Krinsky, Valentin I.

[["dc.bibliographiccitation.firstpage","279"],["dc.bibliographiccitation.lastpage","294"],["dc.bibliographiccitation.seriesnr","20"],["dc.contributor.author","Krinsky, Valentin I."],["dc.contributor.author","Biktashev, Vadim N."],["dc.contributor.author","Otani, Niels F."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.editor","Aranson, Igor S."],["dc.contributor.editor","Pikovsky, Arkady"],["dc.contributor.editor","Rulkov, Nikolai F."],["dc.contributor.editor","Tsimring, Lev S."],["dc.date.accessioned","2019-02-05T14:12:54Z"],["dc.date.available","2019-02-05T14:12:54Z"],["dc.date.issued","2017"],["dc.description.abstract","Methods for termination of three-dimensional electrical vortices in the heart are needed for development of patient-friendly cardiac defibrillation techniques (Nature 475, 235, 2011). The defibrillation technique used today is the delivery of a high-energy electric shock (360 J, 1 kV, 30 A, 12 ms, when applied externally) often associated with severe side effects. Developing low-energy defibrillation methods are hampered by two problems: the unknown locations of the cores of the vortices, and the unpredictable phases of the vortex waves rotating around these cores. The first problem has been resolved through the use of electric field pulses to excite the cores of all pinned vortices simultaneously. Approaches to solve the second problem are being developed. One of them is based on the phase scanning of all pinned vortices in parallel to hit the critical time window (“Vulnerable Window”, VW) of every pinned vortex. We investigate the related physical mechanisms and describe problems created by scanning. We describe also a mechanism by which a 3-dim scroll vortex may be terminated with a VW of the full 2π radians. It makes knowledge of the wave phase no longer required. We describe a mechanism terminating also a free (not pinned) vortex, when the vortex’s core passes not very far from a defect. About 500 experiments with termination of vortices during ventricular fibrillation in pig isolated hearts confirm that pinned vortices, hidden from direct observation, are significant in fibrillation. These results form a physical basis needed for creation of new effective methods for termination vortices underlying fibrillation."],["dc.identifier.doi","10.1007/978-3-319-53673-6_17"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57522"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/166"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.publisher","Springer"],["dc.publisher.place","Cham, Switzerland"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | A02: Bedeutung des Phosphatase-Inhibitors-1 für die SR-spezifische Modulation der Beta- adrenozeptor-Signalkaskade"],["dc.relation","SFB 1002 | A03: Bedeutung CaMKII-abhängiger Mechanismen für die Arrhythmogenese bei Herzinsuffizienz"],["dc.relation.crisseries","Nonlinear Systems and Complexity"],["dc.relation.doi","10.1007/978-3-319-53673-6"],["dc.relation.isbn","978-3-319-53672-9"],["dc.relation.isbn","978-3-319-53673-6"],["dc.relation.ispartof","Advances in Dynamics, Patterns, Cognition. Challenges in Complexity"],["dc.relation.ispartofseries","Nonlinear Systems and Complexity; 20"],["dc.relation.issn","2195-9994"],["dc.relation.issn","2196-0003"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Vortices Termination in the Cardiac Muscle"],["dc.type","book_chapter"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","467"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.lastpage","476"],["dc.bibliographiccitation.volume","120"],["dc.contributor.author","Fenton, Flavio H."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Cherry, Elizabeth M."],["dc.contributor.author","Otani, Niels F."],["dc.contributor.author","Krinsky, Valentin"],["dc.contributor.author","Pumir, Alain"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Gilmour, Robert F."],["dc.date.accessioned","2022-03-01T11:43:52Z"],["dc.date.available","2022-03-01T11:43:52Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1161/CIRCULATIONAHA.108.825091"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/102862"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1524-4539"],["dc.relation.issn","0009-7322"],["dc.title","Termination of Atrial Fibrillation Using Pulsed Low-Energy Far-Field Stimulation"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1077"],["dc.bibliographiccitation.journal","Computing in Cardiology 2016"],["dc.bibliographiccitation.lastpage","1080"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Han, Shuyue"],["dc.contributor.author","Otani, Niels F."],["dc.contributor.author","Krinski, Valentin"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2019-02-05T11:01:00Z"],["dc.date.available","2019-02-05T11:01:00Z"],["dc.date.issued","2016"],["dc.description.abstract","Introduction. Recently, there has been a major effort to develop new, low-energy defibrillation methods that would be less damaging and less traumatic for the patient, and would save battery energy. However, these methods have not been entirely successful, due in part to an incomplete understanding of all the mechanisms present that may help or hinder the process of terminating the rotating waves present during fibrillation. Here we describe new mechanisms whereby a far-field electric field pulse terminates unpinned waves that are rotating in the vicinity of a blood vessel, plaque deposit or other heterogeneity in the gap junction conductivity. Methods. We ran a series of two-dimensional computer simulations of a spiral wave rotating in the vicinity of a non-conducting obstacle. Application of a low-energy electric field pulse caused a semicircular action potential wave to be launched from the heterogeneity which then interacted with the rotating wave. Results and Conclusions: We found, that, when this interaction is combined with, importantly, the presence of nearby non-conductive boundaries, termination of the rotating waves can occur via a number of new mechanisms, overa wide range of timings of the electric field pulse, and for a number of different initial locations of the rotating wave. The mechanisms only require the rotating wave to be nearby, but not necessarily pinned to the heterogeneity, and thus extends the effectiveness of the electric field pulses used in low-energy defibrillation. Consideration of these mechanisms together with those already discovered could result in the development of improved, low-energy defibrillation protocols."],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57521"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/258"],["dc.language.iso","en"],["dc.notes.status","fcwi"],["dc.publisher","Computing in Cardiology"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.conference","Computing in Cardiology 2016"],["dc.relation.eventend","2016-09-14"],["dc.relation.eventlocation","Vancouver, Canada"],["dc.relation.eventstart","2016-09-11"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","A New Defibrillation Mechanism: Termination of Reentrant Waves by Propagating Action Potentials Induced by Nearby Heterogeneities"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","068102"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Physical Review Letters"],["dc.bibliographiccitation.volume","123"],["dc.contributor.author","Otani, Niels F."],["dc.contributor.author","Wheeler, Kayleigh"],["dc.contributor.author","Krinsky, Valentin"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2022-03-01T11:47:01Z"],["dc.date.available","2022-03-01T11:47:01Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1103/PhysRevLett.123.068102"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103882"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation.eissn","1079-7114"],["dc.relation.issn","0031-9007"],["dc.rights.uri","https://link.aps.org/licenses/aps-default-license"],["dc.title","Termination of Scroll Waves by Surface Impacts"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]