Müller, Jürgen L.

[["dc.bibliographiccitation.firstpage","3241"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Sexual Medicine"],["dc.bibliographiccitation.lastpage","3249"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Mueller, Juergen Leo"],["dc.date.accessioned","2018-11-07T08:50:22Z"],["dc.date.available","2018-11-07T08:50:22Z"],["dc.date.issued","2011"],["dc.description.abstract","Introduction. Pathologies of the amygdala and the hippocampus have been argued to be critically involved in autism as well as in sadomasochism. In line with Kluver and Bucy syndrome, clinical observations, animal models and a few case reports emphasize that temporal brain changes are important for the etiopathogenesis of sexual deviant behaviour. In particular, the amygdalohippocampal region has been linked to hypersexuality, transvestitism and fetishism. While cases and studies are rare, the impact of amygdalohippocampal changes in criminal behaviour remains unclear so far. Aim. To demonstrate the impact of subcortical neurobiological changes in the etiopathogenesis of autism and sadomasochism. Methods. We report on a forensic psychiatric inpatient due to murderer with autism and sadomasochism who had amgdalohippocampal abnormalities bilaterally. Studies on the neurobiological underpinnings of autism and of sadomasochism are reviewed in particular regarding amygdalohippocampal region. Results. In this patient, MRI scan showed hypointensities in amygdala-hippocampal complex bilaterally medial to both cornua inferiores corresponding to an amygdalo-hippocampal atrophy. Conclusions. In line with the literature, this case report links autism and sadomasochism to amygdalohippocampal pathology emphasising its impact in the etiopathogenesis of both disorders. Further research is needed to elucidate the interaction of amygdalohippocampal changes, disturbed emotion precessing and sex offenses. Muller JL. Are sadomasochism and hypersexuality in autism linked to amygdalohippocampal lesion? J Sex Med 2011;8:3241-3249."],["dc.identifier.doi","10.1111/j.1743-6109.2009.01485.x"],["dc.identifier.isi","000296712200030"],["dc.identifier.pmid","19751388"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21680"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1743-6095"],["dc.title","Are Sadomasochism and Hypersexuality in Autism Linked to Amygdalohippocampal Lesion?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","365"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Psychiatrische Praxis"],["dc.bibliographiccitation.lastpage","367"],["dc.bibliographiccitation.volume","40"],["dc.contributor.author","Mueller, Juergen Leo"],["dc.contributor.author","Falkai, Peter"],["dc.contributor.author","Schneider, Frank"],["dc.contributor.author","Hauth, Iris"],["dc.contributor.author","Maier, Wolfgang"],["dc.date.accessioned","2018-11-07T09:18:48Z"],["dc.date.available","2018-11-07T09:18:48Z"],["dc.date.issued","2013"],["dc.identifier.doi","10.1055/s-0033-1349560"],["dc.identifier.isi","000330534100003"],["dc.identifier.pmid","24101137"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28485"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","1439-0876"],["dc.relation.issn","0303-4259"],["dc.title","Psychiatry Caught Between Emergency Response and Therapy: Compulsory Treatment Following the Jurisprudence of the Federal Constitutional Court and the Federal Supreme Court"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","902"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Journal of Virology"],["dc.bibliographiccitation.lastpage","912"],["dc.bibliographiccitation.volume","67"],["dc.contributor.author","Lang, S M"],["dc.contributor.author","Weeger, M"],["dc.contributor.author","Stahl-Hennig, C"],["dc.contributor.author","Coulibaly, C"],["dc.contributor.author","Hunsmann, G"],["dc.contributor.author","Müller, J"],["dc.contributor.author","Müller-Hermelink, H"],["dc.contributor.author","Fuchs, D"],["dc.contributor.author","Wachter, H"],["dc.contributor.author","Daniel, M M"],["dc.date.accessioned","2022-10-06T13:25:39Z"],["dc.date.available","2022-10-06T13:25:39Z"],["dc.date.issued","1993"],["dc.description.abstract","The importance of the vpr gene for simian immunodeficiency virus (SIV) replication, persistence, and disease progression was examined by using the infectious pathogenic molecular clone called SIVmac239. The ATG start codon of the vpr gene was converted to TTG by site-specific mutagenesis. The constructed Vpr- mutant virus is identical with the parental SIVmac239/nef-stop virus with the exception of this one nucleotide. These viruses replicated with similar kinetics and to similar extents in rhesus monkey lymphocyte cultures and in the human CEMX174 cell line. Five rhesus monkeys were inoculated with the Vpr- variant of SIVmac239/nef-stop, and two monkeys received SIVmac239/nef-stop as controls. Both controls showed reversion of the TAA stop signal in nef by 2 weeks postinfection, as has been observed previously. Reversion of the TAA stop codon in nef also occurred in the five monkeys that received the Vpr- variant, but reversion was delayed on average to about 4 weeks. Thus, the mutation in vpr appeared to delay the rapidity with which reversion occurred in the nef gene. Reversion of the TTG sequence in vpr to