Gruss, Peter

[["dc.bibliographiccitation.firstpage","319"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Developmental Biology"],["dc.bibliographiccitation.lastpage","328"],["dc.bibliographiccitation.volume","233"],["dc.contributor.author","Pires-daSilva, A."],["dc.contributor.author","Nayernia, K."],["dc.contributor.author","Engel, Wolfgang"],["dc.contributor.author","Torres, M."],["dc.contributor.author","Stoykova, A."],["dc.contributor.author","Chowdhury, K."],["dc.contributor.author","Gruss, P."],["dc.date.accessioned","2018-11-07T09:03:50Z"],["dc.date.available","2018-11-07T09:03:50Z"],["dc.date.issued","2001"],["dc.description.abstract","Spermatid perinuclear RNA-binding protein (SPNR) is a microtubule-associated RNA-binding protein that localizes to the manchette in developing spermatids. The Spur mRNA is expressed at high levels in testis, ovary, and brain and is present in these tissues in multiple forms. We have generated a gene trap allele of the murine Spur, named Spnr(+/GT). Spnr(GT/GT) mutants show a high rate of mortality, reduced weight, and an abnormal clutching reflex. In addition to minor anatomical abnormalities in the brain males exhibit defects in spermatogenesis that include a thin seminiferous epithelium and disorganization of spermatogenesis. Most of the sperm from mutant males display defects in the flagellum and consequently show decreased motility and transport within the oviducts. furthermore, sperm from mutant males achieve in vitro fertilization less frequently. Our findings suggest that SPNR plays an important role in normal spermatogenesis and sperm function. Thus, the Spnr(GT/GT) mutant male mouse provides a unique model for some human male infertility cases. (C) 2001 Academic Press."],["dc.identifier.doi","10.1006/dbio.2001.0169"],["dc.identifier.isi","000168931800006"],["dc.identifier.pmid","11336498"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/24978"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Academic Press Inc"],["dc.relation.issn","0012-1606"],["dc.title","Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","1121"],["dc.bibliographiccitation.issue","7148"],["dc.bibliographiccitation.journal","Nature"],["dc.bibliographiccitation.lastpage","U14"],["dc.bibliographiccitation.volume","447"],["dc.contributor.author","Fimia, Gian Maria"],["dc.contributor.author","Stoykova, Anastassia"],["dc.contributor.author","Romagnoli, Alessandra"],["dc.contributor.author","Giunta, Luigi"],["dc.contributor.author","Di Bartolomeo, Sabrina"],["dc.contributor.author","Nardacci, Roberta"],["dc.contributor.author","Corazzari, Marco"],["dc.contributor.author","Fuoco, Claudia"],["dc.contributor.author","Ucar, Ahmet"],["dc.contributor.author","Schwartz, Peter J."],["dc.contributor.author","Gruss, Peter"],["dc.contributor.author","Piacentini, Mauro"],["dc.contributor.author","Chowdhury, Kamal"],["dc.contributor.author","Cecconi, Francesco"],["dc.date.accessioned","2018-11-07T11:01:23Z"],["dc.date.available","2018-11-07T11:01:23Z"],["dc.date.issued","2007"],["dc.description.abstract","Autophagy is a self-degradative process involved both in basal turnover of cellular components and in response to nutrient starvation or organelle damage in a wide range of eukaryotes(1-3). During autophagy, portions of the cytoplasm are sequestered by double-membraned vesicles called autophagosomes, and are degraded after fusion with lysosomes for subsequent recycling(4). In vertebrates, this process acts as a pro-survival or pro-death mechanism in different physiological and pathological conditions, such as neurodegeneration and cancer(2,5-7); however, the roles of autophagy during embryonic development are still largely uncharacterized(3). Beclin1 (Becn1; coiled-coil, myosin-like BCL2-interacting protein) is a principal regulator in autophagosome formation, and its deficiency results in early embryonic lethality(8,9). Here we show that Ambra1 (activating molecule in Beclin1-regulated autophagy), a large, previously unknown protein bearing a WD40 domain at its amino terminus, regulates autophagy and has