Krinsky, Valentin I.

[["dc.bibliographiccitation.artnumber","170024"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Royal Society Open Science"],["dc.bibliographiccitation.volume","4"],["dc.contributor.author","Hornung, Daniel"],["dc.contributor.author","Biktashev, V. N."],["dc.contributor.author","Otani, N. F."],["dc.contributor.author","Shajahan, T. K."],["dc.contributor.author","Baig, T."],["dc.contributor.author","Berg, S."],["dc.contributor.author","Han, Sang Who"],["dc.contributor.author","Krinsky, V. I."],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2018-11-07T10:26:28Z"],["dc.date.available","2018-11-07T10:26:28Z"],["dc.date.issued","2017"],["dc.description.abstract","We propose a solution to a long-standing problem: how to terminate multiple vortices in the heart, when the locations of their cores and their critical time windows are unknown. We scan the phases of all pinned vortices in parallel with electric field pulses (E-pulses). We specify a condition on pacing parameters that guarantees termination of one vortex. For more than one vortex with significantly different frequencies, the success of scanning depends on chance, and all vortices are terminated with a success rate of less than one. We found that a similar mechanism terminates also a free (not pinned) vortex. A series of about 500 experiments with termination of ventricular fibrillation by E-pulses in pig isolated hearts is evidence that pinned vortices, hidden from direct observation, are significant in fibrillation. These results form a physical basis needed for the creation of new effective low energy defibrillation methods based on the termination of vortices underlying fibrillation."],["dc.identifier.doi","10.1098/rsos.170024"],["dc.identifier.isi","000398107700049"],["dc.identifier.pmid","28405398"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14953"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43052"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/167"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation","info:eu-repo/grantAgreement/EC/FP7/241526/EU//EUTRIGTREAT"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","2054-5703"],["dc.relation.orgunit","Fakultät für Physik"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights","CC BY 4.0"],["dc.title","Mechanisms of vortices termination in the cardiac muscle"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","103012"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.volume","10"],["dc.contributor.affiliation","Bittihn, Philip;"],["dc.contributor.affiliation","Luther, Gisela;"],["dc.contributor.affiliation","Bodenschatz, Eberhard;"],["dc.contributor.affiliation","Krinsky, Valentin;"],["dc.contributor.affiliation","Parlitz, Ulrich;"],["dc.contributor.affiliation","Luther, Stefan;"],["dc.contributor.author","Bittihn, Philip"],["dc.contributor.author","Luther, Gisela"],["dc.contributor.author","Bodenschatz, Eberhard"],["dc.contributor.author","Krinsky, Valentin"],["dc.contributor.author","Parlitz, Ulrich"],["dc.contributor.author","Luther, Stefan"],["dc.date.accessioned","2018-11-07T11:10:06Z"],["dc.date.available","2018-11-07T11:10:06Z"],["dc.date.issued","2008"],["dc.date.updated","2022-02-09T13:17:44Z"],["dc.description.abstract","Removing anchored spirals from obstacles is an important step in terminating cardiac arrhythmia. Conventional anti-tachycardia pacing (ATP) has this ability, but only under very restrictive conditions. In a generic model of excitable media, we demonstrate that for unpinning spiral waves from obstacles this profound limitation of ATP can be overcome by far field pacing (FFP). More specifically, an argument is presented for why FFP includes and thus can only extend the capabilities of ATP in the configurations considered. By numerical simulations, we show that in the model there exists a parameter region in which unpinning is possible by FFP but not by ATP. The relevance of this result regarding clinical applications is discussed."],["dc.identifier.doi","10.1088/1367-2630/10/10/103012"],["dc.identifier.eissn","1367-2630"],["dc.identifier.fs","441448"],["dc.identifier.isi","000259958200001"],["dc.identifier.ppn","583657737"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/4322"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/53145"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Iop Publishing Ltd"],["dc.relation.issn","1367-2630"],["dc.relation.orgunit","Fakultät für Physik"],["dc.rights","Goescholar"],["dc.rights.uri","https://goedoc.uni-goettingen.de/licenses"],["dc.title","Far field pacing supersedes anti-tachycardia pacing in a generic model of excitable media"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","043012"],["dc.bibliographiccitation.firstpage","1"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","New Journal of Physics"],["dc.bibliographiccitation.lastpage","7"],["dc.bibliographiccitation.volume","18"],["dc.contributor.author","Shajahan, T. K."],["dc.contributor.author","Berg, Sebastian"],["dc.contributor.author","Luther, Stefan"],["dc.contributor.author","Krinski, Valentin"],["dc.contributor.author","Bittihn, Philip"],["dc.date.accessioned","2019-02-27T14:16:19Z"],["dc.date.available","2019-02-27T14:16:19Z"],["dc.date.issued","2016"],["dc.description.abstract","Spiral waves in cardiac tissue can pin to tissue heterogeneities and form stable pinned waves. These waves can be unpinned by electric stimuli applied close to the pinning center during the vulnerable window of the spiral. Using a phase transition curve (PTC), we quantify the response of a pinned wave in a cardiac monolayer to secondary excitations generated electric field pulses. The PTC can be used to construct a one-dimensional map that faithfully predicts the pinned wave’s response to periodic field stimuli. Based on this 1D map, we predict that pacing at a frequency greater than the spiral frequency, over drive pacing, leads to phase locking of the spiral to the stimulus, which hinders unpinning. In contrast, under drive pacing can lead to scanning of the phase window of the spiral, which facilitates unpinning. The predicted mechanisms of phase scanning and phase locking are experimentally tested and confirmed in the same monolayers that were used to obtain the PTC. Our results have the potential to help choose optimal parameters for low energy antifibrillation pacing schemes."],["dc.identifier.doi","10.1088/1367-2630/18/4/043012"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57648"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/168"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C03: Erholung nach Herzinsuffizienz: Analyse der transmuralen mechano-elektrischen Funktionsstörung"],["dc.relation.issn","1367-2630"],["dc.relation.workinggroup","RG Luther (Biomedical Physics)"],["dc.rights","CC BY 3.0"],["dc.title","Scanning and resetting the phase of a pinned spiral wave using periodic far field pulses"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]