Now showing 1 - 5 of 5
  • 2012Journal Article
    [["dc.bibliographiccitation.firstpage","6363"],["dc.bibliographiccitation.issue","31"],["dc.bibliographiccitation.journal","Organic & Biomolecular Chemistry"],["dc.bibliographiccitation.lastpage","6374"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","de Meijere, Armin"],["dc.contributor.author","Korotkov, Vadim S."],["dc.contributor.author","Lygin, Alexander V."],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","Sokolov, Viktor V."],["dc.contributor.author","Graef, Tine"],["dc.contributor.author","Es-Sayed, Mazen"],["dc.date.accessioned","2018-11-07T09:15:11Z"],["dc.date.available","2018-11-07T09:15:11Z"],["dc.date.issued","2012"],["dc.description.abstract","Successful biochemical studies of the natural products belactosin A and C and their acylated congeners have shown a beta-lactonecarboxamide moiety to be a possible core structure of powerful proteasome inhibitors. As a part of further investigations, variously decorated simplified beta-lactonecarboxamides have been synthesized in order to understand structure-biological activity relations in detail, to find ways of improving their biological activity and stability and to reduce the complexity of their preparation. Biological tests showed that the best compounds possess a high potential against phytopathogenic fungi in the greenhouse."],["dc.identifier.doi","10.1039/c2ob25586c"],["dc.identifier.isi","000306480100015"],["dc.identifier.pmid","22735304"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10202"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/27613"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","1477-0520"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Synthesis and biological activity of simplified belactosin C analogues"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2003Journal Article
    [["dc.bibliographiccitation.firstpage","67"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of the Serbian Chemical Society"],["dc.bibliographiccitation.lastpage","76"],["dc.bibliographiccitation.volume","68"],["dc.contributor.author","Valenti´c, Nataésa V."],["dc.contributor.author","Vitnik, éZeljko"],["dc.contributor.author","Kozhushkov, Sergei I."],["dc.contributor.author","Meijere, Armin de"],["dc.contributor.author","Ués´cumli´c, Gordana S."],["dc.contributor.author","Juranic, Ivan O."],["dc.date.accessioned","2019-07-10T08:13:05Z"],["dc.date.available","2019-07-10T08:13:05Z"],["dc.date.issued","2003"],["dc.description.abstract","The principles of linear free energy relationships were applied to the 13C substituent chemical shifts (SCS) of the carbon atoms in the unsaturated chain of 3-methylene-4-substituted-1,4-pentadienes. Correlations of the SCS with the substituent parameters of Swain and Lupton provide a mutually consistent picture of the electronic effects in these compounds. The pattern of the electronic effects can be fully rationalized by a model based on the direct transmission of substituent effects through-space (direct through-space field effects), and via conjugative interactions (resonance effects), or by substituent-induced polarization of the p-system in the unsaturated chain (p-polarization effect). Semi-empirical MNDO-PM3 calculations suggest the s-cis conformation of 3-methylene-4-substituted-1,4- -pentadienes as the one with minimal heat of formation. Keywords: [3]dendralenes ; unsaturated chain carbon 13C SCS ; substituent effects ; reverse 13C SCS effect ; MNDO-PM3 calculations"],["dc.format.mimetype","application/pdf"],["dc.identifier.ppn","571579841"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4443"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/61119"],["dc.language.iso","en"],["dc.notes.intern","Migrated from goescholar"],["dc.relation.issn","0352-5139"],["dc.rights","Goescholar"],["dc.rights.access","openAccess"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.subject.ddc","547"],["dc.title","Effect of substituents on the 13C-NMR chemical shifts of 3-methylene-4-substituted-1,4-pentadienes. Part I."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2011Journal Article