ATG was observed in three of the five test animals. Reversion in vpr was first observed in these three animals 4 to 8 weeks postinfection. No vpr revertants were found over the entire 66 weeks of observation in the other two test animals that received the vpr mutant. Antibodies to vpr developed in those three animals in which reversion of vpr was documented, but antibodies to vpr were not observed in the two animals in which reversion of vpr was not detected. Antibody responses to gag and to whole virus antigens were of similar strength in all seven animals. Both control animals and two of the test animals in which vpr reverted maintained high virus loads and developed progressive disease. Low virus burden and no disease have been observed in the two animals in which vpr did not revert and in the one animal in which vpr reversion was first detected only at 8 weeks. The reversion of vpr in three of the five test animals indicates that there is significant selective pressure for functional forms of vpr in vivo. Furthermore, the results suggest that both vpr and nef are important for maximal SIV replication and persistence in vivo and for disease progression."],["dc.identifier.doi","10.1128/jvi.67.2.902-912.1993"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/114885"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-602"],["dc.relation.eissn","1098-5514"],["dc.relation.issn","0022-538X"],["dc.relation.orgunit","Deutsches Primatenzentrum"],["dc.rights.uri","https://journals.asm.org/non-commercial-tdm-license"],["dc.title","Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","138"],["dc.bibliographiccitation.journal","International Journal of Methods in Psychiatric Research"],["dc.bibliographiccitation.lastpage","144"],["dc.bibliographiccitation.volume","96"],["dc.contributor.author","Jordan, Kirsten"],["dc.contributor.author","Fromberger, Peter"],["dc.contributor.author","Müller, Isabel"],["dc.contributor.author","Wernicke, Martina"],["dc.contributor.author","Stolpmann, Georg"],["dc.contributor.author","Müller, Jürgen L."],["dc.date.accessioned","2020-06-30T06:41:57Z"],["dc.date.available","2020-06-30T06:41:57Z"],["dc.date.issued","2018"],["dc.description.abstract","Sexual child abuse is one of the most destructive events for child development. One possible approach to avert it is the preventive treatment of individuals with a sexual interest in children. The aim of the current eye tracking study was to compare people with a self-reported sexual interest in children who participate in the outpatient preventive treatment project “PsM”, pedophilic forensic inpatients, and a non-pedophilic control group. Groups were compared with respect to sexual interest and attentional control in the presence of sexual stimuli, both assessed independently of self-report. Two approaches were applied, namely the initial orientation approach for measuring sexual interest, and a sexual distractor task for measuring attentional control. Our data showed for the first time that outpatients with a self-reported sexual interest in children differed from pedophilic forensic inpatients with respect to attentional control but not with regard to sexual interest. Outpatients showed similar sexual interest in children as pedophilic forensic inpatients. They demonstrated significantly better attentional control than pedophilic forensic inpatients in the face of adult sexual stimuli, but the difference regarding child sexual stimuli did not reach significance. This might reflect a higher capacity for self-control and self-regulation in these patients. Nevertheless, child stimuli remain to be important distractors for them. Our results provide valuable additional information for the diagnosis and therapy of outpatients with a self-reported sexual interest in children. Obviously, these data are preliminary and further studies with larger groups should examine if they are replicable."],["dc.identifier.doi","10.1016/j.jpsychires.2017.10.004"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66778"],["dc.language.iso","en"],["dc.title","Sexual interest and sexual self-control in men with self-reported sexual interest in children – A first eye tracking study"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","3008"],["dc.bibliographiccitation.issue","11"],["dc.bibliographiccitation.journal","Journal of Sexual Medicine"],["dc.bibliographiccitation.lastpage","3029"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Jordan, Kirsten"],["dc.contributor.author","Fromberger, Peter"],["dc.contributor.author","Stolpmann, Georg"],["dc.contributor.author","Mueller, Juergen Leo"],["dc.date.accessioned","2018-11-07T08:50:21Z"],["dc.date.available","2018-11-07T08:50:21Z"],["dc.date.issued","2011"],["dc.description.abstract","Introduction. Antiandrogen therapy has been used for 30 years to treat paraphilic patients and sexual offenders. Yet the therapeutic success of antiandrogens is uncertain. Furthermore, there is still a lack of comprehensive knowledge about the effects of androgen-lowering therapy in paraphilic patients. Aim. We discuss endocrinological, neurobiological, and therapeutic aspects of paraphilia with the aim of integrating these on the basis of the current neurobiological and clinical knowledge on testosterone that was set out in Part