Zelarayan, Laura Cecilia

[["dc.bibliographiccitation.artnumber","P4479"],["dc.bibliographiccitation.firstpage","937"],["dc.bibliographiccitation.issue","suppl_1"],["dc.bibliographiccitation.journal","European Heart Journal"],["dc.bibliographiccitation.volume","38"],["dc.contributor.author","Iyer, L. M."],["dc.contributor.author","Noack, C."],["dc.contributor.author","Nagarajan, S."],["dc.contributor.author","Woelfer, M."],["dc.contributor.author","Schoger, E."],["dc.contributor.author","Pang, S. T."],["dc.contributor.author","Kari, V."],["dc.contributor.author","Zafeiriou, M. P."],["dc.contributor.author","Toischer, K."],["dc.contributor.author","Hasenfuss, G."],["dc.contributor.author","Johnsen, S. A."],["dc.contributor.author","Zelarayan, L. C."],["dc.date.accessioned","2019-02-19T13:47:43Z"],["dc.date.available","2019-02-19T13:47:43Z"],["dc.date.issued","2017"],["dc.identifier.doi","10.1093/eurheartj/ehx504.P4479"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/57586"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/177"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C07: Kardiomyozyten Wnt/β-catenin Komplex Aktivität im pathologischen Herz-Remodeling - als gewebespezifischer therapeutischer Ansatz"],["dc.relation.issn","0195-668X"],["dc.relation.workinggroup","RG Hasenfuß (Transition zur Herzinsuffizienz)"],["dc.relation.workinggroup","RG Toischer (Kardiales Remodeling)"],["dc.relation.workinggroup","RG Zelarayán-Behrend (Developmental Pharmacology)"],["dc.title","B-catenin/TCF7L2 signaling orchestrates initiation of pathological hypertrophic cardiac remodeling by inducing chromatin modifications"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","361"],["dc.bibliographiccitation.issue","6"],["dc.bibliographiccitation.journal","Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],["dc.bibliographiccitation.lastpage","369"],["dc.bibliographiccitation.volume","1811"],["dc.contributor.author","Zafiriou, Maria-Patapia"],["dc.contributor.author","Zelarayan, Laura Cecilia"],["dc.contributor.author","Noack, Claudia"],["dc.contributor.author","Renger, Anke"],["dc.contributor.author","Nigam, Santosh"],["dc.contributor.author","Siafaka-Kapadai, Athanassia"],["dc.date.accessioned","2018-11-07T08:55:31Z"],["dc.date.available","2018-11-07T08:55:31Z"],["dc.date.issued","2011"],["dc.description.abstract","Pancreatic beta-cells have a deficit of scavenging enzymes such as catalase (Cat) and glutathione peroxidase (GPx) and therefore are susceptible to oxidative stress and apoptosis. Our previous work showed that, in the absence of cytosolic GPx in insulinoma RINm5F cells, an intrinsic activity of 12 lipoxygenase (12(S)-LOX) converts 12S-hydroperoxyeicosatetraenoic acid (12(S)-HpETE) to the bioactive epoxide hepoxilin A(3) (HXA(3)). The aim of the present study was to investigate the effect of HXA(3) on apoptosis as compared to its precursor 12(S)-HpETE and shed light upon the underlying pathways. In contrast to 12(S)-HpETE, which induced apoptosis via the extrinsic pathway, we found HXA(3) not only to prevent it but also to promote cell proliferation. In particular, HXA3 suppressed the pro-apoptotic BAX and upregulated the anti-apoptotic Bcl-2. Moreover, HXA(3) induced the anti-apoptotic 12(S)-LOX by recruiting heat shock protein 90 (HSP90), another anti-apoptotic protein. Finally, a co-chaperone protein of HSP90, protein phosphatase 5 (PP5), was upregulated by HXA(3), which counteracted oxidative stress-induced apoptosis by dephosphorylating and thus inactivating apoptosis signal-regulating kinase 1 (ASK1). Taken together, these findings suggest that HXA(3) protects insulinoma cells from oxidative stress and, via multiple signaling pathways, prevents them from undergoing apoptosis. (C) 2011 Elsevier B.V. All rights reserved."],["dc.description.sponsorship","Deutsche Forschungsgemeinschaft, Bonn [Ni242/27-1]"],["dc.identifier.doi","10.1016/j.bbalip.2011.03.002"],["dc.identifier.isi","000291192600001"],["dc.identifier.pmid","21420506"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/22928"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Elsevier Science Bv"],["dc.relation.issn","1388-1981"],["dc.title","Hepoxilin A(3) protects beta-cells from apoptosis in contrast to its precursor, 12-hydroperoxyeicosatetraenoic acid"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","S1"],["dc.bibliographiccitation.journal","The FASEB Journal"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Kararigas, Georgios"],["dc.contributor.author","Zelarayan, Laura"],["dc.contributor.author","Toischer, Karl"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Jarry, Hubertus"],["dc.contributor.author","Regitz‐Zagrosek, Vera"],["dc.date.accessioned","2021-12-08T12:27:38Z"],["dc.date.available","2021-12-08T12:27:38Z"],["dc.date.issued","2015"],["dc.identifier.doi","10.1096/fasebj.29.1_supplement.966.1"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/95409"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-476"],["dc.relation.eissn","1530-6860"],["dc.relation.issn","0892-6638"],["dc.rights.uri","http://onlinelibrary.wiley.com/termsAndConditions#vor"],["dc.title","In C57Bl/6N Female Mice 17β‐Estradiol Leads to Cardiac Mass and Function Loss via a β‐Catenin Mechanism"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1537"],["dc.bibliographiccitation.issue","6562"],["dc.bibliographiccitation.journal","Science"],["dc.bibliographiccitation.lastpage","1540"],["dc.bibliographiccitation.volume","373"],["dc.contributor.author","Chen, Yanpu"],["dc.contributor.author","Lüttmann, Felipe F."],["dc.contributor.author","Schoger, Eric"],["dc.contributor.author","Schöler, Hans R."],["dc.contributor.author","Zelarayán, Laura C."],["dc.contributor.author","Kim, Kee-Pyo"],["dc.contributor.author","Haigh, Jody J."],["dc.contributor.author","Kim, Johnny"],["dc.contributor.author","Braun, Thomas"],["dc.date.accessioned","2021-10-01T09:58:23Z"],["dc.date.available","2021-10-01T09:58:23Z"],["dc.date.issued","2021"],["dc.identifier.doi","10.1126/science.abg5159"],["dc.identifier.pmid","34554778"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/90052"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/404"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-469"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C07: Kardiomyozyten Wnt/β-catenin Komplex Aktivität im pathologischen Herz-Remodeling - als gewebespezifischer therapeutischer Ansatz"],["dc.relation.eissn","1095-9203"],["dc.relation.issn","0036-8075"],["dc.relation.workinggroup","RG Zelarayán-Behrend (Developmental Pharmacology)"],["dc.title","Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.issue","21"],["dc.bibliographiccitation.journal","Circulation"],["dc.bibliographiccitation.volume","124"],["dc.contributor.author","Noack, Claudia"],["dc.contributor.author","Renger, Anke"],["dc.contributor.author","Zafiriou, Maria-Patapia"],["dc.contributor.author","Dietz, Rainer"],["dc.contributor.author","Schaeffer, Hans-Joerg"],["dc.contributor.author","Bergmann, Martin"],["dc.contributor.author","Zelarayan, Laura"],["dc.date.accessioned","2018-11-07T08:49:44Z"],["dc.date.available","2018-11-07T08:49:44Z"],["dc.date.issued","2011"],["dc.identifier.isi","000299738706353"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/21532"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Lippincott Williams & Wilkins"],["dc.publisher.place","Philadelphia"],["dc.relation.issn","0009-7322"],["dc.title","Interaction of Krueppel-Like Factor (klf) 15 and Wnt-Signaling Pathway and its Role in Adult Cardiac Precursor Cell Regulation"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","European Journal of Heart Failure"],["dc.bibliographiccitation.volume","17"],["dc.contributor.author","Kararigas, Georgios"],["dc.contributor.author","Zelarayan, Laura