Bickeböller, Heike

[["dc.bibliographiccitation.firstpage","66"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Theoretical Population Biology"],["dc.bibliographiccitation.lastpage","90"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Thompson, Elizabeth A."],["dc.date.accessioned","2022-06-08T07:58:11Z"],["dc.date.available","2022-06-08T07:58:11Z"],["dc.date.issued","1996"],["dc.identifier.doi","10.1006/tpbi.1996.0023"],["dc.identifier.pii","S0040580996900234"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110335"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.issn","0040-5809"],["dc.title","Distribution of Genome Shared IBD by Half-Sibs: Approximation by the Poisson Clumping Heuristic"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.volume","39"],["dc.contributor.author","Friedrichs, Stefanie"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Christiani, David"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Brueske, Irene"],["dc.contributor.author","Caporaso, Neil E."],["dc.contributor.author","Landi, Maria Teresa"],["dc.contributor.author","Rafnar, Thorunn"],["dc.contributor.author","Bickeboeller, Heike"],["dc.date.accessioned","2018-11-07T09:49:47Z"],["dc.date.available","2018-11-07T09:49:47Z"],["dc.date.issued","2015"],["dc.format.extent","549"],["dc.identifier.isi","000363340500056"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/35571"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","Annual Meeting of the International-Genetic-Epidemiology-Society (IGES)"],["dc.relation.eventlocation","Baltimore, MD"],["dc.relation.issn","1098-2272"],["dc.relation.issn","0741-0395"],["dc.title","Kernel-based Pathway Meta-Analysis in ILCCO / TRICL Genome-wide Association Studies"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","98"],["dc.bibliographiccitation.journal","Annals of Human Genetics"],["dc.bibliographiccitation.lastpage","115"],["dc.bibliographiccitation.volume","70"],["dc.contributor.author","Kohler, K."],["dc.contributor.author","Bickeboeller, Heike"],["dc.date.accessioned","2018-11-07T10:29:23Z"],["dc.date.available","2018-11-07T10:29:23Z"],["dc.date.issued","2006"],["dc.description.abstract","In case-control association studies unobserved population stratification may act as a confounder, leading to an increased number of false positive results. Methods accounting for population structure by using additional genetic markers broadly follow one of two concepts: Genomic Control (GC) and Structured Association (SA). While extending existing methods of Structured Association we show that it is necessary to incorporate phenotypic information when inferring population structure, otherwise a systematic bias is introduced. Moreover, for moderate population stratification a Wald test statistic should be preferred as a Structured Association test statistic in comparison to a likelihood ratio test. The introduced extensions are compared to existing methods of Structured Association, as well as to Genomic Control, in a simulation study which is based on realistic situations of large case-control studies with moderate population stratification. A disadvantage of Genomic Control turns out to be the large variation in estimating the variance inflation factor, as well as the power loss if population structure increases. We come to the overall conclusion that Structured Association, if applied correctly, is superior to Genomic Control, at least in the case of simple population structure as simulated here."],["dc.identifier.doi","10.1111/j.1529-8817.2005.00214.x"],["dc.identifier.isi","000234974100008"],["dc.identifier.pmid","16441260"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/43635"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Blackwell Publishing"],["dc.relation.issn","0003-4800"],["dc.title","Case-control association tests correcting for population stratification"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","S22"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.lastpage","S33"],["dc.bibliographiccitation.volume","31"],["dc.contributor.author","Bickebller, Heike"],["dc.contributor.author","Goddard, Katrina A. B."],["dc.contributor.author","Igo, Robert P., Jr."],["dc.contributor.author","Kraft, Peter"],["dc.contributor.author","Lozano, Jingky P."],["dc.contributor.author","Pankratz, Nathan"],["dc.date.accessioned","2018-11-07T11:06:35Z"],["dc.date.available","2018-11-07T11:06:35Z"],["dc.date.issued","2007"],["dc.description.abstract","Genetic association studies have the potential to identify causative genetic variants with small effects in complex diseases, but it is not at all clear which study designs best balance power with sample size, especially when taking into account the difficulty of obtaining a sample of the necessary structure. The 14 contributions from the Genetic Analysis Workshop 15 group 3 used data sets with rheumatoid arthritis as primary phenotype from problem 2 (real data) and Problem 3 (simulated data) to investigate design and analysis problems that arise in candidate-gene, candidate-region, and