Heinrich, Ralf

[["dc.bibliographiccitation.artnumber","e25613"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","PLoS ONE"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Kunst, Michael"],["dc.contributor.author","Pfoertner, Ramona"],["dc.contributor.author","Aschenbrenner, Katja"],["dc.contributor.author","Heinrich, Ralf"],["dc.date.accessioned","2018-11-07T08:51:38Z"],["dc.date.available","2018-11-07T08:51:38Z"],["dc.date.issued","2011"],["dc.description.abstract","The central complex selects and coordinates the species-and situation-specific song production in acoustically communicating grasshoppers. Control of sound production is mediated by several neurotransmitters and modulators, their receptors and intracellular signaling pathways. It has previously been shown that muscarinic cholinergic excitation in the central complex promotes sound production whereas both GABA and nitric oxide/cyclic GMP signaling suppress its performance. The present immunocytochemical and pharmacological study investigates the question whether GABA and nitric oxide mediate inhibition of sound production independently. Muscarinic ACh receptors are expressed by columnar output neurons of the central complex that innervate the lower division of the central body and terminate in the lateral accessory lobes. GABAergic tangential neurons that innervate the lower division of the central body arborize in close proximity of columnar neurons and thus may directly inhibit these central complex output neurons. A subset of these GABAergic tangential neurons accumulates cyclic GMP following the release of nitric oxide from neurites in the upper division of the central body. While sound production stimulated by muscarine injection into the central complex is suppressed by co-application of sodium nitroprusside, picrotoxin-stimulated singing was not affected by co-application of this nitric oxide donor, indicating that nitric oxide mediated inhibition requires functional GABA signaling. Hence, grasshopper sound production is controlled by processing of information in the lower division of the central body which is subject to modulation by nitric oxide released from neurons in the upper division."],["dc.identifier.doi","10.1371/journal.pone.0025613"],["dc.identifier.isi","000295936900081"],["dc.identifier.pmid","21980504"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/8338"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21982"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Public Library Science"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.5"],["dc.title","Neurochemical Architecture of the Central Complex Related to Its Function in the Control of Grasshopper Acoustic Communication"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","763"],["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY"],["dc.bibliographiccitation.lastpage","776"],["dc.bibliographiccitation.volume","194"],["dc.contributor.author","Weinrich, Anja"],["dc.contributor.author","Kunst, Michael"],["dc.contributor.author","Wirmer, Andrea"],["dc.contributor.author","Holstein, Gay R."],["dc.contributor.author","Heinrich, Ralf"],["dc.date.accessioned","2018-11-07T11:12:31Z"],["dc.date.available","2018-11-07T11:12:31Z"],["dc.date.issued","2008"],["dc.description.abstract","The central complex of acridid grasshoppers integrates sensory information pertinent to reproduction-related acoustic communication. Activation of nitric oxide (NO)/cyclic GMP-signaling by injection of NO donors into the central complex of restrained Chorthippus biguttulus females suppresses muscarine-stimulated sound production. In contrast, sound production is released by aminoguanidine (AG)-mediated inhibition of nitric oxide synthase (NOS) in the central body, suggesting a basal release of NO that suppresses singing in this situation. Using anti-citrulline immunocytochemistry to detect recent NO production, subtypes of columnar neurons with somata located in the pars intercerebralis and tangential neurons with somata in the ventro-median protocerebrum were distinctly labeled. Their arborizations in the central body upper division overlap with expression patterns for NOS and with the site of injection where NO donors suppress sound production. Systemic application of AG increases the responsiveness of unrestrained females to male calling songs. Identical treatment with the NOS inhibitor that increased male song-stimulated sound production in females induced a marked reduction of citrulline accumulation in central complex columnar and tangential neurons. We conclude that behavioral situations that are unfavorable for sound production (like being restrained) activate NOS-expressing central body neurons to release NO and elevate the behavioral threshold for sound production in female grasshoppers."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft [HE 3301/2]"],["dc.identifier.doi","10.1007/s00359-008-0347-x"],["dc.identifier.isi","000258655900007"],["dc.identifier.pmid","18574586"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?goescholar/3512"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53685"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.issn","0340-7594"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Suppression of grasshopper sound production by nitric oxide-releasing neurons of the central complex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","UNSP 89"],["dc.bibliographiccitation.journal","Frontiers in Neuroscience"],["dc.bibliographiccitation.volume","6"],["dc.contributor.affiliation","Heinrich, Ralf; 1Department of Cellular Neurobiology, Institute for Zoology and Anthropology, University of Göttingen Göttingen, Germany"],["dc.contributor.affiliation","Kunst, Michael; 2Department of Cellular and Molecular Physiology, Yale School of Medicine New Haven, CT, USA"],["dc.contributor.affiliation","Wirmer, Andrea; 3Institute for Neurobiology, University of Ulm Ulm, Germany"],["dc.contributor.author","Heinrich, Ralf"],["dc.contributor.author","Kunst, Michael"],["dc.contributor.author","Wirmer, Andrea"],["dc.date.accessioned","2018-11-07T09:16:16Z"],["dc.date.available","2018-11-07T09:16:16Z"],["dc.date.issued","2012"],["dc.date.updated","2022-02-09T13:23:03Z"],["dc.description.abstract","The interplay of neural and hormonal mechanisms activated by entero- and extero-receptors biases the selection of actions by decision making neuronal circuits. The reproductive behavior of acoustically communicating grasshoppers, which is regulated by short-term neural and longer-term hormonal mechanisms, has frequently been used to study the cellular and physiological processes that select particular actions from the species-specific repertoire of behaviors. Various grasshoppers communicate with species- and situation-specific songs in order to attract and court mating partners, to signal reproductive readiness, or to fend off competitors. Selection and coordination of type, intensity, and timing of sound signals is mediated by the central complex, a highly structured brain neuropil known to integrate multimodal pre-processed sensory information by a large number of chemical messengers. In addition, reproductive activity including sound production critically depends on maturation, previous mating experience, and oviposition cycles. In this regard, juvenile hormone released from the corpora allata has been identified as a decisive hormonal signal necessary to establish reproductive motivation in grasshopper females. Both regulatory systems, the central complex mediating short-term regulation and the corpora allata mediating longer-term regulation of reproduction-related sound production mutually influence each other's activity in order to generate a coherent state of excitation that promotes or suppresses reproductive behavior in respective appropriate or inappropriate situations. This review summarizes our current knowledge about extrinsic and intrinsic factors that influence grasshopper reproductive motivation, their representation in the nervous system and their integrative processing that mediates the initiation or suppression of reproductive behaviors."],["dc.identifier.doi","10.3389/fnins.2012.00089"],["dc.identifier.eissn","1662-4548"],["dc.identifier.isi","000209165300098"],["dc.identifier.pmid","22737107"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/9776"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27897"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Frontiers Research Foundation"],["dc.relation.eissn","1662-4548"],["dc.relation.issn","1662-453X"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Reproduction-related sound production of grasshoppers regulated by internal state and actual sensory environment"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]