Cecilia"],["dc.contributor.author","Toischer, Karl"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Jarry, Hubertus"],["dc.contributor.author","Regitz-Zagrosek, Vera"],["dc.date.accessioned","2018-11-07T09:57:25Z"],["dc.date.available","2018-11-07T09:57:25Z"],["dc.date.issued","2015"],["dc.format.extent","247"],["dc.identifier.isi","000366200402401"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37151"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-blackwell"],["dc.publisher.place","Hoboken"],["dc.relation.issn","1879-0844"],["dc.relation.issn","1388-9842"],["dc.title","Loss of cardiac mass and function induced by 17beta-oestradiol via a beta-catenin mechanism in C57Bl/6N female mice"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.journal","The FASEB Journal"],["dc.bibliographiccitation.volume","29"],["dc.contributor.author","Kararigas, Georgios"],["dc.contributor.author","Zelarayan, Laura"],["dc.contributor.author","Toischer, Karl"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Jarry, Hubertus"],["dc.contributor.author","Regitz-Zagrosek, Vera"],["dc.date.accessioned","2018-11-07T09:58:41Z"],["dc.date.available","2018-11-07T09:58:41Z"],["dc.date.issued","2015"],["dc.identifier.isi","000361722706441"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/37416"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Federation Amer Soc Exp Biol"],["dc.publisher.place","Bethesda"],["dc.relation.eventlocation","Boston, MA"],["dc.relation.issn","1530-6860"],["dc.relation.issn","0892-6638"],["dc.title","In C57Bl/6N Female Mice 17 beta-Estradiol Leads to Cardiac Mass and Function Loss via a beta-Catenin Mechanism"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","6"],["dc.bibliographiccitation.issue","1"],["dc.bibliographiccitation.journal","Circulation Research"],["dc.bibliographiccitation.lastpage","24"],["dc.bibliographiccitation.volume","126"],["dc.contributor.author","Schoger, Eric"],["dc.contributor.author","Carroll, Kelli J."],["dc.contributor.author","Iyer, Lavanya M."],["dc.contributor.author","McAnally, John R."],["dc.contributor.author","Tan, Wei"],["dc.contributor.author","Liu, Ning"],["dc.contributor.author","Noack, Claudia"],["dc.contributor.author","Shomroni, Orr"],["dc.contributor.author","Salinas, Gabriela"],["dc.contributor.author","Groß, Julia"],["dc.contributor.author","Herzog, Nicole"],["dc.contributor.author","Doroudgar, Shirin"],["dc.contributor.author","Bassel-Duby, Rhonda"],["dc.contributor.author","Zimmermann, Wolfram-H."],["dc.contributor.author","Zelarayán, Laura C."],["dc.date.accessioned","2020-12-10T18:38:00Z"],["dc.date.available","2020-12-10T18:38:00Z"],["dc.date.issued","2020"],["dc.identifier.doi","10.1161/CIRCRESAHA.118.314522"],["dc.identifier.pmid","31730408"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/77162"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/332"],["dc.language.iso","en"],["dc.notes.intern","DOI Import GROB-354"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | C04: Fibroblasten-Kardiomyozyten Interaktion im gesunden und erkrankten Herzen: Mechanismen und therapeutische Interventionen bei Kardiofibroblastopathien"],["dc.relation","SFB 1002 | C07: Kardiomyozyten Wnt/β-catenin Komplex Aktivität im pathologischen Herz-Remodeling - als gewebespezifischer therapeutischer Ansatz"],["dc.relation","SFB 1002 | S01: In vivo und in vitro Krankheitsmodelle"],["dc.relation.workinggroup","RG Zelarayán-Behrend (Developmental Pharmacology)"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.title","CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","109"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Der Kardiologe"],["dc.bibliographiccitation.lastpage","114"],["dc.bibliographiccitation.volume","16"],["dc.contributor.author","Hasenfuß, Gerd P."],["dc.contributor.author","Kaul, Axel"],["dc.contributor.author","Lehnart, Stephan Elmar"],["dc.contributor.author","Linke, Wolfgang Albrecht"],["dc.contributor.author","Zelarayan, Laura