genome-wide association studies. We identified three major themes that were addressed by multiple groups: (1) comparing family-based and case-control study designs with each other and with hybrid designs incorporating both related and unrelated individuals; (2) exploring and comparing techniques of combining information from multiple, correlated single-nucleotide polymorphisms; and (3) comparing analyses that select the model(s) of best fit with the ultimate aim of detecting the joint effects of several unlinked single-nucleotide polymorphisms. These contributions achieved some success in improving upon existing methods. For example, tests using related cases and unrelated controls can achieve higher power than the tests using unrelated cases and unrelated controls. Aside from these successes, the group 3 contributions highlight some interesting areas for future research."],["dc.description.sponsorship","NHLBI NIH HHS [T32 HL 07567]"],["dc.identifier.doi","10.1002/gepi.20277"],["dc.identifier.isi","000251674000004"],["dc.identifier.pmid","18046763"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/52353"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","15th Genetic Analysis Workshop/International-Genetic-Epidemiology-Society Meeting"],["dc.relation.eventlocation","St Pete Beach, FL"],["dc.relation.issn","1098-2272"],["dc.relation.issn","0741-0395"],["dc.title","Issues in association mapping with high-density SNP data and diverse family structures"],["dc.type","conference_paper"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","8"],["dc.bibliographiccitation.journal","Biological Psychiatry"],["dc.bibliographiccitation.volume","71"],["dc.contributor.author","Kaestner, Anne"],["dc.contributor.author","Malzahn, Doerthe"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2018-11-07T09:11:08Z"],["dc.date.available","2018-11-07T09:11:08Z"],["dc.date.issued","2012"],["dc.format.extent","87S"],["dc.identifier.isi","000302466000276"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/26656"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Inc"],["dc.publisher.place","New york"],["dc.relation.conference","67th Annual Meeting of the Society-of-Biological-Psychiatry"],["dc.relation.eventlocation","Philadelphia, PA"],["dc.relation.issn","0006-3223"],["dc.title","Introducing ORNI, the 'Odor Recognition, Naming and Interpretation Test', a Simple and Specific Measure of Sensory-Cognitive-Emotional Processing in Schizophrenia"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","216"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Molecular Carcinogenesis"],["dc.bibliographiccitation.lastpage","224"],["dc.bibliographiccitation.volume","57"],["dc.contributor.author","Feng, Yun"],["dc.contributor.author","Wang, Yanru"],["dc.contributor.author","Liu, Hongliang"],["dc.contributor.author","Liu, Zhensheng"],["dc.contributor.author","Mills, Coleman"],["dc.contributor.author","Owzar, Kouros"],["dc.contributor.author","Xie, Jichun"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Qian, David C."],["dc.contributor.author","Hung RJ, Rayjean J."],["dc.contributor.author","Wei, Qingyi"],["dc.contributor.author","Bickeböller, Heike"],["dc.contributor.author","Rosenberger, Albert"],["dc.date.accessioned","2022-06-08T07:57:59Z"],["dc.date.available","2022-06-08T07:57:59Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1002/mc.22748"],["dc.identifier.issn","0899-1987"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110280"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.issn","0899-1987"],["dc.title","Novel genetic variants in the P38MAPK pathway gene ZAK and susceptibility to lung cancer"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","npj Precision Oncology"],["dc.bibliographiccitation.volume","6"],["dc.contributor.author","Yang, Wenjun"],["dc.contributor.author","Liu, Hongliang"],["dc.contributor.author","Zhang, Ruoxin"],["dc.contributor.author","Freedman, Jennifer A."],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Brhane, Yonathan"],["dc.contributor.author","McLaughlin, John"],["dc.contributor.author","Brennan, Paul"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Wei, Qingyi"],["dc.date.accessioned","2022-09-01T09:50:09Z"],["dc.date.available","2022-09-01T09:50:09Z"],["dc.date.issued","2022"],["dc.description.abstract","Abstract\n \n Limited efforts have been made in assessing the effect of genome-wide profiling of RNA splicing-related variation on lung cancer risk. In the present study, we first identified RNA splicing-related genetic variants linked to lung cancer in a genome-wide profiling analysis and then conducted a two-stage (discovery and replication) association study in populations of European ancestry. Discovery and validation were conducted sequentially with a total of 29,266 cases and 56,450 controls from both the Transdisciplinary Research in Cancer of the Lung and the International Lung Cancer Consortium as well as the OncoArray database. For those variants identified as significant in the two datasets, we further