Krinsky, Valentin I.

[["dc.bibliographiccitation.artnumber","170024"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Royal Society Open Science"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","Biktashev, V. N."],["dc.contributor.author","Otani, N. F."],["dc.contributor.author","Shajahan, T. K."],["dc.contributor.author","Baig, T."],["dc.contributor.author","Berg, S."],["dc.contributor.author","Han, Sang Who"],["dc.contributor.author","Krinsky, V. I."],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2018-11-07T10:26:28Z"],["dc.date.available","2018-11-07T10:26:28Z"],["dc.date.issued","2017"],["dc.description.abstract","We propose a solution to a long-standing problem: how to terminate multiple vortices in the heart, when the locations of their cores and their critical time windows are unknown. We scan the phases of all pinned vortices in parallel with electric field pulses (E-pulses). We specify a condition on pacing parameters that guarantees termination of one vortex. For more than one vortex with significantly different frequencies, the success of scanning depends on chance, and all vortices are terminated with a success rate of less than one. We found that a similar mechanism terminates also a free (not pinned) vortex. A series of about 500 experiments with termination of ventricular fibrillation by E-pulses in pig isolated hearts is evidence that pinned vortices, hidden from direct observation, are significant in fibrillation. These results form a physical basis needed for the creation of new effective low energy defibrillation methods based on the termination of vortices underlying fibrillation."],["dc.identifier.doi","10.1098/rsos.170024"],["dc.identifier.isi","000398107700049"],["dc.identifier.pmid","28405398"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14953"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43052"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/167"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/241526/EU//EUTRIGTREAT"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","2054-5703"],["dc.relation.orgunit","Fakultät für Physik"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights","CC BY 4.0"],["dc.title","Mechanisms of vortices termination in the cardiac muscle"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","043012"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.lastpage","7"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Shajahan, T. K."],["dc.contributor.author","Berg, Sebastian"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Krinski, Valentin"],["dc.contributor.author","Bittihn, Philip"],["dc.date.accessioned","2019-02-27T14:16:19Z"],["dc.date.available","2019-02-27T14:16:19Z"],["dc.date.issued","2016"],["dc.description.abstract","Spiral waves in cardiac tissue can pin to tissue heterogeneities and form stable pinned waves. These waves can be unpinned by electric stimuli applied close to the pinning center during the vulnerable window of the spiral. Using a phase transition curve (PTC), we quantify the response of a pinned wave in a cardiac monolayer to secondary excitations generated electric field pulses. The PTC can be used to construct a one-dimensional map that faithfully predicts the pinned wave’s response to periodic field stimuli. Based on this 1D map, we predict that pacing at a frequency greater than the spiral frequency, over drive pacing, leads to phase locking of the spiral to the stimulus, which hinders unpinning. In contrast, under drive pacing can lead to scanning of the phase window of the spiral, which facilitates unpinning. The predicted mechanisms of phase scanning and phase locking are experimentally tested and confirmed in the same monolayers that were used to obtain the PTC. Our results have the potential to help choose optimal parameters for low energy antifibrillation pacing schemes."],["dc.identifier.doi","10.1088/1367-2630/18/4/043012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57648"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/168"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","1367-2630"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights","CC BY 3.0"],["dc.title","Scanning and resetting the phase of a pinned spiral wave using periodic far field pulses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","20190420"],["dc.bibliographiccitation.issue","2230"],["dc.bibliographiccitation.journal","Proceedings of the Royal Society of London. Series A, Mathematical, Physical and Engineering Sciences"],["dc.bibliographiccitation.volume","475"],["dc.contributor.author","Punacha, Shreyas"],["dc.contributor.author","Berg, Sebastian"],["dc.contributor.author","Sebastian, Anupama"],["dc.contributor.author","Krinski, Valentin