Krinsky, Valentin I.

[["dc.bibliographiccitation.firstpage","20190420"],["dc.bibliographiccitation.issue","2230"],["dc.bibliographiccitation.journal","Proceedings of the Royal Society of London. Series A, Mathematical, Physical and Engineering Sciences"],["dc.bibliographiccitation.volume","475"],["dc.contributor.author","Punacha, Shreyas"],["dc.contributor.author","Berg, Sebastian"],["dc.contributor.author","Sebastian, Anupama"],["dc.contributor.author","Krinski, Valentin I."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Shajahan, T. K."],["dc.date.accessioned","2022-03-01T11:46:52Z"],["dc.date.available","2022-03-01T11:46:52Z"],["dc.date.issued","2019"],["dc.description.abstract","Rotating spiral waves of electrical activity in the heart can anchor to unexcitable tissue (an obstacle) and become stable pinned waves. A pinned rotating wave can be unpinned either by a local electrical stimulus applied close to the spiral core, or by an electric field pulse that excites the core of a pinned wave independently of its localization. The wave will be unpinned only when the pulse is delivered inside a narrow time interval called the unpinning window (UW) of the spiral. In experiments with cardiac monolayers, we found that other obstacles situated near the pinning centre of the spiral can facilitate unpinning. In numerical simulations, we found increasing or decreasing of the UW depending on the location, orientation and distance between the pinning centre and an obstacle. Our study indicates that multiple obstacles could contribute to unpinning in experiments with intact hearts."],["dc.description.abstract","Rotating spiral waves of electrical activity in the heart can anchor to unexcitable tissue (an obstacle) and become stable pinned waves. A pinned rotating wave can be unpinned either by a local electrical stimulus applied close to the spiral core, or by an electric field pulse that excites the core of a pinned wave independently of its localization. The wave will be unpinned only when the pulse is delivered inside a narrow time interval called the unpinning window (UW) of the spiral. In experiments with cardiac monolayers, we found that other obstacles situated near the pinning centre of the spiral can facilitate unpinning. In numerical simulations, we found increasing or decreasing of the UW depending on the location, orientation and distance between the pinning centre and an obstacle. Our study indicates that multiple obstacles could contribute to unpinning in experiments with intact hearts."],["dc.identifier.doi","10.1098/rspa.2019.0420"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103830"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/314"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.eissn","1471-2946"],["dc.relation.issn","1364-5021"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights.uri","https://royalsociety.org/journals/ethics-policies/data-sharing-mining/"],["dc.title","Spiral wave unpinning facilitated by wave emitting sites in cardiac monolayers"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","151"],["dc.bibliographiccitation.lastpage","152"],["dc.contributor.author","Shajahan, T. K."],["dc.contributor.author","Krinski, Valentin I."],["dc.contributor.author","Knyazeva, Svetlana"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2019-02-26T15:19:38Z"],["dc.date.available","2019-02-26T15:19:38Z"],["dc.date.issued","2014"],["dc.description.abstract","Fibrillation in the heart often consists of multiple spiral waves of electrical activation in cardiac tissue. To terminate these multiple waves, recently proposed Low Energy Antifibrillation Pacing (LEAP) uses a series of low energy pulses. This achieves an energy reduction of about 80% in animal experiments. To understand the mechanism of LEAP we study the interaction of electric pulses with pinned spiral waves in monolayers of cardiac cells. Optical mapping and controlled placing of heterogeneities allow us to observe the activation dynamics in these monolayers during field pulsing. We show that a pinned wave can be terminated by a series of pulses when one of the pulses falls in the vulnerable window of the pinned spiral."],["dc.identifier.doi","10.1109/ESGCO.2014.6847564"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57624"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/55"],["dc.language.iso","en"],["dc.notes.status","fcwi"],["dc.publisher","IEEE"],["dc.publisher.place","Piscataway, NJ"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.conference","8th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)"],["dc.relation.eventend","2014-05-28"],["dc.relation.eventlocation","Trento, Italy"],["dc.relation.eventstart","2014-05-25"],["dc.relation.isbn","978-1-4799-3970-1"],["dc.relation.isbn","978-1-4799-3969-5"],["dc.relation.isbn","978-1-4799-3968-8"],["dc.relation.ispartof","2014 8th Conference of the European Study Group on Cardiovascoular Oscillations (ESGCO 2014)"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Eliminating Pinned Spiral Waves in Cardiac Monolayer by Far Field Pacing"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]