Riechers, Claas-Christian

[["dc.bibliographiccitation.firstpage","480"],["dc.bibliographiccitation.issue","2"],["dc.bibliographiccitation.journal","Brain"],["dc.bibliographiccitation.lastpage","489"],["dc.bibliographiccitation.volume","129"],["dc.contributor.author","Sirén, Anna-Leena"],["dc.contributor.author","Radyushkin, Konstantin"],["dc.contributor.author","Boretius, Susann"],["dc.contributor.author","Kämmer, Daniel"],["dc.contributor.author","Riechers, Claas-Christian"],["dc.contributor.author","Natt, Oliver"],["dc.contributor.author","Sargin, Derya"],["dc.contributor.author","Watanabe, Takashi"],["dc.contributor.author","Sperling, Swetlana"],["dc.contributor.author","Michaelis, Thomas"],["dc.contributor.author","Price, Jack"],["dc.contributor.author","Meyer, Barbara"],["dc.contributor.author","Frahm, Jens"],["dc.contributor.author","Ehrenreich, Hannelore"],["dc.date.accessioned","2017-09-07T11:45:33Z"],["dc.date.available","2017-09-07T11:45:33Z"],["dc.date.issued","2006"],["dc.description.abstract","In humans, neurotrauma is suspected to cause brain atrophy and accelerate slowly progressive neurodegenerative disorders, such as Alzheimer's disease or schizophrenia. However, a direct link between brain injury and subsequent delayed global neurodegeneration has remained elusive. Here we show that juvenile (4-week-old) mice that are given a discrete unilateral lesion of the parietal cortex, develop to adulthood without obvious clinical symptoms. However, when monitored 3 and 9 months after lesioning, using high-resolution three-dimensional MRI and behavioural testing, the same mice display global neurodegenerative changes. Surprisingly, erythropoietin, a haematopoietic growth factor with potent neuroprotective activity, prevents behavioural abnormalities, cognitive dysfunction and brain atrophy when given for 2 weeks after acute brain injury. This demonstrates that a localized brain lesion is a primary cause of delayed global neurodegeneration that can be efficiently counteracted by neuroprotection."],["dc.identifier.doi","10.1093/brain/awh703"],["dc.identifier.doi","10.1093/brain/awh703"],["dc.identifier.gro","3150392"],["dc.identifier.uri","https://resolver.sub.uni-goettingen.de/purl?gro-2/7151"],["dc.language.iso","en"],["dc.notes.status","final"],["dc.relation.issn","0006-8950"],["dc.subject","EPO; MRI; neuroprotection; neurodegeneration; neurotrauma; schizophrenia"],["dc.title","Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin"],["dc.type","journal_article"],["dc.type.internalPublication","unknown"],["dc.type.peerReviewed","no"],["dspace.entity.type","Publication"]]