Bickeböller, Heike

[["dc.bibliographiccitation.artnumber","e0177875"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","PloS one"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Carreras-Torres, Robert"],["dc.contributor.author","Johansson, Mattias"],["dc.contributor.author","Haycock, Philip C."],["dc.contributor.author","Wade, Kaitlin H."],["dc.contributor.author","Relton, Caroline L."],["dc.contributor.author","Martin, Richard M."],["dc.contributor.author","Davey Smith, George"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Aldrich, Melinda C."],["dc.contributor.author","Andrew, Angeline"],["dc.contributor.author","Arnold, Susanne M."],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Bojesen, Stig E."],["dc.contributor.author","Brunnström, Hans"],["dc.contributor.author","Manjer, Jonas"],["dc.contributor.author","Brüske, Irene"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Christian, W. Jay"],["dc.contributor.author","Doherty, Jennifer A."],["dc.contributor.author","Duell, Eric J."],["dc.contributor.author","Field, John K."],["dc.contributor.author","Davies, Michael P. A."],["dc.contributor.author","Marcus, Michael W."],["dc.contributor.author","Goodman, Gary E."],["dc.contributor.author","Grankvist, Kjell"],["dc.contributor.author","Haugen, Aage"],["dc.contributor.author","Hong, Yun-Chul"],["dc.contributor.author","Kiemeney, Lambertus A."],["dc.contributor.author","van der Heijden, Erik H. F. M."],["dc.contributor.author","Kraft, Peter"],["dc.contributor.author","Johansson, Mikael B."],["dc.contributor.author","Lam, Stephen"],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Lazarus, Philip"],["dc.contributor.author","Le Marchand, Loïc"],["dc.contributor.author","Liu, Geoffrey"],["dc.contributor.author","Melander, Olle"],["dc.contributor.author","Park, Sungshim L."],["dc.contributor.author","Rennert, Gad"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Haura, Eric B."],["dc.contributor.author","Scelo, Ghislaine"],["dc.contributor.author","Zaridze, David"],["dc.contributor.author","Mukeriya, Anush"],["dc.contributor.author","Savić, Milan"],["dc.contributor.author","Lissowska, Jolanta"],["dc.contributor.author","Swiatkowska, Beata"],["dc.contributor.author","Janout, Vladimir"],["dc.contributor.author","Holcatova, Ivana"],["dc.contributor.author","Mates, Dana"],["dc.contributor.author","Schabath, Matthew B."],["dc.contributor.author","Shen, Hongbing"],["dc.contributor.author","Tardon, Adonina"],["dc.contributor.author","Teare, M. Dawn"],["dc.contributor.author","Woll, Penella"],["dc.contributor.author","Tsao, Ming-Sound"],["dc.contributor.author","Wu, Xifeng"],["dc.contributor.author","Yuan, Jian-Min"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","McKay, James"],["dc.contributor.author","Brennan, Paul"],["dc.date.accessioned","2019-07-09T11:43:32Z"],["dc.date.available","2019-07-09T11:43:32Z"],["dc.date.issued","2017"],["dc.description.abstract","BACKGROUND: Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help to identify the metabolic drivers of lung cancer. METHODS AND FINDINGS: We identified genetic instruments for potential metabolic risk factors and evaluated these in relation to risk using 29,266 lung cancer cases (including 11,273 adenocarcinomas, 7,426 squamous cell and 2,664 small cell cases) and 56,450 controls. The MR risk analysis suggested a causal effect of body mass index (BMI) on lung cancer risk for two of the three major histological subtypes, with evidence of a risk increase for squamous cell carcinoma (odds ratio (OR) [95% confidence interval (CI)] = 1.20 [1.01-1.43] and for small cell lung cancer (OR [95%CI] = 1.52 [1.15-2.00]) for each standard deviation (SD) increase in BMI [4.6 kg/m2]), but not for adenocarcinoma (OR [95%CI] = 0.93 [0.79-1.08]) (Pheterogeneity = 4.3x10-3). Additional analysis using a genetic instrument for BMI showed that each SD increase in BMI increased cigarette consumption by 1.27 cigarettes per day (P = 2.1x10-3), providing novel evidence that a genetic susceptibility to obesity influences smoking patterns. There was also evidence that low-density lipoprotein cholesterol was inversely associated with lung cancer overall risk (OR [95%CI] = 0.90 [0.84-0.97] per SD of 38 mg/dl), while fasting insulin was positively associated (OR [95%CI] = 1.63 [1.25-2.13] per SD of 44.4 pmol/l). Sensitivity analyses including a weighted-median approach and MR-Egger test did not detect other pleiotropic effects biasing the main results. CONCLUSIONS: Our results are consistent with a causal role of fasting insulin and low-density lipoprotein cholesterol in lung cancer etiology, as well as for BMI in squamous cell and small cell carcinoma. The latter relation may be mediated by a previously unrecognized effect of obesity on smoking behavior."],["dc.identifier.doi","10.1371/journal.pone.0177875"],["dc.identifier.pmid","28594918"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/14558"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/58904"],["dc.language.iso","en"],["dc.notes.intern","Merged from goescholar"],["dc.relation.issn","1932-6203"],["dc.rights","CC BY 4.