I."],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Shajahan, T. K."],["dc.date.accessioned","2022-03-01T11:46:52Z"],["dc.date.available","2022-03-01T11:46:52Z"],["dc.date.issued","2019"],["dc.description.abstract","Rotating spiral waves of electrical activity in the heart can anchor to unexcitable tissue (an obstacle) and become stable pinned waves. A pinned rotating wave can be unpinned either by a local electrical stimulus applied close to the spiral core, or by an electric field pulse that excites the core of a pinned wave independently of its localization. The wave will be unpinned only when the pulse is delivered inside a narrow time interval called the unpinning window (UW) of the spiral. In experiments with cardiac monolayers, we found that other obstacles situated near the pinning centre of the spiral can facilitate unpinning. In numerical simulations, we found increasing or decreasing of the UW depending on the location, orientation and distance between the pinning centre and an obstacle. Our study indicates that multiple obstacles could contribute to unpinning in experiments with intact hearts."],["dc.description.abstract","Rotating spiral waves of electrical activity in the heart can anchor to unexcitable tissue (an obstacle) and become stable pinned waves. A pinned rotating wave can be unpinned either by a local electrical stimulus applied close to the spiral core, or by an electric field pulse that excites the core of a pinned wave independently of its localization. The wave will be unpinned only when the pulse is delivered inside a narrow time interval called the unpinning window (UW) of the spiral. In experiments with cardiac monolayers, we found that other obstacles situated near the pinning centre of the spiral can facilitate unpinning. In numerical simulations, we found increasing or decreasing of the UW depending on the location, orientation and distance between the pinning centre and an obstacle. Our study indicates that multiple obstacles could contribute to unpinning in experiments with intact hearts."],["dc.identifier.doi","10.1098/rspa.2019.0420"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/103830"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/314"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-531"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.eissn","1471-2946"],["dc.relation.issn","1364-5021"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights.uri","https://royalsociety.org/journals/ethics-policies/data-sharing-mining/"],["dc.title","Spiral wave unpinning facilitated by wave emitting sites in cardiac monolayers"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","151"],["dc.bibliographiccitation.lastpage","152"],["dc.contributor.author","Shajahan, T. K."],["dc.contributor.author","Krinski, Valentin I."],["dc.contributor.author","Knyazeva, Svetlana"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2019-02-26T15:19:38Z"],["dc.date.available","2019-02-26T15:19:38Z"],["dc.date.issued","2014"],["dc.description.abstract","Fibrillation in the heart often consists of multiple spiral waves of electrical activation in cardiac tissue. To terminate these multiple waves, recently proposed Low Energy Antifibrillation Pacing (LEAP) uses a series of low energy pulses. This achieves an energy reduction of about 80% in animal experiments. To understand the mechanism of LEAP we study the interaction of electric pulses with pinned spiral waves in monolayers of cardiac cells. Optical mapping and controlled placing of heterogeneities allow us to observe the activation dynamics in these monolayers during field pulsing. We show that a pinned wave can be terminated by a series of pulses when one of the pulses falls in the vulnerable window of the pinned spiral."],["dc.identifier.doi","10.1109/ESGCO.2014.6847564"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57624"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/55"],["dc.language.iso","en"],["dc.notes.status","fcwi"],["dc.publisher","IEEE"],["dc.publisher.place","Piscataway, NJ"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.conference","8th Conference of the European Study Group on Cardiovascular Oscillations (ESGCO)"],["dc.relation.eventend","2014-05-28"],["dc.relation.eventlocation","Trento, Italy"],["dc.relation.eventstart","2014-05-25"],["dc.relation.isbn","978-1-4799-3970-1"],["dc.relation.isbn","978-1-4799-3969-5"],["dc.relation.isbn","978-1-4799-3968-8"],["dc.relation.ispartof","2014 8th Conference of the European Study Group on Cardiovascoular Oscillations (ESGCO 2014)"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.title","Eliminating Pinned Spiral Waves in Cardiac Monolayer by Far Field Pacing"],["dc.type","conference_paper"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]