Kruse, Niels

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[["dc.bibliographiccitation.journal","Journal of Neurology"],["dc.bibliographiccitation.volume","251"],["dc.contributor.author","Bayas, A."],["dc.contributor.author","Stasiolek, Mariusz"],["dc.contributor.author","Kruse, Niels"],["dc.contributor.author","Toyka, Klaus V."],["dc.contributor.author","Selmaj, K."],["dc.contributor.author","Gold, Ralf"],["dc.date.accessioned","2018-11-07T10:48:35Z"],["dc.date.available","2018-11-07T10:48:35Z"],["dc.date.issued","2004"],["dc.format.extent","43"],["dc.identifier.isi","000222500400152"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/48231"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Dr Dietrich Steinkopff Verlag"],["dc.publisher.place","Darmstadt"],["dc.relation.conference","14th Meeting of the European-Neurological-Society"],["dc.relation.eventlocation","Barcelona, SPAIN"],["dc.relation.issn","0340-5354"],["dc.title","Altered regulatory function of plasmacytoid dendritic cells in multiple sclerosis"],["dc.type","conference_abstract"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","123"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Cellular Immunology"],["dc.bibliographiccitation.lastpage","130"],["dc.bibliographiccitation.volume","237"],["dc.contributor.author","Hofstetter, Harald H."],["dc.contributor.author","Ibrahim, S. M."],["dc.contributor.author","Koczan, D."],["dc.contributor.author","Kruse, Niels"],["dc.contributor.author","Weishaupt, Andreas"],["dc.contributor.author","Toyka, Klaus V."],["dc.contributor.author","Gold, Ralf"],["dc.date.accessioned","2018-11-07T10:55:11Z"],["dc.date.available","2018-11-07T10:55:11Z"],["dc.date.issued","2005"],["dc.description.abstract","Experimental autoimmune encephalomyelitis (EAE) is widely regarded as an animal model of the human disease multiple sclerosis. A multitude of studies has investigated the neuroantigen-specific T-cell mediated cytokine pattern present in animals with EAE. In particular, the role of the so-called Th1- and Th2-cytokines has been addressed. In a recent study.. it has been demonstrated that IL-23 rather than IL-12 is critical for modulating the character of the developing immune response towards a proinflammatory response and leading to EAE. IL-17 is a crucial effector cytokine, whose production is specifically triggered by IL-23, and it has been shown to be an essential,,g inflammatory mediator in other autoimmune diseases and inflammatory conditions. This led us to investigate the role of IL-17 in EAE. Strong antigen-specific production of IL-17 was demonstrated both in peripheral immune organs and in the CNS in acute and chronic EAE, as demonstrated by ELISPOT and RT-PCR analysis. Therapeutic neutralization of IL-17 with IL-17-receptor-Fc-protein in acute EAE ameliorated clinical symptoms. Neutralization of IL-17 with a monoclonal antibody also ameliorated the disease course. We conclude that IL-17 is crucially involved in the cytokine network as an effector cytokine in EAE. (c) 2005 Elsevier Inc. All rights reserved."],["dc.identifier.doi","10.1016/j.cellimm.2005.11.002"],["dc.identifier.isi","000235248700006"],["dc.identifier.pmid","16386239"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/49727"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc Elsevier Science"],["dc.relation.issn","0008-8749"],["dc.title","Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

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