Trautmann, Sandra

[["dc.bibliographiccitation.firstpage","440"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Immunology"],["dc.bibliographiccitation.lastpage","445"],["dc.bibliographiccitation.volume","46"],["dc.contributor.author","Schminke, Boris"],["dc.contributor.author","Trautmann, Sandra"],["dc.contributor.author","Mai, Burkhard"],["dc.contributor.author","Miosge, Nicolai"],["dc.contributor.author","Blaschke, Sabine"],["dc.date.accessioned","2018-08-20T12:24:05Z"],["dc.date.available","2018-08-20T12:24:05Z"],["dc.date.issued","2016"],["dc.description.abstract","Mesenchymal stem cells are known to exert immunomodulatory effects in inflammatory diseases. Immuneregulatory cells lead to progressive joint destruction in rheumatoid arthritis (RA). Proinflammatory cytokines, such as tumour necrosis factor α (TNF-α) and interleukins (ILs) are the main players. Here, we studied progenitor cells from RA cartilage (RA-CPCs) that are positive for IL-17 receptors to determinate the effects of inflammation on their chondrogenic potenial. IL-17A/F reduced the chondrogenic potential of these cells via the upregulation of RUNX2 protein and enhanced IL-6 protein and MMP3 mRNA levels. Blocking antibodies against IL-17 positively influenced their repair potential. Furthermore, treating the RA-CPCs with the anti-human IL-17 antibody secukinumab or the anti-TNF-α antibody adalimumab reduced the proinflammatory IL-6 protein level and positively influenced the secretion of anti-inflammatory IL-10 protein. Additionally, adalimumab and secukinumab in particular reduced RUNX2 protein to promote chondrogenesis. The amelioration of inflammation, particularly via IL-17 antagonism, might be a new therapeutic approach for enhancing intrinsic cartilage repair mechanisms in RA patients."],["dc.identifier.doi","10.1002/eji.201545910"],["dc.identifier.pmid","26558442"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14042"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/15432"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","final"],["dc.relation.eissn","1521-4141"],["dc.relation.eissn","0014-2980"],["dc.rights","CC BY-NC-ND 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc-nd/4.0"],["dc.title","Interleukin 17 inhibits progenitor cells in rheumatoid arthritis cartilage"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]