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.subject.ddc","610"],["dc.title","Obesity, metabolic factors and risk of different histological types of lung cancer: A Mendelian randomization study."],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","4980"],["dc.bibliographiccitation.issue","22"],["dc.bibliographiccitation.journal","Human Molecular Genetics"],["dc.bibliographiccitation.lastpage","4995"],["dc.bibliographiccitation.volume","21"],["dc.contributor.author","Timofeeva, Maria N."],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Rafnar, Thorunn"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Field, John K."],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","McKay, James D."],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Dai, Juncheng"],["dc.contributor.author","Gaborieau, Valerie"],["dc.contributor.author","McLaughlin, John R."],["dc.contributor.author","Brenner, Darren"],["dc.contributor.author","Narod, Steven A."],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Thun, Michael"],["dc.contributor.author","Eisen, Timothy"],["dc.contributor.author","Wichmann, Heinz-Erich"],["dc.contributor.author","Rosenberger, Albert"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Chen, Wei"],["dc.contributor.author","Zhu, D."],["dc.contributor.author","Spitz, Margaret R."],["dc.contributor.author","Wu, X."],["dc.contributor.author","Pande, Mala"],["dc.contributor.author","Zhao, Yang"],["dc.contributor.author","Zaridze, David"],["dc.contributor.author","Szeszenia-Dabrowska, Neonilia"],["dc.contributor.author","Lissowska, Jolanta"],["dc.contributor.author","Rudnai, Peter"],["dc.contributor.author","Fabianova, Eleonora"],["dc.contributor.author","Mates, Dana"],["dc.contributor.author","Bencko, Vladimir"],["dc.contributor.author","Foretova, Lenka"],["dc.contributor.author","Janout, Vladimir"],["dc.contributor.author","Krokan, Hans E."],["dc.contributor.author","Gabrielsen, Maiken Elvestad"],["dc.contributor.author","Skorpen, Frank"],["dc.contributor.author","Vatten, Lars"],["dc.contributor.author","Njolstad, Inger"],["dc.contributor.author","Chen, Chu"],["dc.contributor.author","Goodman, Gary"],["dc.contributor.author","Lathrop, Mark"],["dc.contributor.author","Benhamou, Simone"],["dc.contributor.author","Vooder, Tonu"],["dc.contributor.author","Vaelk, Kristjan"],["dc.contributor.author","Nelis, Mari"],["dc.contributor.author","Metspalu, Andres"],["dc.contributor.author","Raji, Olaide Y."],["dc.contributor.author","Chen, Ying"],["dc.contributor.author","Gosney, John"],["dc.contributor.author","Liloglou, Triantafillos"],["dc.contributor.author","Muley, Thomas"],["dc.contributor.author","Dienemann, Hendrik"],["dc.contributor.author","Thorleifsson, Gudmar"],["dc.contributor.author","Shen, Hongbing"],["dc.contributor.author","Stefansson, Kari"],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","Landi, Maria Teresa"],["dc.date.accessioned","2018-11-07T09:03:28Z"],["dc.date.available","2018-11-07T09:03:28Z"],["dc.date.issued","2012"],["dc.description.abstract","Recent genome-wide association studies (GWASs) have identified common genetic variants at 5p15.33, 6p216p22 and 15q25.1 associated with lung cancer risk. Several other genetic regions including variants of CHEK2 (22q12), TP53BP1 (15q15) and RAD52 (12p13) have been demonstrated to influence lung cancer risk in candidate- or pathway-based analyses. To identify novel risk variants for lung cancer, we performed a meta-analysis of 16 GWASs, totaling 14 900 cases and 29 485 controls of European descent. Our data provided increased support for previously identified risk loci at 5p15 (P 7.2 10(16)), 6p21 (P 2.3 10(14)) and 15q25 (P 2.2 10(63)). Furthermore, we demonstrated histology-specific effects for 5p15, 6p21 and 12p13 loci but not for the 15q25 region. Subgroup analysis also identified a novel disease locus for squamous cell carcinoma at 9p21 (CDKN2A/p16(INK4A)/p14(ARF)/CDKN2B/p15(INK4B)/ANRIL; rs1333040, P 3.0 10(7)) which was replicated in a series of 5415 Han Chinese (P 0.03; combined analysis, P 2.3 10(8)). This large analysis provides additional evidence for the role of inherited genetic susceptibility to lung cancer and insight into biological differences in the development of the different histological types of lung cancer."],["dc.identifier.doi","10.1093/hmg/dds334"],["dc.identifier.isi","000310369000016"],["dc.identifier.pmid","22899653"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10648"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24907"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press"],["dc.relation.issn","1460-2083"],["dc.relation.issn","0964-6906"],["dc.rights","CC