch, Sebastian"],["dc.contributor.author","Phillip, Veit"],["dc.contributor.author","Reichel, Stephanie"],["dc.contributor.author","Rau, Bettina M."],["dc.contributor.author","Zapf, Christian"],["dc.contributor.author","Rosendahl, Jonas"],["dc.contributor.author","Halms, Ulrich"],["dc.contributor.author","Zachaeus, Markus"],["dc.contributor.author","Mueller, Martin"],["dc.contributor.author","Kleger, Alexander"],["dc.contributor.author","Neesse, Albrecht"],["dc.contributor.author","Hampe, Jochen"],["dc.contributor.author","Ellrichmann, Mark"],["dc.contributor.author","Rueckert, Felix"],["dc.contributor.author","Strauss, Peter"],["dc.contributor.author","Arlt, Alexander"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Gress, Thomas M."],["dc.contributor.author","Hartwig, Werner"],["dc.contributor.author","Klar, Ernst"],["dc.contributor.author","Moessner, Joachim"],["dc.contributor.author","Post, Stephen G."],["dc.contributor.author","Schmid, Roland M."],["dc.contributor.author","Seufferlein, Thomas"],["dc.contributor.author","Siech, Marco"],["dc.contributor.author","Werner, Jens"],["dc.contributor.author","Will, Uwe"],["dc.contributor.author","Alguel, Hana"],["dc.date.accessioned","2018-11-07T10:08:18Z"],["dc.date.available","2018-11-07T10:08:18Z"],["dc.date.issued","2016"],["dc.description.abstract","Background Necrotising pancreatitis, and particularly infected necrosis, are still associated with high morbidity and mortality. Since 2011, a step-up approach with lower morbidity rates compared to initial open necrosectomy has been established. However, mortality and complication rates of this complex treatment are hardly studied thereafter. Methods The German Pancreatitis Study Group performed a multicenter, retrospective study including 220 patients with necrotising pancreatitis requiring intervention, treated at 10 hospitals in Germany between January 2008 and June 2014. Data were analysed for the primary endpoints \"severe complications\" and \"mortality\" as well as secondary endpoints including \"length of hospital stay\", \"follow up\", and predisposing or prognostic factors. Results Of all patients 13.6% were treated primarily with surgery and 86.4% underwent a step-up approach. More men (71.8%) required intervention for necrotising pancreatitis. The most frequent etiology was biliary (41.4%) followed by alcohol (29.1%). Compared to open necrosectomy, the step-up approach was associated with a lower number of severe complications (primary composite endpoint including sepsis, persistent multiorgan dysfunction syndrome (MODS) and erosion bleeding: 44.7% vs. 73.3%), lower mortality (10.5% vs. 33.3%) and lower rates of diabetes mellitus type 3c (4.7% vs. 33.3%). Low hematocrit and low blood urea nitrogen at admission as well as a history of acute pancreatitis were prognostic for less complications in necrotising pancreatitis. A combination of drainage with endoscopic necrosectomy resulted in the lowest rate of severe complications. Conclusion A step-up approach starting with minimal invasive drainage techniques and endoscopic necrosectomy results in a significant reduction of morbidity and mortality in necrotising pancreatitis compared to a primarily surgical intervention."],["dc.identifier.doi","10.1371/journal.pone.0163651"],["dc.identifier.isi","000384167300063"],["dc.identifier.pmid","27668746"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/13762"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39449"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Open Surgical versus Minimal Invasive Necrosectomy of the Pancreas-A Retrospective Multicenter Analysis of the German Pancreatitis Study Group"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Hematology & Oncology"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Solovey, Maria"],["dc.contributor.author","Wang, Ying"],["dc.contributor.author","Michel, Christian"],["dc.contributor.author","Metzeler, Klaus H."],["dc.contributor.author","Herold, Tobias"],["dc.contributor.author","Göthert, Joachim R."],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Hessmann, Elisabeth"],["dc.contributor.author","Gattenlöhner, Stefan"],["dc.contributor.author","Neubauer, Andreas"],["dc.contributor.author","Pavlinic, Dinko"],["dc.contributor.author","Benes, Vladimir"],["dc.contributor.author","Rupp, Oliver"],["dc.contributor.author","Burchert, Andreas"],["dc.date.accessioned","2020-12-10T18:39:03Z"],["dc.date.available","2020-12-10T18:39:03Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1186/s13045-019-0765-y"],["dc.identifier.eissn","1756-8722"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/16533"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77525"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","304"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","BMC Gastroenterology"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Ammer-Herrmenau, C."],["dc.contributor.author","Asendorf, T."],["dc.contributor.author","Beyer, G."],["dc.contributor.author","Buchholz, S. M."],["dc.contributor.author","Cameron, S."],["dc.contributor.author","Damm, M."],["dc.contributor.author","Frost, F."],["dc.contributor.author","Henker, R."],["dc.contributor.author","Jaster, R."],["dc.contributor.author","Phillip, V."],["dc.contributor.author","Placzek, M."],["dc.contributor.author","Ratei, C."],["dc.contributor.author","Sirtl, S."],["dc.contributor.author","van den