I of this review. Methods. Our review of the human literature comprises the current knowledge about the neurobiology of paraphilia and the known endocrinological, pathophysiological, and genetic aspects of this disorder. The role of testosterone is discussed. A survey of antiandrogen therapy and its outcome in paraphilic patients and sex offenders is provided. Results. Although not all data are consistent, current imaging research suggests that structural and functional changes in pedophilia appear for the most part in brain regions also involved in sexual functions. Not exclusively testosterone but also some other endocrinological and neurochemical parameters could be disturbed in pedophilic patients and child molesters; these include changes in hypothalamic-pituitary function, prolactin levels, and dopaminergic or serotonergic functions. There appears to be a sex-steroid-related genetic influence on antisocial traits, externalizing behavior, and sexual behavior. Most of the studies in which antiandrogen therapy in paraphilic patients and sex offenders have been examined were case reports, or observational or open-label studies, and many did not include adequate control groups. Only a few placebo-controlled double-blind studies have been published with inconsistent results concerning treatment effects. Outcome measures differ between the studies and do not seem ideally suited to their purpose. Conclusions. On the basis of the current knowledge about testosterone and its effects on brain and behavior as described in Part I, and of available results on the relationship between testosterone and paraphilia as well as antiandrogen therapy, we present from a neurobiological perspective an extended scientific proposal for design features to investigate the effects of antiandrogen treatment in large clinical trials. Jordan K, Fromberger P, Stolpmann G, and Muller JL. The role of testosterone in sexuality and paraphilia-A neurobiological approach. Part II: Testosterone and paraphilia. J Sex Med 2011;8:3008-3029."],["dc.identifier.doi","10.1111/j.1743-6109.2011.02393.x"],["dc.identifier.isi","000296712200005"],["dc.identifier.pmid","21797985"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21678"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","1743-6095"],["dc.title","The Role of Testosterone in Sexuality and Paraphilia-A Neurobiological Approach. Part II: Testosterone and Paraphilia"],["dc.type","review"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","421"],["dc.bibliographiccitation.issue","08"],["dc.bibliographiccitation.journal","Psychiatrische Praxis"],["dc.bibliographiccitation.lastpage","422"],["dc.bibliographiccitation.volume","48"],["dc.contributor.author","Müller, Jürgen L."],["dc.date.accessioned","2021-12-01T09:20:59Z"],["dc.date.available","2021-12-01T09:20:59Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1055/a-1624-3779"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/94317"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-478"],["dc.relation.eissn","1439-0876"],["dc.relation.issn","0303-4259"],["dc.title","Kommentar zu Norbert Schalast et al.: Zum Ertrag der Unterbringung in einer Entziehungsanstalt und zu methodischen Einwänden gegen die Essener Evaluationsstudie"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Der Nervenarzt"],["dc.contributor.author","Müller, Jürgen L."],["dc.contributor.author","Böcker, Felix M."],["dc.contributor.author","Eusterschulte, Beate"],["dc.contributor.author","Koller, Matthias"],["dc.contributor.author","Muysers, Jutta"],["dc.contributor.author","Pollmächer, Thomas"],["dc.date.accessioned","2021-06-01T09:42:47Z"],["dc.date.available","2021-06-01T09:42:47Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1007/s00115-021-01109-w"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/85355"],["dc.language.iso","de"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1433-0407"],["dc.relation.issn","0028-2804"],["dc.title","Neuregelung des § 64 StGB aus psychiatrischer Sicht – Positionspapier einer Task-Force der DGPPN"],["dc.title.translated","Revision of §64 of the German Penal Code from a psychiatric perspective—Position paper of a task force of the German Association for Psychiatry, Psychotherapy and Psychosomatics"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","395"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Psychiatrische Praxis"],["dc.bibliographiccitation.lastpage","399"],["dc.bibliographiccitation.volume","43"],["dc.contributor.author","Steinert, Tilman"],["dc.contributor.author","Heinz, Andreas"],["dc.contributor.author","Hohl-Radke, Felix"],["dc.contributor.author","Koller, Manfred"],["dc.contributor.author","Mueller, Juergen"],["dc.contributor.author","Mueller, Sabine"],["dc.contributor.author","Zinkler, Martin"],["dc.date.accessioned","2018-11-07T10:07:46Z"],["dc.date.available","2018-11-07T10:07:46Z"],["dc.date.issued","2016"],["dc.description.abstract","The term of a considerable damage to one's health is central in German guardianship law with respect to judge's decisions on involuntary commitment and coercive treatment. A legal definition has not been provided, and up to now no explanations from the part of medicine have been available what a considerable damage to one's health is in the case of mental