Hellriegel, Simin

[["dc.bibliographiccitation.firstpage","1107"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","British Journal of Dermatology"],["dc.bibliographiccitation.lastpage","1109"],["dc.bibliographiccitation.volume","164"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Krone, Bernd"],["dc.contributor.author","Beckmann, I."],["dc.contributor.author","Ritter, K."],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:56:30Z"],["dc.date.available","2018-11-07T08:56:30Z"],["dc.date.issued","2011"],["dc.description.abstract","P>Background Infantile haemangioma (IH) is a tumour of the microvasculature composed predominantly of proliferating endothelial cells. It expresses markers associated with endothelial, haematopoietic and mesenchymal lineages. We have previously shown that the cells forming the capillary endothelium of proliferating IH express cell surface markers and transcriptions factors consistent with it being a haemogenic endothelium. Objectives We wished to determine whether the expression of transcription factors associated with the erythroid lineage was of physiological relevance and sufficient for IH tissue cultured in vitro to undergo erythropoiesis. Methods Immunohistochemical staining of paraffin-embedded sections of proliferating IHs was undertaken and expression of the embryonically associated haemoglobin zeta (HBZ) chain and the erythropoietin receptor (EPO-R) was determined. Relative expression of mRNA encoding these proteins was determined by quantitative reverse transcription-polymerase chain reaction using snap-frozen biopsy samples. Differentiation towards erythrocytes was investigated using freshly resected tissue cultured as explants in Matrigel. Results The endothelium of the microvessels, but not the pericyte layer, was strongly immunoreactive for the EPO-R and the embryonically associated HBZ chain. Abundant expression of transcripts encoding these proteins was also detected, corroborating the immunohistochemical staining. When tissue was grown in culture the cells emanating from IH explants were able to generate enucleated erythrocytes in vitro. The erythrocytes were immunoreactive for the erythrocyte-specific marker glycophorin A. Conclusions The microvessels in IH are a functional haemogenic endothelium that expresses the embryonically associated HBZ chain and is able to form erythrocytes in vitro. IH thus represents a possible extramedullary site for tumour-associated primitive erythropoiesis."],["dc.identifier.doi","10.1111/j.1365-2133.2010.10188.x"],["dc.identifier.isi","000289898200028"],["dc.identifier.pmid","21166659"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23170"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0007-0963"],["dc.title","Successful treatment of classic kaposi sarcoma with low-dose intramuscular immunoglobulins"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Krone, Bernd"],["dc.contributor.author","Beckmann, I."],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:39:47Z"],["dc.date.available","2018-11-07T08:39:47Z"],["dc.date.issued","2010"],["dc.format.extent","758"],["dc.identifier.isi","000281219100079"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19082"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","1610-0379"],["dc.title","Succesful Treatment of a classic Kaposi's Sarcoma with low-dose intramuscular Immunoglobulin"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","13"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Brehmer, Franziska"],["dc.contributor.author","Baltzer, Anne"],["dc.contributor.author","Al Ghazal, Philipp"],["dc.contributor.author","Thoms, Kai Martin"],["dc.date.accessioned","2018-11-07T09:53:40Z"],["dc.date.available","2018-11-07T09:53:40Z"],["dc.date.issued","2015"],["dc.format.extent","13"],["dc.identifier.isi","000360219800034"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/36372"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0387"],["dc.relation.issn","1610-0379"],["dc.title","Factors with Influence on the Amount of Fuid Drainage after radical Lymphadenectomy in Melanoma"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","120"],["dc.bibliographiccitation.issue","3"],["dc.bibliographiccitation.journal","Lymphology"],["dc.bibliographiccitation.lastpage","130"],["dc.bibliographiccitation.volume","50"],["dc.contributor.author","Kretschmer, L."],["dc.contributor.author","Hellriegel, S."],["dc.contributor.author","Thoms, K. M."],["dc.contributor.author","Schon, M. P."],["dc.contributor.author","Al Ghazal, P."],["dc.contributor.author","Zapf, A."],["dc.date.accessioned","2019-01-29T10:49:53Z"],["dc.date.available","2019-01-29T10:49:53Z"],["dc.date.issued","2017"],["dc.description.abstract","Lymphedema (LE) following lymph node dissection is a major problem for cancer patients, and radiation therapy, extended surgery, groin dissection, obesity, and older age are well-established risk factors of LE. We studied whether these risk factors are further associated with high volumes of postoperative drainage fluid after complete lymph node dissection (CLND) for melanoma metastases. Moreover, we examined whether a high amount of drainage fluid after sentinel lymph node biopsy (SLNB) can predict a high amount of drainage fluid after subsequent CLND. Using descriptive statistics and regression analyses, we analyzed the cumulative volumes of postoperative drainage fluid for 836 melanoma patients with lymph node excision in the axilla or groin. In multiple regression analyses, the well-established risk factors of LE, i.e., increased body mass index, older age, and ilioinguinal versus inguinal versus axillary dissection predicted a high drainage volume after CLND. Of note, a high drainage fluid volume after SLNB also predicted a high drainage volume after subsequent CLND. In patients with groin dissections, who are particularly susceptible to swelling, extended iliac dissection, age above 60, and a cumulative drainage volume of more than 100 ml in the preceding SLNB were predictors of the cumulative drainage volume. We find that common risk factors predict the volume of postoperative drainage fluid after CLND and postoperative LE. Further, high postoperative drainage volume may therefore function as a potential early predictor of LE following CLND."],["dc.identifier.pmid","30234248"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57419"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.eissn","2522-7963"],["dc.title","The volume of postoperative drainage fluid as a potential early predictor of lymphedema after lymph node excision for metastatic melanoma"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","360"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Nuclear Medicine and Molecular Imaging"],["dc.bibliographiccitation.lastpage","361"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Bertsch, Hans Peter"],["dc.contributor.author","Bardzik, Pawel"],["dc.contributor.author","Meller, Johannes"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Schön, Michael Peter"],["dc.contributor.author","Sahlmann, Carsten Oliver"],["dc.date.accessioned","2021-06-01T10:49:07Z"],["dc.date.available","2021-06-01T10:49:07Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1007/s00259-014-2968-3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86177"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1619-7089"],["dc.relation.iserratumof","/handle/2/38030"],["dc.relation.issn","1619-7070"],["dc.title","Erratum to: The impact of nodal tumour burden on lymphoscintigraphic imaging in patients with melanomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","221"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Plastic Surgery and Hand Surgery"],["dc.bibliographiccitation.lastpage","226"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Cevik, Naciye"],["dc.contributor.author","Hartmann, Franziska"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Schön, Michael P."],["dc.date.accessioned","2020-12-10T18:15:29Z"],["dc.date.available","2020-12-10T18:15:29Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1080/2000656X.2019.1582427"],["dc.identifier.eissn","2000-6764"],["dc.identifier.issn","2000-656X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74859"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Axillary sentinel node biopsy in prone position for melanomas on the upper back or nape"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","360"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Nuclear Medicine and Molecular Imaging"],["dc.bibliographiccitation.lastpage","361"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Bertsch, Hans Peter"],["dc.contributor.author","Bardzik, Pawel"],["dc.contributor.author","Meller, Johannes"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Sahlmann, Carsten Oliver"],["dc.date.accessioned","2018-11-07T10:01:29Z"],["dc.date.available","2018-11-07T10:01:29Z"],["dc.date.issued","2015"],["dc.identifier.isi","000349367800021"],["dc.identifier.pmid","25492805"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38030"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.haserratum","/handle/2/86177"],["dc.relation.issn","1619-7089"],["dc.relation.issn","1619-7070"],["dc.title","The impact of nodal tumour burden on lymphoscintigraphic imaging in patients with melanomas (vol 42, pg 231, 2015)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]