Berg, T."],["dc.contributor.author","Weingarten, M. J."],["dc.contributor.author","Woitalla, J."],["dc.contributor.author","Mayerle, J."],["dc.contributor.author","Ellenrieder, V."],["dc.contributor.author","Neesse, A."],["dc.date.accessioned","2021-11-25T11:03:17Z"],["dc.date.accessioned","2022-08-18T12:35:27Z"],["dc.date.available","2021-11-25T11:03:17Z"],["dc.date.available","2022-08-18T12:35:27Z"],["dc.date.issued","2021-07-31"],["dc.date.updated","2022-07-29T12:07:19Z"],["dc.description.abstract","Abstract\r\n \r\n Background\r\n Acute pancreatitis (AP) is an inflammatory disorder that causes a considerable economic health burden. While the overall mortality is low, around 20% of patients have a complicated course of disease resulting in increased morbidity and mortality. There is an emerging body of evidence that the microbiome exerts a crucial impact on the pathophysiology and course of AP. For several decades multiple clinical and laboratory parameters have been evaluated, and complex scoring systems were developed to predict the clinical course of AP upon admission. However, the majority of scoring systems are determined after several days and achieve a sensitivity around 70% for early prediction of severe AP. Thus, continued efforts are required to investigate reliable biomarkers for the early prediction of severity in order to guide early clinical management of AP patients.\r\n\r\n \r\n \r\n Methods\r\n We designed a multi-center, prospective clinical-translational study to test whether the orointestinal microbiome may serve as novel early predictor of the course, severity and outcome of patients with AP. We will recruit 400 AP patients and obtain buccal and rectal swabs within 72 h of admission to the hospital. Following DNA extraction, microbiome analysis will be performed using 3rd generation sequencing Oxford Nanopore Technologies (ONT) for 16S rRNA and metagenomic sequencing. Alpha- and beta-diversity will be determined and correlated to the revised Atlanta classification and additional clinical outcome parameters such as the length of hospital stay, number and type of complications, number of interventions and 30-day mortality.\r\n \r\n \r\n Discussion\r\n If AP patients show a distinct orointestinal microbiome dependent on the severity and course of the disease, microbiome sequencing could rapidly be implemented in the early clinical management of AP patients in the future.\r\n Trial registration: ClinicalTrials.gov Identifier: NCT04777812"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.citation","BMC Gastroenterology. 2021 Jul 31;21(1):304"],["dc.identifier.doi","10.1186/s12876-021-01885-4"],["dc.identifier.pii","1885"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/93521"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/112940"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-448"],["dc.publisher","BioMed Central"],["dc.relation.eissn","1471-230X"],["dc.rights","CC BY 4.0"],["dc.rights.holder","The Author(s)"],["dc.subject","Acute pancreatitis"],["dc.subject","Biomarker"],["dc.subject","Orointestinale microbiome"],["dc.subject","Metagenomic sequencing"],["dc.subject","Multicentric"],["dc.subject","Oxford nanopore technologies"],["dc.subject","ONT"],["dc.subject","P-MAPS"],["dc.subject","Prospective"],["dc.subject","Severity"],["dc.subject","NCT04777812"],["dc.title","Study protocol P-MAPS: microbiome as predictor of severity in acute pancreatitis—a prospective multicentre translational study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","e25111"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Medicine"],["dc.bibliographiccitation.volume","100"],["dc.contributor.author","Mechie, Nicolae-Catalin"],["dc.contributor.author","Burmester, Merle"],["dc.contributor.author","Mavropoulou, Eirini"],["dc.contributor.author","Pilavakis, Yiannis"],["dc.contributor.author","Kunsch, Steffen"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Amanzada, Ahmad"],["dc.date.accessioned","2021-06-01T10:47:00Z"],["dc.date.available","2021-06-01T10:47:00Z"],["dc.date.issued","2021"],["dc.description.sponsorship","Open-Access-Publikationsfonds 2021"],["dc.identifier.doi","10.1097/MD.0000000000025111"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17849"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85446"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.notes.intern","Merged from goescholar"],["dc.relation.eissn","1536-5964"],["dc.relation.issn","0025-7974"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Evaluation of ustekinumab trough levels during induction and maintenance therapy with regard to disease activity status in difficult to treat Crohn disease patients"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","58"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Cells"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Hasselluhn, Marie C."],["dc.contributor.author","Klein, Lukas"],["dc.contributor.author","Patzak, Melanie S."],["dc.contributor.author","Buchholz, Sören M."],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Ellenrieder, Volker"],["dc.contributor.author","Maisonneuve, Patrick"],["dc.contributor.author","Neesse, Albrecht"],["dc.date.accessioned","2021-04-14T08:27:45Z"],["dc.date.available","2021-04-14T08:27:45Z"],["dc.date.issued","2019-12-24"],["dc.description.sponsorship","Deutsche Krebshilfe"],["dc.identifier.doi","10.3390/cells9010058"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/82390"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-399"],["dc.publisher","MDPI"],["dc.relation.eissn","2073-4409"],["dc.rights","https://creativecommons.org/licenses/by/4.0/"],["dc.title","Stromal Features of the Primary Tumor Are Not Prognostic in Genetically Engineered Mice of Pancreatic Cancer"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]