BY-NC 2.5"],["dc.rights.uri","https://creativecommons.org/licenses/by-nc/2.5"],["dc.title","Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.artnumber","dju061"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","JNCI Journal of the National Cancer Institute"],["dc.bibliographiccitation.volume","106"],["dc.contributor.author","Park, S. L."],["dc.contributor.author","Fesinmeyer, Megan D."],["dc.contributor.author","Timofeeva, Maria N."],["dc.contributor.author","Caberto, Christian P."],["dc.contributor.author","Kocarnik, Jonathan M."],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Love, Shelly-Ann"],["dc.contributor.author","Young, Alicia"],["dc.contributor.author","Dumitrescu, Logan"],["dc.contributor.author","Lin, Y. I."],["dc.contributor.author","Goodloe, Robert"],["dc.contributor.author","Wilkens, Lynne R."],["dc.contributor.author","Hindorff, Lucia"],["dc.contributor.author","Fowke, Jay H."],["dc.contributor.author","Carty, Cara"],["dc.contributor.author","Buyske, Steven"],["dc.contributor.author","Schumacher, Frederick R."],["dc.contributor.author","Butler, Anne"],["dc.contributor.author","Dilks, Holli"],["dc.contributor.author","Deelman, Ewa"],["dc.contributor.author","Cote, Michele L."],["dc.contributor.author","Chen, Wei"],["dc.contributor.author","Pande, Mala"],["dc.contributor.author","Christiani, David C."],["dc.contributor.author","Field, John K."],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Wang, Y."],["dc.contributor.author","Eisen, Timothy"],["dc.contributor.author","Houlston, Richard S."],["dc.contributor.author","Thun, Michael"],["dc.contributor.author","Albanes, Demetrius"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Peters, Ulrike"],["dc.contributor.author","North, Kari E."],["dc.contributor.author","Heiss, Gerardo"],["dc.contributor.author","Crawford, Dana C."],["dc.contributor.author","Bush, William S."],["dc.contributor.author","Haiman, Christopher A."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Kooperberg, Charles"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Le Marchand, Loic"],["dc.contributor.author","Cheng, Iona"],["dc.date.accessioned","2018-11-07T09:41:48Z"],["dc.date.available","2018-11-07T09:41:48Z"],["dc.date.issued","2014"],["dc.description.abstract","Background Genome-wide association studies have identified hundreds of genetic variants associated with specific cancers. A few of these risk regions have been associated with more than one cancer site; however, a systematic evaluation of the associations between risk variants for other cancers and lung cancer risk has yet to be performed. Methods We included 18 023 patients with lung cancer and 60 543 control subjects from two consortia, Population Architecture using Genomics and Epidemiology (PAGE) and Transdisciplinary Research in Cancer of the Lung (TRICL). We examined 165 single-nucleotide polymorphisms (SNPs) that were previously associated with at least one of 16 non-lung cancer sites. Study-specific logistic regression results underwent meta-analysis, and associations were also examined by race/ethnicity, histological cell type, sex, and smoking status. A Bonferroni-corrected P value of 2.5 x 10(-5) was used to assign statistical significance. Results The breast cancer SNP LSP1 rs3817198 was associated with an increased risk of lung cancer (odds ratio [OR] = 1.10; 95% confidence interval [CI] = 1.05 to 1.14; P = 2.8 x 10(-6)). This association was strongest for women with adenocarcinoma (P = 1.2 x 10(-4)) and not statistically significant in men (P = .14) with this cell type (P-het by sex = .10). Two glioma risk variants, TERT rs2853676 and CDKN2BAS1 rs4977756, which are located in regions previously associated with lung cancer, were associated with increased risk of adenocarcinoma (OR = 1.16; 95% CI = 1.10 to 1.22; P = 1.1 x 10(-8)) and squamous cell carcinoma (OR = 1.13; CI = 1.07 to 1.19; P = 2.5 x 10(-5)), respectively. Conclusions Our findings demonstrate a novel pleiotropic association between the breast cancer LSP1 risk region marked by variant rs3817198 and lung cancer risk."],["dc.identifier.doi","10.1093/jnci/dju061"],["dc.identifier.isi","000334691500032"],["dc.identifier.pmid","24681604"],["dc.identifier.purl","https://resolver.sub.uni-goettingen.de/purl?gs-1/10659"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/33814"],["dc.notes.intern","Merged from goescholar"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Oxford Univ Press Inc"],["dc.relation.issn","1460-2105"],["dc.relation.issn","0027-8874"],["dc.rights","CC BY 3.0"],["dc.rights.uri","https://creativecommons.org/licenses/by/3.0"],["dc.title","Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.version","published_version"],["dspace.entity.type","Publication"]]