performed stratified analyses by smoking status and histological type and investigated their effects on gene expression and potential regulatory mechanisms. We identified three genetic variants significantly associated with lung cancer risk: rs329118 in\n JADE2\n (\n P\n  = 8.80E−09), rs2285521 in\n GGA2\n (\n P\n  = 4.43E−08), and rs198459 in\n MYRF\n (\n P\n  = 1.60E−06). The combined effects of all three SNPs were more evident in lung squamous cell carcinomas (\n P\n  = 1.81E−08,\n P\n  = 6.21E−08, and\n P\n  = 7.93E−04, respectively) than in lung adenocarcinomas and in ever smokers (\n P\n  = 9.80E−05,\n P\n  = 2.70E−04, and\n P\n  = 2.90E−05, respectively) than in never smokers. Gene expression quantitative trait analysis suggested a role for the SNPs in regulating transcriptional expression of the corresponding target genes. In conclusion, we report that three RNA splicing-related genetic variants contribute to lung cancer susceptibility in European populations. However, additional validation is needed, and specific splicing mechanisms of the target genes underlying the observed associations also warrants further exploration."],["dc.description.sponsorship"," National Natural Science Foundation of China https://doi.org/10.13039/501100001809"],["dc.description.sponsorship"," Foundation for the National Institutes of Health https://doi.org/10.13039/100000009"],["dc.identifier.doi","10.1038/s41698-022-00281-9"],["dc.identifier.pii","281"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/113632"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-597"],["dc.relation.eissn","2397-768X"],["dc.rights.uri","https://creativecommons.org/licenses/by/4.0"],["dc.title","Deciphering associations between three RNA splicing-related genetic variants and lung cancer risk"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1227"],["dc.bibliographiccitation.issue","10"],["dc.bibliographiccitation.journal","Transplantation Journal"],["dc.bibliographiccitation.lastpage","1228"],["dc.bibliographiccitation.volume","88"],["dc.contributor.author","Ludajic, Katarina"],["dc.contributor.author","Rosenmayr, Agathe"],["dc.contributor.author","Fae, I."],["dc.contributor.author","Fischer, Gottfried F."],["dc.contributor.author","Balavarca, Yesilda"],["dc.contributor.author","Bickeboeller, Heike"],["dc.contributor.author","Kalhs, Peter"],["dc.contributor.author","Greinix, Hildegard T."],["dc.date.accessioned","2018-11-07T11:21:50Z"],["dc.date.available","2018-11-07T11:21:50Z"],["dc.date.issued","2009"],["dc.identifier.doi","10.1097/TP.0b013e3181bbb8fe"],["dc.identifier.isi","000272223200013"],["dc.identifier.pmid","19935378"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/55876"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.relation.issn","0041-1337"],["dc.title","Association of HLA-E Polymorphism With the Outcome of Hematopoietic Stem-Cell Transplantation With Unrelated Donors"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","577"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.lastpage","582"],["dc.bibliographiccitation.volume","12"],["dc.contributor.author","Bickeböller, H."],["dc.contributor.author","Margaritte-Jeannin, P."],["dc.contributor.author","Babron, M.-C."],["dc.contributor.author","Clerget-Darpoux, F."],["dc.date.accessioned","2022-06-08T07:57:38Z"],["dc.date.available","2022-06-08T07:57:38Z"],["dc.date.issued","2005"],["dc.identifier.doi","10.1002/gepi.1370120609"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/110158"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-575"],["dc.relation.issn","0741-0395"],["dc.title","Systematic search of susceptibility loci with methods using gametic disequilibrium"],["dc.title.alternative","Application of Gametic Disequilibrium Tests"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Genetic Epidemiology"],["dc.bibliographiccitation.volume","36"],["dc.contributor.author","Sohns, Melanie"],["dc.contributor.author","Viktorova, Elena"],["dc.contributor.author","Fehringer, Gord"],["dc.contributor.author","Gaborieau, Valerie"],["dc.contributor.author","Han, Younghun"],["dc.contributor.author","Chang-Claude, Jenny"],["dc.contributor.author","Heinrich, Joachim"],["dc.contributor.author","Risch, Angela"],["dc.contributor.author","Amos, Christopher I."],["dc.contributor.author","Brennan, P. C."],["dc.contributor.author","Hung, Rayjean J."],["dc.contributor.author","Bickeboeller, Heike"],["dc.date.accessioned","2018-11-07T09:04:08Z"],["dc.date.available","2018-11-07T09:04:08Z"],["dc.date.issued","2012"],["dc.format.extent","756"],["dc.identifier.isi","000309913200133"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/25044"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.conference","Annual Meeting of the International-Genetic-Epidemiology-Society (IGES)"],["dc.relation.eventlocation","Stevenson, WA"],["dc.relation.issn","0741-0395"],["dc.title","Application of the Empirical Hierarchical Bayes Approach for Gene-Environment Interaction to TRICL Lung Cancer GWAS"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]