    [["dc.bibliographiccitation.firstpage","7791"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Organic & Biomolecular Chemistry"],["dc.bibliographiccitation.lastpage","7798"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Korotkov, Vadim S."],["dc.contributor.author","Ludwig, Antje"],["dc.contributor.author","Larionov, Oleg V."],["dc.contributor.author","Lygin, Alexander V."],["dc.contributor.author","Groll, Michael"],["dc.contributor.author","de Meijere, Armin"],["dc.date.accessioned","2018-11-07T09:01:51Z"],["dc.date.available","2018-11-07T09:01:51Z"],["dc.date.issued","2011"],["dc.description.abstract","Successful biochemical studies of the natural products belactosin A and C as well as their more stable acylated derivatives have proved them to be powerful proteasome inhibitors and thereby potential candidates as pharmacologically relevant active compounds. In order to understand their structure-biological activity relations in detail and to findways of improving their biological activity, four new modified belactosin congeners have been synthesized and tested. One of them (compound 6) turned out to be a more potent inhibitor against HeLa cells than the known proteasome inhibitor MG132."],["dc.description.sponsorship","Degussa Foundation (Evonik Industries AG)"],["dc.identifier.doi","10.1039/c1ob05661a"],["dc.identifier.isi","000296203700029"],["dc.identifier.pmid","21946808"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10465"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24529"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Royal Soc Chemistry"],["dc.relation.issn","1477-0520"],["dc.rights","Goescholar"],["dc.rights.uri","https://goescholar.uni-goettingen.de/licenses"],["dc.title","Synthesis and biological activity of optimized belactosin C congeners"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2017Journal Article
    [["dc.bibliographiccitation.firstpage","1932"],["dc.bibliographiccitation.journal","Beilstein Journal of Organic Chemistry"],["dc.bibliographiccitation.lastpage","1939"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Rassadin, Valentin A"],["dc.contributor.author","Scholz, Mirko"],["dc.contributor.author","Klochkova, Anastasiia A"],["dc.contributor.author","de Meijere, Armin"],["dc.contributor.author","Sokolov, Victor V"],["dc.date.accessioned","2020-12-10T18:47:28Z"],["dc.date.available","2020-12-10T18:47:28Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.3762/bjoc.13.187"],["dc.identifier.eissn","1860-5397"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/17019"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/78775"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.notes.intern","Merged from goescholar"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Synthesis of benzannelated sultams by intramolecular Pd-catalyzed arylation of tertiary sulfonamides"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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  • 2014Journal Article
    [["dc.bibliographiccitation.firstpage","2844"],["dc.bibliographiccitation.journal","Beilstein Journal of Organic Chemistry"],["dc.bibliographiccitation.lastpage","2857"],["dc.bibliographiccitation.volume","10"],["dc.contributor.author","de Meijere, Armin"],["dc.contributor.author","Kozhushkov, Sergei I."],["dc.contributor.author","Yufit, Dmitry S."],["dc.contributor.author","Grosse, Christian"],["dc.contributor.author","Kaiser, Marcel"],["dc.contributor.author","Raev, Vitaly A."],["dc.date.accessioned","2018-11-07T09:31:31Z"],["dc.date.available","2018-11-07T09:31:31Z"],["dc.date.issued","2014"],["dc.description.abstract","Efficient and scalable syntheses of enantiomerically pure (2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-mono(di,tri)fluoromethylcyclopropyl]alanines 9a-c, as well as allo-D-threonine (4) and (2S,3R)-beta-methylphenylalanine (3), using the Belokon' approach with (S)- and (R)-2-[(N-benzylprolyl)amino]benzophenone [(S)- and (R)-10] as reusable chiral auxiliaries have been developed. Three new fluoromethyl analogues of the naturally occurring octadepsipeptide hormaomycin (1) with (fluoromethylcyclopropyl)alanine moieties have been synthesized and subjected to preliminary tests of their antibiotic activity."],["dc.description.sponsorship","Land Niedersachsen"],["dc.identifier.doi","10.3762/bjoc.10.302"],["dc.identifier.isi","000346467000001"],["dc.identifier.pmid","25550751"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/11913"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/31547"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Beilstein-institut"],["dc.relation.issn","1860-5397"],["dc.rights","CC BY 2.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/2.0"],["dc.title","(2R,1 ' S,2 ' R)- and (2S,1 ' S,2 ' R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]
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