illness and how it can be determined. A consensus paper of the German Association of Psychiatry and Psychotherapy (DGPPN) explains four possible scenarios of manifestation of such kind of damage, corresponding to somatic illnesses: evidence of structural brain lesions (rare), subjective suffering (sufficient, but not necessary), impairment of functioning in important areas of life, and severe impairment of social participation (e.g. by dangerous behaviour against others). This view corresponds with the WHO's bio-psycho-social concept of health."],["dc.identifier.doi","10.1055/s-0042-116649"],["dc.identifier.isi","000386347200008"],["dc.identifier.pmid","27733009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/39342"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Georg Thieme Verlag Kg"],["dc.relation.issn","1439-0876"],["dc.relation.issn","0303-4259"],["dc.title","What is a \"Considerable Damage to One's Health\" in the Sense of German Guardianship Law? A Consensus Statement by the German Association of Psychiatry and Psychotherapy, Task Force Patient's Autonomy"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","253"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Monatsschrift für Kriminologie und Strafrechtsreform / Journal of Criminology an Penal Reform"],["dc.bibliographiccitation.lastpage","265"],["dc.bibliographiccitation.volume","94"],["dc.contributor.author","Mueller, Juergen Leo"],["dc.contributor.author","Stolpmann, Georg"],["dc.contributor.author","Fromberger, Peter"],["dc.contributor.author","Haase, Kessy Ann"],["dc.contributor.author","Jordan, Kirsten"],["dc.date.accessioned","2018-11-07T08:53:22Z"],["dc.date.available","2018-11-07T08:53:22Z"],["dc.date.issued","2011"],["dc.description.abstract","Since its introduction in 2004, the additional preventative detention (\"nachtragliche Sicherungsverwahrung\") in Germany has been discussed controversially and emotionally. There are few empirical data about additional preventative detention. We report initial results of a country wide study of the legal probation and danger prognoses of individuals considered to be too dangerous for society but who have served their time in prison. We analyzed expert testimonies from 25 judicial decisions which did not result in additional preventative detention-due to a recent change in the law. It was found that two years after release from prison 28 % of the individuals had committed a serious offense and 38 % had committed a minor offense. About 40 % of the former candidates for additional preventative detention did not reoffend in that time."],["dc.identifier.isi","000295664500003"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22390"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Carl Heymanns Verlag Kg"],["dc.relation.issn","0026-9301"],["dc.title","Legal Probation after Psychiatric Assessments for Additional Preventative Detention"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","130"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Forensische Psychiatrie, Psychologie, Kriminologie"],["dc.bibliographiccitation.lastpage","139"],["dc.bibliographiccitation.volume","9"],["dc.contributor.author","Müller, Jürgen Leo"],["dc.contributor.author","Fromberger, Peter"],["dc.contributor.author","Jordan, Kirsten"],["dc.date.accessioned","2020-06-30T06:26:44Z"],["dc.date.available","2020-06-30T06:26:44Z"],["dc.date.issued","2015"],["dc.description.abstract","In der 5. Auflage des Diagnostischen und Statistischen Manuals psychischer Störungen (DSM-5) werden psychophysiologische Verfahren als diagnostische Marker bei der Pädophilie eingeführt. Das DSM-5 ist als statistisches und diagnostisches Manual nicht zur Beantwortung rechtlicher Fragen konzipiert. Aus einer forensisch-psychiatrischen Perspektive aktualisiert der Verweis auf diese Techniken dennoch die Frage, ob und wie psychophysiologische Ansätze zur Beantwortung rechtlicher Fragestellungen genutzt bzw. wie diese in die etablierte Begutachtungsmethodik integriert werden können. Dies wird im Folgenden am Beispiel der Pädophilie hinsichtlich der Diagnostik, der Verhaltensinhibition sowie der Prognose diskutiert."],["dc.description.abstract","In the fifth edition of the diagnostic and statistical manual of mental disorders (DSM-5) psychophysiological procedures are included as diagnostic markers for pedophilia. The DSM-5 as a statistical and diagnostic manual is not concipated for answering legal questions; however, from a forensic psychiatric perspective the reference to these techniques updates the question whether and how psychophysiological approaches can be used to answer legal questions and how they can be integrated into established assessment methodologies. These points are discussed in this article with respect to diagnostics, behavioral inhibition and prognosis using pedophilia as an example."],["dc.identifier.doi","10.1007/s11757-015-0321-8"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/66773"],["dc.language.iso","de"],["dc.title","Wie können psychophysiologische Techniken zu Diagnose und Prognose beitragen am Beispiel der Pädophilie?"],["dc.title.alternative","How can psychophysiological techniques contribute to diagnosis and prognosis using pedophilia as an example?"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]