a crucial role in embryogenesis. We found that Ambra1 is a positive regulator of the Becn1-dependent programme of autophagy, as revealed by its overexpression and by RNA interference experiments in vitro. Notably, Ambra1 functional deficiency in mouse embryos leads to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic cell death. In addition to identifying a new and essential element regulating the autophagy programme, our results provide in vivo evidence supporting the existence of a complex interplay between autophagy, cell growth and cell death required for neural development in mammals."],["dc.description.sponsorship","Telethon [TCR04004]"],["dc.identifier.doi","10.1038/nature05925"],["dc.identifier.isi","000247564600039"],["dc.identifier.pmid","17589504"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/51141"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Nature Publishing Group"],["dc.relation.issn","0028-0836"],["dc.title","Ambra1 regulates autophagy and development of the nervous system"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","405"],["dc.bibliographiccitation.issue","4"],["dc.bibliographiccitation.journal","Gene Expression Patterns"],["dc.bibliographiccitation.lastpage","412"],["dc.bibliographiccitation.volume","7"],["dc.contributor.author","Chang, Yuh-Shin"],["dc.contributor.author","Stoykova, Anastassia"],["dc.contributor.author","Chowdhury, Kamal"],["dc.contributor.author","Gruss, Peter"],["dc.date.accessioned","2021-06-01T10:49:47Z"],["dc.date.available","2021-06-01T10:49:47Z"],["dc.date.issued","2007"],["dc.identifier.doi","10.1016/j.modgep.2006.11.009"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/86413"],["dc.language.iso","en"],["dc.notes.intern","DOI-Import GROB-425"],["dc.relation.issn","1567-133X"],["dc.title","Graded expression of Zfp462 in the embryonic mouse cerebral cortex"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dspace.entity.type","Publication"]]

[["dc.bibliographiccitation.firstpage","2574"],["dc.bibliographiccitation.issue","9"],["dc.bibliographiccitation.journal","Developmental Dynamics"],["dc.bibliographiccitation.lastpage","2585"],["dc.bibliographiccitation.volume","235"],["dc.contributor.author","Vogel, Tanja"],["dc.contributor.author","Stoykova, Anastassia"],["dc.contributor.author","Gruss, Peter"],["dc.date.accessioned","2018-11-07T09:18:13Z"],["dc.date.available","2018-11-07T09:18:13Z"],["dc.date.issued","2006"],["dc.description.abstract","Polycomb group (PcG) genes are regulators of body segmentation and cell growth, therefore being important players during development. PcG proteins form large complexes (PRC) that fulfil mostly repressive regulative functions on homeotic gene expression. Although expression of PcG genes in the brain has been noticed, the involvement of PcG genes in the processes of brain development is not understood. In this study, we analysed the expression patterns of PRC1 complex members to reveal PcG proteins that might be relevant for mouse brain development. Using in situ hybridisation, we show PRC1 activity in proliferative progenitor cells during neurogenesis, but also in maturated neuronal structures. PRC1 complex compositions vary in a spatial and temporal controlled manner during mouse brain development, providing cellular tools to act in different developmental contexts of cell proliferation, cell fate determination, and differentiation. Developmental Dynamics 235:2574-2585, 2006. (c) 2006 Wiley-Liss, Inc."],["dc.identifier.doi","10.1002/dvdy.20876"],["dc.identifier.isi","000240262000025"],["dc.identifier.pmid","16786585"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/28357"],["dc.notes.status","zu prüfen"],["dc.notes.submitter","Najko"],["dc.publisher","Wiley-liss"],["dc.relation.issn","1058-8388"],["dc.title","Differential expression of polycomb repression complex 1 (PRC1) members in the developing mouse brain reveals multiple complexes"],["dc.type","journal_article"],["dc.type.internalPublication","yes"],["dc.type.peerReviewed","yes"],["dc.type.status","published"],["dspace.entity.type","Publication"]]