Dominguez-Vargas, Adan-Ulises

[["dc.bibliographiccitation.firstpage","367"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Journal of Neurophysiology"],["dc.bibliographiccitation.lastpage","391"],["dc.bibliographiccitation.volume","123"],["dc.contributor.author","Schneider, Lukas"],["dc.contributor.author","Dominguez-Vargas, Adan-Ulises"],["dc.contributor.author","Gibson, Lydia"],["dc.contributor.author","Kagan, Igor"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2020-12-10T18:37:39Z"],["dc.date.available","2020-12-10T18:37:39Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1152/jn.00432.2019"],["dc.identifier.eissn","1522-1598"],["dc.identifier.issn","0022-3077"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77054"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Eye position signals in the dorsal pulvinar during fixation and goal-directed saccades"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.contributor.author","Schneider, Lukas"],["dc.contributor.author","Dominguez-Vargas, Adan-Ulises"],["dc.contributor.author","Gibson, Lydia"],["dc.contributor.author","Kagan, Igor"],["dc.contributor.author","Wilke, Melanie"],["dc.date.accessioned","2019-07-30T07:42:00Z"],["dc.date.available","2019-07-30T07:42:00Z"],["dc.date.issued","2019"],["dc.description.abstract","Most sensorimotor cortical areas contain eye position information thought to ensure perceptual stability across saccades and underlie spatial transformations supporting goal-directed actions. One pathway by which eye position signals could be relayed to and across cortical areas is via the dorsal pulvinar. Several studies demonstrated saccade-related activity in the dorsal pulvinar and we have recently shown that many neurons exhibit post-saccadic spatial preference long after the saccade execution. In addition, dorsal pulvinar lesions lead to gaze-holding deficits expressed as nystagmus or ipsilesional gaze bias, prompting us to investigate the effects of eye position. We tested three starting eye positions (-15°/0°/15°) in monkeys performing a visually-cued memory saccade task. We found two main types of gaze dependence. First, ~50% of neurons showed an effect of static gaze direction during initial and post-saccadic fixation. Eccentric gaze preference was more common than straight ahead. Some of these neurons were not visually-responsive and might be primarily signaling the position of the eyes in the orbit, or coding foveal targets in a head/body/world-centered reference frame. Second, many neurons showed a combination of eye-centered and gaze-dependent modulation of visual, memory and saccadic responses to a peripheral target. A small subset showed effects consistent with eye position-dependent gain modulation. Analysis of reference frames across task epochs from visual cue to post-saccadic target fixation indicated a transition from predominantly eye-centered encoding to representation of final gaze or foveated locations in non-retinocentric coordinates. These results show that dorsal pulvinar neurons carry information about eye position, which could contribute to steady gaze during postural changes and to reference frame transformations for visually-guided eye and limb movements."],["dc.identifier.doi","10.1101/681130"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/62175"],["dc.language.iso","en"],["dc.title","Eye position signals in the dorsal pulvinar during fixation and goal-directed saccades"],["dc.type","preprint"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]