Hellriegel, Simin

[["dc.bibliographiccitation.firstpage","1107"],["dc.bibliographiccitation.issue","5"],["dc.bibliographiccitation.journal","British Journal of Dermatology"],["dc.bibliographiccitation.lastpage","1109"],["dc.bibliographiccitation.volume","164"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Krone, Bernd"],["dc.contributor.author","Beckmann, I."],["dc.contributor.author","Ritter, K."],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:56:30Z"],["dc.date.available","2018-11-07T08:56:30Z"],["dc.date.issued","2011"],["dc.description.abstract","P>Background Infantile haemangioma (IH) is a tumour of the microvasculature composed predominantly of proliferating endothelial cells. It expresses markers associated with endothelial, haematopoietic and mesenchymal lineages. We have previously shown that the cells forming the capillary endothelium of proliferating IH express cell surface markers and transcriptions factors consistent with it being a haemogenic endothelium. Objectives We wished to determine whether the expression of transcription factors associated with the erythroid lineage was of physiological relevance and sufficient for IH tissue cultured in vitro to undergo erythropoiesis. Methods Immunohistochemical staining of paraffin-embedded sections of proliferating IHs was undertaken and expression of the embryonically associated haemoglobin zeta (HBZ) chain and the erythropoietin receptor (EPO-R) was determined. Relative expression of mRNA encoding these proteins was determined by quantitative reverse transcription-polymerase chain reaction using snap-frozen biopsy samples. Differentiation towards erythrocytes was investigated using freshly resected tissue cultured as explants in Matrigel. Results The endothelium of the microvessels, but not the pericyte layer, was strongly immunoreactive for the EPO-R and the embryonically associated HBZ chain. Abundant expression of transcripts encoding these proteins was also detected, corroborating the immunohistochemical staining. When tissue was grown in culture the cells emanating from IH explants were able to generate enucleated erythrocytes in vitro. The erythrocytes were immunoreactive for the erythrocyte-specific marker glycophorin A. Conclusions The microvessels in IH are a functional haemogenic endothelium that expresses the embryonically associated HBZ chain and is able to form erythrocytes in vitro. IH thus represents a possible extramedullary site for tumour-associated primitive erythropoiesis."],["dc.identifier.doi","10.1111/j.1365-2133.2010.10188.x"],["dc.identifier.isi","000289898200028"],["dc.identifier.pmid","21166659"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/23170"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.relation.issn","0007-0963"],["dc.title","Successful treatment of classic kaposi sarcoma with low-dose intramuscular immunoglobulins"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.volume","8"],["dc.contributor.author","Thoms, Kai Martin"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Krone, Bernd"],["dc.contributor.author","Beckmann, I."],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Kretschmer, Lutz"],["dc.date.accessioned","2018-11-07T08:39:47Z"],["dc.date.available","2018-11-07T08:39:47Z"],["dc.date.issued","2010"],["dc.format.extent","758"],["dc.identifier.isi","000281219100079"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/19082"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Malden"],["dc.relation.issn","1610-0379"],["dc.title","Succesful Treatment of a classic Kaposi's Sarcoma with low-dose intramuscular Immunoglobulin"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","925"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","JDDG Journal der Deutschen Dermatologischen Gesellschaft"],["dc.bibliographiccitation.lastpage","926"],["dc.bibliographiccitation.volume","11"],["dc.contributor.author","Hoffmann, S."],["dc.contributor.author","Buhl, Timo"],["dc.contributor.author","Holzkamp, R."],["dc.contributor.author","Samhaber, Kinga T."],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Jantke, M."],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.date.accessioned","2018-11-07T09:20:49Z"],["dc.date.available","2018-11-07T09:20:49Z"],["dc.date.issued","2013"],["dc.identifier.isi","000323202300078"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28964"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1610-0379"],["dc.title","Results of a prospective Study comprising Interviews and clinical Examination: Multiple atypical Naevi allow for a significantly improved early Diagnosis of Melanoma"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","Modern Pathology"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Mitteldorf, Christina"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Leha, Andreas"],["dc.contributor.author","Fichtner, Alexander"],["dc.contributor.author","Ströbel, Philipp"],["dc.contributor.author","Schön, Michael P."],["dc.contributor.author","Bremmer, Felix"],["dc.date.accessioned","2021-07-05T15:00:28Z"],["dc.date.available","2021-07-05T15:00:28Z"],["dc.date.issued","2021"],["dc.description.abstract","Abstract Sentinel lymph node (SN) tumor burden is becoming increasingly important and is likely to be included in future N classifications in melanoma. Our aim was to investigate the prognostic significance of melanoma infiltration of various anatomically defined lymph node substructures. This retrospective cohort study included 1250 consecutive patients with SN biopsy. The pathology protocol required description of metastatic infiltration of each of the following lymph node substructures: intracapsular lymph vessels, subcapsular and transverse sinuses, cortex, paracortex, medulla, and capsule. Within the SN with the highest tumor burden, the SN invasion level (SNIL) was defined as follows: SNIL 1 = melanoma cells confined to intracapsular lymph vessels, subcapsular or transverse sinuses; SNIL 2 = melanoma infiltrating the cortex or paracortex; SNIL 3 = melanoma infiltrating the medulla or capsule. We classified 338 SN-positive patients according to the non-metric SNIL. Using Kaplan–Meier estimates and Cox models, recurrence-free survival (RFS), melanoma-specific survival (MSS) and nodal basin recurrence rates were analyzed. The median follow-up time was 75 months. The SNIL divided the SN-positive population into three groups with significantly different RFS, MSS, and nodal basin recurrence probabilities. The MSS of patients with SNIL 1 was virtually identical to that of SN-negative patients, whereas