Cecilia"],["dc.contributor.author","Zimmermann, Wolfram-Hubertus"],["dc.date.accessioned","2022-05-12T08:45:14Z"],["dc.date.available","2022-05-12T08:45:14Z"],["dc.date.issued","2022"],["dc.identifier.doi","10.1007/s12181-022-00540-w"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/107839"],["dc.identifier.url","https://sfb1002.med.uni-goettingen.de/production/literature/publications/423"],["dc.relation","SFB 1002: Modulatorische Einheiten bei Herzinsuffizienz"],["dc.relation","SFB 1002 | Z: Zentrale Organisation und Verwaltung"],["dc.relation.issn","1864-9718"],["dc.relation.issn","1864-9726"],["dc.relation.workinggroup","RG Hasenfuß (Transition zur Herzinsuffizienz)"],["dc.relation.workinggroup","RG Lehnart (Cellular Biophysics and Translational Cardiology Section)"],["dc.relation.workinggroup","RG Linke (Kardiovaskuläre Physiologie)"],["dc.relation.workinggroup","RG Zelarayán-Behrend (Developmental Pharmacology)"],["dc.relation.workinggroup","RG Zimmermann (Engineered Human Myocardium)"],["dc.title","Modulatorische Einheiten bei Herzinsuffizienz"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.subtype","original_ja"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2667"],["dc.bibliographiccitation.issue","7"],["dc.bibliographiccitation.journal","Endocrinology"],["dc.bibliographiccitation.lastpage","2676"],["dc.bibliographiccitation.volume","155"],["dc.contributor.author","Kararigas, Georgios"],["dc.contributor.author","Nguyen, Ba Tiep"],["dc.contributor.author","Zelarayan, Laura Cecilia"],["dc.contributor.author","Hassenpflug, Maike"],["dc.contributor.author","Toischer, Karl"],["dc.contributor.author","Sanchez-Ruderisch, Hugo"],["dc.contributor.author","Hasenfuß, Gerd"],["dc.contributor.author","Bergmann, Martin W."],["dc.contributor.author","Jarry, Hubertus"],["dc.contributor.author","Regitz-Zagrosek, Vera"],["dc.date.accessioned","2017-09-07T11:45:42Z"],["dc.date.available","2017-09-07T11:45:42Z"],["dc.date.issued","2014"],["dc.description.abstract","Estrogen regulates several biological processes in health and disease. Specifically, estrogen exerts antihypertrophic effects in the diseased heart. However, its role in the healthy heart remains elusive. Our initial aim was to identify the effects of 17 beta-estradiol (E2) on cardiac morphology and global gene expression in the healthy mouse heart. Two-month-old C57BL/6J mice were ovariectomized and treated with E2 or vehicle for 3 months. We report that E2 induced physiological hypertrophic growth in the healthy C57BL/6J mouse heart characterized by an increase in nuclear beta-catenin. Hypothesizing that beta-catenin mediates these effects of E2, we employed a model of cardiac beta-catenin deletion. Our surprising finding is that E2 had the opposite effects in wild-type littermates, which were actually on the C57BL/6N background. Notably, E2 exerted no significant effect in hearts of mice with depleted beta-catenin. We further demonstrate an E2-dependent increase in glycogen synthase kinase 3 beta (GSK3 beta) phosphorylation and endosomal markers in C57BL/6J but not C57BL/6N mice. Together, these findings indicate an E2-driven inhibition of GSK3 beta and consequent activation of beta-catenin in C57BL/6J mice, whereas the opposite occurs in C57BL/6N mice. In conclusion, E2 exerts divergent effects on postnatal cardiac growth in mice with distinct genetic backgrounds modulating members of the GSK3 beta/beta-catenin cascade."],["dc.identifier.doi","10.1210/en.2013-2180"],["dc.identifier.gro","3142091"],["dc.identifier.isi","000342343400033"],["dc.identifier.pmid","24731099"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/4444"],["dc.notes.intern","WoS Import 2017-03-10"],["dc.notes.status","final"],["dc.notes.submitter","PUB_WoS_Import"],["dc.relation.eissn","1945-7170"],["dc.relation.issn","0013-7227"],["dc.title","Genetic Background Defines the Regulation of Postnatal Cardiac Growth by 17 beta-Estradiol Through a beta-Catenin Mechanism"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.subtype","original"],["dspace.entity.type","Publication"]]