outgrowth of the metastasis from the parenchyma into the fibrous capsule or the medulla of the lymph node indicated a very poor prognosis. Thus, the SNIL may help to better assess the benefit-risk ratio of adjuvant therapies in patients with different SN metastasis patterns."],["dc.description.abstract","Abstract Sentinel lymph node (SN) tumor burden is becoming increasingly important and is likely to be included in future N classifications in melanoma. Our aim was to investigate the prognostic significance of melanoma infiltration of various anatomically defined lymph node substructures. This retrospective cohort study included 1250 consecutive patients with SN biopsy. The pathology protocol required description of metastatic infiltration of each of the following lymph node substructures: intracapsular lymph vessels, subcapsular and transverse sinuses, cortex, paracortex, medulla, and capsule. Within the SN with the highest tumor burden, the SN invasion level (SNIL) was defined as follows: SNIL 1 = melanoma cells confined to intracapsular lymph vessels, subcapsular or transverse sinuses; SNIL 2 = melanoma infiltrating the cortex or paracortex; SNIL 3 = melanoma infiltrating the medulla or capsule. We classified 338 SN-positive patients according to the non-metric SNIL. Using Kaplan–Meier estimates and Cox models, recurrence-free survival (RFS), melanoma-specific survival (MSS) and nodal basin recurrence rates were analyzed. The median follow-up time was 75 months. The SNIL divided the SN-positive population into three groups with significantly different RFS, MSS, and nodal basin recurrence probabilities. The MSS of patients with SNIL 1 was virtually identical to that of SN-negative patients, whereas outgrowth of the metastasis from the parenchyma into the fibrous capsule or the medulla of the lymph node indicated a very poor prognosis. Thus, the SNIL may help to better assess the benefit-risk ratio of adjuvant therapies in patients with different SN metastasis patterns."],["dc.identifier.doi","10.1038/s41379-021-00835-5"],["dc.identifier.pii","835"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/87832"],["dc.language.iso","en"],["dc.notes.intern","DOI Import DOI-Import GROB-441"],["dc.relation.eissn","1530-0285"],["dc.relation.issn","0893-3952"],["dc.title","The sentinel node invasion level (SNIL) as a prognostic parameter in melanoma"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","360"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Nuclear Medicine and Molecular Imaging"],["dc.bibliographiccitation.lastpage","361"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Bertsch, Hans Peter"],["dc.contributor.author","Bardzik, Pawel"],["dc.contributor.author","Meller, Johannes"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Schön, Michael Peter"],["dc.contributor.author","Sahlmann, Carsten Oliver"],["dc.date.accessioned","2021-06-01T10:49:07Z"],["dc.date.available","2021-06-01T10:49:07Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1007/s00259-014-2968-3"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86177"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.eissn","1619-7089"],["dc.relation.iserratumof","/handle/2/38030"],["dc.relation.issn","1619-7070"],["dc.title","Erratum to: The impact of nodal tumour burden on lymphoscintigraphic imaging in patients with melanomas"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","erratum_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","785"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","JAMA Dermatology"],["dc.bibliographiccitation.lastpage","787"],["dc.bibliographiccitation.volume","150"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Bertsch, Hans-Peter"],["dc.contributor.author","Emmert, Steffen"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Haenssle, Holger Andreas"],["dc.date.accessioned","2018-11-07T09:38:04Z"],["dc.date.available","2018-11-07T09:38:04Z"],["dc.date.issued","2014"],["dc.identifier.doi","10.1001/jamadermatol.2013.8635"],["dc.identifier.isi","000339652400029"],["dc.identifier.pmid","24740398"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/32983"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Amer Medical Assoc"],["dc.relation.issn","2168-6084"],["dc.relation.issn","2168-6068"],["dc.title","Elastosis Perforans Serpiginosa: A Case of a Penicillamine-Induced Degenerative Dermatosis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dc.type.subtype","letter_note"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","221"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Journal of Plastic Surgery and Hand Surgery"],["dc.bibliographiccitation.lastpage","226"],["dc.bibliographiccitation.volume","53"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Cevik, Naciye"],["dc.contributor.author","Hartmann, Franziska"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Schön, Michael P."],["dc.date.accessioned","2020-12-10T18:15:29Z"],["dc.date.available","2020-12-10T18:15:29Z"],["dc.date.issued","2019"],["dc.identifier.doi","10.1080/2000656X.2019.1582427"],["dc.identifier.eissn","2000-6764"],["dc.identifier.issn","2000-656X"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/74859"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.title","Axillary sentinel node biopsy in prone position for melanomas on the upper back or nape"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","360"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","European Journal of Nuclear Medicine and Molecular Imaging"],["dc.bibliographiccitation.lastpage","361"],["dc.bibliographiccitation.volume","42"],["dc.contributor.author","Kretschmer, Lutz"],["dc.contributor.author","Bertsch, Hans Peter"],["dc.contributor.author","Bardzik, Pawel"],["dc.contributor.author","Meller, Johannes"],["dc.contributor.author","Hellriegel, Simin"],["dc.contributor.author","Thoms, Kai-Martin"],["dc.contributor.author","Schoen, Michael Peter"],["dc.contributor.author","Sahlmann, Carsten Oliver"],["dc.date.accessioned","2018-11-07T10:01:29Z"],["dc.date.available","2018-11-07T10:01:29Z"],["dc.date.issued","2015"],["dc.identifier.isi","000349367800021"],["dc.identifier.pmid","25492805"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/38030"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Springer"],["dc.relation.haserratum","/handle/2/86177"],["dc.relation.issn","1619-7089"],["dc.relation.issn","1619-7070"],["dc.title","The impact of nodal tumour burden on lymphoscintigraphic imaging in patients with melanomas (vol 42, pg 231, 2015)"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]